32 results about "Pyridinium bromide" patented technology

Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.

The various embodiments herein provide a method of preparation of a nano-material for dechlorination of polychlorobiphenyls (PCB) from oil. The method involves preparing a modified bentonite prepared by treating with hexadecyl pyridinium bromide surfactant and dispersing the modified bentonite in cyclohexane. Aqueous solutions of metal ion such as Cadmium Nitrate or Zinc Nitrate and sulfide ions such as sodium sulfide are added alternately to obtain metal sulphide nano-particles. zinc nitrate is more preferable. The method of dechlorination of polychlorobiphenyls from oil involves irradiating a mixture of oil, nano-material and a solvent such as toluene under UV light for 2-6 h. A nano-material including a modified bentonite with a mono-layer of surfactant and metal sulphide nano-particles such as ZnS and CdS for remediation of oil containing PCB, is also provided.

The invention discloses fireproof emulsion paint. The fireproof emulsion paint comprises acrylic acid emulsion, polyurethane emulsion, epoxy resin, a fire retardant, expanded perlite, titanium dioxide, nanometer silica sol, silicon powder, nanometer titanium dioxide, zinc trifluoroacetylacetonate, dodecafluoroheptyl methacrylate, a film forming auxiliary agent, sorbitan monopalmitate, lauric acid, an antifoaming agent, hydroxyethyl cellulose, methyl ethyl ketone, N-phenyl-N'-cyclohexyl p-phenylenediamine, potassium citrate, dimethyldiallylammonium chloride and water. The fire retardant comprises dimethyl phosphite, methylvinyldichlorosilane, 3-aminopropyltriethoxysilane, 5-ethyl-5-butyl-2-chloro-1,3,2-dioxaphosphorinane, potassium tripolyphosphate, cetyl pyridinium bromide, decabromodiphenyl ethane, aluminum dihydrogen phosphate, calcium borate, melamine and cyanuric acid. The fireproof emulsion paint has excellent flame resistance, good fire retardancy, good adhesion to a base material and good decorative effects.

The invention discloses a polypropylene flame-retardant masterbatch and a preparation method thereof. The masterbatch is prepared through the following raw materials in parts by weight: 14-20 parts of polypropylene, 80-90 parts of modified bentonite, 4-8 parts of polypropylene wax, 3-5 parts of zinc stearate, 2.5-2.8 parts of titanate coupling agent, 15-20 parts of aluminum hydroxide, and 8-10 parts of expansible graphite. The preparation method comprises the following steps: (1) heating a high-speed mixer to reach the temperature of 180-200 DEG C, and maintaining the temperature for 5-10min; (2) adding modified bentonite and titanate coupling agent; stirring for 15-20min; adding aluminum hydroxide and expansible graphite; continuously stirring for 10-15min; and then cooling to reach the temperature of 110-120 DEG C; (3) adding polypropylene wax and zinc stearate; continuously stirring for 4-5min; then adding polypropylene; mixing and stirring for 4-5min; and discharging and cooling; and (4) extruding the cooled material, and pelletizing to obtain the polypropylene flame-retardant masterbatch. According to the preparation method, tetradecy pyridinium bromide modified bentonite is added, so that the compatibility of modified bentonite and bentonite is improved, and the prepared masterbatch is easily dispersed in polypropylene, and as a result, the flame retardance of polypropylene can be improved.

