133 results about "Metal Chelating Agents" patented technology

Laundry additive compositions that include a metal sequestration agent and that may be characterized by an acidic pH. Related methods of treating a fabric, for example with a wash liquor and a rinse liquor, with such compositions and / or agents. Uses of such laundry additive compositions.

The inhalation suspension preparation containing the SGC receptor stimulant comprises the SGC receptor stimulant with an effective therapeutic dose or pharmaceutically acceptable salt of the SGC receptor stimulant, and pharmaceutically acceptable auxiliary materials of the suspension preparation, the pharmaceutically acceptable auxiliary materials of the suspension preparation comprise at least one of a surfactant, a pH regulator, an osmotic pressure regulator and a metal complexing agent; the inhalation suspension preparation containing the riociguat shows good lung absorption efficiency, is beneficial to reaching the same or better treatment level by reducing the administration dosage, can directly act on a diseased region through an administration route, takes effect more quickly compared with oral administration of the riociguat, and has a good application prospect. Gastrointestinal discomfort and systemic hypotension side effects caused by gastrointestinal tract contact and absorption entering a circulatory system can be avoided, the treatment cycle of an oral dosage form dosage titration administration scheme is shortened, and a better treatment scheme is provided for relieving dyspnea and syncope symptoms of pulmonary hypertension patients treated at home.

The invention belongs to the field of daily chemicals, and particularly relates to a body cleaning composition containing folium artemisiae argyi extract and a preparation method of the body cleaning composition. 14%-20% of a surfactant; 0.5-5% of a skin conditioner; 0.01%-0.1% of a metal chelating agent; 0.01%-1.2% of a preservative; 0.01%-1% of a pH regulator; 1 to 1.5 percent of flavoring agent; 0.01%-1% of a viscosity modifier; and the balance of deionized water. The plant functional composition comprises a folium artemisiae argyi extract and a rosa canina fruit extract. The folium artemisiae argyi extract and the rosa canina fruit extract in the composition can achieve a synergistic effect, free radicals can be effectively removed, release of cell factors and inflammatory mediators can be inhibited, and the composition has anti-inflammatory and soothing effects, can relieve uncomfortable symptoms such as skin redness and itching and has a certain whitening effect.

The invention discloses an inflorescence gene silencing method which comprises the following steps: firstly, synthesizing a specific nucleotide fragment according to a target gene, and constructing the specific nucleotide fragment to a plant virus vector; introducing the constructed plant virus vector and the corresponding helper plasmid into the inflorescence; soaking the inflorescence in a metal chelating agent salt solution; and finally, screening to obtain plants with inflorescences subjected to target gene silencing. The chrysanthemum capitulum is selected as an infection object, the silencing method is optimized, the target gene silencing efficiency is remarkably improved, the phenotype detection period after infection is remarkably shortened, and the method is efficient, convenient and high in operability. Meanwhile, the method can effectively avoid the cross protection phenomenon of plants, overcomes the obstacle of limited transmission range of viral vectors, does not need to consider the problems of death and growth cycle of tissue culture seedlings or seedlings after infection, and provides a feasible means for rapid identification of chrysanthemum gene functions and large-scale development of chrysanthemum gene function research.

The application discloses a preparation method of a thermal gradient self-adaptive hybrid modified retarder, and the method comprises the following steps: dissolving a metal chelating agent monomer and a hydroxide into water and stirring to obtain a first solution; adding an organic small molecule into the first solution to react and obtain a second solution; adding a reaction agent dropwise into the second solution to react and obtain a third solution; and filtering the third solution to obtain the retarder. The thickening time of the cement slurry added with the retarder can meet the construction requirements of high temperature and high pressure, and the cement slurry still has good early strength and other characteristics under the condition of lower temperature, so that the purpose of temperature self-adaptation is achieved, and the construction safety and quality of the ultra-deep well cementing are ensured.

