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10 results about "Pharmaceutical sciences" patented technology
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The pharmaceutical sciences are a group of interdisciplinary areas of study concerned with the design, action, delivery, disposition, inorganic, physical, biochemical and analytical biology, epidemiology, statistics, chemometrics, mathematics, physics, and chemical engineering, and applies their principles to the study of drugs. The pharmaceutical sciences are further subdivided into several specific specialties, with four main branches: Pharmacology: the study of the biochemical and physiological effects of drugs on human beings. Pharmacodynamics: the study of the cellular and molecular interactions of drugs with their receptors. Simply "What the drug does to the body" Pharmacokinetics: the study of the factors that control the concentration of drug at various sites in the body. Simply "What the body does to the drug" Pharmaceutical toxicology: the study of the harmful or toxic effects of drugs. Pharmacogenomics: the study of the inheritance of characteristic patterns of interaction between drugs and organisms. Pharmaceutical chemistry: the study of drug design to optimize pharmacokinetics and pharmacodynamics, and synthesis of new drug molecules.
Application of NAT10 antagonists in the preparation of drugs for the prevention and / or treatment of epilepsy
ActiveCN117159541BOrganic active ingredientsNervous disorderPharmaceutical drugPharmaceutical sciences
This invention relates to the field of pharmaceutical science, and more particularly to the application of NAT10 antagonists in the preparation of medicaments for the prevention and / or treatment of epilepsy. This invention provides the application of NAT10 antagonists in the preparation of medicaments for the prevention and / or treatment of neurological diseases characterized by epileptic seizures. This invention is the first to demonstrate through pharmacological experiments that a NAT10 antagonist, remodelin, has anti-epileptic effects, thus possessing high clinical application value and development prospects.
Owner:NANHUA UNIV
Novel heterocyclic compounds
The present invention provides novel heterocyclic compounds, their hydrates, solvates, or pharmaceutically acceptable salts as 15-PGDH inhibitors. The novel heterocyclic compounds of the present invention have been confirmed to exhibit excellent 15-PGDH inhibitory activity and to be usable for the prevention or treatment of 15-PGDH-related diseases. Therefore, the novel heterocyclic compounds of the present invention can be usefully used in the prevention or treatment of 15-PGDH-related diseases in the fields of medicine and pharmaceutical science.
Owner:INNOVO THERAPEUTICS INC
A sea anemone polypeptide, and methods of making and using the same
This invention relates to the field of pharmaceutical science, specifically to a sea anemone polypeptide, its preparation method, and its applications. The sea anemone polypeptide has the N-terminal sequence YPDQKMFELFWLEENNA, a molecular weight of 6027 Da, and an isoelectric point of 7.25. Preparation process: Fresh sea anemone is precipitated with 10%-70% acetone. After dialysis to remove salt from the active component, it is purified by ion exchange chromatography, gel filtration chromatography, and HPLC to obtain a sea anemone polypeptide with a molecular weight of 6027 Da. Experiments on tumor cells confirm that the sea anemone polypeptide has a significant inhibitory effect on the growth of various tumor cells but no inhibitory effect on the growth of normal cells.
Owner:SHANDONG UNIV OF POLITICAL SCI & LAW
Compound for modulating rlr, tlr, oas and / or oncostatin m pathways, use thereof for preparing a medicine, composition, method for modulating said pathways and method of treatment
The invention falls within the fields of pharmaceutical sciences, immunology and methods of treatment of cancer Methods. More specifically, the invention relates to a compound for modulating one or more innate immune pathways selected from RLR, TLR, OAS and / or oncostatin M, said compound being amblyomin-×or peptides derived from amblyomin-X. Use of said compound for preparing medicines; a pharmaceutical composition comprising said compound, a method for modulating said pathways in vitro and a method of treatment are also described.
Owner:INSTITUTO BUTANTAN
Systems and methods for in vitro mechanical testing
PCT designated stageWO2026044185A1Mechanical counters/curvatures measurementsPreparing sample for investigationRotational axisShape change
In vitro systems and methods can be used to detect one or more mechanical properties of one or more samples. A rotator can be configured to rotate around a rotational axis to produce centrifugal force that deforms at least one sample located in a deformation area. The sample can be pushed towards a deformation wall that is perpendicular to direction of the centrifugal force. At least one measurement sensor can be configured collect data related to shape changes of the at least one sample as it deforms or relaxes after deformation to reveal the one or more mechanical properties. The one or more mechanical properties are related to material sciences, life sciences, pharmaceutical sciences, or drug screening.
