21 results about "Pharmaceutics technology" patented technology

The embodiment of the invention provides a double-inlet capture column switching device for step-by-step purification of multispecific antibodies, and relates to the technical field of biological pharmacy, the double-inlet capture column switching device comprises a first capture column, a switchable valve and a second capture column; a first inlet is formed in the upper end of the first capturing column; the switchable valve is of a three-way structure and comprises a second inlet, a second outlet and a third outlet. The upper end of the second capturing column is provided with a first inlet and a second inlet, and the lower end is provided with a fourth outlet; the second inlet communicates with the first outlet through a pipeline, the second outlet directly communicates with an external outflow pipeline, and the third outlet is connected to the first inflow port through a pipeline; the second flow inlet is directly connected with an external mobile phase pipeline; a double-inlet switching structure is arranged at the upper end of the second capturing column, and the first inflow port or the second inflow port can be selectively opened. The device has the effects of short operation time and low cross contamination risk.

The invention provides a traditional Chinese medicine composition for treating sudden deafness, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is prepared from 17 traditional Chinese medicinal materials including firethorn fruit, hematoxylon, murraya paniculata, aspongopus, fructus choerospondiatis, lignum dalbergiae odoriferae, ruddle, oyster, borneol, asarum, rhizoma iridis tectori, equisetum, sophora flower, folium turpiniae, medlar, mulberry and hawthorn leaf, and all the medicinal materials are combined to achieve the effects of activating blood and promoting qi circulation, opening orifices and improving hearing, regulating qi and dissipating blood stasis, clearing heat and purging intense heat, nourishing liver and kidney and combining purgation and tonification. When the traditional Chinese medicine composition is used for treating qi stagnation and blood stasis type sudden deafness, the hemodynamics of a patient can be remarkably improved, hearing impairment of the patient can be recovered, clinical symptoms of the patient can be improved, the clinical curative effect can be effectively improved, and the traditional Chinese medicine composition has high safety.

The utility model relates to the field of biopharmaceutical technology, disclose a valve assembly, including valve body and sealing washer, wherein the valve body is equipped with the sealing washer installation groove for installing sealing washer, is equipped with one -way exhaust structure in sealing washer installation groove, it includes the air vent and elastic protective sheath, the air vent intercommunication sealing washer installation groove with elastic protective sheath, elastic protective sheath covers air vent in its inside, when the inside pressure of elastic protective sheath is greater than the outside pressure, elastic protective sheath is pressed and occurs expansion, its outer diameter is larger and exceeds the boss outer diameter, forms the gap between with boss outer wall, air vent opens, gas is discharged to the outside through the gap, realizes the pressure reduction inside container, when the inside pressure of elastic protective sheath is less than or equal to the outside pressure, elastic protective sheath contracts, sticks boss outer wall, closes side wall hole, air vent closes, prevents the outside gas or pollutant to enter the inside container, the utility model realizes the demand of equipment sterile transmission through one -way exhaust structure.

The application belongs to the technical field of pharmacy and relates to a method for preparing cefixime by using an enzyme method. The method comprises the following steps: performing an enzymatic hydrolysis reaction on cefixime alkyl ester in water in the presence of a hydrolytic enzyme at a pH of 7-8.5 to obtain cefixime. According to the method for preparing cefixime by using the enzyme method, the reaction condition becomes milder, the generation of impurities in the reaction process is effectively controlled, and the product quality and yield of cefixime are both improved.

This application relates to the field of traditional Chinese medicine pharmaceutical technology, and discloses a traditional Chinese medicine for treating diabetic neuropathy and its preparation method. The traditional Chinese medicine is prepared from Coptis chinensis, Corydalis yanhusuo, Schisandra chinensis, Cornus officinalis, Astragalus membranaceus, and Cinnamomum cassia. The preparation method includes: low-temperature differential pretreatment of the raw materials; gas-phase assisted mechanical activation of components A and C under pressurized carbon dioxide environment, utilizing in-situ generation of carbamate intermediates in the gas phase to reduce lattice energy; subsequently, component B is added and pulsed milling is performed, directionally assembling into a hydrophobic ion-pair complex through a thermodynamically driven ligand substitution reaction; finally, the pressure and temperature are increased in situ to convert the reaction medium into a supercritical fluid for integrated extraction. This invention achieves the transformation of the active ingredient from a hydrophilic to a lipophilic chemical form through a gas-phase activation and stepwise substitution strategy, enabling it to effectively penetrate the blood-nerve barrier. Simultaneously, the low-temperature, anaerobic environment throughout the process effectively avoids the degradation of heat-sensitive components.

