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35 results about "Morphan" patented technology

Morphan is a chemical compound. It is the base of the benzomorphan family of drugs.

Tandem Process for Preparing N-Alkyl Morphinans

The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis / alkylation reactions for the synthesis of N-alkyl morphinans.
Owner:SPECGX LLC

Morphan and Morphinan Analogues, and Methods of Use

The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
Owner:ALKERMES PHARMA IRELAND LTD

Preparation of 6-Keto, 3-Alkoxy Morphinans

The present invention provides processes for the preparation of saturated 6-keto, 3-alkoxy morphinans from unsaturated 6-hydroxy, 3-hydroxy morphinans, In particular, the invention provides processes that utilize catalytic isomerization and alkylation reactions for the preparation of saturated 6-keto, 3-alkoxy morphinans.
Owner:MALLINCKRODT INC

Preparation of Saturated Ketone Morphinan Compounds by Catalytic Isomerization

The present invention provides processes for the preparation of saturated ketone morphinan compounds by catalytic isomerization. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an allyl-transition metal catalyst.
Owner:SPECGX LLC

Quinolinomorphinane derivatives and medicinal use thereof

InactiveUS6172078B1Good effectCuring and preventing worseningBiocideOrganic chemistryCerebral paralysisQuinoline
The present invention provides a quinolinomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing or preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I):(wherein R1 represents cyclopropylmethyl or the like; R2 and R3 independently represent hydroxy, methoxy, or the like; R4 represents hydrogen, methyl, amino or the like; and (R5)m represents hydrogen, substituted benzo, or the like. The compounds of the present invention prevent damages of the cerebral nerve cells and are useful as medicine for curing or preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases. The compounds of the present invention also ameliorate the after-effects of these diseases and prevent the recurrence of these diseases by inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders, and damages of the cerebral nerve cells caused by various nerve degenerations.
Owner:TORAY IND INC

Therapeutic or prophylactic agent for biliary diseases

Disclosed is a novel medicinal agent which has an excellent therapeutic effect on biliary diseases and is therefore is useful for the treatment or prevention of biliary diseases. Specifically disclosed is a therapeutic or prophylactic agent for biliary diseases, which comprises a compound having a specific morphinan backbone typified by compound 1 or a pharmacologically acceptable acid addition salt thereof as an active ingredient.
Owner:TORAY IND INC

Dicranostigma leptopodum (maxim) fedde alkaloid effective part preparation method

The present invention discloses a dicranostigma leptopodum (maxim) fedde alkaloid effective part preparation method, wherein the dicranostigma leptopodum (maxim) fedde alkaloid effective part obtained through chemical steps is a brownish-black powdery solid, and comprises aporphine alkaloid, morphinane alkaloid, protopine alkaloid, protoberberine alkaloid and isoquinoline alkaloid. According to the present invention, with the method, the concentration of the active compound can be effectively improved, the drug taking dose can be lowered, and the pharmacological activity of the dicranostigma leptopodum (maxim) fedde alkaloid can be significantly improved.
Owner:LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Preparation of Saturated Ketone Morphinan Compounds

The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.
Owner:SPECGX LLC

Alkaloid compound and its preparation method and use

The invention belongs to the technical field of medicine, and relates to alkaloid compounds and their preparation methods and medical applications, in particular to morphinanes and bisbenzylisoquinoline alkaloids and their preparation methods and their preparation for the prevention or treatment of neurodegenerative diseases, Application in antitumor drugs, the structure of the compound is as follows: wherein, R 1 , R 2 is hydroxyl, C1‑C4 acyl; R 3 is C1‑C4 aldehyde group, R 4 , R 9 is C1‑C4 alkoxy, R 5 for hydrogen, R 6 and R 7 form methylenedioxy, R 8 is C1‑C4 alkyl; R 1 'is C1‑C4 alkyl, R 2 ', R 3 ', R 5 ', R 7 'is C1‑C4 alkoxy, R 4 ' is hydrogen, R 6 ' is a C1-C4 aldehyde group.
Owner:SHENYANG PHARMA UNIVERSITY

Processes for the Preparation of Morphinane and Morphinone Compounds

The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.
Owner:BROCK UNIVERSITY

Alkaloid compound as well as preparation method and application thereof

The invention belongs to the technical field of medicine, and relates to an alkaloid compound and a preparation method and medical application thereof, in particular to morphine alkane and bisbenzyl isoquinoline alkaloids and a preparation method thereof and application of the morphine alkane and bisbenzyl isoquinoline alkaloids in preparation of medicine for preventing or treating neurodegenerative diseases and resisting tumors. The structure of the compounds is shown in the specification, and in the structure formula, R1 and R2 are hydroxyl or C1-C4 acyl, R3 is a C1-C4 aldehyde group, R4 andR9 are C1-C4 alkoxy groups, R5 is hydrogen, R6 and R7 form a methylenedioxy group, R8 is a C1-C4 alkyl group, R1' is a C1-C4 alkyl group, R2', R3', R5' and R7' are C1-C4 alkoxy groups, R4' is hydrogen, and R6' is a C1-C4 aldehyde group.
Owner:SHENYANG PHARMA UNIVERSITY

Therapeutic or prophylactic agent for cachexia

The present invention addresses the problem of providing a therapeutic or prophylactic agent for cachexia, which has few side effects in the treatment of cachexia and exhibits a significant drug effect. The present invention provides a therapeutic or prophylactic agent for cachexia, which is obtained by combining a compound having a morphinane skeleton represented by the following compound or a pharmacologically acceptable acid addition salt thereof with a starvation receptor agonist.
Owner:TORAY IND INC
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