88 results about "Postherpetic polyneuropathy" patented technology

Disclosed is an analgesic agent for a non-inflammatory pain disease, which comprises a sialic acid or a pharmaceutically acceptable salt thereof as an active ingredient. The sialic acid which is an active ingredient for the agent has an analgesic effect on a disease model animal of neurogenic pain which is a non-inflammatory pain. Therefore, the analgesic agent is useful as a pharmaceutical agent for the treatment of a non-inflammatory pain disease such as a neurogenic pain disease, e.g. trigeminal neuralgia, postherpetic neuralgia, entrapment neuropathy, complex regional pain syndrome, diabetic neuropathy, traumatic neuropathy, phantom limb pain, central pain after spinal cord injury or stroke, and neuropathy caused by pharmacotherapy or radiation therapy, or the like.

Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neurotoxin component or Clostridium neurotoxin component encoding DNA to the subject using a needleless syringe.

A tolperisone-related compound or a compound of Formula Z is administered for the prevention and treatment of periodic paralyses and myotonias of several types, long QT syndrome, Brugada syndrome, malignant hyperthermia, myasthenia, epilepsy, ataxia, migraine, Alzheimer's Disease, Parkinson's Disease, schizophrenia, and hyperekplexia, neuropathic pain, and pain associated with nervous system disorders including, but not limited to, painful diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, complex regional pain syndrome, Guillain-Barre syndrome (GBS), Charcot-Marie-Tooth (CMT) disease, complex regional pain syndrome, type 1 (CRPS-1), ischemic neuropathy, fibromyalgia, chronic fatigue syndrome, painful spasticities, and other nervous system disorders that have pain as an attendant sign and / or symptom.

A preparation for transdermal absorption is disclosed which is suited for alleviating lasting pains caused by herpes zoster or postherpetic neuralgia and is practical and more improved in drug efficacy, safety and application characteristics. This tape preparation for transdermal absorption is obtained by causing an adhesive mass prepared by incorporating 1–30 parts by weight of a local anesthetic as an active ingredient in 100 parts by weight of a nonaqueous adhesive mass base comprising 5–50% by weight of a styrene-isoprene-styrene block copolymer, 1–60% by weight of an alicyclic saturated hydrocarbon resin, 5–60% by weight of liquid paraffin and 1–30% by weight of butyl rubber to be supported on a backing.

The invention relates to a formula for a traditional Chinese medicine for external administration, which cures Postherpetic neuralgia. The formula comprises the following components by percentage: 16% of fossilia spiriferis, 14% of rhubarb, 9.5% of frankincense, 9.5% of myrrh, 9.5% of notoginseng, 6% of garter snake, 6% of dragon's blood, 6% of periostracum cicadae, 6% of processed radix aconiti, 5.5% of processed radix aconiti kusnezoffii, 6% of angelica dahurica and 6% of borneol. The preparation method comprises the following steps: grinding rhubarb, frankincense, myrrh, notoginseng, dragon's blood and angelica dahurica into coarse powder; soaking in ethanol; percolating to obtain the medicament liquid; dissolving borneol with 75% of ethanol; and mixing the three liquids. The formula allows the medicine to permeate into the skin so as to relieve and dispel neuralgia, has the advantages of convenient administration, no side effect and significant curative effect and is of great popularization and application values.

The present invention provides medicinal agents that are useful for the prevention or treatment of neuropathic pain which comprises as an active ingredient a β2 adrenoceptor stimulant. In addition, the present invention provides formulations for the prevention or treatment of neuropathic pain such as painful diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, or postoperative or traumatic chronic pain, that are characterized by the use in combination of an α2-adrenoceptor stimulant and a β2-adrenoceptor stimulant, or by containing a compound that has both α2-adrenoceptor stimulation and β2-adrenoceptor stimulation activities as an active ingredient or the like.

