87 results about "Fructosediphosphates" patented technology

The invention discloses a preparation method of a fructose diphosphate sodium powder injection, comprising the following steps of: decoloring, degerming, roughly filtering and finely filtering a fructose diphosphate sodium water solution; and punching, separating and crystallizing with ethanol or acetone and filling to obtain the aseptic powder injection. The fructose diphosphate sodium powder injection prepared by the method has higher purity, fewer impurities and more stable quality compared with the traditional products and is convenient to store and transport. The invention is simple to operate, has mild process condition and low cost and is suitable for industrial production.

The invention relates to a preparation method of fructose sodium diphosphate injection, belonging to the technical field of medicine. The preparation method is: medical solution is treated by cation exchange resin, which can reduce acidity, remove metal cation, absorb colorful impurities and pyrogens, increase the clarity of the medical solution, avoid the defects of decreasing the product purity, increase osmotic pressure, and influencing medication safety caused by acid radical ion when acid is used to regulate acidity, and provides a stable fructose sodium diphosphate injection with high purity. The fructose sodium diphosphate injection is applied to intravenous injection or intravenous drip in clinical practice, and is suitable for low phosphorus acidemia. The preparation method has the advantages: the preparation method is simple and controllable, and the prepared product quality is stable and safe for clinical use.

The invention provides a fructose combination medicament or a fructose diphosphate sodiumcombination medicament. The fructose combination medicament or the fructose diphosphate sodium combination medicament is characterized by comprising the following activated pharmaceutical ingredients in part by weight: 3.75 to 50 parts of fructose, 0.01 to 0.05 part of composition consisting of vitamin C and glutathione in the weight ratio of 1:1 and 0.00015 to 0.00020 part of disodium edentate. The invention also provides a method for preparing the fructose combination medicament. The fructose combination medicament and the fructose diphosphate sodium combination medicament are mainly used for treating shock, coronary heart diseases, angina pectoris, acute myocardial infarction and ischemia myocardial, heart failure, peripheral vascular diseases, acute adult respiratory distress and anesthetic accidents, and used for parenteral nutrition therapy for critical patients, heart surgery extracorporeal circulation and the adjuvant therapy for patients requiring multiple times of blood transfusion.

The invention provides a medicine composition containing a fructose sodium diphosphate compound, comprising fructose sodium diphosphate, sodium hydrogen sulfite, mannitol and water for injection. A preparation method for the medicine composition comprises the following steps of: sequentially dissolving fructose sodium diphosphate, sodium hydrogen sulfite and mannitol with the water for injection by stirring; adding active carbon to decolour; filtering and removing carbon; and filtering and removing bacteria. The fructose diphosphate medicine composition provided by the invention is simple in prescription, high in stability, capable of alleviating pain during injection, and conducive to application and popularization for fructose sodium diphosphate injection solution clinically. Additionally, high-temperature sterilization is avoided in the preparation method disclosed by the invention, the generation of related substances can be reduced, and the safety is improved.

The invention provides a method and a kit for detecting the human fructosediphosphate aldolase B gene. The detection kit comprises a primer pair for specifically amplifying three polymorphic sites on the human fructosediphosphate aldolase B gene, wherein the three polymorphic sites are respectively A150P, A175D and N335K, the primer pair comprises a common upstream primer and genotyping downstream primers, and the genotyping downstream primers comprise a wild type specific primer and a mutant type specific primer. With the adoption of the kit, the genotypes of the three polymorphic sites on the human fructosediphosphate aldolase B gene can be rapidly and efficiently detected, and the kit belongs to the kit for screening the human fructosediphosphate aldolase B gene, which is rapid, easy and convenient to operate, and is economical and efficient.

The invention provides a fructose diphosphate sodium granule and a preparation of the fructose diphosphate sodium granule. The fructose diphosphate sodium granule of the invention comprises effective amount of fructose diphosphate sodium and medical subsidiary substances. The medical subsidiary substances comprise thinner, bond and flavoring agent; wherein, the thinner can be one or a plurality of substances among amylum pregelatinisatum, lactose, crystallite fibrin or mannitol; the bond is one or a plurality of substances among polyvinylpyrrolidone K30, ethyl cellulose or hydroxypropyl methyl cellulose; the flavoring agent is one or a plurality of substances among aspartame, citric acid, stevioside, lemon essence or orange essence. And the weight ratio of the medical subsidiary substances is: the fructose diphosphate sodium: the thinner: the bond: the flavoring agent is equal to 100: 30 to 200: 1 to 30:1 to 30. The invention also provides the preparation method of the fructose diphosphate sodium granule. The invention has the advantages that medicine-taking is convenient; the manufacturing cost is low; special equipment are not needed; taking and delivering are convenient and stable, etc.

