143 results about "Multi-component reaction" patented technology

Mixing and dispensing apparatus and methods for use with, e.g., a multi-component reactive material process is disclosed. In one embodiment, the apparatus comprises a series of positive displacement pumps adapted for stacked or “piggy-back” mating to a common motive source. At least one of the pumps is supplied by a sealed and collapsible reservoir bag and flexible tubing, thereby allowing removal (and optionally disposal) of one or more complete material pathways within the system. Such a configuration allows for, inter alia, rapid colorant changing with minimal material waste, obviates the use of hazardous solvents, and increases process efficiency and worker productivity. This arrangement also obviates complex metering apparatus common to prior art systems, thereby allowing it to be as small and power / cost efficient as possible.

A fragment-based strategy, involving “multicomponent reaction chemistry” (MCR), can identify novel chemotypes that disrupt the p53 / MDM2 or p53 / MDM4 complex employs. This approach uses high resolution structural information to delineate the region of a first protein or a ligand that is nestled within the binding pocket of a second target protein. The identified region is imported into a database containing MCR scaffolds to generate a virtual library of compounds, which subsequently are docked into the binding pocket of the target protein. Results from docking then are used to select compounds for synthesis and screening. A complementary, NMR-based methodology allows for screening the ability of compounds, selected using MCR, to disrupt the p53 / MDM2 or p53 / MDM4 complex.

A mod of combustion and a multi-component reactor to accomplish this mode of combustion are disclosed which produces fullerenes and fullerenic material by combustion. This mode consists of de-coupling an oxidation region of a flame from a post-flame region, thus giving greater control over operating parameters, such as equivalence ratio, temperature, and pressure; allows conditions of the operating parameters of the combustion reaction to be attained which would not be easily attained by conventional methods; and offers the ability to more easily stabilize the combustion reactions to allow for higher throughputs of fuel and oxidant. Several embodiments of a primary zone of a multicomponent reactor are also disclosed. Said primary zone serves as the oxidation region, operates on the principle of providing recycle to the reacting combustion mixture, and which may be operated as approximately a well-mixed reactor. A secondary zone is also disclosed which provides further residence time for reaction and the ability to control operating parameters, operates on the principle of minimizing recycle of the reacting combustion mixture. The secondary zone may be operated as approximately a plug-flow reactor. The primary and secondary zones may be operated in conjunction or either one alone.

A frangible projectile, and weapon cartridge containing same, is provided, in which the frangible projectile is comprised of a hollow outer body composed of, for example, a plastic or polymeric material, configured to provide a payload material. Preferably, the hollow outer body has an interior surface having a divider formed or disposed therein, for controlling the movement of the payload material after firing. The hollow outer body of the frangible projectile, upon impact, rapidly fragments upon impact into relatively harmless pieces, and releases / mixes the payload material. However, the payload material may be chosen to provide sufficient mass, and accordingly sufficient kinetic energy, to provide desired target effects, such as powder metals. Alternatively, payload materials, such as reactive chemical components, marking agents, chemiluminescent compositions, incapacitants, multi component reactive compositions, etc., preferably contained within one or more payload containers, are provided.

The invention relates to a polishing pad, a polyurethane polishing layer and a preparation method thereof, and belongs to the field of a polishing technology for chemical mechanical planarization processing. The polyurethane polishing layer with the coefficient of thermal expansion being 70 to 200ppm / DEG C contains a reaction product generated by multi-component reaction. The multiple components comprise an isocyanate end-capped prepolymer, a hollow microporous polymer and a curing agent composition. The curing agent composition comprises 5-55 weight percent of aliphatic diamine composition, 0-8 weight percent of polyamine composition, and 40-90 weight percent of aromatic bifunctional composition. The polyurethane polishing layer has the density being 0.6- 1.1g / cm<3>, the shore harness being 45-70 D, and the elongation at break being 50-450 percent. A preparation process of the polyurethane polishing layer is simple, low in cost and small in energy consumption, and the polyurethane polishing layer prepared through the process has the advantages of high hydrolytic stability, uniform density, stable removal rate and the like.