The present invention relates to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases, and more particularly, to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases containing, as active ingredients, any one or two or more compounds selected from a group consisting of the compound of chemical formula 1, the compound of chemical formula 2, and the acceptable salts thereof.The pharmaceutical composition repairs nerve tissue damaged by herpes zoster to reduce the acute pain caused by herpes zoster, prevents postherpetic neuralgia, and enables a fundamental treatment through the recovery of nerve tissue in the postherpetic neuralgia. Further, the pharmaceutical composition can be effectively used for neuronal damage, including sciatic nerve crushing damage or the like, in a neuropathy including diabetic neuropathy or the like and for neuropathic pain, as well as for a variety of diseases caused by nerve tissue damage, such as brain diseases including strokes or the like.

The present disclosure relates to substituted amides that are inhibitors of fatty acid amide hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable Salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prevention, management or adjunctive treatment of all medical conditions associated with the inhibition of fatty acid amide hydrolase (FAAH), such as pain, including acute and postoperative pain, chronic pain, Cancer pain, pain from cancer chemotherapy, neuralgia, nociceptive pain, inflammatory pain, back pain, pain from various sources such as: diabetic neuropathy, neurotropism involving human immunodeficiency virus (HIV) type viral diseases, herpes zoster such as postherpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve damage, carpal tunnel syndrome, immunological mechanisms such as multiple sclerosis; sleep disorders, anxiety and depression, inflammatory diseases, Weight and eating disorders, Parkinson's disease, addiction, cramps, high blood pressure, or other medical conditions. The present disclosure also relates to a preparation method of the amide compound. Formula 1). The disclosure also relates to processes for the preparation of such compounds, and to pharmaceutical compositions containing them.

The invention belongs to the field of traditional Chinese medicinal preparations for shingles, and provides a drug for treating the shingles and postherpetic neuralgia thereof to solve the problems that treatment methods in the prior art may cause adverse reaction of the whole body and have poor effect. The drug is made from goldthread, Chinese rhubarb, cortex phellodendri, raw pinellia ternate, arisaema heterophyllum blume, Chinese gall, dried alum, mirabilite, semen strychni, centipedes, realgar, paris polyphylla smith, frankincense, myrrh, flos daturae, toad skin, borneol, edible tulips, bee wax and linseed oil according to a certain ratio and a method. The drug for treating the shingles and the postherpetic neuralgia thereof has good analgesic effect, quick action and small side effect.

The invention relates to a Chinese traditional medicine used for treating postherpetic neuralgia, which aims at developing a Chinese traditional medicine used for treating postherpetic neuralgia by adopting the theory of Chinese traditional medicine. The formula of the invention includes magnet, turmeric, dyers woad leaf, radix isatidis, cape jasmine fruit, radix scutellariae, Chinese thorowax root, rehmanniae praeparatum, semen plantaginis, liquoric root, angelica and white paeony root. The invention has the advantages of low price, good curative effect, being not easy to recur and extremely good social and economic benefits. The total effective rate of the medicine of the invention can reach more than 94.70%.

The invention particularly discloses a traditional Chinese medicine for treating postherpetic neuralgia. The traditional Chinese medicine is prepared from peach kernels, safflower carthamus, angelica sinensis, radix rehmanniae recens, ligusticum wallichii, radix paeoniae rubra, platycodon grandiflorum, szechwan chinaberry fruit, corydalis tuber, radix bupleuri, fructus aurantii, liquorice, the root of bidentate achyranthes and astragalus mongholicus in parts by weight. The all traditional Chinese medicines are decocted by water to obtain juice, and one dosage of juice is taken in a warm manner each day. The traditional Chinese medicine is simple to prepare, obvious in curative effect, low in side effect and high in safety.