A method for inhibiting or preventing polymerization of a polymerization composition comprises: adding at least one inhibitor(s) to the polymerization composition to stabilize and inhibit the polymerization of the polymerization composition, wherein the polymerization composition contains disilacyclobutane monomers, wherein the inhibitor is selected from amine compounds, quaternary ammonium salts or metal chelating agents.

Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially free of intra- or intermolecular crosslinking. In certain aspects, the functionalized dextran is an amine dextran, an alkynyl dextran, or a thiol dextran. In exemplary implementations, the functionalized dextran is an amine dextran. In further embodiments, one and only one carboxylic acid group on the chelating agent is derivatized as a N-hydroxysuccinimide (NHS) ester.

The application discloses a low-temperature rapid curing epoxy adhesive and a preparation method thereof. A component A is composed of an epoxy resin, a diluent and a filler, is uniformly stirred and mixed, and is vacuum degassed to obtain the component A; a component B is composed of a flow agent, a tertiary amine accelerator, a free radical scavenger, a chelating agent and a filler, the thiol, the chelating agent, the filler and the free radical scavenger are uniformly stirred, are slowly stirred and matured for at least 24 hours after passing through a three-roller machine, and then the tertiary amine accelerator is added, and the component B is vacuum degassed to obtain the component B. The thiol and the tertiary amine accelerator are used in combination, the curing speed is the fastest at room temperature, and the gel time of 60s / 25g can be achieved; the metal chelating agent and the free radical scavenger are combined to prevent the thiol from being skinned during storage, and the stable storage time is more than 6 months without skinning. The maturation of the component B enables the chelating agent to fully act on metal ions in the filler, and reduces the influence of the chelating agent on the promoting effect of the tertiary amine accelerator.

The present disclosure relates to a method of inhibiting nuclease activity in a biological sample. In accordance with certain embodiments of the present disclosure, the method comprises mixing a biological sample with a metal-chelating agent complex. The present disclosure also discloses a method of isolating a cell nucleus from a cell in a biological sample by using the metal-chelating agent complex, and a method of adding a deoxyribonucleotide to the 3'terminal of a deoxyribonucleic acid.

The invention relates to a cleaning agent and a preparation method thereof, the cleaning agent comprises bioactive hydrolase, polyol, a metal chelating agent, an alkaline pH regulator, a nonionic surfactant and water, and the polyol contains at least four hydroxyl groups. A dense hydrogen bond network and a space wrapping effect are formed by a polyhydroxy structure of polyhydric alcohol and enzyme molecules, so that the stability of enzyme in an alkaline environment and a high-temperature condition is remarkably improved, and the applicable temperature and pH range of the cleaning agent is greatly widened due to the characteristic; the problem that the use condition of a traditional enzymatic cleaning agent is limited due to the fact that enzyme is prone to inactivation is solved.

A method and gel buffer for capillary electrophoresis (CE) separation of proteins. The gel buffer solution comprises a buffer component, a hydrophilic polymer, an organic additive, a detergent and a metal chelating agent. By adopting a gel buffer solution, the separation degree of a main peak and an acromion can be improved when protein is separated by capillary electrophoresis (CE).

The invention belongs to the technical field of refined cotton production processes, and particularly relates to a cooking aid for controlling cotton linter cooking polymerization reduction and a production process. The cooking auxiliary agent is prepared from the following components in percentage by mass: 0.35%-1.1% of magnesium chloride, 61.2%-87.7% of a reducing agent and 11.8%-37.7% of a metal chelating agent, totaling 100%. By means of the synergistic effect of the cooking auxiliaries, disordered degradation of cellulose can be effectively blocked in the cotton linter cooking process, the polymerization degree of alkalized cotton is greatly improved, and the polymerization degree can stably reach 3,250 DP or above; the purpose of removing impurities can be achieved; therefore, a guarantee can be provided for obtaining refined cotton with qualified impurity indexes and higher polymerization degree.

