The invention belongs to the technical field of biological medicines, and relates to a combined drug-dosing micelle of a targeted integrin receptor and a preparation method thereof. Pluronic COOH which is modified by a terminal carboxyl is synthesized, and RGD (arginine-glycine-aspartic acid) polypeptides are connected with carboxyl by amido bonds to obtain a RGD polypeptide-modified Pluronic copolymer (RGD-Pluronic); and after copolymerization of drug doxorubicin (DOX) and Pluronic, another drug PTX (paclitaxel) is coated and loaded by a thin-film hydration method to prepare a mixed micelle (RGD-FP-DP). According to the preparation method, drug loading capacity of the micelle can be improved, the drug concentration of anti-tumor drugs in a target site can be increased, accumulation of the anti-tumor drugs in a non target site can be reduced, and the therapeutic index of the drugs can be effectively improved.