6 results about "Galactosides" patented technology

This invention discloses a firming and wrinkle-reducing eye cream, comprising a moisturizer, a whitening agent, a skin repair additive composition, a thickener, a preservative, a film-forming agent, a skin moisturizer, and a surfactant. The weight ratio of the moisturizer, whitening agent, anti-aging additive composition, thickener, preservative, film-forming agent, skin moisturizer, and surfactant is 20:1:2:3:0.3:0.5:1:0.2. The moisturizer includes butylene glycol, glycerin, polydimethylsiloxane, and hydrogenated polyisobutylene. The skin-repairing additive composition includes hydroxypropyl tetrahydropyranotriol, adenosine, cell growth factors, ceramides, and salicylic acid, comprising olefins, betaine, trehalose, 1,2-hexanediol, hydrogenated lecithin, allantoin, and Euglena galactosides. The film-forming agents include polyacrylamide, cyclohexylsiloxane, and polydimethylsiloxane alcohol. The emollients include C13-14 isoparaffins, polydimethylsiloxane / vinyl dimethylsiloxane crosspolymers, and cyclopentamethoxysiloxane. This invention can repair cells and provide long-lasting anti-wrinkle and whitening protection for the corners of the eyes.

The present application relates to a kind of methods for synthesizing alkyl galactoside using immobilized cells with monosaccharide as glycosyl donor.The method comprises the following steps: (1) culturing beta-galactosidase-producing yeast; (2) treating the yeast cells with ethanol; (3) adding genipin to the ethanol-treated yeast cells to construct a cross-linking system; reacting the cross-linking system for 0.5-4 h, centrifuging to obtain immobilized cells; (4) mixing galactose and alkyl alcohol uniformly, adding the immobilized cells, reacting for 2-16 h, centrifuging to separate the solid and liquid, taking the supernatant to obtain alkyl galactoside. The present application provides a green and efficient method for synthesizing alkyl galactoside, which is the first time to use immobilized yeast cells to synthesize glycoside with monosaccharide as glycosyl donor. The reaction system only contains alkyl glycoside and residual substrate after completion, the product types are few, easy to purify, suitable for large-scale synthesis of alkyl glycoside, and has broad application prospects.

The invention relates to the technical field of microbial culture, in particular to a klebsiella pneumoniae chromogenic medium as well as a preparation method and application thereof. The klebsiella pneumoniae chromogenic medium is prepared from the following raw materials: a core nutrient component, a composite salt system, a synergistic compound chromogenic system, a targeted composite antibacterial agent, a function enhancer, agar and deionized water, the synergistic compound color developing system comprises a composite color developing agent and a color developing synergist, wherein the composite color developing agent is prepared from 5-bromo-4-chloro-3-indole-beta-D-galactoside, indole acetate and naphthol-AS-D-acetate according to the weight ratio of (3.5 to 4.5) to (2.5 to 3.5) to (2.5 to 3.5); the targeted composite antibacterial agent comprises penicillin antibiotics and erythromycin in a weight ratio of (5-8): (2-4). The comprehensive advantages of high separation positive rate, comprehensive infectious microbe inhibition, high color development specificity, outstanding anti-interference capability and excellent stability are realized.

The invention discloses a liver-targeted sorafenib prodrug as well as a preparation method and application thereof, and relates to the field of chemical pharmacy, the liver-targeted sorafenib prodrug is simple to prepare, sorafenib is selected as a core drug component, and the sorafenib is covalently linked with beta-galactoside. Due to the hydrophilicity of the beta-galactoside and the existence of a plurality of hydroxyl groups, after the sorafenib which is originally poor in solubility in water is covalently connected with the beta-galactoside, the solubility of the sorafenib is greatly improved. Due to the characteristic, the preparation process of the medicine is simplified, and a good foundation is laid for application of subsequent medicine in a solution system and in-vivo transportation and absorption. The molecular structure of the prepared liver targeting sorafenib prodrug S-Gal contains a galactoside bond. When the S-Gal enters a body, the S-Gal can be actively taken by ASGPR on the surface of a hepatoma carcinoma cell, and is hydrolyzed under the action of beta-Gal over-expressed in the cell to release a sorafenib raw drug, so that the liver targeting of the drug is enhanced, and the systemic toxicity is reduced.

The invention relates to the technical field of analysis and detection, and discloses a method for separating and detecting flavonoid components in chrysanthemum, which comprises the following steps: extracting a chrysanthemum sample to be detected by using a methanol aqueous solution to obtain an extracting solution; octadecylsilane chemically bonded silica is adopted as a chromatographic column filler, high performance liquid chromatography detection is performed on the extracting solution according to a specific elution procedure, and a chromatogram is obtained; and performing qualitative and / or quantitative analysis on the flavonoid components in the chrysanthemum sample to be detected according to the chromatogram. The method is used; according to the present invention, a variety of flavonoid components such as chlorogenic acid luteolin-7-O-beta-D-glucoside, quercetin-3-O-B-D-galactoside, isochlorogenic acid B, kaempferol-3-O-rutinoside, isochlorogenic acid A, isochlorogenic acid C, diosmetin-7-O-B-D-glucoside, luteolin and apigenin can be effectively separated from chrysanthemum, synchronous detection of the components is realized, interference of other components in the chrysanthemum can be prevented, and the method has relatively high detection accuracy.