The invention discloses an external Chinese medicine composition for treating postherpetic neuralgia and a preparation method of the composition. The external Chinese medicine composition is prepared from the following crude medicaments in parts by weight: 10-25 parts of spina gleditsiae, 3-9 parts of pseudo-ginseng, 3-6 parts of chrysanthemum, 3-6 parts of basil leaves, 3-15 parts of cortex lycii radicis, 3-9 parts of semen armeniacae amarae, 3-6 parts of rhizoma cimicifugae, 3-15 parts of red paeonia, 3-15 parts of toad, 3-6 parts of felwort, 1-3 parts of periostracum cicada, 10-30 parts of calcined concha margaritifera, 3-9 parts of lithospermum purpurocaeruleum, 3-9 parts of rhizoma arisaematis, 3-12 parts of angelica, 3-15 parts of cortex lycii radicis, 3-15 parts of radix sophorae flavescentis, 3-9 parts of angelica, 1-3 parts of wild ginger, 3-9 parts of corydalis tuber, 3-9 parts of Chinese lobelia, 1-3 parts of mint, 3-15 parts of ash bark, 3-15 parts of phellodendron amurense and 0.5-1.0 parts of borneol. A preparation method of the external Chinese medicine composition comprises the following steps: crushing the above raw materials into fine powder; and soaking in vegetable oil, and filtering to obtain oil. The external Chinese medicine composition has the advantages of remarkable curative effect, no adverse reaction, short treatment period, and is convenient for medical use and low expense.

The invention discloses a pain-relieving ointment for shingles and a preparation method thereof. The parts by weight of the components are as follows: 20-40 parts of phellodendron, 20-40 parts of coptis root, 20-40 parts of rheum officinale, 3-8 parts of centipede, 20-40 parts of natural indigo, 20-40 parts of red orpiment, 20-40 parts of borneol, 15-35 parts of prepared frankincense, 15-35 parts of prepared myrrh, 800-1,200 parts of sesame oil, and 50-80 parts of white wax. The centipede, natural indigo, red orpiment, borneol, prepared frankincense and prepared myrrh are ground into fine powder, mixed and added into the extract of phellodendron, coptis root, rheum officinale and sesame oil, then the ointment is prepared. The invention has the advantages of full play of drug effects, long duration, excellent pain-relieving effect and reduced occurrence rate of postherpetic neuralgia.

The invention discloses an external preparation of a lidocaine-prilocaine medicinal composition. The content of the lidocaine-prilocaine medicinal composition is 1%-10%. The external preparation comprises a patch containing lidocaine-prilocaine oily eutectic, a non-hydrophilic matrix material and pharmaceutically acceptable external preparation auxiliary materials, and a gel patch containing lidocaine-prilocaine O / W microemulsion, a hydrophilic gel matrix material and pharmaceutically acceptable external preparation auxiliary materials. The patch and the gel patch can be used for local superficial anesthesia or relieving local pains such as post-injection pain, post-puncture pain, pain caused by intravenous injection, postherpetic neuralgia, touch pain caused by herpes zoster and protrusion of intervertebral disc. The external preparation and the application have the advantages that the lidocaine-prilocaine eutectic is taken as an active ingredient, so that the percutaneous penetrationrate and the absorption degree of lidocaine and prilocaine can be obviously improved, the beneficial effects of synergy are produced, meanwhile, the occurrence rate of toxic and side effects of the lidocaine and the prilocaine is reduced, and a new choice is provided for analgesia and anesthesia requirements of patients and medical staff.

To control neuropathic pain produced by various mechanisms. Disclosed is a composition for elimination, relief or reduction of neuropathic pain comprising, as an active ingredient, at least one substance selected from the group consisting of D-allose, a derivative of D-allose, D-psicose and a derivative of D-psicose preferably in an amount of 0.01 to 90% by weight. The composition may comprise a mixture of D-allose and / or a derivative thereof and D-psicose and / or a derivative thereof at a ratio of 1:1 to 10:1. The neuropathic pain may be one induced by a disease selected from the group consisting of trigeminal neuralgia, postoperative pain, periodontitis, gingivitis, gingivostomatitis, oral ulcer, herpes zoster, postherpetic neuralgia, diabetic neuritis, causalgia, phantom limb pain and malignant tumor. Also disclosed is use of the composition for elimination, relief or reduction of neuropathic pain by administering the composition to a patient with neuropathic pain in such an amount that 0.01 to 100 g of the at least one substance can be taken by the patient per day.

