52 results about "Pharmaceutics technology" patented technology

The present invention relates to the technical field of chemical pharmacy, and in particular to a compound for degradation of a targeted interleukin-1 receptor-associated kinase 4 (IRAK4), and a pharmaceutically acceptable salt of the compound. The compound can be used for treating or preventing IRAK4-mediated immune diseases, inflammatory diseases, and cancers.

The invention discloses a peristaltic pump for herpes zoster virus liquid ultrafiltration and an ultrafiltration process, and relates to the technical field of biological pharmacy, the peristaltic pump comprises an energy-saving motor, a main wheel, a substitute wheel, a vertical seat and a pump pipe, an extension cylinder is fixedly arranged on the rear side face of the vertical seat, and the energy-saving motor is fixedly connected to the side face of the extension cylinder. A group of main wheels and a group of substitute wheels are arranged in the peristaltic pump shell, a switching assembly is arranged in the peristaltic pump shell, the peristaltic pump can creep when the main wheels are in a normal state, and when the main wheels of the peristaltic pump are damaged, a user can quickly move the main wheels away from the creep station through the switching assembly, so that the peristaltic pump is convenient to use. And then the secondary wheel is arranged at a peristaltic station, so that long-time shutdown waiting is avoided, the working continuity and the production efficiency of equipment are effectively improved, the peristaltic pump can be ensured to recover to work as soon as possible when a fault occurs, the dependence on high-skill workers is also reduced, and the maintenance work is simpler and more efficient.

The invention provides a fermentation method of clavulanic acid, and relates to the technical field of biological pharmacy. The method comprises the following steps: inoculating streptomyces clavuliformis into a shake flask seed culture medium, and carrying out shake flask seed culture; inoculating the cultured shake flask seeds to a seed culture medium, and performing seed tank culture; the method comprises the following steps: inoculating a strain into a fermentation culture medium, culturing in a fermentation tank, centrifugally separating the obtained fermentation liquid, and separating and purifying the supernatant liquid to obtain clavulanic acid; wherein in the 20th hour of fermentation, glycerol is supplemented; supplementing the mixed supplementary material at the 40th hour of fermentation; the mixed supplementary material comprises L-glutamic acid, magnesium chloride, dipotassium phosphate, glacial acetic acid and potassium hydroxide. According to the method disclosed by the invention, the glycerol and the mixed supplementary material are supplemented at a specific time point in the fermentation process of the clavulanic acid, so that the fine regulation and control of the fermentation process are realized, and the technical effect of remarkably improving the titer of the clavulanic acid is achieved.

The invention relates to the technical field of pharmacy, and discloses a linagliptin preparation method, which comprises: 1, reacting a compound a and a compound b under an alkaline condition, according to the preparation method of the linagliptin, the high-purity linagliptin is prepared through reaction steps of aromatic nucleophilic substitution reaction, substitution, deprotection and the like and screening reaction conditions of proper material proportion, reaction time, reaction temperature, post-treatment mode and the like, and the process reaction of the method is relatively mild in conditions in the preparation process of an intermediate g; the reaction time is greatly shortened, the mixed solvent is used for crystallization, effective solidification of the product can be realized, the product can be efficiently separated, the product purity is improved, in the process of removing tert-butyl carbonyl protection, efficient dissociation of impurities of a dimer can be realized under the alkaline condition, so that the high-purity linagliptin raw material is obtained, the new raw material is easy to obtain, the production cost is low, and the method is suitable for industrial production. The industrial production requirements of linagliptin can be met to the greatest extent.

