13 results about "Fructosediphosphates" patented technology

A family of sulfonyl-azole compounds are described which include small molecule activators of phosphofructokinase-1, liver isoform (PFKL). The small molecule activators selectively form covalent adducts with PFKL, including particularly lysine 677 of the human PFKL. Also provided are methods for using the small molecule activators to activate PFKL, e.g., to provide increased glycolysis and / or T cell activation, to treat cancers and / or tumors, and / or to enhance fructose-1,6-bisphosphate (FBP) content in cells.

The invention belongs to the field of medicaments, and discloses a nano-medicinal preparation capable of treating diabetes and a preparation method of the nano-medicinal preparation. The preparation method comprises the following steps: carrying out hydrothermal reaction on fructose-1, 6-strontium diphosphate, vanadium pentoxide and ergothioneine to prepare strontium-vanadate organic framework nanoparticles; the strontium-vanadate organic framework nano-particles, dopamine and polylysine are blended, embedding of polydopamine is achieved under the alkaline condition, polylysine-polydopamine co-embedded organic framework nano-particles are formed, and the nano-drug preparation for treating diabetes is obtained. The nano medicinal preparation can release the vanadyl complex and the ergothioneine and improve the blood strontium concentration and the half-life period thereof, so that the blood sugar is controlled, the symptoms of diabetes mellitus are improved, and the symptoms of osteoporosis, arteriosclerosis and the like complicated by diabetes mellitus are improved.

The invention relates to the technical field of medicine preparation, in particular to decolorizing equipment in a fructose diphosphate processing technology, which comprises a tank body and a sealing cover arranged at the top of the tank body, an activated carbon adsorption plate is arranged in the tank body, and the tank body comprises a decolorizing cavity and a concentrating cavity. The decolorizing cavity is used for accommodating a fructose sodium diphosphate solution to be decolorized and a decolorizing agent and carrying out decolorizing reaction, and when in use, the decolorizing cavity, the concentration cavity, the circulating pipeline, the spiral stirring belt and the isolation plate are arranged in the tank body and are matched with the driving part I and the driving part II to jointly complete decolorizing and concentration operations; the activated carbon adsorption plate is driven to lift and the isolation plate is driven to open and close; meanwhile, the spiral stirring belt is driven to perform unique intermittent rotation and lifting actions, so that channels between the chambers can be opened only after decoloration is completed and activated carbon is preliminarily compacted, concentration and refining are synchronously performed in the decoloration process, the color reversion phenomenon is avoided, and the chromaticity index of a final concentrated solution is ensured.

The present application relates to the technical field of oral liquid, in particular to a kind of oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow and preparation method thereof, it is characterized in that, the oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow is made of the following components, by weight parts: artemisia capillaris 200~300 parts, gardenia 150~200 parts, bupleurum 100~150 parts, polygonatum 50~100 parts, radix paeoniae alba 50~100 parts, liquorice 10~50 parts, nicotinic acid 1~10 parts, propylene glycol 200~300 parts, fructose diphosphate sodium 1~10 parts, pure water 200~400 parts.The oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow can prevent and treat ketosis, fatty liver and liver damage at the same time, comprehensively improve the constitution of new cow, improve immunity, improve physical indicators and reproductive performance, increase economic benefits.

A perfusion stock composition, for preserving a donor organ for transplantation, comprising: a source of 60 to 100 mM Na+; a source of 10 to 20 mM K+; a source of 5 to 10 mM Mg2+; a source of 0.25 to 0.75 mM Ca2+; 10 to 40 mM Tris(hydroxymethyl)aminomethane hydrochloride (Tris or THAM), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 3-(N-morpholino)propanesulfonic acid (MOPS), 2-(N-morpholino)ethanesulfonic acid (IviES), N,N-bis-(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), or N / -tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES); a source of 10 to 30 mM HCO3; 1 to 30 mM glucose; 1 to 20 U / L insulin; 1 to 10 mM fructose diphosphate or a salt thereof, 1 to 40 mM aspartate or glutamate; 1 to 10 mM adenosine, cAMP or cGMP; 1 to 10 mM reduced glutathione; and 30 to 100 mM lactobionate or mannitol; and, optionally, a diluent. The present disclosure also provides a perfusion composition, a kit, a method, and a perfusion apparatus, each related to the perfusion stock composition.