The invention discloses traditional Chinese medicine formulas for treating diabetes and a preparation process. The traditional Chinese medicine formulas comprise a formula for common diabetes, a formula for diabetes constipation, a formula for diabetes complicated with urticaria, a formula for diabetes insomnia, a formula for diabetes complicated with erysipelas, a formula for diabetes complicated with postherpetic neuralgia, a formula for diabetes enteropathy, a formula for diabetic atherosclerosis obliterans and a formula for diabetic peripheral neuropathy; multiple diabetes formulas are provided, the medicine is applied according to indications for patients with different diseases detailedly, and side effects of the medicine are prevented from being caused to the patients with different diseases; by means of the preparation process, the property and flavor and effect of the traditional Chinese medicine are kept for the product, the quality is stable and reliable, the traditional Chinese medicine formulas are suitable for needs of dialectical implementation and recipe changes of clinical diagnosis of traditional Chinese medicine, and the traditional Chinese medicine formulas have the advantages that decocting is not needed, the medicine is convenient to take, absorption is rapid and convenient, the dosage is accurate, safety and cleanliness are achieved, and carrying is convenient.

The present invention relates to an agent for preventing and / or treating neuropathic pain comprising a 2-[(substituted-inden-7-yloxy)methyl]morpholine of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The invention is useful for providing an excellent agent for preventing and / or treating neuropathic pain, and particularly useful for providing an agent for preventing and / or treating allodynia, hyperalgesia, hyperesthesia, spontaneous pain, cancer pain, trigeminal neuralgia, phantom limb pain, postherpetic neuralgia, fibromyalgia, low back / leg pain, thalamic pain, entrapment (compressive) peripheral neuropathy, atypical facial pain, pain accompanying spinal cord injury, pain accompanying multiple sclerosis, pain accompanying chemotherapy-induced neuropathy, cancer pain on which an analgesic effect of a narcotic analgesic such as morphine is insufficient, pain accompanying diabetic neuropathy, and the like.

The invention relates to traditional Chinese medicinal analgesic spray for treating postherpetic neuralgia, and the traditional Chinese medicinal analgesic spray can be used for effectively solving a problem on medication for treating postherpetic neuralgia. The analgesic spray consists of 25-35g of fossilia spiriferis, 25-35g of rheum officinale, 13-17g of pseudo-ginseng, 13-17g of dragon blood, 15-25g of raw frankincense, 15-25g of raw myrrh, 13-17g of sliced cornu cervi, 13-17g of nidus vespae, 13-17g of gardeniae, 13-17g of notopterygium root, 13-17g of radix angelicae and 2-4g of borneol. A method for preparing the analgesic spray comprises the following steps: grinding the rheum officinale, the raw myrrh, the raw frankincense, the pseudo-ginseng, the borneol and the radix angelicae into powder, soaking the powder in alcohol and percolating to obtain a percolate; breaking the notopterygium root, the gardeniae, the nidus vespae, the sliced cornu cervi and the dragon blood, decocting in water, filtering and concentrating the filtrate to obtain a concentrated medicine liquid; mixing the percolate, the concentrated medicine liquid and the fossilia spiriferis, boiling and cooling to obtain the analgesic spray. The analgesic spray disclosed by the invention is simple in preparation method, low in cost and convenient to use; the analgesic spray has the functions of clearing away heat and removing dampness, promoting blood circulation and arresting toxicity, removing stasis to unblock the meridians and relieving swelling and pain; the analgesic spray is an innovation of medicines for treating postherpetic neuralgia and various neuralgia.

The invention discloses a BAPTA and an application of a derivant thereof, in particular to an application of the derivant in preparing analgesic drugs. Clinical indications include headache, prosopalgia, dysmenorrheal, postoperative pain, cancer pain, viscera pain, postherpetic neuralgia, phantom limb pain, HIV, pathologic pain related to multiple sclerosis, morphine class medicine tolerance or addiction patient pain and serious chronic intractable pain or usual clinical pain diseases.