The invention relates to a hybrid micro-fluidic chip based on a micro / nano structure and a preparation method thereof. A micro-channel and the micro / nano structure are formed on the surface of the micro-fluidic chip; solution is efficiently mixed through the micro / nano structure on the surface of the micro-channel to quickly and efficiently mix micro-fluidic solution; and the hybrid micro-fluidic chip is mainly applied to the relevant fields of biological assay, phase change reaction, multi-component reaction and the like. The micro-fluidic chip and the preparation method thereof have the benefits that the operation is simple, efficient mixing of the micro-fluidic solution is realized, the mixing cost of the micro-fluidic solution is greatly reduced, the micro-fluidic chip has the characteristics of convenience in carrying, economy, quickness and high efficiency, and a brand-new analysis technology is provided for efficient and uniform mixing of the micro-fluidic solution.

A dispensing apparatus and methods for use with, e.g., a multi-component reactive material process. In one embodiment, the apparatus comprises a completely disposable static mixer, manifold and atomizer cap assembly. Such a configuration allows for, inter alia, reduced cost, rapid component changes with minimal material waste, as well as reducing or eliminating the use of hazardous solvents. Precise and repeatable configuration of the dispensing assembly is also provided by way of the substantially fixed relationship of the critical components and surfaces therein.

The invention relates to an L-proline trifluoromethanesulfonic acid ammonium salt and an application thereof. The L-proline trifluoromethanesulfonic acid ammonium salt is prepared from trifluoromethanesulfonic acid and L-proline. The L-proline trifluoromethanesulfonic acid ammonium salt can be applied to catalyze a condensation reaction of three components of aldehyde, amide and phenol, wherein the condensation reaction of the three components of the aldehyde, the amide and the phenol is completely carried out in an organic solvent under the action of a trifluoromethanesulfonic acid ammonium salt by using the phenol and the aldehyde and the amine as raw materials, and then reaction liquid is separated and purified to obtain a corresponding multicomponent condensation product. The inventiondevelops a novel trifluoromethanesulfonic acid ammonium salt, thereby promoting the application of acid organic catalysts of a new generation in multicomponent reactions and meanwhile promoting the further development of the multicomponent reactions.

The invention provides a multi-component reaction preparing method for a functional nanometer porous polymer material. The multi-component reaction preparing method comprises the following steps: a, preparing an aldehyde reactant containing double bonds by a multi-component synthesis technology; b, utilizing 4-(allyloxy)benzaldehyde which is prepared in step a to realize Ugi four-component reaction so as to prepare a functional monomer; c, polymerizing reaction: using divinyl benzene as a crosslinking monomer, adding an initiator, and carrying out copolymerization reaction on the divinyl benzene and a proper quantity of Ugi reaction product by a solvothermal process so as to obtain the functional nanometer porous polymer material, wherein the mass ratio of the divinyl benzene to the functional monomer is 1.0-4.0, the mass ratio of the initiator to the divinyl benzene is 0.01-0.05, the mass ratio of a solvent to the divinyl benzene is 4.0-10.0, the polymerizing temperature is in a range between 60 DEG C and 200 DEG C, the pressure is controlled between 0.1MPa and 5.0MPa, and the reaction lasts for 12-48 hours.

A flexible composite release sheet providing a replicative surface with a desired surface effect and a method of manufacturing such a release sheet is disclosed. The release sheet is suitable for use in multicomponent reactive urethane casting systems. The invention further provides flexible composite release sheets having a first acrylic functional coating layer containing the desired surface effect and a second silicone release coating layer overlying the acrylic functional coating layer.

A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma, etc.), antibacterial agents, and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-kappaB as well as potent activity against the Gram (+) bacterium. The compositions are also useful for treating autoimmune diseases and for inhibiting rejection of organ and tissue transplants.

A new class of imidazolines as 4-position esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma, etc.), antibacterial agents, and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-κB as well as potent activity against the Gram (+) bacterium. The compositions are also useful for treating autoimmune diseases and for inhibiting rejection of organ and tissue transplants.