The invention relates to the technical field of chemical pharmacy, and discloses a method for preparing high-purity R-lipoic acid, which comprises the following steps: S1, adding (S)-6, 8-dichloro ethyl caprylate, sulfur, water and a combined catalyst into a reaction flask; s2, dropwise adding a sodium sulfide aqueous solution for a certain time and at a certain temperature; s3, after dropwise adding is completed, heat preservation is conducted till the reaction is completed, cooling is conducted, acid water is dropwise added, the system pH is adjusted, stirring and filtering are conducted continuously, water is added into a filter cake, and heating and stirring are conducted; and S4, cooling, carrying out suction filtration, and drying to obtain the product. By adding the combined catalyst, impurities such as trisulfide and S-lipoic acid can be reduced at the same time, dozens of times of water is not needed for refining, the yield of the whole process is increased to 95% from 85%, and the optical purity of the product is increased to 99.8% from 99.5%.

The utility model belongs to the technical field of biological pharmacy, and particularly relates to a chick embryo allantoic fluid collecting device which comprises a syringe needle, a needle stem and a pintle. The anti-blocking filtering piece comprises a sleeve, a housing and a connecting piece, the front end of the needle stem is covered with the housing, the risk that yolk is damaged in the collecting process can be reduced by means of the characteristics that the outer surface of the housing is smooth and free of edges and corners, and the egg yolk collecting device is convenient, rapid and high in yield and provides convenient conditions for follow-up production; a plurality of liquid inlet holes are formed outside the housing, so that liquid inlet paths can be dispersed, and the blocking risk caused by a single channel is reduced; the needle stem is sleeved with the sleeve, stable support is provided for the housing, and the stability of the collecting process is guaranteed; and finally, the connecting piece is arranged to be detachably connected with the pintle, so that assembling and disassembling can be facilitated, and cleaning and replacement are facilitated.

This invention discloses an ultrafiltration system with real-time protein concentration control, belonging to the field of biopharmaceutical technology. The system includes a replenishment tank, a recirculation tank, an ultrafiltration unit, and a controller. The recirculation tank is connected to the replenishment tank via a replenishment pipe, which is equipped with a replenishment pump and a valve, with the valve located between the replenishment pump and the recirculation tank. A protein concentration detection component A is located at the bottom of the recirculation tank. The ultrafiltration unit is connected to the recirculation tank via a delivery pipe and a return pipe. A circulation pump is installed on the delivery pipe, and a back pressure component and a protein concentration detection component B are installed on the return pipe. This system can improve the consistency of protein concentration in the recirculation tank during constant-volume dialysis, reduce batch-to-batch differences in protein concentration, and thus improve the uniformity of product quality. It can also prevent concentration polarization caused by excessively high protein concentration from affecting protein stability.

This application relates to the field of traditional Chinese medicine pharmaceutics technology, specifically disclosing a cold-maceration preparation method for fermented medicinal wine. The method includes the following steps: S1, pulverizing a traditional Chinese medicine composition to obtain coarse powder, wherein the composition includes a principal drug array, an assistant drug array, a adjuvant drug array, and a guiding drug array, and the principal drug array is made from raw materials containing the following parts by weight: 8-12 parts artificial musk, 45-55 parts camphor, and 45-55 parts borneol; S2, mixing the coarse powder obtained in S1 with white wine, sealing and soaking to obtain an soaking mixture; S3, opening the seal and stirring the soaking mixture obtained in S2 to obtain fermented medicinal wine. The cold-maceration preparation method for fermented medicinal wine of this application has the unique advantages of a clear distinction between the principal, assistant, adjuvant, and guiding drug layers in the formulation design, synergistic effects, and a preparation process that can fully and stably extract the effective components of each drug array, resulting in a medicinal wine with concentrated and targeted medicinal power, especially suitable for dispelling deep-seated cold pathogens and clearing meridian blockages.

The utility model relates to the technical field of biopharmacy, in particular to a biopharmacy extracting, pressurizing and filtering device which comprises a lower box body, supporting legs, a sealing ring, a conical fine filter cartridge, a connecting bolt, an upper box body, a filter screen, a blocking mechanism, a cleaning mechanism and a filter pressing mechanism, by means of the structural design of the filter screen, when the filter holes in the screen body are blocked, the inner rods of the four telescopic rods stretch out at the same time to jack up the bearing plate, and the ejector rods on the bearing plate are jacked into the filter holes, so that the filter holes in the screen body are cleaned, and blocking is avoided; then the push plate is pushed to move above the filter screen through the extension and retraction of the inner rod of the telescopic push rod, so that filter residues on the filter screen are pushed to the opened discharge hole, the filter residues are discharged through the discharge hole, and a filter plate on the filter device is conveniently cleaned.

