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37 results about "Salmonella Paratyphi" patented technology
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Specific double antibody sandwich method for detecting salmonella in food based on monoclonal antibody
ActiveCN104792991ASuitable for testing requirementsImprove throughputBiological material analysisBALB/cImmune profiling
The invention discloses a specific double antibody sandwich method for detecting salmonella in food based on a monoclonal antibody, and belongs to the field of immunoassay. The specific double antibody sandwich method comprises the following steps: immunizing a 7-week-old BALB / c mouse by using smooth salmonella typhimurium LPS-coupled bovine serum albumin according to a sodium periodate method, and carrying out immunization, fusion and screening to obtain 12 monoclonal antibodies for specifically identifying salmonella LPS; marking the 12 monoclonal antibodies with horseradish peroxidase HRP respectively, and pairing the 12 monoclonal antibodies with salmonella paratyphi bacteria; using 8G3 as a coated antibody and 8G3-HRP as a detection antibody to establish the salmonella detecting specific double antibody sandwich method, so that salmonella paratyphi with the LOD of 1000000 CFU / mL can be detected. The specific double antibody sandwich method has cross reactions with all salmonella bacteria, but does not have cross sections with E.coli, E.coli O157:H7, enterobacter sakazakii, staphylococcus aureus and listeria monocytogenes, so that an overall, reliable, fast and efficient analysis method is provided for detection of the salmonella in the food.
Owner:JIANGNAN UNIV
Salmonella broad-spectrum virulent bacteriophage as well as preparation method and application thereof
ActiveCN112662636AHigh potencyHas cracking abilityAntibacterial agentsDigestive systemSalmonella paratyphi ASerotype
The invention provides a salmonella broad-spectrum virulent bacteriophage. The preservation number of the bacteriophage is CCTCC NO: M 2020839. The invention also provides a preparation process and application of the salmonella broad-spectrum virulent bacteriophage, and the preparation process comprises fermentation and extraction; in the step of fermentation, a salmonella gallinarum attenuated vaccine strain is used as host bacteria for bacteriophage fermentation. The bacteriophage XPARCPS02 disclosed by the invention can be used for cracking salmonella of various serotypes and also has different degrees of cracking effects on drug-resistant bacteria; the salmonella typhimurium lysate lysate has a cracking capability on salmonella typhimurium, salmonella typhimurium drug-resistant bacteria, salmonella gallinarum, salmonella enteritidis, salmonella enteritidis drug-resistant bacteria, salmonella typhimurium, salmonella pullorum, salmonella paratyphi A, salmonella paratyphi B and salmonella dubicularis.
Owner:山东仙普爱瑞科技股份有限公司
Salmonella bacteriophage RDP-NSA-19050 with wide lysis spectrum and application thereof
ActiveCN112831474AHas a strong cracking effectPromote lysisAntibacterial agentsBiocideEscherichia coliSalmonella Phage
The invention discloses a salmonella phage RDP-NSA-19050 with a wide lysis spectrum, wherein the preservation number is CGMCC No.21415, the gene length is 87591 bp; after sequencing is carried out on whole genes, it is found that the salmonella phage RDP-NSA-19050 does not have virulence genes and lyogenic genes, and the salmonella phage RDP-NSA-19050 has a good lysis spectrum. The salmonella bacteriophage RDP-NSA-19050 provided by the invention can be used for cracking a plurality of pathogenic bacteria such as salmonella steulani, salmonella gallinarum, salmonella typhimurium, salmonella paratyphi A, salmonella paratyphi B, salmonella typhimurium, salmonella enteritidis and salmonella kkinensis; the salmonella bacteriophage RDP-NSA-19050 has the characteristics of wide splitting spectrum and high splitting rate, can be independently used, can also be compounded with bacteriophages of other escherichia coli and salmonella and probiotics for use, and can effectively reduce the death rate of chicken infected with salmonella.
Owner:RECOM QINGDAO BIOTECH CO LTD
Attenuated Salmonella enterica serovar paratyphi A and uses thereof
ActiveUS8137930B2Peptide preparation methodsDepsipeptidesSalmonella enterica serovar Paratyphi AConjugate vaccine
The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjugate vaccine.