The invention discloses an HRP chemiluminescent substrate system, a kit and a preparation method, the HRP chemiluminescent substrate system is composed of a liquid A and a liquid B which are physically isolated and stored; the solution A is an alkaline buffer system with the pH value of 9.0-9.6, and comprises isoluminol or a salt substrate thereof, a cationic surface active agent CTAC and a metal chelating agent diethylene triamine pentaacetic acid; and the solution B is an acidic solution with the pH value of 4.5-5.5, and comprises an oxidizing agent and a reinforcing agent N-(3-chloro-4-hydroxyphenyl) acetanilide. According to the invention, the reinforcing agent N-(3-chloro-4-hydroxyphenyl) acetanilide is placed in the acidic liquid B, when the acidic liquid B is mixed with the alkaline liquid A, the mixed system is maintained at a specific pH value of 8.3-8.6, and the reinforcing agent is rapidly dissociated into phenoxy anions; and carrying out in-situ capture and enrichment on a micelle interface by CTAC cationic micelles with positive charges, which exist in the solution A in advance, through electrostatic attraction. And in cooperation with a low-ion-strength environment brought by no buffer salt in the liquid B, the system ensures the high activity of the HRP enzyme, realizes directional interface catalysis of the enhancer, and significantly improves the luminous efficiency and stability.

The application discloses a heavy metal chelating agent and a preparation method thereof. The heavy metal chelating agent is obtained by controlling the synthesis of melamine formaldehyde resin prepolymer and introducing a dithiocarbamate salt group with a chelating function into the structure of the melamine formaldehyde resin prepolymer. The heavy metal chelating agent has the characteristics of high efficiency and stability, high heavy metal removal rate, fast settling speed of chelation products, low leaching, and low cost, and is suitable for industrialized treatment of heavy metal pollution in fly ash and industrial wastewater.

A polymer breaking solution usable in fracking and other downhole applications comprises a solution of aqueous hydrogen peroxide, an anionic surfactant, a metal chelating agent, an acidic pH buffer, a soluble zinc compound, and in some embodiments, a viscosifying agent. In other embodiments, the solution may additionally comprise a linear hydrophobic surfactant. At treatment concentrations of between 500 ppm to 1,500 ppm, the solution is non-toxic and usable at a wide range of downhole temperatures (32° C. to 82° C.).

The present invention provides a cleaning agent composition for hard surfaces that exhibits excellent sustained effectiveness in suppressing the occurrence of urine scale stains and yellow stains derived from urine on hard surfaces, and a method for cleaning hard surfaces using the same. [Solution] A cleaning agent composition for hard surfaces, comprising the following components (a), (b), (c), and water, wherein the mass ratio (c) / [(a)+(b)] of the content of component (c) to the total content of components (a) and (b) is 0.005 or more and 0.3 or less. (a) Ingredients: Metal chelating agent (b) Component: Foaming surfactant (c) Component: Water-soluble polymer

The invention relates to the technical field of soil heavy metal remediation, in particular to a humic acid slow-release fertilizer for improving the remediation efficiency of barbadosnut on cadmium-contaminated soil and a preparation method of the humic acid slow-release fertilizer. The fertilizer specifically comprises the following components: polyvinyl alcohol, span 80, urea, calcium hydrophosphate, potassium sulfate, magnesium oxide, humic acid, DA-6, IAA, IBA, EGTA, corn straw compost and the like. The humic acid slow-release fertilizer and the application method thereof, provided by the invention, have remarkable beneficial effects in the aspect of improving the remediation efficiency of the barbadosnut on the cadmium-polluted soil. According to the slow-release fertilizer, humic acid, plant hormones, a metal chelating agent and nutrient elements are scientifically proportioned, and corn straw compost is combined as an organic carrier, so that slow release and efficient utilization of nutrients are realized. The high-activity extraction process of humic acid ensures the strong complexing ability of rich functional groups and heavy metals, and significantly enhances the cadmium absorption and transport ability of jatropha curcas.