The invention relates to the technical field of fructose sodium diphosphate processing, in particular to fructose sodium diphosphate processing and impurity removing equipment, a main liquid inlet pipe and a liquid outlet pipe are designed to achieve automatic feeding and taking, after centrifugation is finished, centrifugal pipe fittings are reset under the action of gravity, square connectors can be automatically inserted into square connectors, and the centrifugal pipe fittings are automatically separated from the square connectors. Therefore, the solution backflow connecting assembly for material taking can also be automatically connected after centrifugation is finished, the whole process does not need to be operated by manually opening centrifugal equipment, and the operation is simple and convenient. An innovative square interface connecting mechanism is matched with an electromagnetically-controlled sealing assembly, so that the filtering unit is quickly disassembled and assembled, and the maintenance time is shortened. Due to the design of the detachable crystal precipitation box, the complicated pipeline dismounting process is avoided, the labor intensity of operators is greatly reduced, and the operation process is simplified. The three-stage purification system for centrifugal separation, filtration interception and precipitation collection has a synergistic effect, so that impurity particles with different particle sizes can be effectively removed, and the purification efficiency is improved.

The utility model relates to the field of pharmaceutical chemical equipment, and discloses a crystallizing tank for fructose diphosphate raw material medicine production, which comprises an outer tank, an inner tank is fixedly connected in the outer tank, a stirring mechanism is arranged in the inner tank, a sealing cover is arranged at the top of the inner tank, an exhaust mechanism is arranged at the top of the sealing cover, and the exhaust mechanism is arranged in the outer tank. The outer side of the sealing cover is fixedly connected with a feeding pipe, the bottom of the outer tank is fixedly connected with a discharging pipe and penetrates through the bottom of the inner tank, the stirring mechanism comprises a motor, the motor is fixedly connected to the middle of the sealing cover, the output end of the motor is fixedly connected with a square rod, and the outer side of the square rod is slidably connected with a sleeve. And the outer side of the sleeve is fixedly connected with a swash plate. According to the utility model, the square rod is in sliding fit with the sleeve, and the swash plate is linked with the roller structure, so that the stirring shaft reciprocates up and down, and the stirring uniformity is improved; and in combination with a scraper type anti-sticking assembly, crystals are effectively prevented from being attached to the wall, the crystallization quality is optimized, and the operation efficiency and continuity of equipment are improved.

The invention relates to the technical field of fructose sodium diphosphate production, in particular to waste liquid separation equipment in the fructose sodium diphosphate production process, and online self-cleaning of the inner wall of a carbon rod is achieved through a composite cleaning mechanism that a cleaning part is driven by high-pressure water flow. Compared with the traditional mode that the carbon rod needs to be replaced after shutdown in the background technology, the service life of the carbon rod is prolonged by more than times, the influence on the production process is reduced, and the cost is reduced. High-pressure water flow is matched with the impeller to drive the expansion part to drive the wall scraping piece to rotate, the high-pressure water flow can further push the wall scraping piece to stretch out and abut against the inner wall of the carbon rod, impurities attached to the inner wall of the carbon rod are effectively scraped away, meanwhile, the high-pressure water flow is sprayed out through the water spraying holes, and the further cleaning effect is achieved. When cleaning is needed, high-pressure water flow is conveyed to push the whole cleaning piece and the connecting pipe to move to the rightmost end of the carbon rod, and unified cleaning of the inner wall of the whole carbon rod is achieved.

The invention relates to the field of microorganisms, and discloses recombinant escherichia coli, a construction method and application thereof and a method for producing L-leucine. The recombinant escherichia coli simultaneously contains a coding gene of an overexpressed pyruvic acid transport protein, a coding gene of an overexpressed glucose transport protein and a coding gene of an overexpressed 6-phosphofructokinase, and does not contain a coding gene of fructose-1, 6-diphosphatase. The recombinant Escherichia coli provided by the invention can significantly improve the utilization rate of the raw material glucose, improve the yield of L-leucine and inhibit the generation of byproducts. In a preferred embodiment of the invention, when the recombinant escherichia coli is fermented for 20 hours in a 5L fermentation tank, the yield of L-leucine reaches 70 g / L, the saccharic acid conversion rate reaches 36%, the daily yield is remarkably increased, and the production cost is greatly saved.

