19 results about "Multi-component reaction" patented technology

The invention discloses a carboxymethyl beta-cyclodextrin modified D-A COF material and a preparation method and application thereof.Benzotrithiophene is used as an electron donor, triazine is used as an electron withdrawing unit, imine-connected D-A COFs are successfully synthesized through a solvothermal method, the imino COFs and carboxymethyl beta-cyclodextrin are treated through a Ugi multi-component reaction, and the COF material is prepared. And the COFBTT-TAPT photoactive material containing the beta-cyclodextrin group is obtained through preparation. COFBTT-TAPT-beta-CD and Mxene form a heterojunction to further enhance the photoelectric conversion efficiency of the photoactive material, and the photoactive material is used for preparing a photoelectrochemical sensor, so that high-sensitivity field screening of PFOS (perfluorooctane sulfonate) can be carried out in a low concentration range.

The invention discloses a bio-based modified high polymer material and a preparation method thereof, and relates to the technical field of high polymer materials. When the bio-based modified high polymer material is prepared, firstly, lignin reacts with terephthalaldehyde to prepare formylated lignin; carrying out multi-component reaction on the aldehyde lignin to obtain modified lignin; the preparation method comprises the following steps: reacting 4-mercaptophenylboronic acid with 1-mercaptoglycerol to prepare a dimercaptoborate cross-linking agent; the preparation method comprises the following steps: reacting isophorone diisocyanate with polytetrahydrofuran ether glycol, and then reacting with a flame-retardant chain extender, 1, 2-propylene glycol and hydroxyethyl methylacrylate to prepare modified polyurethane; and mixing the modified polyurethane, the modified lignin and a dimercaptoborate cross-linking agent, casting and curing to obtain the bio-based modified high polymer material. The bio-based modified high polymer material prepared by the invention has the advantages of flame retardance, antibacterial property, aging resistance, self-repairing property, repeatable processing and high mechanical strength.

The invention discloses a compound containing a bicyclic hemiketal structure and a preparation method thereof, alkynyl allyl carbonate is used as a raw material, in the presence of a nucleophilic catalyst, alkynyl allyl carbonate reacts with a benzoylacetonitrile derivative, ABB'multi-component reaction is carried out through a continuous [5 + 1] / addition / cyclization reaction sequence, and the compound containing the bicyclic hemiketal structure is obtained. Bicyclic hemiketal derivatives commonly seen in natural product structures are obtained with good to excellent diastereoselectivity. The method has the advantages of good diastereoselectivity products, excellent chemical selectivity, greenness, mild reaction conditions, convenience in operation, few byproducts and the like, the synthesis steps are good in economy, and four chemical bonds and three continuous chiral centers are simultaneously constructed through one-step operation. Meanwhile, the compound with the bicyclic hemiketal structure has important application value in multiple fields of medicinal chemistry, natural product chemistry, traditional Chinese medicine chemistry and the like, and an efficient preparation means and a series of candidate compounds are provided for development of functionality or biological activity of related compounds with the bicyclic hemiketal / hemiacetal structure.

The invention discloses a chitin-based fluorescent film for Zr < 4 + > detection and a preparation method thereof. The material takes a chitin film as a substrate and is chemically modified in situ by a one-pot method. The method comprises the following steps: firstly, dissolving chitin in an alkali / urea system, preparing a chitin film through a tape casting method, and washing the film with deionized water until the pH value is neutral; then, a multi-component Mannich reaction is adopted, the chitin thin film obtained after hot pressing reacts with quercetin molecules and aldehyde compounds, and the modified covalent grafted chitin-based fluorescent thin film is obtained. Through introduction of quercetin molecules, the chitin film is endowed with fluorescence performance, and meanwhile, carbonyl and polyhydroxy structures of quercetin have the capability of easily forming strong complexes with metal ions, so that the modified chitin-based fluorescent film has the characteristic of quantitatively detecting the metal ions. The preparation method disclosed by the invention accords with green chemistry, is simple to operate and stable in performance, and can be used for rapidly and highly selectively detecting zirconium (IV) ions.

The application discloses a polymer type nitrogen and phosphorus flame retardant as well as preparation and application thereof, and belongs to the technical field of high polymer material modification. The polymer type nitrogen and phosphorus flame retardant is prepared through a multi-component reaction, the method has mild reaction conditions, does not need an external catalyst, and has high atomic economy. The polymer type nitrogen and phosphorus flame retardant prepared has high thermal decomposition temperature, good compatibility when used for preparing a flame-retardant polylactic acid product, and can synergistically prevent the polylactic acid from burning through the two kinds of flame-retardant elements of nitrogen and phosphorus; the limiting oxygen index reaches 31%, the flame-retardant grade requirement of UL-94 V-0 is met, and the mechanical property is excellent.

This invention provides an O,O'-monothiocarbonate compound and its preparation method, belonging to the field of organic chemical synthesis technology. This invention discloses a multi-component reaction of a silicon ether, elemental sulfur, and a difluorocarbene reagent under the action of an organic base to synthesize O,O'-monothiocarbonate compounds. Furthermore, the preparation method disclosed in this invention uses readily available and commercially available reactants, avoiding the use of hazardous and scarce reagents. The reaction conditions disclosed in this invention are mild, easy to operate, and yield a high quantity of O,O'-monothiocarbonates.

