40 results about "Monoamine Oxidase Type B" patented technology

The invention discloses coumarin / pyridone heterozygous derivatives represented by a formula (I) shown in the description or a pharmaceutically-acceptable salt of the derivatives. The preparation method of the coumarin / pyridone heterozygous derivatives comprises the following steps: one pyridone derivative represented by a formula 3 shown in the description is obtained by a series of synthesis by using one hydroxypyrone with different substituent groups represented by a formula 1 shown in the description as a raw material; and a compound represented by a formula 4 shown in the description is subjected to a condensation reaction to obtain a compound represented by a formula 5 shown in the description, one-step bromination is performed to obtain a compound represented by a formula 6 shown inthe description, the compound represented by the formula 6 and the pyridone derivative represented by the formula 3 are subjected to a one-step nucleophilic substitution reaction to obtain a compoundrepresented by a formula 7 shown in the description, and finally an alkyl protecting group in a pyridone structure is removed to obtain one target compound represented by the formula (I). The compounds provided by the invention are a novel series of single-molecular multi-target series drugs, and have iron chelation, targeted MAO-B inhibitory activity, antioxidant activity, unique advantages for an Alzheimer disease with complicated pathogenesis, a clear mechanism of action and excellent activity.

The invention provides a diarylethene type compound, a medicine composition using the diarylethene type compound as an active ingredient and application of the diarylethene type compound in preparation of a MAO-B (Monoamine Oxidase B) inhibitor and preparation of PD (Parkinson's Disease) treatment medicine. The MAO-B is proved to have close relationship with the PD pathogenesis and is a classic target for PD medicine development. The diarylethene type compound provided by the invention can be used for preparing the MAO-B inhibitor. In vitro kinase activity experiments prove that the series ofcompounds have the obvious MAO-B inhibition effect.

The invention discloses an amine alkoxychalcone compound and its preparation method and use, comprising the following steps: (1) using 3-hydroxybenzaldehyde as a starting material, under a first solvent and a first basic condition , react with dibromo compound to obtain bromoalkoxybenzaldehyde; (2) bromoalkoxybenzaldehyde reacts with secondary amine under the second solvent and the second basic condition to obtain amine alkoxybenzaldehyde; (3 ) amine alkoxy benzaldehyde and 2-hydroxyacetophenone under the third solvent and the third basic condition, obtain the target compound amine alkoxy chalcone compound. The compound of the present invention has selective butyrylcholinesterase inhibitory activity, selective monoamine oxidase B inhibitory activity, selective metal ion chelation activity, and Aβ aggregation inhibitory activity in vitro, and can be used for treating and / or preventing neurodegenerative related diseases.