2 results about "Pyridinium bromide" patented technology

The invention belongs to the field of post-treatment of organic chemical synthesis methods, and relates to a post-treatment method for propiconazole synthesis. A crude propiconazole product is used as a raw material and is subjected to an isomerization reaction under the combined action of a bromine-containing ionic liquid and sodium alkoxide to generate cis-propiconazole. The bromine-containing ionic liquid is imidazolium bromine salt: [CnH2n + 1-MIM] + Br <-> (n = 2-4) or pyridinium bromine salt: [CmH2m + 1-Py] + Br <-> (m = 2-4). The method is mild in process condition, low in reaction temperature, short in process path, simple to operate and high in safety, efficient conversion of low-efficiency trans-propiconazole and ineffective isomers is achieved, the content of cis-propiconazole in a treated sample is as high as 99%, the yield is as high as 97%, the economical efficiency of the process is improved, and the method is suitable for industrial production. And the ionic liquid used in the reaction can be further recycled, so that the atom utilization rate is increased.

The application discloses an aggregation-induced emission luminophore and a preparation method and application thereof, and the AIE luminophore is (E)-1-butyl-4-(2-(4-(1,2,2-triphenylvinyl)-4-methoxystyryl)pyridinium bromide. The application determines CYP3A5 as a key intervention node, and successfully constructs a hydrophobic enhanced AIE molecule TPy-BU through Heck coupling and quaternization reaction. The TPy-BU interferes with the endoplasmic reticulum function related to CYP3A5 selectively through its photodynamic effect, and destroys the metabolism and signal transmission coupling between the endoplasmic reticulum and mitochondria. In addition, the TPy-BU also adjusts the NF-kappa B signal pathway, and synergistically inhibits the proliferation, migration and invasion of tumor cells, and promotes the death of cancer cells, thereby providing a new molecular design principle and potential intervention way for the precise treatment of cervical adenocarcinoma.