3 results about "Protein kinase C" patented technology

The application belongs to the technical field of medicine, and particularly relates to application of acacetin or 6-hydroxyflavone in preparation of anti-angina pectoris drugs, and aims to solve the problems of adverse reactions such as blood pressure drop, reflex tachycardia and the like caused by non-selective vasodilation of existing anti-angina pectoris drugs, wherein the drug improves myocardial blood supply by selectively dilating coronary vessels of the heart, wherein acacetin dilates coronary vessels of the heart by inhibiting cardiac coronary vessel myosin light chain kinase and activating myosin light chain phosphatase, and 6-hydroxyflavone dilates coronary vessels of the heart by inhibiting protein kinase C and enhancing myosin light chain phosphatase activity; and the acacetin or 6-hydroxyflavone significantly reduces the symptoms of myocardial ischemia of rats caused by isopropyl adrenaline, improves characteristic ECG abnormal changes of angina pectoris, does not affect heart rate and systemic blood pressure, and is safer, thereby providing a potential drug selection for anti-angina pectoris treatment.

PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.

The invention belongs to the field of agricultural biology, and particularly relates to an aquaporin phosphokinase activator and a preparation method and application thereof.According to the activator, adenosine polyethylene glycol forskolin and a lipoic acid hexamethylenediamine protein kinase C activator serve as core components, and plant hormones such as gibberellin, abscisic acid and jasmonic acid methyl ester are cooperated to prepare the aquaporin phosphokinase activator. Auxiliary materials such as chitosan, glycine betaine, trehalose, glycerol, polysorbate, urea and calcium chloride are compounded, and specific low-temperature dissolution, step-by-step mixing and ultrasonic emulsification processes are carried out, so that the water-retaining agent is prepared. The preparation can specifically activate crop fruit aquaporin phosphorylation kinase, and promote crop aquaporin to keep open conformation by regulating and controlling key phosphorylation sites, so that the fruit moisture transmembrane transport efficiency is improved. After being diluted, the fruit preservative is sprayed on leaf surfaces in the middle and later periods of fruit ripening, so that the water conductivity of fruits can be effectively improved, the absorption of water and nutrient substances of the fruits is promoted, the water replenishing and weight increasing of the fruits are realized, the integrity of cell structures is enhanced, the fruit cracking rate is obviously reduced, and the flavor and quality of the fruits are improved or maintained.