The utility model relates to the technical field of biological pharmacy, in particular to an online PH meter electrode protection device in TZV preparation, which comprises a reaction kettle, a sealing cover is arranged at the top end of the reaction kettle, a feeding pipe is communicated with the top end of the sealing cover, a discharging pipe is communicated with the bottom end of the reaction kettle, and a PH meter main body is further arranged on the inner side of the sealing cover. The electrodes of the PH meter main body can be protected through the protective shell, the electrodes of the PH meter main body can be prevented from being exposed in the air, the accuracy of data detected by the PH meter main body can be guaranteed, the service life of the PH meter main body can be guaranteed, after the reaction kettle is filled with reaction liquid, the air bag can float upwards along with the reaction liquid at the moment, and the safety of the reaction kettle is guaranteed. At the moment, the air bag can stir the connecting rod to rotate on the rotating frame, the sliding disc can slide downwards along the limiting rod, the PH meter main body can slide downwards along the through hole, the PH meter main body can extend into the reaction liquid, and the PH value of the reaction liquid can be conveniently monitored.

The utility model relates to the technical field of chemical pharmacy, and discloses a grinding device for chemical pharmacy, which comprises a grinding machine, the top end of the grinding machine is provided with a mortar driving part, the top end of the mortar driving part is fixedly connected with a limiting assembly, the right side of the grinding machine is provided with a protection assembly, the limiting assembly comprises a limiting rod, and the limiting rod is fixedly connected with the grinding machine. The limiting rod is fixedly connected to the top end of the mortar driving part, a circular ring is slidably connected to the outer wall of the limiting rod, a first sliding groove is formed in the front surface of the circular ring, a clamping block is fixedly connected to the position, close to the left side of the first sliding groove, of the bottom end of the circular ring, and the limiting rod slides on the inner wall of the first sliding groove. According to the agate mortar assembly and disassembly device, the agate mortar is aligned to the mortar driving part and then moves downwards, so that the limiting rod extrudes the clamping block and then slides into the second sliding groove, then the agate mortar is rotated to drive the circular ring to rotate, and then the limiting rod slides into the first sliding groove to limit the circular ring and the agate mortar, and therefore the agate mortar can be conveniently disassembled and assembled, and the agate mortar assembly and disassembly device is convenient and fast to use.

The embodiment of the invention provides a double-inlet capture column switching device for step-by-step purification of multispecific antibodies, and relates to the technical field of biological pharmacy, the double-inlet capture column switching device comprises a first capture column, a switchable valve and a second capture column; a first inlet is formed in the upper end of the first capturing column; the switchable valve is of a three-way structure and comprises a second inlet, a second outlet and a third outlet. The upper end of the second capturing column is provided with a first inlet and a second inlet, and the lower end is provided with a fourth outlet; the second inlet communicates with the first outlet through a pipeline, the second outlet directly communicates with an external outflow pipeline, and the third outlet is connected to the first inflow port through a pipeline; the second flow inlet is directly connected with an external mobile phase pipeline; a double-inlet switching structure is arranged at the upper end of the second capturing column, and the first inflow port or the second inflow port can be selectively opened. The device has the effects of short operation time and low cross contamination risk.

The present invention belongs to a biopharmaceutical technology, and specifically relates to a fusion polypeptide and a derivative thereof, and the use thereof in the preparation of a drug for treating alopecia, acne, dermatitis and other related diseases. Disclosed is a fusion polypeptide, wherein the fusion polypeptide sequentially consists of an O peptide or a derivative peptide thereof, and an I peptide or a derivative peptide thereof from the N-terminus to the C-terminus, and the two structural functional domains are connected via a linker peptide linker or directly; or the fusion polypeptide sequentially consists of an I peptide or a derivative peptide thereof, and an O peptide or a derivative peptide thereof from the N-terminus to the C-terminus, and the two structural functional domains are directly connected via a linker peptide. The provided fusion polypeptide can simultaneously activate GPR158 and / or GPRC6A and / or GPR37 pathways, and simultaneously activate the integrin receptor pathway, has the remarkable advantages of high activity in promoting hair growth, rapid onset of action and long action duration in regulating hormone, thereby providing a new drug for treating alopecia, acne, dermatitis and other related diseases.

