6 results about "Hormone release" patented technology

The present application relates to azapeptide compounds of formula (I) derived from melanocyte-stimulating hormone release-inhibiting factor-1. A method to obtain compounds of formula (I) is also described herein. The compounds of formula (I) have been shown to be suitable for the treatment of dopamine-related disorders of the central nervous system. These compounds showed enhanced potency as positive allosteric modulators of the dopamine D2 receptors in comparison with the melanocyte-stimulating hormone release- inhibiting factor-1 and, in general, do not exhibit meaningful cytotoxicity.

The invention discloses a regulation and control method for enhancing photosynthetic efficiency through hormone signal transduction between grafted rootstocks and scions, and particularly relates to the field of photosynthetic efficiency regulation and control. The regulation and control method comprises the steps that hormone release data of rootstocks, photosynthetic response data of scions and corresponding time labels are obtained, and according to the time difference between hormone change and photosynthetic response, the photosynthetic response data of the scions are obtained; constructing a state sequence with a delay tag; and defining an action set according to the delay characteristics marked in the state sequence. By constructing a state transition structure of delayed response perception and a regulation strategy generation mechanism based on a time recursion feature, an onset time point of a hormone signal and a feedback response track of a scion are captured, and accurate identification and intervention opportunity optimization of a regulation window in a non-dominant coupling chain are realized; therefore, the problems that an existing model cannot effectively model a time evolution structure, strategy execution is distorted, and improvement of photosynthetic efficiency is difficult to stably capture are solved.

An implant that can be implanted non-invasive or minimally-invasively into the sphenoid cavity of a subject for delivery of stimulation to deep brain reward circuit nodes of the brain and / or to drive hormonal release through stimulation of nuclei in the hippocampus or cells in the pituitary or nearby structures such as blood vessels. The implant is alternatively or additionally capable of sensing signals in the deep brain, and for powering deep-brain implants (i.e., devices placed in the brain that are difficult to power from the scalp due to distance).

The invention discloses a probiotic medicinal and edible medicinal material composition as well as a preparation method and application thereof. The composition comprises combined probiotics and medicinal and edible medicinal materials, the combined probiotics comprise Lactobacillus plantarum JY001 and Lactobacillus plantarum JY002, and the medicinal and edible medicinal materials comprise cistanche deserticola, semen raphani, peach kernels, astragalus membranaceus, codonopsis pilosula and pericarpium citri reticulatae. The composition takes medicinal and edible medicinal materials as raw materials, has the effect of improving endocrine hormone disorder caused by chronic stress after being fermented by combined probiotics, and can be applied to preparation of products for improving endocrine hormone disorder caused by chronic stress; the composition is especially applied to preparation of products for reversing reduction of thyroid stimulating hormone release hormone, adrenocorticotropic hormone and / or testosterone secretion level caused by chronic stress, and meanwhile, the composition also meets the requirements of people for resisting fatigue and improving constipation due to intestinal dryness.

The present invention relates to cancer vaccines and methods of treatment using the same. Disclosed is a vaccine composition, the present invention relates to a composition comprising one or more nucleic acids encoding one or more amino acid sequences selected from the group consisting of a tyrosinase, a tyrosinase-associated protein 1, a tyrosinase-associated protein 2, a melanoma-associated antigen 4 protein, a growth hormone releasing hormone, a MART-1 / melan-A antigen, a cancerous testis antigen NY-ESO-1, a cancerous testis antigen NY-ESO-2, the amino acid sequences of the antigen, the Vilms tumor 1 and the human telomerase reverse transcriptase are preferentially expressed in the melanoma. The vaccine compositions may further comprise nucleic acids encoding one or more other antigens, including prostate-specific antigens. Also disclosed are methods of preventing or treating cancer in a subject in need thereof, comprising administering to the subject a vaccine composition comprising a specific amount of cancer antigens to treat or prevent a specific cancer.

The invention relates to the technical field of treatment of diabetic nephropathy, in particular to application of a growth hormone releasing hormone GHRH agonist in preparation of a medicine for preventing and treating kidney diseases. The invention provides an application of a growth hormone releasing hormone GHRH agonist in preparation of a medicine for preventing and / or treating kidney diseases, verifies that the growth hormone releasing hormone GHRH agonist GHRH-6A can relieve diabetic nephropathy by relieving oxidative stress and inhibiting ferroptosis for the first time, and has important significance in prevention and treatment of diabetic nephropathy. And a new thought is provided for prevention and treatment of diabetic nephropathy.