Owner:THE GENERAL HOSPITAL CORP
Analysis Method for the Relationship between Process Impurities and Degradation Impurities Based on Big Data Analysis Technology
ActiveCN119811549BChemical processes analysis/designSystems biologyPharmaceutical industryPhysical chemistry
The present invention relates to an analysis method for the relationship between process impurities and degradation impurities based on big data analysis technology. The correlation coefficients among process impurities, typical impurity variables, and degradation impurities are calculated through the canonical correlation analysis method, and then the transfer relationships among various impurities, typical impurity variables, and various degradation impurities are constructed by screening the correlation coefficients, so as to judge the correlation degree between process impurities and degradation impurities. The analysis method involved in the present invention comprehensively analyzes the impurity formation rules of drugs during the production, storage, and use processes, deeply explores the correlation relationship between process impurities and degradation impurities, reveals the internal relevance of different impurities, which not only helps to guide the direction of impurity profile research, provides a scientific basis for the control of key impurities of drugs and process optimization, but also helps to improve the safety and effectiveness of drugs, and promotes the further development of pharmaceutical science and the pharmaceutical industry.
Owner:NAT INST FOR FOOD & DRUG CONTROL
Quick-acting insulin (variant) compositions
The invention relates to the field of pharmaceutical science and medicine, in particular to a composition of a quick-acting insulin preparation. More specifically, the present invention relates to a composition comprising quick-acting insulin and an amino acid as a stabilizer wherein the amino acid may be selected from lysine and / or a salt thereof, or a combination of lysine and / or a salt thereof and arginine and / or a salt thereof. Compared with the closest prior art, the composition disclosed by the invention shows better chemical and physical stability.
Owner:OBSHCHESTVO S OGRANICHENNOJ OTVETABTVENNOSTJU GEROFARM
Salts of compounds and their crystal forms
This invention belongs to the field of pharmaceutical science and provides pharmaceutically acceptable salts of the compound (S)-7-(4-(1-(methylsulfonyl)-piperidin-4-yl)phenyl)-N-(morpholino-2-ylmethyl)pyrido[3,4-b]pyrazine-5-amine, their crystal forms, solvates and crystal forms, pharmaceutical compositions thereof, their preparation methods and applications.
Owner:HUTCHMED LIMITED
Patient medication guidance and pharmaceutical science popularization pushing method based on hospital medicine codes
PendingCN121350338ADigital data information retrievalDrug and medicationsDrug utilisationMedication information
The invention relates to the field of medical treatment, and discloses a patient medication guidance and pharmaceutical science popularization pushing method based on hospital medicine codes, comprising the following steps: S1, constructing a knowledge base, the content of the knowledge base comprising characters, voice, videos and information of medicines, and marking keywords; s2, inputting hospital medicine codes into a system by using an H25 system, matching the hospital medicine codes with a knowledge base, and generating indexes according to the medicine codes and the medicine information; and S3, performing organic correlation on the specific information of the medicine and the corresponding medication guidance information or the pharmaceutical science popularization knowledge by using a data correlation technology so as to realize one-stop acquisition of the information. The current situation that pharmacist resources are insufficient is effectively made up, guidance is accurately provided according to drugs used by patients, the pertinence and practicability of pharmaceutical science popularization are greatly enhanced, the patients can conveniently obtain personalized medication information and science popularization knowledge, and the medication safety consciousness and the self-management ability are improved.
Owner:ANSTEEL GRP CORP GENERAL HOSPITAL (ANSTEEL EMERGENCY CENT)
Use of pegylated indocyanine dye conjugated paclitaxel prodrug type compounds in anti-tumor cells
This invention belongs to the field of pharmaceutical science, specifically relating to the application of a PEGylated indocyanine dye-conjugated paclitaxel prodrug compound in antitumor cells. The application of this PEGylated indocyanine dye-conjugated paclitaxel prodrug compound in antitumor cells is characterized by the following structure: after targeting tumor cells, this compound generates a large amount of reactive oxygen species (ROS) under near-infrared light irradiation, causing mitochondrial damage to tumor cells, thereby exerting cytotoxic effects while simultaneously combining photodynamic therapy to kill tumor cells.
Owner:SHENYANG PHARMA UNIV