The utility model provides a fermentation tank for biopharmacy, which relates to the technical field of biopharmacy and comprises a tank body, a top cover is arranged at the top of the tank body, a rotating column penetrates through the bottom of the top cover and is rotatably connected with a bearing at the position close to the center, and a rotating rod penetrates through the bottom of the rotating column and is rotatably connected with a bearing at the bottom of the rotating column. A square annular plate is fixedly connected to the bottom of the rotating column, inclined arc plates are fixedly connected to the two ends of the square annular plate, and the surface of the rotating rod is sleeved with and fixedly connected with a conveying auger. A third bevel gear is driven by a driving motor to rotate, the third bevel gear rotates to drive the other two bevel gears to rotate in opposite directions, at the moment, a rotating column and a rotating rod can drive a square annular plate and a conveying auger to rotate respectively, and the square annular plate rotates to drive an inclined arc plate to push liquid medicine on the edge to the middle position; meanwhile, the conveying auger rotates to convey the liquid medicine at the center and the bottom upwards, so that the effect of improving the mixing degree of the liquid medicine can be achieved, and the effect of improving the fermentation efficiency of the liquid medicine can be achieved.

The invention provides a traditional Chinese medicine composition for treating sudden deafness, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is prepared from 17 traditional Chinese medicinal materials including firethorn fruit, hematoxylon, murraya paniculata, aspongopus, fructus choerospondiatis, lignum dalbergiae odoriferae, ruddle, oyster, borneol, asarum, rhizoma iridis tectori, equisetum, sophora flower, folium turpiniae, medlar, mulberry and hawthorn leaf, and all the medicinal materials are combined to achieve the effects of activating blood and promoting qi circulation, opening orifices and improving hearing, regulating qi and dissipating blood stasis, clearing heat and purging intense heat, nourishing liver and kidney and combining purgation and tonification. When the traditional Chinese medicine composition is used for treating qi stagnation and blood stasis type sudden deafness, the hemodynamics of a patient can be remarkably improved, hearing impairment of the patient can be recovered, clinical symptoms of the patient can be improved, the clinical curative effect can be effectively improved, and the traditional Chinese medicine composition has high safety.

The utility model relates to the technical field of chemical pharmacy, and discloses a stirring tank for preparing halofuginone, which comprises a main body mechanism, a feed sealing mechanism and a moving mechanism, the feed sealing mechanism is arranged outside the main body mechanism, the moving mechanism is arranged outside the main body mechanism, the main body mechanism comprises a stirring tank body, and the stirring tank body is arranged in the stirring tank body. A handrail is fixedly connected to the outer wall of the stirring tank body, a motor is fixedly connected to the outer wall of the stirring tank body, and a rotating rod is fixedly connected to the outer wall of the motor. The motor works to rotate the rotating rod, the rotating rod rotates the first gear, the outer wall of the first gear is connected with the second gear in a meshed mode, the second gear rotates through the limiting rod, the outer wall of the second gear is connected with the third gear in a meshed mode, the third gear rotates the scraping plate, and the scraping plate drives the tank wall scraping teeth to scrape materials adhering to the inner wall of the stirring tank body. The scraping plate drives the tank bottom scraping teeth to scrape off materials adhered to the bottom wall in the stirring tank body, and then the stirring blades are rotated through the rotating rod to fully stir the materials in the stirring tank body.

The utility model discloses a medicinal material grinding and pouring integrated device, which relates to the technical field of pharmacy and is characterized in that a top plate of a rectangular frame is provided with a through groove, and a bottom plate of the rectangular frame is provided with a placing groove for placing a collecting box; the grinding mechanism comprises a grinding disc, a grinding groove and a telescopic assembly, a base is arranged at one end of the top of the rectangular frame, the telescopic assembly is horizontally arranged on the base and connected with a regulation and control plate, the top of the grinding groove penetrates through the through groove, the grinding disc is arranged in the grinding groove, rotating shafts are arranged on the two sides of the grinding disc, the outer ends of the rotating shafts are rotationally connected to a square block, and a guide rod is arranged at the top of the square block. The tops of the guide rods penetrate through the regulation and control plate and then are connected with convex plates, springs are arranged on the peripheries of the guide rods, and the two ends of the springs are connected with the regulation and control plate and the square blocks correspondingly; the lifting turnover mechanism is arranged on the rectangular frame, connected with the grinding groove and used for enabling the grinding groove to move downwards and be separated from the through groove, and then turnover material pouring is conducted. According to the scheme, automatic grinding and automatic pouring can be achieved.