The present invention relates to the use of 2-indanylamino derivatives for the treatment of chronic pain. In particular the invention relates to the use of 2-(2-indanylamino)-acetamide for the treatment of neuropathic pain, i.e. the pain associated with postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy and nerve distruction by the human immunodeficiency virus (HIV).

The invention belongs to the field of traditional Chinese medicine, and particularly relates to Pien Tze Huang and new application of a preparation thereof in preparing a drug for treating herpes zoster. An in-vitro experiment shows that Pien Tze Huang can dose-dependently inhibit duplication of chicken varicella-herpes zoster viruses (VZV). A clinical study finds that the combination of Pien Tzehuang and anti-virus drugs of valaciclovir and acyclovir has an obvious curative effect on alert period zoster viruses due to liver yu heat from the line, improvement of clinical symptoms of a patientcan be promoted, incrustation of herpes can be quickly promoted, new herpes can be stopped from generating, pain can be relieved, and the treatment time can also be shortened; besides, the incidenceof postherpetic neuralgia and the occurrence rate of adverse reactions occurring after treatment can also be lowered, and the clinical application has obvious advantages.

The invention relates to a Chinese medicine for treating postherpetic neuralgia. The Chinese medicine is prepared from the following medicinal materials in part by weight: 10 to 20 parts of Chinese thorowax root, 10 to 20 parts of kudzuvine root, 10 to 20 parts of notopterygium root, 10 to 20 parts of peony, 10 to 20 parts of angelica dahurica, 10 to 20 parts of kudzuvine root, 10 to 20 parts of decumbent bugle herb, 10 to 20 parts of baikal skullcap root, 10 to 20 parts of gypsum, 20 to 30 parts of ginger and 20 to 30 parts of Chinese date. Trials prove that Chinese medicine can safely and effectively treat postherpetic neuralgia.

The invention relates to the fields of medicines and pharmacology, in particular to a medicine for treating postherpetic neuralgia and a preparation method of the medicine. On the basis of the theory of traditional Chinese medicine and the latest pharmaceutical research achievement and through the utilization of modern technological means, the medicine is prepared into an oral preparation, preferably into capsules, tablets and granules, from radix dipsaci, herba polygoni perfoliati, panax notoginseng, garlic, rhizoma ligustici wallichii, rhizoma curcumae longae, katsumade galangal seed, radix aucklandiae, diverse wormwood herb, amaranthus viridis, flos carthami, fructus amomi, lalang grass rhizome, sweet broomwort herb, folium hibisci, rhizoma paridis and the like. Pharmacodynamic experiment researches show that the medicine provided by the invention has an ideal inhibitory effect on PHN, and the medicine provided by the invention is convenient to use, good in safety and free from drug dependency; the medicine, which is completely prepared from natural medicinal herbs, is free from any chemical additives, and the medicine, when taken for a long time, is safe and reliable; the tolerance and the compliance of patients can be improved to a great extent, so that a novel optional scheme is provided for the long-term treatment of the patients with the PHN; and the medicine can meet current clinical demands.

The invention discloses a medicinal composition for treating neuropathic pain. The medicine provided by the invention is prepared by magnoflorine, ranunculin, piperine and eugenol as raw material medicines and can be prepared into various dosage forms according to a conventional preparation technology. With the adoption of the medicinal composition for treating neuropathic pain, the defects in the prior art can be overcome, and the invention provides the safe medicinal composition for treating neuropathic pain with significant efficacy. The medicine provided by the invention is simple in preparation method and low in cost, and clinical tests prove that the medicine for treating the neuropathic pain has significant clinical effects, including prosopalgia, ischialgia, radicular pain, postherpetic neuralgia and diabetic peripheral neuritis and the like.