Owner:MARYLAND UNIV OF
Bacterial polysaccharide protein conjugate vaccine using hepatitis B surface antigen as carrier protein and preparation method of bacterial polysaccharide protein conjugate vaccine
InactiveCN104383532AAddressing Immunization IssuesPlay a role in preventionAntibacterial agentsAntiviralsAntigenConjugate vaccine
The invention discloses a bacterial polysaccharide protein conjugate vaccine using a hepatitis B surface antigen as carrier protein and a preparation method of the bacterial polysaccharide protein conjugate vaccine. According to the vaccine, protein is the hepatitis B surface antigen, and a bacterial polysaccharide is selected from any one or more of a haemophilus influenza type b polysaccharide, group A, group C, group Y and group W135 meningococcal polysaccharides, a salmonella typhi type Vi polysaccharide, a group B streptococcus type Ia polysaccharide and the like, pneumococcus serotype type 1, 2 and the like, and salmonella paratyphi type A or salmonella paratyphi type B. Animal experiments show that the antibody positive conversion rates of the bacterial polysaccharide and the hepatitis B surface antigen in the vaccine are both more than 85%, so that the vaccine is relatively high in antibody positive conversion rate; carrier protein plays a role in transforming the bacterial polysaccharide from a T-cell-independent antigen into a T-cell-dependent antigen, and also can be used for preventing diseases caused by hepatitis B virus; and by adopting the bacterial polysaccharide protein conjugate vaccine disclosed by the invention, the problem of performing immunization inoculation on infants and young children under 2 years old can be solved, the function of one injection with multiple immune effects also can be achieved, and the use crowd and coverage rate of the vaccine can be expanded.
Owner:云南沃森生物技术股份有限公司
Method for detecting live salmonella typhimurium, salmonella paratyphi b and salmonella typhi in food simultaneously and rapidly
InactiveCN102676684AHigh speedImprove efficiencyMicrobiological testing/measurementMicroorganism based processesBiotechnologyMicroorganism
The invention belongs to the field of microbiological detection and discloses a method for detecting live salmonella typhimurium, salmonella paratyphi b and salmonella typhi in food simultaneously and rapidly. A special primer is designed aiming at salmonella typhimurium, salmonella paratyphi b and salmonella typhi, hydrazoic brominated c ingot processing is adopted to remove interference of dead bacteria, and finally deoxyribonucleic acids (DNAs) are extracted to perform multiplex polymerase chain reaction. Compared with a classical bacterium separating and identifying method and a serologic typing method, the method for detecting live salmonella typhimurium, salmonella paratyphi b and salmonella typhi in the food simultaneously and rapidly is rapid and accurate.
Owner:NANCHANG UNIV
Typhoid fever salmonella and salmonella paratyphi fluorescent quantitative polymerase chain reaction (PCR) detection kit and application thereof
ActiveCN102978282AAvoid cycleAvoid cumbersome steps and other deficienciesMicrobiological testing/measurementFluorescence/phosphorescenceParaffin oilsBuffer solution
Owner:深圳生科原生物有限公司
ADP-ribosylating bacterial toxins
InactiveUS7928192B2Diminishing the ADP-ribosylating enzymatic activityAntibacterial agentsVirusesEscherichia coliStreptococcus pyogenes
ADP-ribosylating toxins from Neisseria meningitidis, Streptomyces coelicolor, Mycoplasma pneumoniae, Salmonella typhimurium, Salmonella paratyphi, and Streptococcus pyogenes are disclosed, together with mutant toxins and uses therefor. There is only a low level of sequence identity between these toxins and toxins such as cholera toxin and E. coli heat labile toxin.
Owner:NOVARTIS AG
Primers, probes, a test kit and a test method for triple real-time fluorescence PCR detection of four bacteria
ActiveCN103060447AMicrobiological testing/measurementFluorescence/phosphorescenceSalmonella GallinarumFluorescence
The invention discloses primers, probes, a test kit and a test method for triple real-time fluorescence PCR detection of Salmonella choleraesuis, Salmonella paratyphi, Salmonella typhi, and Salmonella gallinarum. According to the present invention, a triple real-time PCR method is used, wherein a consensus sequence of Salmonella choleraesuis and Salmonella paratyphi is used for the detection of Salmonella choleraesuis and Salmonella paratyphi, a specific sequence of Salmonella typhi is used for the detection of Salmonella typhi, and a specific sequence of Salmonella gallinarum is used for the detection of Salmonella gallinarum. Whether a sample is contaminated by Salmonella choleraesuis, Salmonella paratyphi, Salmonella typhi, and Salmonella gallinarum is determined via a real-time fluorescence PCR amplification, and then Salmonella choleraesuis and Salmonella paratyphi are distinguished via a single fluorescent PCR amplification; the detection is rapid, the process of preparing sample and issuing test results can be finished in 31hours, the results are reliable, and sensitivity and specificity are high.