The utility model relates to the field of biopharmaceutical technology, disclose a valve assembly, including valve body and sealing washer, wherein the valve body is equipped with the sealing washer installation groove for installing sealing washer, is equipped with one -way exhaust structure in sealing washer installation groove, it includes the air vent and elastic protective sheath, the air vent intercommunication sealing washer installation groove with elastic protective sheath, elastic protective sheath covers air vent in its inside, when the inside pressure of elastic protective sheath is greater than the outside pressure, elastic protective sheath is pressed and occurs expansion, its outer diameter is larger and exceeds the boss outer diameter, forms the gap between with boss outer wall, air vent opens, gas is discharged to the outside through the gap, realizes the pressure reduction inside container, when the inside pressure of elastic protective sheath is less than or equal to the outside pressure, elastic protective sheath contracts, sticks boss outer wall, closes side wall hole, air vent closes, prevents the outside gas or pollutant to enter the inside container, the utility model realizes the demand of equipment sterile transmission through one -way exhaust structure.

The invention discloses a method for detecting isomer impurities in L-glutamic acid diethyl ester hydrochloride by HPLC (High Performance Liquid Chromatography), and belongs to the technical field of chemical engineering and pharmacy. D-isomer impurities in L-glutamic acid diethyl ester hydrochloride are detected by adopting high performance liquid chromatography, a CHIRALPAK AY-H column is adopted as a chromatographic column, an ethanol solution of 0.05% diethylamine is adopted as a mobile phase, isocratic elution is carried out, and the content of the D-isomer impurities in L-glutamic acid diethyl ester hydrochloride is detected. According to the present invention, the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the column temperature is 35 DEG C and the detection wavelength is 220 nm, the L-glutamic acid diethyl ester hydrochloride and the D-isomer thereof can be effectively separated and the content thereof can be quantitatively detected, the method has characteristics of simple operation, strong specificity, high sensitivity, high accuracy and good linearity, and the quality of the p-fluorothiophenol product can be effectively controlled.

The utility model relates to the technical field of biopharmacy, in particular to a TZV floor material liquid cleaning and collecting device which comprises a fixed material suction pipe, a three-way connector is arranged at the bottom end of the fixed material suction pipe in a sleeved mode, auxiliary material suction pipes are arranged on the two sides of the bottom end of the three-way connector in a sleeved mode, and rolling material suction assemblies are arranged at the bottom ends of the auxiliary material suction pipes. After the fixed material suction pipe is pushed, the ball at the bottom end of the sealing head can rotate on the ground, friction between the auxiliary material suction pipe and the ground can be reduced, and the fixed material suction pipe can conveniently and rapidly slide on the ground; according to the workshop floor cleaning device, sewage generated after cleaning can be rapidly and thoroughly sucked, cleaning and collecting of the sewage are facilitated, the workshop floor is kept clean, the length between the fixed suction pipe and the movable suction pipe can be adjusted, a user can conveniently adjust the device according to actual needs, and the use experience can be improved.

The invention provides a nereis polypeptide antithrombotic preparation, and belongs to the technical field of biological pharmacy. In-vitro tests show that the nereis fibrinolytic protease polypeptide can inhibit thrombin and fibrinogen from reacting to generate fibrin, so that the blood coagulation reaction is inhibited. In-vitro anti-platelet aggregation activity determination is carried out on the nereis fibrinolytic protease polypeptide, and the inhibition rate of 640 [mu] g / ml of nereis fibrinolytic protease polypeptide for resisting platelet aggregation is 75.68%, which is close to the inhibition effect of 1 mg / ml of aspirin. A nereis fibrinolytic protease polypeptide antithrombotic effect test shows that the nereis fibrinolytic protease polypeptide group has the pharmacodynamic effect of reducing the weight of thrombus and the weight-length ratio of the thrombus, has a good antithrombotic effect and can be used as a nereis polypeptide antithrombotic preparation.

