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49 results about "Pim kinases" patented technology
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Pim kinases are constitutively active serine/threonine kinases that promote growth factor-independent proliferation by phosphorylating, and thus inhibiting, a range of cellular proteins. They are serine/threonine kinases that control cell growth, differentiation and apoptosis.
Methods for inhibiting protein kinases
InactiveUS20070082900A1Shorten the progressBiocideOrganic active ingredientsPim kinasesMolecular biology
The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
Owner:SCHERING CORP
Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors
ActiveUS7750007B2Inhibitory activityBiocideOrganic chemistryProtein kinase inhibitor activityPTK Inhibitors
The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II):or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
![Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/7d3e1e07-4aea-462e-858e-a93a49cbb310/US07750007-20100706-D00001.png "Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors")
![Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/7d3e1e07-4aea-462e-858e-a93a49cbb310/US07750007-20100706-D00002.png "Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors")
![Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/7d3e1e07-4aea-462e-858e-a93a49cbb310/US07750007-20100706-D00003.png "Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors")
Owner:SUMITOMO PHARMA ONCOLOGY INC
Novel tricyclic protein kinase modulators
InactiveUS20110071136A1Good treatment effectReduce cell proliferationBiocideSenses disorderInflammationImmunologic disease
The invention provides compounds that inhibit CK2 and / or Pim kinases and compositions containing such compounds. These tricyclic compounds and compositions containing them are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, pathogenic infections, and certain immunological disorders.
Owner:SENHWA BIOSCIENCES INC
Protein kinase modulators
InactiveUS20090239859A1Good treatment effectReduce cell proliferationBiocideNervous disorderFms-Like Tyrosine KinasePolymerase L
The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and / or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
Owner:SENHWA BIOSCIENCES INC
4-substituted pyridin-3-yl-carboxamide compounds and methods of use
The invention relates to compounds of formula (I) which are useful as kinase inhibitors, more specifically useful as PIM kinase inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same, either alone or in combination, to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Owner:GENENTECH INC
Methods to treat allergic conditions
ActiveUS20120114663A1Suppresses Th differentiationInhibition of differentiationBiocidePeptide/protein ingredientsAllergic conditionHypersensitivity Diseases
Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are methods to treat allergic conditions in a subject by administering a composition that induces expression of Runx3.
Owner:NAT JEWISH HEALTH
Rhodanines and related heterocycles as kinase inhibitors
InactiveUS20100331315A1Good treatment effectIncreased apoptosisBiocideOrganic chemistryImmunologic disordersMedicine
The invention provides compounds that inhibit PIM kinases and / or CK2, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders.
Owner:SENHWA BIOSCIENCES INC
Pharmaceutically useful heterocycle-substituted lactams
The invention provides compounds that inhibit CK2 and / or Pim kinases and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, infections, and certain immunological disorders.
Owner:SENHWA BIOSCIENCES INC
Protein kinase modulators
The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and / or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
Owner:SENHWA BIOSCIENCES INC
4-substituted pyridin-3-yl-carboxamide compounds and methods of use
The invention relates to compounds of formula (I) which are useful as kinase inhibitors, more specifically useful as PIM kinase inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same, either alone or in combination, to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Owner:GENENTECH INC
Heterocyclic protein kinase inhibitors
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
Owner:SUMITOMO PHARMA ONCOLOGY INC
IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS
ActiveUS20080261988A1Inhibits protein kinase activityInhibitory activityBiocideOrganic chemistryPTK InhibitorsPim kinases
The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II):or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
![IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS](https://images-eureka.patsnap.com/patent_img/a150dffb-55d3-4769-a69f-86b155ac0e97/US20080261988A1-20081023-D00001.png "IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS")
![IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS](https://images-eureka.patsnap.com/patent_img/a150dffb-55d3-4769-a69f-86b155ac0e97/US20080261988A1-20081023-D00002.png "IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS")
![IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS](https://images-eureka.patsnap.com/patent_img/a150dffb-55d3-4769-a69f-86b155ac0e97/US20080261988A1-20081023-D00003.png "IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS")
Owner:SUMITOMO PHARMA ONCOLOGY INC
Protein kinase modulators
The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and / or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
Owner:SENHWA BIOSCIENCES INC
Novel tricyclic protein kinase modulators
The invention provides compounds that inhibit CK2 and / or Pim kinases and compositions containing such compounds. These tricyclic compounds and compositions containing them are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, pathogenic infections, and certain immunological disorders.
Owner:CYCLENE PHARM INC
Tricyclic compounds and pharmaceutical uses thereof
InactiveUS20110065712A1Good treatment effectIncreased apoptosisAntibacterial agentsBiocideDiseaseInflammation
The invention provides compounds that inhibit CK2 and / or Pim kinases and compositions containing such compounds. These tricyclic compounds and compositions containing them are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, pathogenic infections, and certain immunological disorders.