The present application relates to the technical field of pharmacy, more particularly to a small molecule inhibitor, a synthetic method and an application. The small molecule inhibitor is a chemical structural formula as shown in formula (I) or a pharmaceutically acceptable salt comprising the chemical structural formula as shown in formula (I); the small molecule inhibitor has biological activity and can effectively inhibit cell mitosis, which is of great significance for preventing abnormal cell proliferation and the occurrence of cancer.

The utility model relates to the technical field of biopharmacy, and discloses a biopharmacy degerming and filtering device which comprises a filtering box body, a feeding port is formed in the top of the filtering box body, a discharging port is formed in the side wall of the bottom of the filtering box body, and a detachable filtering screen which divides the filtering box body into a material bin and a degerming bin is arranged in the filtering box body. A liquid storage box capable of being taken out from the discharge port is arranged in the sterilization bin, an exhaust hole is formed in the side wall of the sterilization bin, a booster pump and a steam generator which are communicated with the stock bin and the sterilization bin respectively are arranged on the side wall of the filtering box body, and screen mesh holes distributed in a circular ring sheet shape are formed in the filtering screen mesh. The output end of the steam generator extends into the sterilization bin and is connected with a sterilization pipeline, a plurality of air outlet heads are evenly arranged on the sterilization pipeline, and the screen holes and the air outlet heads are arranged in a staggered mode. Compared with the prior art, the filter has the advantages that the filter is convenient to clean, and disinfection operation can be carried out synchronously during filtering.

This invention provides a traditional Chinese medicine composition for treating chronic enteritis, relating to the field of traditional Chinese medicine pharmaceutical technology. The invention provides a traditional Chinese medicine composition for treating chronic enteritis, composed of Gentiana scabra, Sophora flavescens, Phellodendron chinense, Sparganium stoloniferum, Oroxylum indicum, Areca catechu, Paeonia lactiflora, Rosa laevigata, Hematite, Codonopsis pilosula, Magnolia officinalis, Raphanus sativus, and Prunus persica. This traditional Chinese medicine composition has the effects of clearing heat and drying dampness, strengthening the spleen and replenishing qi, promoting qi circulation and eliminating stagnation, astringing the intestines and stopping diarrhea, and promoting blood circulation and relieving pain. The purpose of this traditional Chinese medicine composition is to regulate the overall function of the body, enhance the spleen and stomach's digestive function, improve intestinal qi and blood circulation and water metabolism, thereby achieving the purpose of treating chronic enteritis. This traditional Chinese medicine composition can significantly alleviate weight loss, fecal condition, and hematochezia in a mouse model of DSS-induced chronic enteritis. It can significantly improve colonic shortening and pathological changes in colonic tissue in the DSS-induced chronic enteritis mouse model, restore damaged tissue structure, reduce the number and infiltration range of inflammatory cells, and has good anti-inflammatory effects. This traditional Chinese medicine composition has broad application prospects in the preparation of drugs for treating chronic enteritis.

This application discloses a skin care ointment and its preparation method, relating to the field of biopharmaceutical technology. The preparation steps include raw material pulverization and sieving pretreatment, extraction followed by mixing with modified Xinjiang Lithospermum extract to obtain antibacterial and anti-inflammatory components, preparation of an oil phase and an aqueous phase, emulsification under nitrogen protection to obtain an emulsion, and finally addition of the antibacterial and anti-inflammatory components and pH adjustment to obtain the finished product. The modified Xinjiang Lithospermum extract is treated with a modifier to improve the stability and purity of the active ingredients. Temperature gradient emulsification, high-speed homogenization, and pH adjustment processes ensure the compatibility and skin suitability of the formulation. The ointment prepared by this method has antibacterial and anti-inflammatory effects, low irritation, and long-lasting stability.

The invention discloses a composition containing oligopeptide PEP4 and melogabalin and application of the composition, and belongs to the technical field of pharmacy, and the composition containing the oligopeptide PEP4 and the melogabalin is prepared from the oligopeptide PEP4 and the melogabalin according to the weight ratio of 1: 3-3: 1. The invention further discloses application of the composition containing the oligopeptide PEP4 and the melogabalin to preparation of a medicine for treating neuropathic pain. According to the animal pharmacodynamic test result, the oligopeptide PEP4 and the melogabalin have the effect of synergistically increasing the pharmacodynamic effect on neuropathic pain.