The application belongs to the technical field of pharmacy and relates to a method for preparing cefixime by using an enzyme method. The method comprises the following steps: performing an enzymatic hydrolysis reaction on cefixime alkyl ester in water in the presence of a hydrolytic enzyme at a pH of 7-8.5 to obtain cefixime. According to the method for preparing cefixime by using the enzyme method, the reaction condition becomes milder, the generation of impurities in the reaction process is effectively controlled, and the product quality and yield of cefixime are both improved.

This application relates to the field of traditional Chinese medicine pharmaceutical technology, and discloses a traditional Chinese medicine for treating diabetic neuropathy and its preparation method. The traditional Chinese medicine is prepared from Coptis chinensis, Corydalis yanhusuo, Schisandra chinensis, Cornus officinalis, Astragalus membranaceus, and Cinnamomum cassia. The preparation method includes: low-temperature differential pretreatment of the raw materials; gas-phase assisted mechanical activation of components A and C under pressurized carbon dioxide environment, utilizing in-situ generation of carbamate intermediates in the gas phase to reduce lattice energy; subsequently, component B is added and pulsed milling is performed, directionally assembling into a hydrophobic ion-pair complex through a thermodynamically driven ligand substitution reaction; finally, the pressure and temperature are increased in situ to convert the reaction medium into a supercritical fluid for integrated extraction. This invention achieves the transformation of the active ingredient from a hydrophilic to a lipophilic chemical form through a gas-phase activation and stepwise substitution strategy, enabling it to effectively penetrate the blood-nerve barrier. Simultaneously, the low-temperature, anaerobic environment throughout the process effectively avoids the degradation of heat-sensitive components.

The utility model discloses a biopharmacy crusher, including bottom plate, crushing device, crushing tank and recycling bin, support transmission subassembly includes vertical frame, transmission motor, screw and belt nut slider, crushing device includes crushing motor and crushing knife, dust collection subassembly includes dust collection bin, leakproof net and dust extraction fan, and the dust collection bin is equipped with the dust extraction fan. And a vibrator is also arranged on the crushing tank. The utility model belongs to the technical field of bio-pharmaceuticals, and particularly relates to a crushing tank which is convenient to collect after crushing by arranging a net-shaped screen, is convenient to clean by the detachable screen, and is capable of recovering powder generated by crushing by arranging a dust collecting assembly, so that waste is reduced, and the environment is protected.

The invention relates to the technical field of chemical pharmacy, and discloses a method for preparing high-purity R-lipoic acid, which comprises the following steps: S1, adding (S)-6, 8-dichloro ethyl caprylate, sulfur, water and a combined catalyst into a reaction flask; s2, dropwise adding a sodium sulfide aqueous solution for a certain time and at a certain temperature; s3, after dropwise adding is completed, heat preservation is conducted till the reaction is completed, cooling is conducted, acid water is dropwise added, the system pH is adjusted, stirring and filtering are conducted continuously, water is added into a filter cake, and heating and stirring are conducted; and S4, cooling, carrying out suction filtration, and drying to obtain the product. By adding the combined catalyst, impurities such as trisulfide and S-lipoic acid can be reduced at the same time, dozens of times of water is not needed for refining, the yield of the whole process is increased to 95% from 85%, and the optical purity of the product is increased to 99.8% from 99.5%.

The utility model belongs to the technical field of biological pharmacy, and particularly relates to a chick embryo allantoic fluid collecting device which comprises a syringe needle, a needle stem and a pintle. The anti-blocking filtering piece comprises a sleeve, a housing and a connecting piece, the front end of the needle stem is covered with the housing, the risk that yolk is damaged in the collecting process can be reduced by means of the characteristics that the outer surface of the housing is smooth and free of edges and corners, and the egg yolk collecting device is convenient, rapid and high in yield and provides convenient conditions for follow-up production; a plurality of liquid inlet holes are formed outside the housing, so that liquid inlet paths can be dispersed, and the blocking risk caused by a single channel is reduced; the needle stem is sleeved with the sleeve, stable support is provided for the housing, and the stability of the collecting process is guaranteed; and finally, the connecting piece is arranged to be detachably connected with the pintle, so that assembling and disassembling can be facilitated, and cleaning and replacement are facilitated.

