The invention relates to the field of wearable intelligent substitutes for human limbs, and medical equipment, and in particular to a multi-sensor closed-chain cascade-type hand prosthesis based on myoelectric control. The hand prosthesis comprises a four-finger mechanism, a thumb mechanism, a hand back plate, a motor support plate, motors and an electrical part, wherein the four-finger mechanismcomprises a fake finger group, a rocker group and a connecting rod group, the thumb mechanism comprises a thumb false finger group, a thumb rocker group and a thumb connecting rod group, the electrical part comprises a sensor group, an electric control group, a display and an electromyography acquisition module, the sensor group comprises a variety of sensor modules, the sensor group is embedded in far finger sections of fake fingers, the electrical control group comprises a core PCB board, a motor drive module and a battery, and the electromyography acquisition module is embedded in a contactposition between the inner side of the motor support plate and a forearm, and fits with the extensor digitorum and flexor digitorum superficialis of the forearm. The hand prosthesis adopts myoelectric control, motor drive, closed-chain cascade-type structure transmission, and multi-sensor feedback control, can be modularly disassembled to adapt to different hand signs, and reproduces and enrichesoriginal hand functions.