11 results about "SGLT Inhibitors" patented technology

A method for preparing compound 1 and compound 2 having a structure as shown below, the method includes the following steps:1) subjecting 2,3-dihydrobenzofuran-7-amine as a raw material to a selective-dibromination with a brominating reagent to obtain 4,6-dibromo-2,3-dihydrobenzofuran-7-amine;2) subjecting 4,6-dibromo-2,3-dihydrobenzofuran-7-amine obtained in the step 1) to Sandmeyer reaction for chlorination to obtain 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran;3-1) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then adding a formylation reagent to obtain compound 1;3-2) selectively debrominating from 4,6-dibromo-7-chloro-2,3-dihydrobenzofuran obtained in the step 2) using a strong base, and then reacting with 4-cyclopropyl benzaldehyde to obtain compound 2.

Provided herein are methods of managing feline diabetes, said methods include administering to a feline in need thereof a total daily dosage of about 5 to 50 mg of Compound 1, having the formula:or a pharmaceutically acceptable form thereof. Also provided herein are methods of managing feline diabetes by administering to a feline in need thereof an effective amount of a SGLT inhibitor, wherein said effective amount is no more than 10 to 30% of the dose required to produce an elevated frequency of diarrhea or loose stool in a healthy feline.

The invention relates to a crystalline complex of 1-cyano-2-(4-cyclotetramethyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene and a natural amino acid, methods for its preparation, as well as its uses for the preparation of medicines.

The present application belongs to the field of pharmaceutical chemistry, and relates to a preparation method of an intermediate of SGLTs inhibitor, wherein the SGLTs inhibitor is a glucopyranosyl derivative. Specifically, the preparation method provided by the present application has the advantages of mild reaction condition, simple post-treatment, easy purification, low requirement for equipment, low production cost, safe and controllable process, high optical purity of the obtained product, and suitability for commercial production.

To provide a novel method for producing a compound of Chemical Formula 9, which is an intermediate useful for the synthesis of an SGLT inhibitor.MEANS FOR SOLVING THE PROBLEM: Developed is a synthesis method utilizing a more commercially available starting material, having a short reaction step and a high total yield. A compound of Chemical Formula 9, which is an important intermediate for a compound of Chemical Formula I as an SGLT inhibitor, can be obtained with high yield and high quality.SELECTED DRAWING: None

An intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor are provided. By employing an intermediate having Chemical Formula 5, the difficulty of purification with existing processes can be solved, the quality requirements for related substances can be achieved with only one purification step, and the quality control problem in each step can be solved by performing several steps in situ. A method for synthesizing a compound of Chemical Formula 1 by using a compound of Chemical Formula 5 enables purification in an earlier step, thereby solving the problems of existing synthesis processes, in which the quality requirements for related substances were difficult to control step-by-step due to a continuous process, thereby minimizing the amount of related substances in the final product. In addition, the yield of a diphenylmethane derivative according to Chemical Formula 1 is increased.

The present invention relates to compositions comprising an SGLT inhibitor and uses thereof. The present invention provides a composition comprising a pharmaceutical agent capable of inhibiting the activity of SGLT. The present invention further relates to methods of treating and / or ameliorating symptoms associated with cystic fibrosis (CF) comprising administering to a subject (e.g., a human patient) a composition comprising one or more pharmaceutical agents that act as an inhibitor of SGLT activity.

To provide methods of managing feline diabetes, the methods comprising administering to a feline in need thereof a total daily dosage of about 5 to 50 mg of Compound 1 having the following formula or a pharmaceutically acceptable form thereof.SOLUTION: Provided herein are methods of managing feline diabetes by administering to a feline in need thereof an effective amount of an SGLT inhibitor, wherein the effective amount is 10 to 30% inclusive of the dose required to produce an elevated frequency of diarrhea or loose stool in a healthy feline.SELECTED DRAWING: Figure 8

An intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor are provided. By employing an intermediate having Chemical Formula 5, the difficulty of purification with existing processes can be solved, the quality requirements for related substances can be achieved with only one purification step, and the quality control problem in each step can be solved by performing several steps in situ. A method for synthesizing a compound of Chemical Formula 1 by using a compound of Chemical Formula 5 enables purification in an earlier step, thereby solving the problems of existing synthesis processes, in which the quality requirements for related substances were difficult to control step-by-step due to a continuous process, thereby minimizing the amount of related substances in the final product. In addition, the yield of a diphenylmethane derivative according to Chemical Formula 1 is increased.

An intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor are provided. By employing an intermediate having Chemical Formula 5, the difficulty of purification with existing processes can be solved, the quality requirements for related substances can be achieved with only one purification step, and the quality control problem in each step can be solved by performing several steps in situ. A method for synthesizing a compound of Chemical Formula 1 by using a compound of Chemical Formula 5 enables purification in an earlier step, thereby solving the problems of existing synthesis processes, in which the quality requirements for related substances were difficult to control step-by-step due to a continuous process, thereby minimizing the amount of related substances in the final product. In addition, the yield of a diphenylmethane derivative according to Chemical Formula 1 is increased.