The invention discloses an experimental kit for chloroplast pigment extraction and separation and application, and belongs to the technical field of photosynthetic pigment extraction and separation, a surfactant and EDTA sodium are added during extraction, and an efficient aluminum foil silica gel thin layer and a composite chromatographic solution are adopted during separation; the chromatography medium is an efficient silica gel thin layer. In the process of extracting and separating the photosynthetic pigment, a surfactant and an EDTA (Ethylene Diamine Tetraacetic Acid) sodium metal chelating agent are added, the ratio of a chromatography medium to a chromatography liquid is optimized, a filtering and chromatography device is simplified, the extraction rate and the separation degree of the pigment are remarkably improved, the operation is simpler and safer, and finally 6-8 kinds of the photosynthetic pigment can be separated from fresh spinach leaves. 13 chloroplast pigments are separated from the leaf dry powder.

The present invention relates to the technical field of nanosilver preparation and discloses a method for preparing nanosilver. The method comprises providing a base liquid containing nanosilver particle seed crystals, a dispersant, a gel material, and a solubilizing agent; adding a silver salt solution and a reducing agent solution to the base liquid in parallel, wherein the silver ions are reduced to elemental silver during the addition process; after the silver salt solution is added, a metal chelating agent is added to the reaction system for a full reaction; after the reaction, a slurry is obtained, and solid nanosilver is extracted from the slurry; the solubilizing agent is selected from at least one of sodium oleate, polysorbate 80, and propylene glycol. This method reduces the difficulty of separating and purifying the obtained nanosilver; and the entire preparation process is simple. The obtained nanosilver has a particle size between 200 and 500 nm and good monodispersity, and has broad application prospects in the field of conductive pastes.

The application discloses a substation oil-filled equipment live extinguishing medium, and the mass concentration ratio of raw materials of the extinguishing medium is as follows: 5-35% of ethylene glycol, 5-20% of non-ionic foaming emulsifier, 3-8% of ethylene glycol butyl ether, 2-5% of non-ionic film-forming spreading agent, 0.2-0.6% of xanthan gum, 0.15-0.5% of non-ionic organic corrosion inhibitor and 0.5-1.5% of metal chelating agent, and the rest is deionized water with conductivity lower than 10 mu s / cm. The product formula uses non-ionic raw materials, and after being mixed with water in a proportion, the conductivity is lower than 200 mu s / cm. The conductivity of the extinguishing agent is prevented from being improved under long-term storage by adding a corrosion inhibitor / chelating agent compound, and the extinguishing agent can be used in combination with a water quality monitoring and processing device to realize spraying and extinguishing for live equipment within the effective period of the extinguishing agent. The extinguishing medium uses a new type of fluorosilicon / fluoroether structure film-forming agent, which can be naturally degraded in the environment on the basis of ensuring hydrophobicity, oleophobicity, film forming and spreading. Meanwhile, by adding a new type of high-efficiency cooling and emulsifying aid, the ability of the product to quickly extinguish and prevent re-ignition is ensured.

The invention belongs to the technical field of phosphate binders, and discloses a magnesium phosphate inorganic adhesive and a preparation method and application thereof, the magnesium phosphate inorganic adhesive comprises the following components by mass: 100 parts of dead burned magnesium oxide, 45-80 parts of potassium dihydrogen phosphate, 1-5 parts of an organic acid metal chelating agent, 1-5 parts of potassium hydroxide, 1-4 parts of borax, 0.7-1.5 parts of calcium chloride hexahydrate, 0.4-0.6 part of barium hydroxide octahydrate, and 20-32 parts of water. The magnesium phosphate inorganic adhesive is modified on the basis of raw material selection and mix proportion design, so that the coagulation time and fluidity of the magnesium phosphate inorganic adhesive are greatly improved, and the problems that the traditional magnesium phosphate inorganic adhesive is short in coagulation time and poor in fluidity, and cannot meet the construction requirements of the adhesive on sufficient infiltration and spreading of carbon fiber cloth are solved; the construction workability of the magnesium phosphate inorganic adhesive serving as the adhesive for reinforcing the carbon fiber cloth is guaranteed, and the magnesium phosphate inorganic adhesive can be applied to the field of reinforcing and repairing of large-quantity and wide-area concrete structures.

