19 results about "Postherpetic polyneuropathy" patented technology

The present disclosure relates to methods for increasing cell-mediated immunity against varicella zoster virus (VZV) in a human subject in need thereof by administration of an immunogenic composition comprising effective amounts of a VZV glycoprotein E antigen and an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for prevention of herpes zoster and / or postherpetic neuralgia.

The present invention belongs to the technical field of pain relief preparations, and particularly relates to a pain relief preparation, a preparation method thereof and an application. The pain relief preparation is composed of (+)-camphene, a propylene glycol extract of Bupleurum chinense DC. and pharmaceutically acceptable excipients. Among them, the mass ratio of (+)-camphene to the propylene glycol extract of Bupleurum chinense DC. is 1-2.5:1. The propylene glycol extract of Bupleurum chinense DC. is prepared by the following method: Bupleurum chinense DC. is ground into powder, mixed with propylene glycol, extracted by ultrasonic treatment, filtered, the filtrate is collected and dried to obtain the propylene glycol extract of Bupleurum chinense DC. The present invention also provides a preparation method of the pain relief preparation, and proves the application of the pain relief preparation in relieving acute pain and postherpetic neuralgia, expanding the types of pain relief preparations.

The invention relates to preparation of a traditional Chinese medicine nanoemulsion gel spray for treating post-herpes zoster neuralgia. The nanoemulsion gel spray is prepared from the following raw material components: rhizoma corydalis, rhizoma chuanxiong, honeysuckle flowers, radix scutellariae, peach kernels, flos carthami, poloxamer 407, soybean oil, glycerol and pure water. Corydalis tuber, ligusticum wallichii, honeysuckle, radix scutellariae, peach kernel and safflower are adopted as traditional Chinese medicine raw material components, the traditional Chinese medicine raw material components are green, natural, free of hormone and capable of being used for a long time, effective components can effectively relieve and treat neuralgia after herpes zoster, soybean oil, glycerol and pure water are adopted as auxiliary materials, the auxiliary materials and the traditional Chinese medicine components are mixed and subjected to ultrasonic treatment, and the nano-emulsion is obtained. Then the nano-emulsion and poloxamer 407 are fully mixed to prepare nano-emulsion gel, and finally the nano-emulsion gel is canned to obtain the spray.

The invention discloses a preparation method of a tetrodotoxin (TTX) external preparation and an application of the tetrodotoxin (TTX) external preparation in treatment of postherpetic neuralgia. The method comprises the following steps: preparing external preparations with different TTX contents, establishing a postherpetic neuralgia animal model, and verifying the treatment effect of the external preparations on the postherpetic neuralgia through animal experiments. TTX is an amino perhydroquinazoline type small molecule compound. A novel preparation is developed on the basis that tetrodotoxin is a voltage-gated sodium ion channel inhibitor. Experiments prove that by inhibiting the tetrodotoxin sensitive voltage-gated sodium ion channel Nav1.7, the tetrodotoxin external preparation shows remarkable postherpetic neuralgia resistance activity, and can be researched and developed as a postherpetic neuralgia medicine.

The present invention provides a traditional Chinese medicine composition for herpes zoster oticus and its application, which relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is obtained by reasonable compatibility in accordance with the principle of syndrome differentiation and treatment of traditional Chinese medicine, and is composed of Scorzonera austriaca, Cimicifuga foetida, Cortex Fraxini, Arisaema heterophyllum, Abutilon theophrasti, Aucklandia lappa, Chrysanthemum indicum, Houttuynia cordata, Cynanchum atratum, and Ginger Peel. The compatibility of various herbs is reasonable, and it has the effects of clearing heat and detoxifying, promoting qi circulation to relieve pain, detumescing and treating sores, and promoting diuresis to reduce swelling. It has good curative effect, short course of treatment, and no toxic and side effects. The traditional Chinese medicine composition of the present invention has a significant improvement effect on the spontaneous pain behavior of rats with postherpetic neuralgia model and aspects such as the levels of serum IL-2, IL-6, and TNF-α, achieving the simultaneous treatment of the symptoms and root causes of herpes zoster oticus. The traditional Chinese medicine composition of the present invention has a significant therapeutic effect on herpes zoster oticus, has a high effective rate, can quickly relieve the clinical symptoms of patients, shorten the recovery time of patients, and relieve the pain of patients.