This invention discloses an ultrafiltration system with real-time protein concentration control, belonging to the field of biopharmaceutical technology. The system includes a replenishment tank, a recirculation tank, an ultrafiltration unit, and a controller. The recirculation tank is connected to the replenishment tank via a replenishment pipe, which is equipped with a replenishment pump and a valve, with the valve located between the replenishment pump and the recirculation tank. A protein concentration detection component A is located at the bottom of the recirculation tank. The ultrafiltration unit is connected to the recirculation tank via a delivery pipe and a return pipe. A circulation pump is installed on the delivery pipe, and a back pressure component and a protein concentration detection component B are installed on the return pipe. This system can improve the consistency of protein concentration in the recirculation tank during constant-volume dialysis, reduce batch-to-batch differences in protein concentration, and thus improve the uniformity of product quality. It can also prevent concentration polarization caused by excessively high protein concentration from affecting protein stability.

The invention relates to the technical field of pharmacy, in particular to a raw material cooking device for biological medicine production, which comprises a heating box, a heater and a casing, the casing is fixedly connected to the top of the heating box, the heater is mounted at the bottom of an inner cavity of the heating box, cooking water is stored in the heating box, and the heater heats the water. Hydraulic oil cylinders are installed at the left end and the right end of the upper surface of the machine shell, a hanging bracket is transversely installed at the output ends of the hydraulic oil cylinders, a hanging basket is clamped to the bottom of the hanging bracket, to-be-cooked medicinal materials are stored through the hanging basket, a temperature control mechanism is installed in the center of the upper surface of the machine shell, and a disinfection mechanism is installed on the right side wall of the machine shell. And the temperature control mechanism is respectively connected with the temperature control mechanism and the disinfection mechanism through pipelines. The device not only can automatically control the cooking degree of medicinal materials and improve the properties of the medicinal materials, but also can automatically replenish water to prevent drying of the medicinal materials caused by untimely water replenishment and avoid failure of the medicinal materials, so that waste heat is recycled, and the aim of sterilizing the medicinal materials or tools is fulfilled.

This application relates to the field of biopharmaceutical technology, and in particular to a method for forming a cylindrical bag. It includes cutting a membrane material to size, welding two cut membrane materials according to specified steps, and then inflating or injecting liquid into the internal space of the welded membrane material to form a finished cylindrical bag. This cylindrical bag forming method eliminates the need for molds and the requirement to produce molds of the corresponding size each time, significantly reducing production costs. Furthermore, the forming process is convenient, quick, simple, practical, and highly efficient.

This application relates to the field of traditional Chinese medicine pharmaceutics technology, specifically disclosing a cold-maceration preparation method for fermented medicinal wine. The method includes the following steps: S1, pulverizing a traditional Chinese medicine composition to obtain coarse powder, wherein the composition includes a principal drug array, an assistant drug array, a adjuvant drug array, and a guiding drug array, and the principal drug array is made from raw materials containing the following parts by weight: 8-12 parts artificial musk, 45-55 parts camphor, and 45-55 parts borneol; S2, mixing the coarse powder obtained in S1 with white wine, sealing and soaking to obtain an soaking mixture; S3, opening the seal and stirring the soaking mixture obtained in S2 to obtain fermented medicinal wine. The cold-maceration preparation method for fermented medicinal wine of this application has the unique advantages of a clear distinction between the principal, assistant, adjuvant, and guiding drug layers in the formulation design, synergistic effects, and a preparation process that can fully and stably extract the effective components of each drug array, resulting in a medicinal wine with concentrated and targeted medicinal power, especially suitable for dispelling deep-seated cold pathogens and clearing meridian blockages.