The invention discloses a traditional Chinese medicine composition for treating sciatica, which comprises the following raw materials by mass: 5-20 parts of prepared common monkshood mother roots, 6-12 parts of prepared kusnezoff monkshood roots, 10-25 parts of Chinese honeylocust spine, 9-18 parts of doubleteeth pubescent angelica roots, 4-12 parts of prepared common monkshood branched roots, 6-15 parts of cassia bark, 4-18 parts of turmeric, 5-15 parts of atractylodes rhizome, 10-20 parts of coix seeds, 6-16 parts of mealy fangji roots, 6-14 parts of manchurian wildginger, 5-15 parts of twotoothed achyranthes roots, 5-16 parts of prepared frankincense, 4-15 parts of prepared myrrh, 5-14 parts of Sichuan lovage rhizome, 2-8 parts of cassia twig and 6-16 parts of liquorice roots. The composition has the effects of dispelling wind, arresting pain, promoting blood circulation and dredging collaterals, and has remarkable curative effects on various neuropathic pains such as root neuropathic pain, sciatica, trigeminal neuralgia, postherpetic neuralgia and diabetic nerve ending inflammation.

The invention discloses an orally-taken traditional Chinese medicine decoction used for treating postherpetic neuralgia. The decoction comprises the following ten traditional Chinese medicines: total snakegourd fruit, white peony root, licorice, safflower, American ginseng, pseudo-ginseng, scorpion, cicada slough, rhizoma corydalis and Sichuan chinaberry fruit. The decoction can soothe the liver, rectify qi, supplement qi and remove blood stasis, implementing tonification and purgation in combination; otherwise, pains are hard to be eliminated. The key points of treatment lie in tonification of qi and reduction in phlegm; if qi flows, blood flows, but if qi stagnates, blood clots; tonification of qi and activation of blood enables blood transportation to be powerful, elimination of blood stasis leads to relaxation of veins, and various diseases heal. The traditional Chinese medicines in the decoction are strictly compatible, carry out tonification and purgation at the same time and are targeted to the pathogenesis of intermingled deficiency and excess, so wind-evil is dispelled out; the decoction has high efficiency in clinical practice and can totally treat symptoms of afterpain.

A traditional Chinese medicine for treating neuralgia caused by herpes zoster. The raw material medicine is composed of: 30g of melon basket, 30g of loofah, 50g of citrus (skin and network), and 10g of angelica. The invention has the advantages of low price, convenient use, short treatment time, no relapse, 100% effective rate and 82% cure rate.

The invention relates to the application of a traditional Chinese medicine composition to preparation of medicines used for treating diseases caused by herpes virus infection. A prescription for the traditional Chinese medicine composition comprises, 80 parts by weight of Rhizoma Atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnolia, 120 parts by weight of dahurian angelica roots, 120 parts by weight of Poria cocos, 120 parts by weight of areca peel, 80 parts by weight of raw pinellia ternate, 10 parts by weight of Extractum Glycyrrhizae, 0.8 part by volume of patchouli oil and 0.4 part by volume of perilla leaf oil. The traditional Chinese medicine composition uses tradition traditional Chinese medicines as raw materials, has small toxic and side effect and obvious treatment effect on herpes zoster, and can prevent and treat postherpetic neuralgia. No matter in a systemic administration manner or a local administration manner, the traditional Chinese medicine composition has better effect compared with the common medicine acyclovir. The traditional Chinese medicine composition can shorten the curing time of herpes, helps patients to get rid of the shadow of disease as early as possible, and is beneficial for the physical and mental health of patients.

The invention discloses a traditional Chinese medicine preparation for preventing and treating herpes zoster and postherpetic neuralgia and a preparation method thereof. The traditional Chinese medicine preparation comprises the following active components in parts by weight: 5-15 parts of ground beetle, 2-7 parts of scorpion, 10-20 parts of radix paeoniae alba and 2-7 parts of liquorice. The traditional Chinese medicine preparation has the functions of tonifying yin and nourishing blood, expelling and removing stasis, activating meridians to stop pain and the like, is used for treating herpes zoster and postherpetic neuralgia, and can be prepared as concentrated water pills, concentrated water honeyed pills, small honeyed pills and big honeyed pills.