The invention relates to the technical field of traditional Chinese medicine, in particular to an oral traditional Chinese medicine composition and an external traditional Chinese medicine composition for treating postherpetic neuralgia, a preparation method and a combined medication method. The oral traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of scutellaria baicalensis, 3-9 parts of rheum officinale, 9-15 parts of rhizoma anemarrhenae, 12-18 parts of lalang grass rhizome, 9-15 parts of asparagus cochinchinensis, 9-15 parts of honeysuckle, 12-18 parts of rhizoma phragmitis, 9-15 parts of burdock, 6-12 parts of cicada slough, 6-12 parts of gastrodia elata, 6-12 parts of moutan bark, 12-18 parts of kudzu vine root, 12-18 parts of dried rehmannia root and 12-18 parts of tortoise shell. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of gypsum, 10-20 parts of gypsum rubrum, 0.1-0.3 part of borneol, 4-8 parts of mint, 3-7 parts of radix sophorae flavescentis, 4-8 parts of cortex dictamni and 1-3 parts of indigo naturalis. The traditional Chinese medicine composition achieves the aims of quickly and thoroughly relieving pain and regulating and improving the whole body.

This invention belongs to the field of biomedical technology, specifically relating to an ointment and its application. The toad oil used in this invention differs significantly in composition from toad venom, and its ointment is effective for various acute and chronic pain conditions. Animal experiments have confirmed that the toad oil ointment significantly reduces the frequency and delays the onset of acetic acid-induced writhing responses, demonstrating a clear analgesic effect. Clinical studies have shown that this ointment is rapidly effective and has a definite therapeutic effect on acute gout attacks, postherpetic neuralgia, and arthritis-related pain and swelling. The formulation effectively improves drug retention and user comfort, and no skin irritation has been observed. This development achieves comprehensive utilization of toad resources, providing an example for the sustainable development of traditional Chinese medicine and the efficient utilization of biological resources.

The invention discloses a traditional Chinese medicine composition for treating herpes zoster. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of realgar, 1-3 parts of centipede, 6-10 parts of indigo naturalis and 3-6 parts of dried alum. The invention also discloses a preparation method of the traditional Chinese medicine composition for treating herpes zoster. The method comprises the following steps: pretreating the raw materials; grinding and mixing raw materials; and preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition can effectively treat herpes zoster, reduce postherpetic neuralgia and improve the life quality of a patient through reasonable medicine compatibility according to the symptoms of herpes zoster, materials are convenient to take, and the preparation method is simple and easy to implement; the traditional Chinese medicine belongs to an external treatment method, is prepared into paste by adding table vinegar during use, is externally applied to an affected part, is convenient to use and has high patient compliance.

This invention provides the application of deoxycholic acid in the treatment of postherpetic neuralgia. This invention is the first to discover that deoxycholic acid is effective in treating postherpetic neuralgia, and that inhibiting the nucleus tractus solitarius-paraventricular nucleus circuit of the thalamus is also effective in treating postherpetic neuralgia. A synergistic therapeutic effect was achieved when deoxycholic acid was combined with an inhibitor of the nucleus tractus solitarius-paraventricular nucleus circuit. This invention provides a new strategy for the treatment of postherpetic neuralgia.

This invention relates to the field of assistive devices for shingles, and more particularly to a hot compress device for relieving postherpetic neuralgia, comprising: a hot compress component. Specifically, the hot compress component includes a heat insulation layer and a covering layer. The covering layer is connected to and separated from the heat insulation layer to form a liquid cavity. The surface of the heat insulation layer has several mounting grooves communicating with the liquid cavity. A phase change heat storage component is embedded inside the mounting grooves. The surface of the covering layer has a water inlet communicating with the liquid cavity. This invention uses a phase change heat storage component to store the heat of hot water injected into the liquid cavity, forming thermal radiation, thereby creating a hot compress effect on the human body surface. Unlike traditional chemical heating and ordinary hot towels or hot water bottles, the phase change heat storage component can maintain the temperature at a relatively mild state and retain heat for a longer period. It provides a good hot compress effect and has the function of long-term use and multiple reuses.