The utility model relates to the technical field of biopharmacy, in particular to a biopharmacy extracting, pressurizing and filtering device which comprises a lower box body, supporting legs, a sealing ring, a conical fine filter cartridge, a connecting bolt, an upper box body, a filter screen, a blocking mechanism, a cleaning mechanism and a filter pressing mechanism, by means of the structural design of the filter screen, when the filter holes in the screen body are blocked, the inner rods of the four telescopic rods stretch out at the same time to jack up the bearing plate, and the ejector rods on the bearing plate are jacked into the filter holes, so that the filter holes in the screen body are cleaned, and blocking is avoided; then the push plate is pushed to move above the filter screen through the extension and retraction of the inner rod of the telescopic push rod, so that filter residues on the filter screen are pushed to the opened discharge hole, the filter residues are discharged through the discharge hole, and a filter plate on the filter device is conveniently cleaned.

The present invention discloses a peristaltic pump for ultrafiltration of varicella-zoster virus liquid and an ultrafiltration process, which relates to the technical field of biopharmaceuticals and includes an energy-saving motor, a main wheel, a backup wheel, a vertical seat, and a pump tube. An extension cylinder is fixedly arranged on the rear side surface of the vertical seat, and the energy-saving motor is fixedly connected to the side surface of the extension cylinder. In the present invention, a set of main wheels and a set of backup wheels are arranged inside the peristaltic pump housing, and a switching component is arranged inside the peristaltic pump housing. Under normal conditions, the main wheels perform the peristaltic work of the peristaltic pump. When the main wheels of the peristaltic pump are damaged, the user can quickly remove the main wheels from the peristaltic position through the switching component, and then place the secondary wheels at the peristaltic position, avoiding long-term downtime waiting, effectively improving the working continuity and production efficiency of the equipment, ensuring that the peristaltic pump can resume work as soon as possible when a failure occurs, and also reducing the dependence on highly skilled workers, making the maintenance work simpler and more efficient.

The invention discloses a method for preparing NMN, and particularly relates to the technical field of biological pharmacy, and the method comprises the following steps: firstly, mixing ribose, polyphosphate, RK enzyme and high-energy substances ATP and PPK1 enzyme in a proper reaction container, and reacting for 1-1.5 hours under the conditions that the temperature is 35-38 DEG C, the pressure is normal and the pH value is 5.0-8.0 to synthesize ribose phosphate; and then taking the reaction liquid, adding nicotinamide, polyphosphate, PRPPS enzyme, NMPRT enzyme and the like, and reacting for 2-4 hours under the conditions of the same temperature, normal pressure and pH to realize the synthesis of NMN. In the process, the PPK1 enzyme and the PPK2 enzyme can recycle ATP, the reaction conversion rate is high, the condition is mild, the cost is effectively reduced, and a new way is provided for efficient preparation of the NMN.

The present application relates to the technical field of pharmacy, more particularly to a small molecule inhibitor, a synthetic method and an application. The small molecule inhibitor is a chemical structural formula as shown in formula (I) or a pharmaceutically acceptable salt comprising the chemical structural formula as shown in formula (I); the small molecule inhibitor has biological activity and can effectively inhibit cell mitosis, which is of great significance for preventing abnormal cell proliferation and the occurrence of cancer.

The utility model relates to the technical field of biopharmacy, and discloses a biopharmacy degerming and filtering device which comprises a filtering box body, a feeding port is formed in the top of the filtering box body, a discharging port is formed in the side wall of the bottom of the filtering box body, and a detachable filtering screen which divides the filtering box body into a material bin and a degerming bin is arranged in the filtering box body. A liquid storage box capable of being taken out from the discharge port is arranged in the sterilization bin, an exhaust hole is formed in the side wall of the sterilization bin, a booster pump and a steam generator which are communicated with the stock bin and the sterilization bin respectively are arranged on the side wall of the filtering box body, and screen mesh holes distributed in a circular ring sheet shape are formed in the filtering screen mesh. The output end of the steam generator extends into the sterilization bin and is connected with a sterilization pipeline, a plurality of air outlet heads are evenly arranged on the sterilization pipeline, and the screen holes and the air outlet heads are arranged in a staggered mode. Compared with the prior art, the filter has the advantages that the filter is convenient to clean, and disinfection operation can be carried out synchronously during filtering.