A system for controlling dispensation of multiple component reactant mixtures. A mixing chamber is positioned adjacent to a part. A metering ram is actuated to pressurize at least two reactant components. The metering ram is stopped if a measured pressure value exceeds a predetermined pressure value. At least one flow meter measures a volume of a reactant component passing through the system.

A mod of combustion and a multi-component reactor to accomplish this mode of combustion are disclosed which produces fullerenes and fullerenic material by combustion. This mode consists of de-coupling an oxidation region of a flame from a post-flame region, thus giving greater control over operating parameters, such as equivalence ratio, temperature, and pressure ; allows conditions of the operating parameters of the combustion reaction to be attained which would not be easily attained by conventional methods; and offers the ability to more easily stabilize the combustion reactions to allow for higher throughputs of fuel and oxidant. Several embodiments of a primary zone of a multicomponent reactor are also disclosed. Said primary zone serves as the oxidation region, operates on the principle of providing recycle to the reacting combustion mixture, and which may be operated as approximately a well-mixed reactor. A secondary zone is also disclosed which provides further residence time for reaction and the ability to control operating parameters, operates on the principle of minimizing recycle of the reacting combustion mixture. The secondary zone may be operated as approximately a plug-flow reactor. The primary and secondary zones may be operated in conjunction or either one alone.

A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma etc.), antibacterial agents and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-κB as well as potent activity against the Gram (+) bacterium B. subtillus and B. cereus with MIC values in the range of 50 μm / mL.

Tapes comprising (A) a first ribbon comprising (1)(a) a polyolefin containing at least one silane functionality, and (1)(b) a hydroxy-terminated silicone polymer, or (2) a blend of a vinyl silane, polyolefin, organic initiator, e.g., peroxide, and a hydroxy-terminated silicone polymer, and (B) a second ribbon comprising a catalyst masterbatch, the second ribbon carried on the first ribbon, allow for the delivery of a consistent mixture of resin and catalyst to an injection molding machine.

A mold for use in a reaction injection molding method and system to make a reinforced polymeric article having reduced surface defects includes a novel gating system. The mold includes a pair of mold sections which define a closed, article-forming cavity, an injection aperture, and an after-mixer which helps to form a plurality of flow paths which extend downstream from the injection aperture toward the article-forming cavity to further mix a curable, multi-component, reaction fluid mixture including a filler. The flow paths are also at least partially defined by an elongated film gate and an elongated runner which extends along and is in fluid communication with the film gate along substantially the entire length of the film gate. The runner has a closed end and an open end into which a fluid mixture for the article flows for distribution by the runner into the film gate.

The invention relates to a polishing pad, a polyurethane polishing layer and a preparation method thereof, and belongs to the field of a polishing technology for chemical mechanical planarization processing. The polyurethane polishing layer with the coefficient of thermal expansion being 70 to 200ppm / DEG C contains a reaction product generated by multi-component reaction. The multiple components comprise an isocyanate end-capped prepolymer, a hollow microporous polymer and a curing agent composition. The curing agent composition comprises 5-55 weight percent of aliphatic diamine composition, 0-8 weight percent of polyamine composition, and 40-90 weight percent of aromatic bifunctional composition. The polyurethane polishing layer has the density being 0.6- 1.1g / cm<3>, the shore harness being 45-70 D, and the elongation at break being 50-450 percent. A preparation process of the polyurethane polishing layer is simple, low in cost and small in energy consumption, and the polyurethane polishing layer prepared through the process has the advantages of high hydrolytic stability, uniform density, stable removal rate and the like.

The invention relates to a dicyclohexyl trifluoromethanesulfonate ammonium salt and application thereof. The dicyclohexyl trifluoromethanesulfonate ammonium salt is prepared from trifluoromethanesulfonate and dicyclohexylamine. The dicyclohexyl trifluoromethanesulfonate ammonium salt can be applied to catalyzing the condensation reaction of three components such as aldehydes, amide and phenol, the condensation reaction of the three components such as the aldehydes, the amide and the phenol takes the phenol, the aldehydes and the amine as raw materials and is completely finished in an organic solvent under the action of the dicyclohexyl trifluoromethanesulfonate ammonium salt, and the reaction solution is separated and purified to obtain the corresponding multi-component condensation product. The invention develops a novel trifluoromethanesulfonate ammonium salt, promotes the application of a new generation of acid organic catalyst in the multi-component reaction, and promotes the further development of the multi-component reaction.

