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1 results about "Pyridinium bromide" patented technology
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Pyridinium perbromide (also called pyridinium bromide perbromide, pyridine hydrobromide perbromide, or pyridinium tribromide) is an organic chemical composed of a pyridinium cation and a tribromide anion. It can also be considered as a complex containing pyridinium bromide—the salt of pyridine and hydrogen bromide—with an added bromine (Br 2).
An aggregation-induced emission luminogen, and a preparation method and application thereof
The application discloses an aggregation-induced emission luminophore and a preparation method and application thereof, and the AIE luminophore is (E)-1-butyl-4-(2-(4-(1,2,2-triphenylvinyl)-4-methoxystyryl)pyridinium bromide. The application determines CYP3A5 as a key intervention node, and successfully constructs a hydrophobic enhanced AIE molecule TPy-BU through Heck coupling and quaternization reaction. The TPy-BU interferes with the endoplasmic reticulum function related to CYP3A5 selectively through its photodynamic effect, and destroys the metabolism and signal transmission coupling between the endoplasmic reticulum and mitochondria. In addition, the TPy-BU also adjusts the NF-kappa B signal pathway, and synergistically inhibits the proliferation, migration and invasion of tumor cells, and promotes the death of cancer cells, thereby providing a new molecular design principle and potential intervention way for the precise treatment of cervical adenocarcinoma.
Owner:SHANGHAI TONGREN HOSPITAL