The invention provides a polysaccharide-rich traditional Chinese medicine composition for relieving pain as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-80 parts of radix curcumae and 20-70 parts of folium artemisiae argyi. The invention also provides a preparation method of the traditional Chinese medicine composition. The percentage content of total polysaccharides in the traditional Chinese medicine composition is 50-90%. The artificial gastric juice and the artificial intestinal juice are used as extraction solvents, so that the method has the advantages of high yield, low cost, easiness in industrial production and the like, and accords with the characteristic of in-vivo absorption of traditional Chinese medicines; the prepared traditional Chinese medicine composition can relieve postherpetic neuralgia caused by dysmenorrhea and herpes zoster, and has great medical potential.

The invention discloses a medicine for treating postherpetic neuralgia and a preparation method thereof, and belongs to the technical field of medicines for herpes zoster. Aiming at postherpetic neuralgia, the traditional Chinese medicine composition treats both symptoms and root causes through the synergistic effect of all the components, gypsum is used, and rhizoma coptidis, radix scutellariae, cortex phellodendri and fructus gardeniae are combined, so that the traditional Chinese medicine composition has the effects of strongly clearing heat, purging fire, detoxifying, removing residual damp-heat toxin and relieving causalgia; salvia miltiorrhiza, radix paeoniae rubra, moutan bark and motherwort synergistically promote blood circulation, remove blood stasis, cool blood and improve microcirculation so as to relieve stabbing pain. Scorpio, centipede, lumbricus and other insect drugs go deep into meridians and collaterals to dispel wind and dredge collaterals and strongly relieve Mangnolia officinalis and trifoliate orange have the effects of promoting qi circulation, reducing phlegm and smoothing qi to promote drug efficacy; radix astragali, glossy privet fruit and sliced cornu cervi tonify qi, nourish yin, warm, dredge and repair, and strengthen healthy qi to promote regeneration of nervous tissues; herba schizonepetae and mint dispel wind and permeate superficies, and guide the medicine to directly reach According to the formula, the neuralgia with various properties can be quickly relieved, inflammation can be radically eliminated, circulation can be improved, and nerves can be repaired.

This invention discloses a magnetic nanoprobe and kit for assessing postherpetic neuralgia. The magnetic nanoprobe is a complex formed by thiolized carbonized polymer dots, a chelating agent, superparamagnetic molecules, and 2-phospho-D-glyceric acid. 2-phospho-D-glyceric acid specifically reacts with NSE, dehydrating to generate phosphoenolpyruvate and releasing water molecules. The magnetic nanoprobe is specific for NSE and can be used for assessing postherpetic neuralgia. The kit includes the magnetic nanoprobe and instructions, and can determine the NSE marker content in a single sample, with a detection limit better than 1 pg / mL, thereby achieving effective assessment of postherpetic neuralgia.

The invention provides an accurate and reliable postherpetic neuralgia prediction method by combining structural magnetic resonance image data with a machine learning technology. According to the method, the risk that the herpes zoster patient develops into the postherpetic neuralgia can be efficiently identified, and the prediction accuracy is greatly improved. Compared with the prior art, the method has the advantages that by comprehensively analyzing multi-dimensional information such as brain structures, functional connections and clinical features, the robustness and generalization ability of the model are enhanced, and the limitation of dependence on single features is reduced. The method also supports early intervention, can provide personalized treatment suggestions for clinic, and helps doctors to formulate more reasonable treatment schemes, so that the life quality of patients is improved, and the method has important clinical application value.