Provided is a reagent for assaying a thrombin-antithrombin complex (TAT) in a blood sample from a subject by latex agglutination assay. The reagent includes a polycation. As a result, TAT complexes can be precisely assayed while circumventing the effect of heparin. The polycation is, for example, hexadimethrine bromide, chitosans, modified dextran, aminodextran, hydroxymethyl cellulose trimethylamine, lysozyme, spermine, spermidine, polylysine, polyarginine, polyornithine, protamine sulfate, hydroxyethyl cellulose trimethylamine, heparin-binding protein, polyallylamine, polyallylamine hydrochloride, poly(diallyl dialkyl amine), polyamideamine, polyamine, polyvinylbenzyltrimethylammonium chloride, polydiallyldimethylammonium chloride, polyethyleneimine, polypropyleneimine, polypropylethyleneimine, polyimidazoline, polyvinylamine, polyvinyl pyridine, poly(acrylamide/methacryloxypropyltrimethylammonium bromide), poly(diaryldimethylammonium chloride/N-isopropylacrylamide), poly(dimethylaminoethyl acrylate/acrylamide), poly(dimethylaminoethyl methacrylate), polydimethylaminoepichlorohydrin, polyethyleneiminoepichlorohydrin, polymethacryloxyethyl-trimethylammonium bromide, hydroxypropylmethacryloyloxyethyl dimethyl ammonium chloride, poly(methyldiethylaminoethylmethacrylate/acrylamide), poly(methyl/guanidine), polymethylvinylpyridinium bromide, poly(vinylpyrrolidone-dimethylaminoethyl methacrylate), or polyvinylmethylpyridinium bromide.

The present invention provides a preparation method of Sugammadex sodium and an intermediate thereof. The method comprises a bromination reaction of a compound of a formula (I) with a brominating reagent, wherein the brominating agent is selected from pyridinium tribromide. The method has the advantages of simple process, high yield, high purity and low pollution, and is suitable for industrial production.

The invention discloses a chemical synthesis method for 2-bromothiophene expressed as structural formula (II) and derivatives thereof, which comprises the following steps: mixing thiophene expressed as structural formula (I) or derivatives thereof and organic solvent, controlling the temperature to between 50 DEG C below zero and 20 DEG C, adding a brominating agent into the mixture, carrying out heat preservation reaction after the adding is finished, separating out an aqueous layer after full reaction, and concentrating and distilling an organic layer to obtain 2-bromothiophene or a derivative product thereof, wherein the brominating agent is selected from one of (1) pyridiniums tribromide, (2) mixture of pyridine compounds and bromine, (3) mixture of pyridine compounds, bromine and hydrogen peroxide, (4) mixture of pyridine compounds, bromine, hydrogen peroxide and hydrobromic acid, (5) mixture of pyridine compounds, hydrobromic acid and hydrogen peroxide, and (6) mixture of pyridine compounds, bromine and hydrobromic acid; and the organic solvent is dichloromethane or chloroform or dichloroethane. The chemical synthesis method has the advantages of cheap and easily obtained raw materials, little toxicity, high chemical reaction selectivity, high yield, good product quality, brominating agent recycle, and the like.

The invention discloses an ocotillol type ginseng sapogenin A ring-aminothiazole ring derivative and a preparation method thereof. The product provided by the invention is prepared according to the following method including: a) by taking 20(S)-protopanaxadiol as a raw material, in the presence of DMAP, protecting 3,12-OH by acetic anhydride, oxidizing by m-CPBA, and removing a protecting group byalkaline hydrolysis to obtain (20S,24R)-epoxy dammar-3beta,12beta,25-triol (OR) and (20S,24S)-epoxy dammarane-3beta,12beta,25-triol (OS); b) respectively oxidizing OR and OS by pyridinium chlorochromate hydrochloride, and then sequentially reacting with pyridinium bromide perbromide and thiourea; c) under the alkaline condition, protecting acid having amino at the terminal end with Boc anhydride;d, in the presence of organic alkali and a condensing agent, reacting the product obtained in the step b with Boc-amino acid; and e) removing Boc under an acidic condition. The invention also discloses a preparation method of the derivatives and a novel application of the derivatives in tumor drug resistance reversion.