Owner:SENHWA BIOSCIENCES INC
Derivatives of tetrabromobenzimidazole, a process for the preparation thereof, a pharmaceutical composition comprising the same, a methof of using the same, a method for modulating or regulating serine/threonine kinases, and serine/threonine kinases modulating agent
InactiveUS20110112091A1Improve effectivenessImprove solubilityBiocideNervous disorderDiseaseThreonine
A derivative of tetrabromobenzimidazole, a process for the preparation thereof, a pharmaceutical composition, a method for using the same, a method for modulating or regulating serine / threonine kinases, and a serine / threonine kinases modulating agent. The invention relates to novel small-molecule compounds with kinase inhibitory activity, having superior properties as pharmaceutical agents, production method thereof and uses thereof. In particular, this invention relates to new derivatives of tetrabromobenzimidazole with Pim kinases inhibitory properties, which exhibits superior pharmacological actions, and can be useful for the treatment of disease conditions, especially cancers depending on Pim kinases, such as leukemias and prostate cancer.
Owner:SELVITA SA
Pyridine derivatives as pim kinase inhibitors and preparation methods and use in medicinal manufacture thereof
ActiveUS20150284363A1Promote apoptosisModulating protein kinase activityBiocideOrganic chemistryDiseaseEnantiomer
PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.
Owner:JIKAI BIOSCI
Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
Owner:JIKAI BIOSCI
Kinase inhibitor, and preparation and application of kinase inhibitor
The invention provides a compound shown as a formula (I), or a stereoisomer, a tautomer, nitrogen oxide, metabolite, a prodrug, pharmaceutically acceptable salt or solvate of the compound, and application of the compound to preparing drugs or drug compositions for treating Pim kinase-mediated diseases.
Owner:CHENGDU DIAO PHARMA GROUP
Compositions and methods for kinase-mediated cytoprotection and enhanced cellular engraftment and persistence
InactiveUS20120128631A1Guaranteed functionImprove the level ofBiocideNervous disorderHematopoietic cellBlood vessel
Disclosed are methods of protecting cells, especially non-vascular system, non-hematopoietic cells and tissues, from apoptosis and enhancing their engraftment, survival, and / or persistence by providing enhanced levels of PIM activity for the cell, including PIM-1 activity. Also disclosed are cells that have been engineered to express enhanced levels of PIM kinase, and methods of administering those cells to vertebrates.
Owner:SAN DIEGO STATE UNIVERSITY
Pharmaceutically useful heterocycle-substituted lactams
The invention provides compounds that inhibit CK2 and / or Pim kinases and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, infections, and certain immunological disorders.
Owner:CYCLENE PHARM INC
Methods for inhibiting protein kinases
The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
Owner:MERCK SHARP & DOHME CORP
Oxindole compounds
The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
Owner:CYCLENE PHARM INC
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
![Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/68457cae-015e-4900-9d58-22a12fabb885/US09416132-20160816-D00001.PNG "Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors")
![Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/68457cae-015e-4900-9d58-22a12fabb885/US09416132-20160816-D00002.PNG "Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors")
![Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/68457cae-015e-4900-9d58-22a12fabb885/US09416132-20160816-D00003.PNG "Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors")
Owner:SUMITOMO PHARMA ONCOLOGY INC
Preparation method of PIM kinase inhibitor and intermediate of PIM kinase inhibitor
The invention relates to a preparation method of a PIM kinase inhibitor and an intermediate of PIM kinase inhibitor. The invention provides a preparation method of a compound as shown in a formula I or pharmaceutical salt thereof, or a compound as shown in a formula V. The preparation method comprises the following steps. The method has the characteristics of simplicity and convenience in production, low production cost, high production efficiency, excellent product quality, stable quality, low pollution, high safety and the like, can effectively solve the problems of reaction impurity uncontrollability and yield reduction caused by raw material instability, and is convenient for industrialized enlargement production.
Owner:SHANGHAI FANGYU HEALTH PHARMA TECH CO LTD
Pim kinase inhibitor combinations
InactiveUS20160175293A1Significant inhibitory activityGood pharmacological propertiesBiocideHeavy metal active ingredientsOncologyMyeloid Neoplasm
The present invention relates to a Pim kinase inhibitor compound that can be used alone or in a pharmaceutical combination. One such combination comprises (a) a JAK inhibitor compound, (b) a Pim kinase inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of a myeloid neoplasm or leukemia; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of myeloid neoplasm or leukemia; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a mammal, especially a human.
Owner:NOVARTIS AG
PIM kinase inhibitors in combination with RNA splicing modulators/inhibitors for treatment of cancers
The present invention provides for a method of treating cancer and / or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates / inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.
Owner:UNIV OF MARYLAND BALTIMORE COUNTY
Tricyclic compounds and pharmaceutical uses thereof
The invention provides compounds that inhibit CK2 and / or Pim kinases and compositions containing such compounds. These tricyclic compounds and compositions containing them are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, pathogenic infections, and certain immunological disorders.
Owner:CYCLENE PHARM INC
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