A perfusion stock composition, for preserving a donor organ for transplantation, comprising: a source of 60 to 100 mM Na+; a source of 10 to 20 mM K+; a source of 5 to 10 mM Mg2+; a source of 0.25 to 0.75 mM Ca2+; 10 to 40 mM Tris(hydroxymethyl)aminomethane hydrochloride (Tris or THAM), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 3-(N-morpholino)propanesulfonic acid (MOPS), 2-(N-morpholino)ethanesulfonic acid (IviES), N,N-bis-(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), or N / -tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES); a source of 10 to 30 mM HCO3; 1 to 30 mM glucose; 1 to 20 U / L insulin; 1 to 10 mM fructose diphosphate or a salt thereof; 1 to 40 mM aspartate or glutamate; 1 to 10 mM adenosine, cAMP or cGMP; 1 to 10 mM reduced glutathione; and 30 to 100 mM lactobionate or mannitol; and, optionally, a diluent. The present disclosure also provides a perfusion composition, a kit, a method, and a perfusion apparatus, each related to the perfusion stock composition.

The utility model discloses a dilution tank with a mixing mechanism for fructose diphosphate production, which comprises a tank body, the top end of the tank body is fixedly connected with a material storage tank, the bottom end of the tank body is fixedly connected with a support column, one side of the bottom end of the tank body is fixedly connected with a discharge valve, the bottom end of the discharge valve is fixedly connected with a discharge pipe, and the discharge pipe is fixedly connected with a mixing mechanism. And one side of the top end of the tank body is fixedly connected with a pressure valve. According to the dilution tank with the mixing mechanism for fructose diphosphate production, stirring blades, a speed reducer, a driving motor, a fixed cylinder and a rotating shaft are arranged, when fructose diphosphate is diluted, after fructose diphosphate and water are added into the tank body in proportion, the driving motor is started, and the rotating shaft is driven to rotate through the speed reducer; the rotating shaft rotates and drives the stirring blades outside the rotating shaft to rotate at the same time, and the stirring blades can stir the materials, so that the mixing of the materials is accelerated, the dilution speed is improved, and the problem that the materials cannot be mixed quickly is solved.

The invention discloses a composition with multiple hypoglycemic mechanisms. The composition comprises a membrane separation balsam pear polysaccharide extract, a membrane separation balsam pear saponin extract, a mulberry leaf extract, a momordica grosvenori extract and inulin, the membrane separation balsam pear polysaccharide extract and the membrane separation balsam pear saponin extract have an inhibition effect on the key enzyme fructose-1, 6-diphosphatase in the gluconeogenesis path; the mulberry leaf extract and the inulin have an inhibition effect on a key enzyme alpha-glucosidase in a sugar absorption path; the momordica grosvenori extract and the inulin enhance the insulin sensitivity; the invention further discloses a preparation method of the composition with the multiple hypoglycemic mechanisms. According to the invention, through synergistic interaction of triple pathways for inhibiting gluconeogenesis, inhibiting sugar absorption and improving insulin sensitivity, a dual hypoglycemic mechanism of'blocking endogenous sugar generation from a source and inhibiting exogenous sugar absorption from a terminal 'is formed, and the hypoglycemic efficiency is obviously improved compared with that of a single mechanism formula.

The invention relates to the field of medicine production equipment, in particular to fructose diphosphate production filling equipment which comprises a machine table and a support fixed to one side of the top of the machine table. A driving source is fixedly installed at the top of the support, the output end of the driving source is connected with a three-way pipeline, and the three-way pipeline is provided with a liquid inlet and a liquid outlet which are formed along the same vertical axis. A piston type volume metering principle is adopted, material liquid is quantitatively extracted and discharged through the accurate stroke of the piston rod in the inverted-L-shaped transparent communicating end, and through the filling amount adjusting mechanism, on one hand, the stroke is rigidly limited by a limiting ring and an adjustable sliding plate and is not affected by the liquid level of a storage tank, the viscosity of the material liquid or pipeline pressure fluctuation, and on the other hand, the filling amount is adjusted; therefore, the volume height of each filling is ensured to be accurate and consistent; on the other hand, the height of the sliding plate can be changed only by rotating the lead screw, so that the effective reset stroke of the piston rod is adjusted in a stepless mode, and the volume of material liquid sucked into the cavity every time is changed.