The invention relates to a nanofiber membrane with whitening and tightening effects and a preparation method of the nanofiber membrane. The nano-fiber membrane is characterized by simultaneously containing pterostilbene, dipalmitoyl hydroxyproline and prinsepia utilis royle oil which serve as oil-soluble whitening and tightening active components and fructose diphosphate trisodium, asiaticoside, hydrolyzed elastin and gynostemma pentaphylla leaf extract which serve as water-soluble whitening and tightening active components, the oil-soluble whitening and firming active component and the water-soluble whitening and firming active component are wrapped by hydrogenated lecithin to prepare a whitening and firming nano-composition, and then the whitening and firming nano-composition is mixed with succinyl glycan, rhizobium gum and deionized water to prepare the nano-fiber membrane through an electrostatic spinning process. The product has the advantages of being good in skin friendliness, good in stability, fast in absorption, convenient to use and the like, meanwhile, the oil-soluble whitening and firming active matter and the water-soluble whitening and firming active matter are loaded, the technical defect that only one of the oil-soluble whitening and firming active matter and the water-soluble whitening and firming active matter can be loaded in the prior art is overcome, and the whitening and firming effect is better.

The invention relates to a leech capsule, and belongs to the technical field of leech deep processing. The preparation method comprises the following steps: removing excrements in leeches, soaking leeches in brine, after leeches die, fishing out leeches, blowing off impurities on the surface of leeches; grinding dried leeches, soaking grinded leeches in ethanol, carrying out sealed soaking; aftersealed soaking, concentrating and drying obtained substance to remove ethanol in the substance; mixing the substance with fructose sodium diphosphate and starch, sieving the mixture by a sieve with asize of 10-20 meshes, drying the mixture at a temperature of 30 to 45 DEG C, carrying out granulation and sterilization, and finally filling granules into capsules. At first, leeches are soaked in brine to change the tension force of the surface cells of leeches, then leeches are grinded, soaked in ethanol, concentrated, and dried so that hirudin is dissolved or to be dissolved, and the problem that the dissolution rate of hirudin in grinded leeches of a conventional oral leech capsule is low is solved.

The invention provides a rapid-release fructose diphosphate sodium tablet, which comprises the active constituent of fructose diphosphate sodium as well as one or more of a filler, a disintegrating agent, a binder, a lubricant, a flow aid, a flavoring agent, a smelling agent and a coloring agent, and further comprises a release accelerator for accelerating the release of the active constituent. The release accelerator can be selected from the following substances of lauryl sodium sulfate, poloxamer, tweens, brominated hexadecane trimethylamine, sodium lauryl sulfate, stearyl alcohol sulfonate sodium, polyoxyethylene higher fatty alcohol, sucrose ester, sorbitol fatty ester, soyabean lecithin, alginic acid, sodium alginate and colloidal magnesium aluminum silicate, and the dosage of the release accelerator accounts for 0.1-5% of the total weight of the tablet.

The invention provides compound sodium fructose diphosphate and fructose orally disintegrating tablets. The compound sodium fructose diphosphate and fructose orally disintegrating tablets are prepared from the following ingredients in percentage by weight: 10-60% of sodium fructose diphosphate, 5-30% of fructose, 5-30% of sublimable substance, 0.5-3% of a surfactant, 4-20% of a disintegrating agent, 0.5-3.0% of a flow aid, 0.5-3.0% of a lubricant, 20.0-58% of a diluent, 0.2-2% of a corrigent, and 3-8% of a coating material. The invention further provides a preparation method of the compound sodium fructose diphosphate and fructose orally disintegrating tablets. The preparation method comprises the following steps: mixing the active ingredients, namely sodium fructose diphosphate and fructose, and pharmaceutical excipients, wherein the sublimable substance is added into the pharmaceutical excipients, tabletting the mixture, coating the obtained semi-finished product tablets, heating the semi-finished product tablets after coating, and drying, thus the sublimable substance sublimates, a plurality of holes are formed in the tablets, and finally, the tablets capable of rapidly disintegrating and with certain strength are obtained. The orally disintegrating tablets can rapidly disintegrate, so that good clinical effects can be obtained; the preparation method is easy and convenient to operate, is suitable for industrial production, and has a large application value.