The present invention relates to a conjugate for use in the treatment of cancer, the conjugate comprising a first moiety A selected from metal chelating agents, a second moiety B selected from lysosomotropic agents; and a linker L that binds moieties A and B together. The invention also relates to their use in the pharmaceutical field, in particular in a method for the treatment of cancer.

The invention discloses a rapidly crystallized anti-aging polylactic acid composition as well as a preparation method and application thereof. The rapidly crystallized anti-aging polylactic acid composition comprises the following components: 70-95 parts of poly-L-lactic acid; 5 to 20 parts of multi-arm D-polylactic acid; 0.1 to 5 parts of acetylated cellulose nanocrystal; 0.05-1 part of a metal chelating agent; the multi-arm dextro polylactic acid is prepared by initiating ring opening polymerization of D-lactide by a polyol initiator, and the polyol initiator is selected from two or more of glycerol, 1, 1, 1-trimethylolpropane, pentaerythritol, erythritol, dipentaerythritol and sorbitol. The metal chelating agent is used for inhibiting hydrolysis of ester bonds, formation of stereocrystals is promoted under the action of the nucleating agent through the multi-arm right-handed polylactic acid of a branched structure, high transparency and heat resistance are obtained, and a blister product prepared from the composition has the advantages of being transparent, resistant to heat, rapid in demolding, stable in size and the like.

The invention belongs to the technical field of inhalation preparations and pulmonary drug delivery, and particularly relates to an atomization preparation for vitamin K inhalation drug delivery and preparation and application thereof. According to the preparation, dipalmitoyl phosphatidylcholine, cholesterol and optional anionic phospholipid are adopted to construct a bionic lung surface activity liposome skeleton LA1, an MK-7 organic phase is intercalated into a liposome double-layer hydrophobic area under the condition of controlling temperature and an energy path, and a continuous phase containing sodium chloride, propylene glycol and a pH regulator is matched to form an isotonic near-neutral environment; a neutral oil phase, a fat-soluble antioxidant, an optional metal chelating agent and a viscosity modifier can be introduced to synergistically optimize the atomization performance. The apparent viscosity of the prepared atomization preparation at 25 DEG C is 1.0-2.5 mPa.s, the osmotic pressure is 280-320 mOsm / kg, the average particle size of lipidosome Z is 80-150 nm, the PDI is not larger than 0.25, the mass median diameter of fog drops atomized by a vibration net type atomizer is 2.0-3.0 microns, the fine particle fraction is not smaller than 60%, and the MK-7 content retention rate is not lower than 90% after 6 months of accelerated storage at 25-40 DEG C.

The application discloses a preparation method of a heavy metal chelating agent composite material, and the method comprises the following steps: S1, montmorillonite is placed in a dilute acid solution for treatment, and then the montmorillonite is washed, dried, crushed, and ground to obtain montmorillonite powder; S2, polyvinyl acetate is dissolved in a solvent to obtain a blending liquid, the montmorillonite powder is added and stirred uniformly, then ionic monomers and an initiator are added and continuously stirred, and then polyvinylpyrrolidone is added and stirred uniformly; after the stirring is completed, the blending liquid is left to stand, and then the blending liquid is filtered; the obtained product is washed and dried to obtain a modified montmorillonite copolymer composite; S3, the modified montmorillonite is placed in a urea solution for heat treatment, and then the modified montmorillonite is filtered; the obtained product is sequentially washed, freeze-dried, and sieved to obtain the heavy metal chelating agent composite material. The chelating agent composite material can effectively remove heavy metal ions in polluted water.

The invention relates to a nadifloxacin emulsifiable paste and a preparation method thereof, the nadifloxacin emulsifiable paste comprises an active component nadifloxacin and pharmaceutic adjuvants, and is a water-in-oil or oil-in-water external emulsifiable paste preparation. The chemical and physical stability of the product is remarkably improved by adopting a buffer type alkaline hydrotropy system formed by sodium hydroxide and diethanol amine in a synergistic manner, an edetate disodium metal chelating agent and a specifically-formed composite oil phase matrix and combining a vacuum emulsification and double homogenization process; and the preparation process parameters are clear, the industrial amplification can be realized, and the technical problems of poor stability, large quality fluctuation, limited curative effect and the like of the existing nadifloxacin external preparation are solved.