Owner:许龙岩 +5
Non-typhoidal salmonella vaccines
Owner:THE UNIV OF BIRMINGHAM
NmpC subunit vaccine of salmonella paratyphi A and preparation method thereof
InactiveCN102206258AImprove expression levelSimple structureAntibacterial agentsMicroorganism based processesAmino acidSubunit vaccines
The invention discloses an NmpC subunit vaccine of salmonella paratyphi A and a preparation method thereof. The vaccine comprises an effective dose of outer membrane proteins NmpC of salmonella paratyphi A and a vaccine adjuvant. Amino acid sequences of the outer membrane proteins NmpC are shown as SEQ ID NO.2. In the preparation method, the vaccine is obtained by obtaining the outer membrane proteins NmpC through in-vitro expression and then mixing the outer membrane proteins NmpC with the vaccine adjuvant. The subunit vaccine provided by the invention has the advantages of low production cost and high yield of target proteins; and the subunit vaccine provided by the invention has important significances for producing NmpC subunit vaccines on a large scale and preventing the infection of the salmonella paratyphi A.
Owner:NAT INST FOR FOOD & DRUG CONTROL
Salmonella paratyphi ompN gene prokaryotic expression system and application of recombination expression protein thereof
InactiveCN104593386AIncrease productionSimple structureAntibacterial agentsBacteriaAgricultural scienceProkaryotic expression
The invention discloses a salmonella paratyphi ompN gene prokaryotic expression system and application of recombination expression protein thereof, and belongs to the technical field of biologics. The nucleotide sequence of the salmonella paratyphi ompN gene is shown in the SEQ ID No: 1. The amino acid sequence of the recombination expression protein of the salmonella paratyphi ompN gene is shown in the SEQ ID NO: 2. The salmonella paratyphi ompN gene disclosed by the invention is wide in distribution and conservative in sequence, the recombination expression product rOmpN has strong immunogenicity and immunoprotection, and can be used as multivalent salmonella paratyphi genetic engineering vaccine candidate antigen.
Owner:ZHEJIANG MEDICAL COLLEGE +1
Compositions and Methods for Preventing and Treating Salmonella Typhi and Salmonella Paratyphi Infection
ActiveUS20160144013A1Avoid interactionBacterial antigen ingredientsSugar derivativesSalmonella danSalmonella Senftenberg
The invention provides compositions and methods for preventing, treating and diagnosing infection by Salmonella enterica serovar typhi (S. typhi) and / or S. paratyphi, i.e., typhoid fever.
Owner:YALE UNIV
Prodigiosin (PG) producing strain as well as preparation method and application thereof
ActiveCN103436476AEfficient fermentationIncrease productionBacteriaMicroorganism based processesStaphylococcus aureusBio engineering
The invention relates to fermentation production and preparation of an active product, belongs to the field of bioengineering and in particular relates to a prodigiosin (PG) producing strain as well as a preparation method and an application thereof. The PG producing strain is Proteus Vulgaris and is preserved on June 24th, 2013 in CGMCC (China General Microbiological Culture Collection Center) and has the preservation number of CGMCCNo.7815 and the preservation unit address of No.3 No.1 Courtyard, West Beichen Road, Chaoyang District, Beijing, Institute of Microbiology of Chinese Academy of Sciences. The PG producing strain can produce PG through fermentation, and an improved inorganic salt culture medium is adopted and is cultured for 18-24 hours at a culture temperature of 20-28 DEG C and a rotating speed of 150-300rpm, and yield of PG can be 80-120mg / L. The produced prodigiosin has an inhibitory activity to staphylococcus aureus, salmonella paratyphi, tritirachium album and pseudomonas aeruginosa and has a good application prospect in bio-preparation of the PG.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
Attenuated salmonella enterica serovar paratyphi a and uses thereof
ActiveUS20120029173A1Peptide preparation methodsDepsipeptidesSalmonella enterica serovar Paratyphi AConjugate vaccine
The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjugate vaccine.