The invention discloses a (4-(2-thiazolylazo)-1,2,3-trihydroxybenzene spectrophotometric method used for determining trace wolfram in steel. According to the (4-(2-thiazolylazo)-1,2,3-trihydroxybenzene spectrophotometric method, in the presence of dilute sulphuric acid medium and cetyl pyridinium bromide (CPB), agent (4-(2-thiazolylazo)-1,2,3-trihydroxybenzene (TATB) and wolfram (VI) are subjected to chromogenic reaction so as to realize determination of trace wolfram in steel. It is shown by research that, a red complex is generated at a TATB/wolfram (VI) ratio of 2:1, and maximum absorption wavelength of the red complex is 530nm. The results obeys Lambert-Beer Law in a 25ml solution when the amount of wolfram ranges from 0 to 40<mu>g, and apparent molar absorption coefficient is 61600L*mol<-1>*cm<-1>. The (4-(2-thiazolylazo)-1,2,3-trihydroxybenzene spectrophotometric method is used for determination of trace wolfram in steel, and results are identical with results obtained via thiocyanate spectrophotometry.

The present invention provides a process for the preparation of key intermediate for the synthesis 5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1-indanone hydrochloride (donepezil hydrochloride). The present invention particularly provides a process for the preparation of 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone comprising condensation of 5,6-dimethoxy-1-indanone with 4-pyridinecarboxaldehyde using an alkali metal hydroxide as a mild base in the presence of demineralized water as a solvent at a temperature in the range of 15° C. to 45° C. to yield 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone, which is subsequently benzylated using benzyl bromide in the presence of solvent at a reflux temperature to yield 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide.

The invention relates to the technical field of wig preparing, and provides a making technology for an antibacterial and static-electricity-preventable wig. By soaking the wig in a solution of laurylsodium sulfate, as the lauryl sodium sulfate and fatty acid sodium have good computability, the lauryl sodium sulfate and the fatty acid sodium are matched, and gaps between hair cuticles on the surface of the wig are filled with negative charge and anions of the lauryl sodium sulfate and the fatty acid sodium; by soaking the wig in a solution of a nanometer silver-ion antibacterial agent, antibacterial effective molecules can be dispersed into gaps of space structures between proteins of hairs; by soaking the wig in a solution of a cationic surface active agent which is cetyl pyridinium bromide, positive charge in cations and negative charge in anions on the surfaces of the hairs can be attracted under the effect of coulomb force, uniform monomolecular films are formed on the surfaces ofthe hairs accordingly, and the antibacterial effective molecules can be locked by the monomolecular films and prevented from falling off from the gaps of the space structures between the proteins.

The invention discloses a preparation method of a nano flower-like VS2 composite particulate CdS photocatalyst. The preparation method comprises the steps that step 1, 0.5-2 mol of cadmium nitrate, 2-4 mol of sodium metavanadate, 0.01-0.05 mol of cetyl pyridinium bromide and 0.001-0.005 mol of deoxy-ribonucleoside triphosphate are taken and mixed to form a mixture; step 2, 40-60 ml of ethanol is added to the mixture, stirred for the first time and dissolved, and 0.15-0.3g of thioacetamide is added, stirred for the second time and dissolved to obtain a solution A; step 3, the solution A is placed in a reaction vessel for hydrothermal reaction at 160-180 DEG C and cooled to the room temperature; and step 4, a solution B is taken out, suction filtration is performed and then filter is dried and ground into powder to obtain the nano flower-like VS2 composite particulate CdS photocatalyst. The prepared nanoflower-like VS2 composite particulate CdS photocatalyst can effectively improve the photocatalytic water splitting performance of CdS.

