4 results about "Hydroxylamine derivatives" patented technology

The invention discloses a real-time reaction monitoring method and a real-time reaction monitoring system for DNA (Deoxyribose Nucleic Acid) base removal sites and small molecule toxic compounds, and belongs to the technical field of biological analysis. The method comprises the following steps: constructing a compound formed by combining a uracil-containing DNA probe and an electrochemical active marker, and hydrolyzing uracil by using UDG enzyme to form a base removal site. A nanopore single-molecule detection technology is adopted, a compound is driven by voltage to pass through a hole, and a characteristic current signal is generated to establish a baseline map. Hydroxylamine derivatives are introduced to react with base removal sites, and dynamic interaction is analyzed according to time domain change of current signals. The system comprises a labeled compound preparation module, an enzymatic reaction module, a nanopore detection module, a small molecule compound reaction module and a central control and data processing module, all the modules cooperate, full-process automation from probe preparation to dynamic reaction monitoring is achieved, traditional sensitivity limitation is broken through, and a high-precision detection means is provided for studying the DNA damage and toxic compound action mechanism.

The present application belongs to the technical field of medicine, and relates to a diphenyl hydroxylamine derivative shown in general formula I, a stereoisomer and a pharmaceutically acceptable salt, a hydrate, a solvate or a prodrug thereof, wherein the substituent groups X, Ar and R have the definitions given in the specification. The present application also relates to a method for preparing the compound of general formula I, a pharmaceutical composition containing the compound, and the use of the compound and the pharmaceutical composition in the preparation of a medicament for treating and preventing diseases caused by superficial bacterial and deep Gram-negative bacterial infections.

The invention provides a low-cost and high-plating-speed pure palladium chemical plating solution for a power chip, which comprises the following components based on the total amount of the plating solution: 0.4-0.6 g / L of water-soluble palladium salt, 20-30 g / L of composite complexing agent, 10-20 g / L of pH buffer agent, 8-12 g / L of double reducing agent, 0.1-0.5 g / L of accelerator and 5-8 mg / L of stabilizer, the composite complexing agent comprises 5-10 g / L of organic amines and 15-20 g / L of amino carboxylic acid; the double reducing agents are selected from two of hydrazine substances, formic acid substances or hydroxylamine substances. The chemical palladium plating solution disclosed by the invention can be used for high-speed pure palladium plating in an aluminum substrate chemical nickel-palladium-gold plating surface treatment process on a power chip, an obtained plating layer is a phosphorus-free pure palladium plating layer, the plating speed of the plating solution under the condition of lower palladium content reaches 0.049 mu m / min, the liquid medicine cost and the time cost in the production process can be effectively reduced, and the production efficiency is improved. And meanwhile, the plating solution further has good stability, and stable operation of five MTOs can be achieved.

The present application mainly relates to the efficient synthesis of a kind of tri-substituted hydroxylamine compound by transition metal Pd catalytic C-O bond coupling.The present application realizes the one-pot reaction of tertiary chloroalkane or secondary chloroalkane and O-acyl hydroxylamine compound under the action of catalyst, ligand and base in argon atmosphere, realizes C-O bond coupling in the case of keeping the fragile N-O bond unbroken, and obtains a kind of big steric hindrance N,N,O-trialkyl substituted hydroxylamine derivative with high chemical selectivity.The present application has the characteristics of excellent chemical selectivity to construct C-O bond, simple experimental operation, wide source of raw materials, high yield, wide substrate application range and excellent functional group tolerance, and the synthesized product is suitable for being contained in drug small molecule screening library for the discovery of lead drug.