Owner:MARYLAND UNIV OF
Target genes for detecting salmonella paratyphi, PCR primer pair as well as detection method and applications thereof
ActiveCN104611433AShorten detection timeReduce testing costsMicrobiological testing/measurementMicroorganism based processesMicrobiologyGel electrophoresis
The invention provides three specific target genes for detecting salmonella paratyphi, a corresponding PCR primer pair and a method for detecting the target genes by using the primer pairs. The PCR primer pair is designed according to the three specific target genes for detecting salmonella paratyphi, the specific target genes are high in stability and strong in specificity, and through reasonably optimizing a PCR system, and adopting gel electrophoresis detection means, salmonella paratyphi can be quickly and accurately identified. The detection method provided by the invention comprises the following steps: (1) extracting the DNA of a sample, and carrying out PCR amplification; (2) detecting an amplified product through gel electrophoresis; and (3) comparing rear electrophoretic bands, if the bands exist at 523 bp, 212 bp and 169 bp positions, proving that the sample contains salmonella paratyphi. According to experimental comparison and analysis, the method disclosed by the invention has the characteristics of strong singularity, reliable detection results, and simple result determination, and can be widely applied in the field of food sanitation.
Owner:NANJING AGRICULTURAL UNIVERSITY
Composition comprising bacteriophages for reducing, eliminating and/or preventing salmonella enteritidis, salmonella typhimurium and salmonella paratyphi b
ActiveUS20190070231A1Inhibition of colonizationBlock cycle of colonizationAntibacterial agentsPeptide/protein ingredientsSlaughter houseDisinfectant
The present invention relates to a new cocktail of bacteriophages with specific lytic activity against Salmonella enteritidis, Salmonella typhimurium and Salmonella paratyphi B., for reducing, eliminating and / or preventing them in farm animals and animals from the poultry sector, such as poultry, hens and breeding hens, in addition to eggs. It may be administered as an additive in the feed, in water or by spray. Moreover, the cocktail may be used as a disinfectant in work areas of farms and abattoirs, and in processed foods, without affecting the organoleptic properties of the product.
Owner:UNIV DE LOS ANDES
Compositions and methods for diagnosing, preventing and treating Salmonella typhi and Salmonella paratyphi infection
The invention provides compositions and methods for preventing, treating and diagnosing infection by Salmonella enterica serovar typhi (S. typhi) and / or S. paratyphi, i.e., typhoid fever.
Owner:YALE UNIV
Prodigiosin producing strain and method for producing prodigiosin through fermentation of prodigiosin producing strain
ActiveCN103436475AHas inhibitory activityEasy to washBacteriaMicroorganism based processesKlebsiella oxytocaStaphylococcus aureus
The invention belongs to the technical field of fermentation engineering and in particular relates to a prodigiosin producing strain and a method for producing prodigiosin through fermentation of the prodigiosin producing strain. The prodigiosin producing strain is acid producing klebsiella (Klebsiella oxytoca), is preserved on June 24th, 2013 in CGMCC (China General Microbiological Culture Collection Center) and has the preservation number of CGMCCNo.7816 and the preservation unit address of No.3 No.1 Courtyard, West Beichen Road, Chaoyang District, Beijing, Institute of Microbiology of Chinese Academy of Sciences. The prodigiosin producing strain can produce the prodigiosin through fermentation, an improved inorganic salt culture medium is adopted and is cultured away from light for 20-26 hours at a temperature of 24-28 DEG C and a rotating speed of 250-360rpm, and pigment yield can be 70-90mg / L. The produced prodigiosin is sensitive to natural light and ultraviolet rays and has an inhibitory activity to staphylococcus aureus, salmonella paratyphi and tritirachium album. The prodigiosin producing strain has a good application prospect in fermentation production of the prodigiosin and the fields of tumour suppression, food, cosmetics and the like.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
Pill containing anise oil and cinnamon oil
InactiveCN105232629AEasy to makeEasy to useAntibacterial agentsDigestive systemStaphylococcus cohniiMotility
The invention discloses a pill containing anise oil and cinnamon oil. The pill comprises the following active pharmaceutical ingredients in parts by weight: 7-10 parts of anise oil and 3-5 parts of cinnamon oil. The pill has relatively strong inhibiting effects for staphylococcus aureus, pneumococcus, corynebacterium diphtheriae, bacillus subtilis, vibrio cholerae, typhoid bacillus, salmonella paratyphi, shigella dysenteriae, escherichia coli and common pathogenic bacteria, and is suitable for treatment for common diseases including influenza, upper respiratory infection, diarrhea, dysentery and the like. The pill further can promote gastrointestinal motility and relieve abdominal pain; the pill has the effect of raising leukocyte and boosting immunity, and is easy to prepare, and convenient to use.