A preparation method and use of a novel pure inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material are disclosed. The surface hydroxyl-rich metasilicic acid is used as the raw material, and by using a sulfonating reagent and / or phosphoric acid, the sulfonic acid group and / or the phosphoric acid group are bonded to the inorganic silicon material by chemical bonding to obtain a pure inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material. The catalytic material can be widely used in many acid-catalyzed organic reactions such as isomerization, esterification, alkylation, hydroamination of olefins, condensation, nitration, etherification, multi-component reactions and oxidation reactions. The inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material of the present invention has the advantages of high acid amount, high activity, good hydrothermal stability, no swelling, simple preparation, low cost, no pollution, no corrosion, easy separation and reusability.

The invention provides a construction method of a light-stable high-photon-number fluorescent probe and application of the light-stable high-photon-number fluorescent probe in single-molecule and super-resolution fluorescence imaging. The probe is efficiently prepared through one-pot multi-component reaction of aldehyde containing cyclooctatetraene, amine containing benzothiazole methyl sulfone, fluorophore carboxylic acid with a click tag and tert-butyl isocyanide. The probe can realize cysteine site specific labeling through nucleophilic aromatic substitution, the cyclooctadiene light stabilizer can effectively quench triplet, photon output and photobleaching resistance are improved synergistically, and the probe and the cyclooctadiene light stabilizer are suitable for super-resolution fluorescence imaging of biomacromolecules such as single molecules and nucleopore proteins. And a high-performance probe is provided for an advanced super-resolution fluorescence microscopy technology.

An additive manufacturing system including a multi-axis additive manufacturing device and a rotating / tilting printing bed for multi-axis movement for multi-component reactive extrusion printing, and methods of using the same, is disclosed.

The invention discloses a method for preparing a drug conjugate through carboxylic acid participated multi-component reaction. The method comprises the following steps: taking an alpha-alkynyl MBH addition product, a carboxylic acid compound and a 2-formyl-3-acrylonitrile compound as raw materials, reacting in a solvent under the action of a catalyst, and separating to obtain a multi-component reaction product. The method has the advantages of simple process, convenience in operation, relatively high yield, relatively few byproducts and the like; meanwhile, the preparation method disclosed by the invention is wide in substrate applicability, can be compatible with various functional groups, and is suitable for various carboxylic acids and 2-formyl-3-acrylonitrile compounds, so that derivatives of various bioactive carboxylic acids are obtained, and a new thought is provided for modification and molecular design of carboxylic acid-containing drug molecules.

The invention discloses a method for preparing imide through a multi-component reaction of olefin and 1, 3-eneyne with peroxybenzoate and acetonitrile under the catalysis of copper, which is characterized by comprising the following steps: in the presence of a copper catalyst, a ligand and peroxyaryl carboxylic acid tert-butyl ester and under the heating condition, carrying out a reaction on 1, 3-eneyne and 1, 3-eneyne in an acetonitrile organic solvent to prepare the imide. Reacting the compound in the formula (1) with a compound in a formula (2) and acetonitrile to generate imides in a formula (3) and a formula (4); and reacting the compound in the formula (5) with the compound in the formula (2) and acetonitrile to generate imides in a formula (6) and a formula (7). The preparation method provided by the invention can be suitable for various aryl olefins, drug-derived olefins, alkyl-substituted 1, 3-enyne, aryl-substituted 1, 3-enyne and silicon-substituted 1, 3-enyne, and has the advantages of simple and easily available substrate and wide universality. The method has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide reaction substrate application range, easy reaction amplification, mild reaction conditions and the like, and can realize industrial production and application.

The application discloses a thermogravimetric analysis device and method for high-humidity multi-component atmosphere reaction kinetics research, and belongs to the technical field of thermogravimetric analysis instruments.The device comprises a reaction module, a heating furnace, a weighing module, a gas distribution module and an analysis module; the reaction module is vertically arranged in the heating furnace, and the core is a reaction tube main body which is open at the lower part; the side surface is connected with a gas inlet pipe and a sampling pipe from top to bottom; the weighing module is located below the reaction module and comprises a weighing balance, a water cooling unit and a weighing support rod; the water cooling unit can control the water vapor condensation area and stabilize the balance temperature; the gas distribution module can provide a multi-component reaction atmosphere containing controllable concentration water vapor; and the analysis module can detect the tail gas composition in real time.The application can realize low gas-solid mass transfer resistance, stable control of a high-humidity environment, wide particle size sample measurement and rapid temperature rise and fall, and is suitable for high-humidity multi-component atmosphere gas-solid reaction kinetics research in the fields of combustion, catalysis, adsorption and the like.