The utility model belongs to the technical field of biological pharmacy, and discloses a KPC connector installation tool which is used for pushing and inserting a male connector of a KPC connector into a female connector, the KPC connector installation tool comprises a first clamping piece and a second clamping piece, the male connector is clamped on the first clamping piece, and the first clamping piece can be held by a human hand; the female connector is clamped on the second clamping piece, the second clamping piece can be held by a hand, and the first clamping piece and the second clamping piece are connected in a sliding fit mode and can be close to each other, so that the male connector can be pushed to be inserted into the female connector. Therefore, a worker can push and insert the male connector of the KPC connector into the female connector more easily and can push the plastic elastic piece of the male connector to the position of the groove of the last grid or two grids of the female connector, and the sealing performance of the KPC connector during use is guaranteed.

The invention belongs to the technical field of pharmacy, and particularly relates to a small molecule, a preparation method, a medicine and application. The micromolecule provided by the invention has a structural formula as shown in a formula I: R1-R2-R3-R4-R5 structural formula I, in which R1 and R5 are the same or different and are independently selected from one or more of R1 and R5; r3 is selected from or; and R2 and R4 are respectively and independently selected from a single bond and alkylidene of C1-C6. The micromolecule can inhibit the function of GATA2 in a targeted manner, so that GSCs can be effectively killed under the condition of reducing side effects to the greatest extent.

The invention discloses a traditional Chinese medicine acupoint patch for preventing and controlling myopia and slowing down degree increase and a preparation method of the traditional Chinese medicine acupoint patch, and particularly relates to the technical field of traditional Chinese medicine pharmacy. The drug storage layer comprises the following components in parts by weight: a core effect component group comprising 6-10 parts of an asiaticoside-soybean phospholipid compound and 5-9 parts of eucommia leaf total flavonoids, the drug loading capacity of the asiaticoside-soybean phospholipid compound is not less than 35%, and the average particle size is 150-250 nanometers. Traditional Chinese medicine components with different effects are loaded on corresponding acupuncture points in a partitioned mode, multi-target collaborative intervention is achieved, sclera abnormal remodeling can be inhibited, periorbital microcirculation can be improved, the transdermal absorption efficiency of insoluble components is remarkably improved through the nano-phospholipid compound technology, the medicine effect is more accurate and lasting through the design that the acupuncture points are matched with the components, and the curative effect is better. The defects of component mixing and drug efficacy dispersion of a traditional patch are overcome, and the patch is convenient to use and high in safety.

This application relates to the field of traditional Chinese medicine pharmaceutics technology, specifically disclosing a method for preparing a traditional Chinese medicine plaster using alcohol. The method includes the following steps: S1, grinding dried traditional Chinese medicine raw materials into a fine powder to obtain traditional Chinese medicine powder; S2, soaking the traditional Chinese medicine powder in alcohol with a concentration of 50%-75% to form a uniform paste; S3, preparing a matrix, mixing the paste obtained in S2 with the matrix, and stirring until uniform to obtain the alcohol-prepared traditional Chinese medicine plaster. This method for preparing a traditional Chinese medicine plaster using alcohol can be used to treat common conditions requiring transdermal drug delivery, such as arthritis, sprains, and skin inflammation. It utilizes alcohol to dissolve the fat-soluble and water-soluble components of the traditional Chinese medicine, enhancing transdermal drug absorption; the matrix provides a stable carrier to prolong the efficacy and reduce skin irritation; it eliminates the need for complex preparation; is easy to operate; and can be adjusted according to the shape of the affected area. It has the advantages of efficient drug release and good dosage form stability.

The application provides a sorafenib derivative, a preparation method and application thereof, and a medicine, and relates to the technical field of pharmacy. 2 The boron atom sp of the sorafenib derivative provided by the application has a broad-spectrum cytotoxicity on tumor cells, and the cytotoxicity on human normal L02 cells is low.

The application provides an antibody against a PHACTR1 protein and an application thereof, and belongs to the technical field of antibody engineering and pharmacy. The antibody against the PHACTR1 protein provided by the application has high specificity, provides effective materials for immunodetection of the PHACTR1 protein, can play a therapeutic effect in related diseases, and has wide practical application value.