Owner:莫兆钦
Prodigiosin (PG) producing strain as well as preparation method and application thereof
ActiveCN103436476BEfficient fermentationIncrease productionBacteriaMicroorganism based processesStaphylococcus aureusBio engineering
The invention relates to fermentation production and preparation of an active product, belongs to the field of bioengineering and in particular relates to a prodigiosin (PG) producing strain as well as a preparation method and an application thereof. The PG producing strain is Proteus Vulgaris and is preserved on June 24th, 2013 in CGMCC (China General Microbiological Culture Collection Center) and has the preservation number of CGMCCNo.7815 and the preservation unit address of No.3 No.1 Courtyard, West Beichen Road, Chaoyang District, Beijing, Institute of Microbiology of Chinese Academy of Sciences. The PG producing strain can produce PG through fermentation, and an improved inorganic salt culture medium is adopted and is cultured for 18-24 hours at a culture temperature of 20-28 DEG C and a rotating speed of 150-300rpm, and yield of PG can be 80-120mg / L. The produced prodigiosin has an inhibitory activity to staphylococcus aureus, salmonella paratyphi, tritirachium album and pseudomonas aeruginosa and has a good application prospect in bio-preparation of the PG.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
Composition comprising bacteriophages for reducing, eliminating and/or preventing Salmonella enteritidis, Salmonella typhimurium and Salmonella paratyphi B
Owner:UNIV DE LOS ANDES
Processing method of Baiji powder
InactiveCN109223982AMeet quality requirementsPlant ingredientsAgainst vector-borne diseasesFreeze-dryingPolysaccharide
The invention discloses a processing method of Baiji powders. The method is characterized in that the method comprises the following steps: 1) raw materials are taken; 2) freeze-dry; 3) sterilizing; 4) pulverize; 5) packaging that powder finished product. The invention can reach the follow quality requirements: 1, Bletilla polysaccharide >= 20%; 2, heavy metal residue <= 20 mg / kg; 3, detecting salmonella paratyphi-free; 4, bile salt-resistant gram-negative bacteria (104 CFU / g.
Owner:湖南衡岳中药饮片有限公司
Primers and method for simultaneously detecting various pathogenic bacteria
ActiveCN102634580BStrong specificityAvoid False Positive ResultsMicrobiological testing/measurementMicroorganism based processesNucleotideShigella flexneri
The invention discloses primers and method for simultaneously detecting various pathogenic bacteria. The nucleotide sequences of the primers are shown in the specification, wherein an invA primer pair is used for detecting salmonella infection and salmonella paratyphi, a hly primer pair is used for detecting Listeria monocytogenes, a toxR primer pair is used for detecting vibrio parahaemolyticus, an ipaH primer pair is used for detecting shigella flexneri, and a vcc primer pair is used for detecting non-O1 Vibrio cholerae. The invention also discloses a multiple PCR (Polymerase Chain Reaction) amplification system built by using all the primers pairs, the system can be used for quickly and accurately detecting whether the corresponding pathogenic bacteria exist in a sample to be detected or not, and the whole detection process costs less than 2 hours, so that the system is simple and convenient to use; as the specificity of each primer pair is very high, a false positive result is avoided; and the primers can be made into a kit and the like, thus being very suitable for the pathogenic bacteria detection of agricultural and sideline products.