The invention relates to a preparation method of a 2-phenyl-imidazo[1,2-a]pyridoquinoxaline-2(1H)-one ketone derivative. The method comprises the following steps: performing a multi-component reactionused as a basis to obtain a condensation product, performing simple post-treatment, deprotecting the post-treated condensation product under an alkaline condition, and performing microwave-assisted ring closure to obtain the 2-phenylimidazo[1,2-a]pyridoquinoxaline-2(1H)-one derivative with potential anticancer activity.

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are useful for the synthesis of chiral vicinal diols by tandem and / or simultaneous reactions involving Heck coupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloid compounds both as an native one and immobilized one in the said matrix support. This invention also relates to a process for preparing vicinal diols by asymmetric dihydroxylation of olefins in presence of cinchona alkaloid compounds employing reusable multifunctional catalysts as heterogeneous catalysts in place of soluble osmium catalysts.

The present invention provides a series of penta-substituted tetrahydropyrimidines with aggregation-induced emission (AIE) characteristics and preparation method and use thereof. The AIE penta-substituted tetrahydropyrimidines have structures shown as formula (I). R1 is selected from a group consisting of linear or branched alkyls and substituted alkyls. R2 and R4 is respectively selected from a group consisting of linear or branched alkyls, substituted alkyls, cycloalkyls, substituted cycloalkyls, aryls, substituted aryls, polycyclic aryls, substituted polycyclic aryls, heterocyclyls, substituted heterocyclyls, aromatic heterocyclyls and substituted aromatic heterocyclyls. R3 is selected from a group consisting of aryls, substituted aryls, polycyclic aryls, substituted polycyclic aryls, aromatic heterocyclyls and substituted aromatic heterocyclyls. The penta-substituted tetrahydropyrimidines can be prepared by multi-component reactions (MCR). There are 1˜3 aryls in the structure of the penta-substituted tetrahydropyrimidines. The penta-substituted tetrahydropyrimidines possess strong AIE properties and can be used for preparing organic electro-luminescence or photo-luminescence devices, or chemical and biological fluorescent sensors or probes.

The invention relates to synthesis and uses of beta-1-imidazole-2,3,4,6-tetrasulfo-D-glucopyranose hydrosulfate and belongs to hydrosulfate chemical synthesis by multi-component reactions and uses of the hydrosulfate. The synthesis includes: subjecting glucose 1 that is adopted as a raw material to acetylation to obtain a compound 2; performing bromination by adopting the compound 2 as a raw material to obtain a compound 3; reacting the compound 3 with 1-methylimidazole to obtain a compound 4; hydrolyzing the compound 4 under alkaline conditions to obtain a target compound 5; and reacting the compound 5 with chlorosulfonic acid to obtain a target product 6 that is the beta-1-imidazole-2,3,4,6-tetrasulfo-D-glucopyranose hydrosulfate. A five-component reaction of 2 equivalents of an aromatic aldehyde, 2 equivalents of an arylamine and 1 equivalent of ethyl acetoacetate is performed by adopting the target product 6 as a catalyst at 40 DEG C under mild conditions to synthesize an ethyl 4-phenylamino-1-phenyl-1,2,5,6-tetrahydro-2,6-diphenylpyridine-3-carboxylate derivative. The synthesis and the uses are characterized in that: (1) the product 10 is obtained rapidly with a high yield; (2) reaction conditions are mild, operation is simple, reaction time is short, the yield is high and after-treatment is simple and convenient; and (3) the synthesis is green, economical and efficient.