The present invention relates to the technical field of energy recovery and biomass conversion, and specifically discloses a heat transfer calculation method for coupling biomass pyrolysis with metallurgical slag waste heat recovery. First, a heat transfer model between biomass particles and high-temperature metallurgical slag particles in a rotary kiln is established. A three-parallel pyrolysis reaction model is used to define the three components of biomass particles, and decomposition is performed according to a single Arrhenius-type reaction to describe the kinetic behavior of the biomass pyrolysis reaction. This comprehensively covers the multi-component reaction paths and characteristics of biomass pyrolysis, and accurately characterizes the pyrolysis behavior of biomass in contact with high-temperature metallurgical slag and its impact on the heat transfer process. By effectively combining these two models, numerical simulation calculations of the biomass-high-temperature metallurgical slag heat transfer process are realized, and the changing patterns of key parameters such as temperature distribution, heat flow transfer, and pyrolysis conversion distribution in the system can be accurately obtained. This contributes to a deeper understanding of the complex mechanism of heat transfer between biomass and high-temperature metallurgical slag.

The invention discloses a multi-component reaction solute transport simulation method based on a physical information neural network. Establishing a multi-component convection-dispersion-reaction (ADR) equation model; constructing a double sub-network, and loading a Runge-Kutta coefficient so as to complete implicit time advance; calculating a solute concentration gradient change rate and a reaction intensity change rate which are respectively used as two types of self-adaptive control indexes, and dynamically adjusting a time step length; and training iteration is carried out by adopting an Adam and L-BFGS combined optimization algorithm, so that recursive prediction of the spatial and temporal distribution of the pollutant concentration is realized. According to the method, the time resolution can be automatically adjusted, the calculation efficiency and the numerical stability are both considered, compared with a traditional PINN and time marching PINN (TM-PINN) method, the long-term prediction precision and the convergence performance are remarkably improved, and the method is suitable for underground water pollution migration simulation and multi-component reaction-diffusion process modeling.

The invention discloses a preparation method of polysaccharide-based functional hydrogel constructed based on multi-component reaction, and belongs to the field of biomedical materials. The method comprises the following steps: preparing dialdehyde cellulose, preparing a chitosan solution, preparing a dialdehyde cellulose-anthocyanin solution and finally forming the hydrogel. Cellulose is oxidized by sodium periodate to prepare dialdehyde cellulose, and the dialdehyde cellulose, a chitosan solution and anthocyanin are subjected to multi-component reaction under mild conditions to form a covalent cross-linked network in situ. According to the invention, the use of toxic chemical cross-linking agents is avoided, the process is simple, the conditions are mild, and the prepared hydrogel has injectability, self-healing property, good swelling property and excellent antibacterial and antioxidant activity and blood compatibility, and is suitable for the biomedical fields of wound dressing, drug delivery and the like.

The invention provides a modified natural polysaccharide, an antibacterial anti-inflammatory self-healing gel material as well as a preparation method and application of the modified natural polysaccharide and the antibacterial anti-inflammatory self-healing gel material. The modified natural polysaccharide is prepared by introducing a 1, 4-dihydropyridine structural unit and a boric acid structural unit with anti-oxidation characteristics into a natural polysaccharide structure through a multi-component reaction. According to the anti-inflammatory self-healing gel material, an interactive dynamic bone scaffold is formed in gel through boric acid ester bonds between modified natural polysaccharide and a compound containing a cis-diol structure, so that the gel has a self-healing characteristic, and the anti-inflammatory self-healing gel material can be prepared by adjusting the content of a grafted boric acid structure unit or the proportion of the modified polysaccharide in a gel system. The mechanical property, the degradability and the swelling property of the gel network are regulated and controlled. The obtained anti-inflammatory self-healing gel material can be applied to repair of different soft tissues such as skin and oral cavity, and has a good application prospect.

Present invention relates to a reactive resin composition comprising a peroxide-free initiator system, a multi-component reactive resin system comprising the reactive resin composition, the use of the reactive resin composition for fastening anchoring means in substrates and a method for the chemical fastening of construction elements in boreholes using the reactive resin composition or the multi-component reactive resin system.

The application relates to a method for synthesizing a bisferrocenyl compound by using a multi-component reaction and application, and the synthesis method is as follows: adding ferrocene formaldehyde, aminoferrocene, a Lewis acid, anhydrous dichloromethane and anhydrous diethyl ether into a reaction bottle, stirring and dissolving for reaction, then adding acetylferrocene, adding trimethylchlorosilane under stirring, continuing the reaction at room temperature, adding an inorganic alkali aqueous solution after the reaction is completed, extracting with an organic solvent, combining the organic phases, concentrating the solvent, and purifying the crude product through silica gel column chromatography to obtain the target compound. The application synthesizes a novel compound 1,3-bisferrocenyl-3-ferrocenylamino propanone containing three ferrocene groups by using acetylferrocene, ferrocene formaldehyde and aminoferrocene as raw materials and through a Mannich three-component reaction under acidic conditions, and the novel compound exhibits superior antioxidant activity, and the antioxidant performance is superior to that of corresponding single ferrocene group compounds and bisferrocene group compounds, and the novel compound has potential application value.