Owner:广州金苗动保科技有限公司
A process for extracting lipopolysaccharide from Salmonella paratyphi A by cold phenol method
Owner:罗益(无锡)生物制药有限公司
A wide lytic spectrum Salmonella phage rdp-nsa-19050 and its application
ActiveCN112831474BHas a strong cracking effectPromote lysisAntibacterial agentsBiocideBacteriophageEnteritides
The invention discloses a Salmonella phage RDP‑NSA‑19050 with a wide lysis spectrum, the preservation number is CGMCCNo.21415, and the gene length is 87591bp. After sequencing the whole gene, it is found that it does not have virulence genes and lysogenic genes. The invention provides The Salmonella phage RDP‑NSA‑19050 can lyse a variety of species including Stanley, Salmonella gallinarum typhi, Salmonella typhimurium, Salmonella paratyphi A, Salmonella paratyphi B, Salmonella typhi, Salmonella enteritidis, and Salmonella Kentucky. Pathogenic bacteria have the characteristics of wide lysis spectrum and high lysis rate. The phage can be used alone or in combination with other Escherichia coli, Salmonella phages and probiotics, which can effectively reduce the mortality of chickens infected with Salmonella.
Owner:RECOM QINGDAO BIOTECH CO LTD
Bee venom antimicrobial preparation and preparation method thereof
InactiveCN109350664AEnhanced inhibitory effectGood killing effectAntibacterial agentsOrganic active ingredientsDiseaseChlorhexidine Acetate
The invention discloses a bee venom antimicrobial preparation and a preparation method thereof. The bee venom antimicrobial preparation is prepared from, by weight, 15-25% of chlorhexidine acetate, 5-10% of a bee venom source solution, 0.7-1.5% of a red date extracting solution, 0.2-0.5% of a rose flower extracting solution, 0.4-0.6% of a honeysuckle flower extracting solution, 0.3-0.8% of vanillyl butyl ether, 0.7-0.9% of propylene glycol and 50-70% of purified water. Accordingly, related symptoms caused by meridian obstruction are relieved, and good inhibiting and killing effects on germs and inflammations of the surface of the skin are achieved; by adding the rose flower extracting solution, the probability that a user has allergy can be effectively lowered, the immune function of the user is improved, and the disease resistance is enhanced; by adding the honeysuckle extracting solution, the certain inhibiting effect can be achieved on staphylococcus aureus, hemolytic streptococcus,escherichia coli, shigella dysenteriae, vibrio cholera, typhoid bacilli, salmonella paratyphi and the like.
Owner:SHEHONG CHONGMING ANTIMICROBIAL AGENTS
Salmonella paratyphi A polysaccharide modified nanoparticles and application thereof
PendingCN112457408AImprove responsivenessIncreased substrate specificityAntibacterial agentsBacteriaPolysaccharide bindingSalmonella paratyphi A
The invention discloses salmonella paratyphi A polysaccharide modified nanoparticles and application thereof. The nanoparticles are salmonella paratyphi A polysaccharide modified protein. The proteinis a) or b) or c) or d) as follows: a) protein composed of an amino acid sequence as shown in SEQ ID No.3; b) fusion protein obtained by fusing a protein label at a carboxyl terminal or / and an amino terminal of the protein shown in a); and c) protein obtained by substituting and / or deleting and / or adding one or more amino acid residues in the amino acid sequence as shown in SEQ ID No.3. Animal experiments show that the antibody level and the protection effect are obviously improved compared with those of single polysaccharide and polysaccharide connected with CTB. It is indicated that a nanoscale polysaccharide conjugate vaccine with higher potential can be prepared by using a biological method, and a direction is provided for the development of the polysaccharide conjugate vaccine in thenext step.
Owner:ACADEMY OF MILITARY MEDICAL SCI
Nucleic acid, kit and detection method for detecting pigeon salmonella paratyphi
ActiveCN108753999AStrong specificityHigh sensitivityMicrobiological testing/measurementMicroorganism based processesPublic healthSerotype
The invention provides a nucleic acid, a kit and a detection method for detecting pigeon salmonella paratyphi. The invention provides a primer pair for detecting pigeon salmonella paratyphi and an internal reference primer pair for detecting salmonella. The size of the amplified fragments is 613 bp for pigeon salmonella paratyphi and 463 bp for salmonella. A rapid and accurate PCR detection methodfor detecting pigeon salmonella paratyphi is established in the invention, and the method can accurately detect clinical suspicious strain samples, distinguish other common pathogenic salmonella serotypes, and the amplified results of non-salmonella pathogenic bacteria are negative. The detection method provided by the invention has the advantages of high specificity, high sensitivity, short detection time, simple operation, easy judgment and low requirements on equipment, and only needs half a day to complete the detection and plays a very important role in the diagnosis and control of epidemic situation, thereby minimizing economic losses and harm to public health.
Owner:BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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