The present invention discloses a pharmaceutical composition, its manufacturing method, and its use, wherein the pharmaceutical composition comprises a first
active ingredient, a second
active ingredient, and a pharmaceutically acceptable carrier or
excipient, the first
active ingredient being a
microbial agent containing one or more of
Staphylococcus aureus,
Bordetella pertussis,
diphtheria toxoid,
tetanus toxoid,
Salmonella typhi, or
Salmonella paratyphi, and the second active ingredient comprising polyinosinic acid, polycytidylic acid, and vitamins. The pharmaceutical composition is an artificial
active immunotherapy for tumors, which, by "stimulating" the entire
immune system, activates the human
immune system using
bacteria to kill
cancer cells, making the treatment extremely stable and reliable, significantly saving and extending the lives of
cancer patients, while simultaneously being extremely safe, having very few toxic side effects, and having low manufacturing costs.