The invention relates to the technical field of bioglycomics analysis, and discloses a general low-cost quaternary ammonium salt sugar chain isotope labeling reagent and a synthesis method thereof. The reagent comprises a labeling reagent deuterated 7-4-methyl-1-(2-hydrazino-2-oxoethyl)-pyridinium bromide in a heavy isotope form and a labeling reagent 4-methyl-1-(2-hydrazino-2-oxoethyl)-pyridinium bromide corresponding to the labeling reagent deuterated 7-4-methyl-1-(2-hydrazino-2-oxoethyl)-pyridinium bromide in a light isotope form. The reagent can be used for mass spectrum high-sensitivity and high-accuracy relative quantitative analysis of biological reducing sugar chains of different molecular weight segments; according to the reagent provided by the invention, the mass spectrometric detection sensitivity of the sugar chain can be greatly improved; meanwhile, the method is suitable for mass spectrum relative quantitative analysis of reducing sugar chains with relatively small and large molecular weights; the synthesis raw materials are low in cost, and the defect that hydrazide quaternary ammonium salt stable isotope labeling reagents synthesized based on deuterated isoquinoline are high in cost is overcome.

The invention discloses an indolizine derivative and a preparation method thereof. The indolizine derivative is prepared from pyridinium bromide and allenic acid ester through [3+2] cycloaddition reaction in a reaction solvent under the action of an inorganic base catalyst and a Lewis base promoter in a nitrogen atmosphere. The reaction substrate of the preparation method is simple, easy to synthesize and low in price; wherein the [3+2] cycloaddition reaction has the advantages of mild reaction conditions, high reaction efficiency, high indolizine derivative yield and high atom economy. Therefore, the indolizine derivative has the advantages of no catalyst residue, high purity and high application value.

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of 2-amino-3,5-dichloro-1-(2-(4-bromophenyl)-2-oxoethyl)pyridinium bromide. The preparation method comprises the following steps of dissolving acetophenone in a certain solvent, making the acetophenone react with liquid bromine at subzero 20 to 40 DEG C according to a certain proportion, so as to obtain 2,4-dibromoacetophenone after 2 to 8 hours, in the certain solvent, making the 2,4-dibromoacetophenone react with a certain proportion of 2-amino-3,5-dichloropyridine for 3 to 15 hours at 0 to 80 DEG C, terminating the reaction, cooling an obtained first mixture to room temperature, extracting the first mixture with ethyl acetate, washing a substance through water and saturated salt water, drying the substance with anhydrous sodium sulfate, carrying out rotary evaporation and concentration to subsequently obtain a product provided by the invention, and recrystallizing the coarse product to obtain a pure product. Raw materials in the reaction are relatively easy to obtain; the price is reasonable; the condition of the reaction is mild; the operation is easy; the control is easy; the post treatment is simple; further, the quality of the product is stable; the purity is high.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis process of procaterol hydrochloride. The invention provides a synthesis method of procaterol hydrochloride. The method sequentially comprises the following steps: step 1, carrying out Fries rearrangement reaction on 8-butyryloxy quinolone and butyryl chloride to obtain a mixture; 2, directly reacting the mixture obtained in the step 1 with a benzyl compound and alkali to obtain a mixture; step 3, enabling the mixture obtained in the step 2 to react with pyridinium tribromide in tetrahydrofuran to obtain 5-(2-bromobutyryl)-8-benzyloxy quinolone; step 4, carrying out ammonolysis reaction on the product in the step 3 and isopropylamine in tetrahydrofuran; 5, the product in the step 4 is subjected to a reduction reaction in an alcohol solvent, and 5-(2-isopropylamine-1-hydroxybutyl)-8-benzyloxy quinolone is obtained; and 6, carrying out hydrogenation reduction reaction on the product obtained in the step 5 under the catalysis of a catalyst, and carrying out salt forming reaction with hydrochloric acid to obtain procaterol hydrochloride.