The invention discloses sodium hyaluronate gel as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The sodium hyaluronate solution is subjected to first pre-crosslinking at a low temperature, so that side reactions can be reduced, the yield of the prepared sodium hyaluronate gel is remarkably improved, meanwhile, secondary crosslinking is controlled at a high temperature, the crosslinking density of the sodium hyaluronate gel can be further improved, rapid degradation of the sodium hyaluronate gel is avoided, and the sodium hyaluronate gel has a good application prospect. The degradation time of the sodium hyaluronate gel is prolonged; by adding the antioxidant and the metal chelating agent, the degradation time of the sodium hyaluronate gel can be further prolonged; besides, by adopting dialysis treatment, impurity residues of the sodium hyaluronate gel can be removed, and the biocompatibility of the sodium hyaluronate gel is improved, so that the sodium hyaluronate gel has a relatively good application prospect in serving as a biological filling material.

The invention provides a composite admixture for red mud-based filling paste, which comprises the following components in percentage by mass: 35-55% of an acid-base regulator which comprises phosphate, organic acid and neutral salt; 30-45% of a rheology modifier, wherein the rheology modifier comprises a water reducing agent, a retarder and an air entraining agent; and 10-25% of a metal anti-leaching agent, wherein the metal anti-leaching agent comprises a metal chelating agent and a waterproof agent. The composite additive is used in the red-mud-based filling paste, the flowing property of the paste can be improved, the compressive strength of the red-mud-based paste can be improved, leaching of metal ions such as aluminum and sodium is reduced, and the requirement for environmental protection is met.

The present invention addresses the problem of providing a photosensitive resin composition which, when formed into a cured film, has high transparency and chemical resistance, has low film stress, and has high adhesion to a metal layer containing molybdenum, aluminum, or nickel. In order to solve this problem, a photosensitive resin composition is provided which contains a siloxane resin having a radical-polymerizable group, a metal chelating agent, and a photo-radical polymerization initiator, and in the siloxane resin having a radical-polymerizable group, the amount of the metal chelating agent in the siloxane resin having a radical-polymerizable group is 100 mol% per 100 mol% of all organosilane units, and the amount of the photo-radical polymerization initiator in the siloxane resin having a radical-polymerizable group is 100 mol% per 100 mol% of all organosilane units. The content of an organosilane unit (D unit) represented by (R) 2SiO2 / 2 (R is an organic group) is 30 mol% or more and 85 mol% or less.

The invention discloses a latex agent containing rhizoma paridis total saponins as well as a preparation method and application of the latex agent. The latex agent is prepared from the following components in percentage by mass: 0.5 to 2 percent of rhizoma paridis total saponins, 0.5 to 2 percent of a film-forming agent, 8 to 12 percent of an emollient, 1 to 4 percent of an emulsifier, 1 to 5 percent of a co-emulsifier, 0.05 to 0.2 percent of a preservative, 0.05 to 0.2 percent of a metal chelating agent, a proper amount of a pH regulator and the balance of purified water. Wherein the mass ratio of the rhizoma paridis total saponins to the film-forming agent is 1: (0.8-1.2). During preparation, the active ingredients and the film-forming agent need to be premixed and then added into an emulsification system. The problems of gastrointestinal stimulation of an oral preparation and flowing property of a biscuit are solved, the stability is remarkably improved through a film-forming agent premixing process (layering is avoided after centrifugation is conducted for 3000 rpm / 20 min and 40 DEG C / 3 months), and the medicine effect is better than that of cream. The latex agent is safe and non-irritant (30 human body tests have no adverse reaction), and is suitable for treating inflammatory diseases such as furuncle and carbuncle swelling, snake and insect bites and the like.