88 results about "Postherpetic polyneuropathy" patented technology

The present invention is directed to certain Aza-Indole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.

The present disclosure relates to substituted amides that are inhibitors of fatty acid amide hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable Salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prevention, management or adjunctive treatment of all medical conditions associated with the inhibition of fatty acid amide hydrolase (FAAH), such as pain, including acute and postoperative pain, chronic pain, Cancer pain, pain from cancer chemotherapy, neuralgia, nociceptive pain, inflammatory pain, back pain, pain from various sources such as: diabetic neuropathy, neurotropism involving human immunodeficiency virus (HIV) type viral diseases, herpes zoster such as postherpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve damage, carpal tunnel syndrome, immunological mechanisms such as multiple sclerosis; sleep disorders, anxiety and depression, inflammatory diseases, Weight and eating disorders, Parkinson's disease, addiction, cramps, high blood pressure, or other medical conditions. The present disclosure also relates to a preparation method of the amide compound. Formula 1). The disclosure also relates to processes for the preparation of such compounds, and to pharmaceutical compositions containing them.

To control neuropathic pain produced by various mechanisms. Disclosed is a composition for elimination, relief or reduction of neuropathic pain comprising, as an active ingredient, at least one substance selected from the group consisting of D-allose, a derivative of D-allose, D-psicose and a derivative of D-psicose preferably in an amount of 0.01 to 90% by weight. The composition may comprise a mixture of D-allose and / or a derivative thereof and D-psicose and / or a derivative thereof at a ratio of 1:1 to 10:1. The neuropathic pain may be one induced by a disease selected from the group consisting of trigeminal neuralgia, postoperative pain, periodontitis, gingivitis, gingivostomatitis, oral ulcer, herpes zoster, postherpetic neuralgia, diabetic neuritis, causalgia, phantom limb pain and malignant tumor. Also disclosed is use of the composition for elimination, relief or reduction of neuropathic pain by administering the composition to a patient with neuropathic pain in such an amount that 0.01 to 100 g of the at least one substance can be taken by the patient per day.