The invention relates to a synthesis method of rucaparib camsylate. The method comprises the following steps: 1) carrying out a reaction on a compound M-1 and pyridinium tribromide by using tetrahydrofuran and/or dichloromethane as a solvent to obtain a compound M-2; 2) carrying out a reaction on the compound M-2 and p-formyl phenylboronic acid under the catalytic action of 1,1'-bis(diphenylphosphine)ferrocene palladium dichloride by using N,N-dimethylacetamide as a solvent to obtain a compound M-3, wherein the reaction temperature is higher than or equal to 90 DEG C; 3) carrying out a reaction on the compound M-3 and methylamine under the catalytic action of p-toluenesulfonic acid by using methanol and/or ethanol as a solvent, adding sodium borohydride, and reducing to obtain a compound M-4; 4) carrying out a reaction on the compound M-4 and an alkali by taking water as a solvent to obtain a compound M-5; and 5) carrying out a reaction on the compound M-5 and camphorsulfonic acid by taking methanol and/or ethanol as a solvent to obtain the rucaparib camsylate. According to the invention, the compounds M-1, M-3 and M-4 react at room temperature, the conditions are mild and controllable, the reaction period is short, the synthesis efficiency can be effectively improved, the production cost is reduced, and the purity of the obtained product reaches 99.95-99.98%.

The invention belongs to the technical field of environment-friendly functional materials, and particularly relates to novel halogenated bismuthate which is a compound composed of bismuth hexaiodide anions and benzyl pyridine cations, and a preparation method of the halogenated bismuthate comprises the following steps: taking a certain amount of benzyl bromide and pyridine, adding a proper amountof solvent, mixing, dissolving, stirring, refluxing, evaporating, concentrating, washing with diethyl ether, to obtain benzyl pyridinium bromide; taking BiI3 and dissolving the BiI3 in a proper amountof concentrated iodic acid, taking a certain amount of benzyl pyridinium bromide and dissolving in a proper amount of solvent, mixing the two solutions, stirring and refluxing, obtaining clear filtrate and performing subjected to freezing crystallization, and obtaining the novel bismuthate iodide. The novel halogenated bismuthate disclosed by the invention emits strong orange light under the irradiation of 365nm ultraviolet light, rapidly degrades rhodamine B and methyl orange under visible light, and has very good cyclic degradation efficiency. The invention also provides a preparation method of the novel bismuthate iodide, and the method has the advantages of high yield, cost saving, easy operation, and facilitation of industrial production.

The invention discloses an electrochemical deep degradation method of a brominated phenolic compound under synergistic adsorption of a surfactant. The method sequentially comprises the following steps: (1) preparing an electrolyte and adding the electrolyte into an electrolytic bath, wherein the solute of the electrolyte is a brominated phenol compound, a cationic surfactant and a supporting electrolyte, the solvent is water, and the cationic surfacetant is selected from at least one of dodecyl trimethyl ammonium bromide, cetyl trimethyl ammonium bromide, octadecyl trimethyl ammonium bromide and cetyl pyridinium bromide; and (2) putting a cathode material and an anode material into an electrolytic bath, and connecting a voltage-stabilized direct-current power supply for electrolysis so as to deeply degrade the brominated phenol compound. The charge transfer process of the electrode reaction is promoted by utilizing the synergistic adsorption effect of the surfactant and the brominated phenol compound on the surface of the electrode, so that the rapid and deep debromination degradation of the brominated phenol compound is realized.

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of pyridinium 2-animo-5-iodo-1-(2-(4-bromophenyl)-2-oxoethyl)bromide. The method comprises the following steps: dissolving acetophenone in a certain solvent, and carrying out reaction with liquid bromine according to a certain ratio at -20-40 DEG C for 2-8 hours to obtain 2,4-dibromoacetophenone; in a certain solvent, carrying out reaction with 2-amino-5-iodopyridine according to a certain ratio at 0-80 DEG C for 3-15 hours; after the reaction finishes, cooling to room temperature, extracting with ethyl acetate, washing with water and a saturated saline solution, drying with anhydrous sodium sulfate, and carrying out rotary evaporation concentration to obtain the pyridinium 2-animo-5-iodo-1-(2-(4-bromophenyl)-2-oxoethyl)bromide crude product; and recrystallizing the crude product to obtain the pure product. The method has the advantages of accessible reaction raw materials, reasonable price, mild reaction conditions and simple after-treatment, and is easy to operate and control; and the product has the advantages of stable quality and high purity.