This disclosure describes a cannabinoid-based nanoplatform for treating shingles, designed to enhance bioavailability and controlled release of active ingredients. The composition includes cannabinoids like cannabidiol (CBD) and cannabigerol (CBG), alongside flavonoids, polyphenols, and alkaloids, in oral and topical formulations. The oral capsule combines cannabinoids with polyphenols and flavonoids to provide systemic anti-inflammatory, antiviral, and neuroprotective effects, particularly for nerve pain and inflammation, including postherpetic neuralgia. The topical cream includes cannabinoids, capsaicin, and aloe vera, offering localized relief from pain, itching, and rash. The method targets both systemic and localized symptoms during the acute phase of shingles, aiming to inhibit varicella-zoster virus replication, disrupt viral assembly, and prevent viral release, while also providing immune modulation and anti-inflammatory benefits. The nanoplatform uses nano-emulsification techniques, producing particles smaller than 200 nm to ensure optimal delivery and therapeutic efficacy, offering comprehensive relief for shingles symptoms.

The present invention relates to the compound 2-hydroxy-octadecene-9-cis-oate for use in the treatment of oncological conditions including grade IV glioblastoma, grade 3 glioma, embryonal tumor, pituitary tumor, meningioma, hemangiopericytoma, hemangioblastoma, mesothelioma, cholangiocarcinoma, exocrine pancreatic cancer, neuroendocrine pancreatic cancer, rectal cancer, urinary tract cancer, bladder adenocarcinoma, and esophageal cancer, as well as for use in the treatment of peripheral diabetic neuropathy, spinal cord injury, postherpetic neuralgia, chemotherapeutic agents, antitumor agents, cancer, fibromyalgia, or neuropathic pain caused by hepatitis. The present invention also relates to pharmaceutical compositions comprising 2-hydroxy-octadecene-9-cis-oate.

This invention relates to a sequential acupuncture and moxibustion treatment method for postherpetic neuralgia, belonging to the field of traditional Chinese medicine acupuncture technology. The method includes: first, selecting Ashi points and Jiaji points for acupuncture, retaining the needles for 30 minutes; immediately after, selecting Shenque (CV8) and Zusanli (ST36) points for gentle moxibustion, moxibustion at each point for 15 minutes, for a total duration of 30 minutes; treatment is given 3 times a week for 4 consecutive weeks. This invention, through the sequential "acupuncture first, moxibustion later" approach, allows acupuncture to quickly unblock meridians and regulate neurotransmitters, while moxibustion provides continuous warm stimulation to synergistically enhance immune regulation. It can significantly upregulate the proportion of peripheral blood regulatory T cells and the level of related anti-inflammatory cytokines, reversing the immune imbalance associated with neuropathic pain, thereby effectively relieving pain, improving the patient's quality of life and psychological state, and demonstrating good safety. This invention provides a standardized, effective, and mechanistic traditional Chinese medicine treatment method for postherpetic neuralgia.

The invention discloses a traditional Chinese medicine formula for treating herpes zoster sequelae, and belongs to the technical field of traditional Chinese medicine formulas for herpes zoster, the traditional Chinese medicine formula comprises the following raw materials by weight: 47-52 parts of phellodendron, 47-52 parts of rheum officinale, 47-52 parts of goldthread root, 47-52 parts of white spirit, 47-52 parts of galactophyllite, 47-52 parts of talc, 47-52 parts of pseudosciaena crocea, 3-8 parts of borneol, 47-52 parts of gypsum rubrum, and 3-8 parts of mirabilite. According to the traditional Chinese medicine composition, the cortex phellodendri, the radix et rhizoma rhei, the rhizoma coptidis, the alumen, the galactophyllite, the talc, the pseudosciaena crocea, the gypsum rubrum and the like which are used for clearing away heat and toxic materials, eliminating dampness and healing sores are used as main materials, and the borneol and the mirabilite are used as auxiliary materials for enhancing the effects of relieving swelling and pain and transdermal absorption; the traditional Chinese medicine composition is especially suitable for symptoms such as postherpetic neuralgia and skin scorching hot stabbing pain, and is high in pertinence and remarkable in curative effect.

This invention relates to the field of biomedical technology, specifically to the role, implementation method, and application of a Prmt6 inhibitor for the prevention and treatment of postherpetic neuralgia. This invention reveals a novel function of Prmt6 and its coding sequence: inhibiting the body's antiviral immune response to herpesviruses during the pathological process of herpes zoster. Targeting and inhibiting the expression and function of Prmt6 can effectively prevent and treat pain abnormalities in postherpetic neuralgia, improving patients' quality of life.