The invention discloses a method for preparing a fructose diphosphate injection. The method comprises the following steps: (1) cooling injection water to below 40 DEG C for later use; (2) weighing a pH regulating agent, and stirring with injection water to dissolve; (3) weighing 20-80 percent by weight of injection water, introducing nitrogen into water, weighing the prescribed fructose diphosphate, adding, stirring and dissolving the fructose diphosphate, regulating the pH value to be 3-4 by using the pH regulating agent solution, and adding an auxiliary material to prepare q liquid medicine; (4) adding activated carbon into the liquid medicine, stirring and adsorbing for 10-40 minutes, filtering and decarburizing, adding the injection water to a prescribed amount, and simultaneously regulating the pH value the same as that in the step (3) by using the pH regulating agent solution; (5) sampling to inspect, filtering with a microfiltration membrane of 0.22 micron after the sample is qualified, filling into a glass bottle which is baked and sterilized at high temperature, plugging, sterilizing, capping and packaging to obtain a finished product. Compared with the prior art, the fructose diphosphate injection prepared by the method is simple in process, safe and reliable, good in stability and convenient in clinical application.

A process for crystallizing pectose-1,6-trisodium biphosphate includes such steps as slowly and proportionally adding sodium acetate and alcohol to FDP solution, stirring at 20-40 deg.C while crystallizing, filtering, washing with alcohol and vacuum drying.

The invention relates to an effervescent tablet containing fructose sodium diphosphate, comprising the fructose sodium diphosphate, citric acid, baking soda, oligosaccharide or other edible sugar in a weight ratio of (10-20):30:7:200. In the invention, the effervescent tablet is prepared with the fructose sodium diphosphate as a functional component, and compared with the other dosage forms, the effervescent tablet is easy to preserve, dissolve and absorb, has good stability and taste, and can be directly drunk after being soaked in water without stir.

The invention relates to a production method of fructose diphosphate sodium sterile powder. The production method comprises the following steps of: dissolving fructose diphosphate sodium non-sterile powder with injection water, and then filtering by using carbon rods; filtering sequentially through a filter with bore diameters of 0.2-0.4 micrometer and a sterilization and filter device; then pressing sterilized compressed air into a crystallizing tank, and adding sterilized alcohol by controlling the liquid temperature to be 28-30 DEG C; adding a qualified fructose diphosphate sodium sterile raw drug as seed crystal to crystallize; after crystallization is finished, compressing a solid-liquid mixture into a vacuum rotary type drier by using sterile air to sequentially separate, wash and dry; and then oscillated screening, weighing, inside packaging and outside packaging to obtain the fructose diphosphate sodium sterile powder. The production method has the advantages of simple operation, lower cost and good quality of the fructose diphosphate sodium sterile powder.

The invention provides a fructose diphosphate sodium liposome solid preparation and a novel application thereof. The fructose diphosphate sodium liposome solid preparation is prepared from fructose diphosphate sodium liposome and auxiliary materials, wherein the fructose diphosphate sodium liposome is prepared from fructose diphosphate sodium, lecithin, cholesterol and polyglycerin ester. The invention also provides the application of the fructose diphosphate sodium liposome solid preparation in improving the immunity of tumor patients undergoing chemotherapy. The fructose diphosphate sodium liposome can be prepared by adopting a thin-film dispersion technology to combine a certain amount of the lecithin, the cholesterol, the polyglycerin ester and the active component fructose diphosphate sodium, and is mixed with a certain amount of the auxiliary materials to prepare various solid preparations, so the invention can well solve the problems of poor in-vivo absorption degree and low curative effect, and obtains satisfactory technical effect.

The invention relates to facial masks, and discloses a facial mask containing fructose sodium diphosphate. The facial mask is prepared from t he following components in parts by weight: 25 to 30 parts of fructose sodium diphosphate, 10 to 15 parts of wheat germ extract, 10 to 15 parts of corn extract, 15 to 20 parts of cherry tomato juice, 8 to 10 parts of honeysuckle flower leaf extract, 12 to 20 parts of dried potato powder and 20 to 50 parts of deionized water. According to the facial mask disclosed by the invention, by taking the fructose sodium diphosphate as the main material and matching a certain proportion of wheat germ extract rich in vitamin E and a certain proportion of cherry tomato juice rich in glutathione, the obvious effects of resisting cellular oxidation, whitening and rapidly repairing cells can be achieved. The invention also discloses a preparation method of the facial mask containing the fructose sodium diphosphate. The preparation method disclosed by the invention is simple in operation, is environment-friendly, economic, efficient and non-toxic, and has wide application prospect. The facial mask prepared by the invention is capable of repairing, whitening, moisturizing and nourishing skin and delaying skin aging.