The invention relates to a preparation method for trans-glycyrrhizic acid. Diammonium glycyrrhizinate is directly placed in carbinol, a proper amount of protonic acid is added for catalysis, and under room temperature conditions, trans-glycyrrhizic acid methyl ester is selectively combined in automatic coherent type multicomponent reactive mode so as to change physical and chemical properties of a glycyrrhizic acid stereoisomer mixture, enable trans-glycyrrhizic acid methyl ester with weak polarity to be dissolved out from reaction liquid and filtered and obtain trans-glycyrrhizic acid methyl ester to be separated from cis-glycyrrhizic acid. Then, single-component trans-glycyrrhizic acid is prepared through saponification, acid neutralization and the like, and cis-glycyrrhizic acid is recycled. The preparation method resolves the technical problem that the glycyrrhizic acid stereoisomer mixture cannot be separated and has the advantages of being simple, low in energy consumption and high in yield and improving utilization ratio of natural glycyrrhizic acid.

A new class of imidazolines as 4-position esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma, etc.), antibacterial agents, and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-κB as well as potent activity against the Gram (+) bacterium. The compositions are also useful for treating autoimmune diseases and for inhibiting rejection of organ and tissue transplants.

A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma, etc.), antibacterial agents, and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-κB as well as potent activity against the Gram (+) bacterium. The compositions are also useful for treating autoimmune diseases and for inhibiting rejection of organ and tissue transplants.

The invention provides a 1,3-cyclodiketone enol ether compound, a 1-asymmetirc donor-receptor cyclopropane as well as synthesis methods thereof. By use of a reaction method for selectively using oxygen atoms of 1,3-cyclodiketone as nucleophilic sits to perform nucleophilic attack on 1-symmetric donor-receptor cyclopropane, a 1,3-cyclodiketone enol ether compound is obtained; a novel 1-asymmetirc donor-receptor cyclopropane 5 is obtained through intracellular conversion of the compound 3. The 1-asymmetirc donor-receptor cyclopropane 5 is obtained efficiently through desymmetrization of 1-asymmetirc donor-receptor cyclopropane through the simple two-step reaction. Meanwhile, the 1-asymmetirc donor-receptor cyclopropane 5 contains a cycloketene structure which is a very good intermediate module for constructing complex compounds in Domino and multi-component reactions.

The invention discloses a tetrahydroindole compound, and a preparation method and an application thereof, and belongs to the technical field of the chemical synthesis. Raw materials comprising a 1,3-cyclohexanedione compound, nitroalkene and amine undergo a one-pot process under microwave radiation in water as a solvent under the action of L-proline as a catalyst to prepare the tetrahydroindole compound in high yield. The catalyst used in the invention is a non-transition metal catalyst having a low price, so the synthesis cost is substantially reduced; the reaction condition in a catalysis system is mild and can be easily controlled, and the product can be obtained through a domino cyclized multi-component one-step reaction; and the method has the advantages of green and pollution-free experiment program, simple and effective experiment operation, and diversified product structure. The method which uses water as a solvent has the characteristics of simple post-treatment, small pollution to the environment, no damages to the health of the body of an operation worker, and easy realization of the industrialized production.

The invention discloses a method for synthesizing a dihydrofuran compound containing a 1, 3-indandione spiro skeleton as shown in a formula III by using a micro-channel reaction device, which comprises the following steps: by using a 2-benzylidene-1, 3-indandione compound I and a benzoyl ethyl acetate compound II as reaction raw materials, carrying out continuous reaction by using the micro-channel reaction device to prepare the dihydrofuran compound containing a 1, 3-indandione spiro skeleton. The micro-channel reaction device comprises a feeding pump, a micro-mixer and a micro-reactor whichare sequentially connected through a pipeline. Compared with the prior art, the new dihydrofuran containing the 1, 3-indandione spiro skeleton is prepared by taking the 2benzylidene 1, 3-indandione compound as the substrate for the first time, and the method avoids multi-component reaction, uses a non-metal catalyst and a low-toxicity solvent, and is a quick, efficient, green and environment-friendly synthetic product, wherein R1 is selected from halogenated benzene, C1-C4 alkyl benzene, C1-C4 alkoxy benzene, nitrobenzene, furan or naphthalene, and R2 is selected from halogenated benzene, C1-C4 alkyl benzene, C1-C4 alkoxy benzene, nitrobenzene, furan, thiophene, pyridyl or naphthalene.