43 results about "Sodium channel blocker" patented technology

The present invention relates to a compound having an inhibitory effect on a plurality of sodium ion channels, or a pharmaceutically acceptable derivative thereof, a pharmaceutical composition comprising same, and a use thereof as a pan-sodium ion channel blocker.

Provided herein are compositions comprising (1) a citrate-based anticoagulant (AC), an aldehyde releaser (AR), a calcium channel blocker, and a sodium channel blocker and (2) a citrate-based anticoagulant (AC), an aldehyde releaser (AR), and a sodium channel blocker, and uses of such compositions for stabilizing components in a blood sample.

The present disclosure relates to sulfonamide compounds, the use thereof for modulat-ing the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present invention relates to an insecticidal and acaricidal composition. The composition contains active component A and active component B, wherein the active component A is selected from compound I; the active component B is selected from one or more of bionic juvenile hormones, chitin biosynthesis inhibitors affecting CHS1, type-1 chitin biosynthesis inhibitors, ecdysone receptor agonists, nicotinic acetylcholine receptor competitive modulators, ryanodine receptor modulators, nicotinic acetylcholine receptor allosteric modulators, glutamate-gated chloride channel allosteric modulators, sodium channel modulators, voltage-dependent sodium channel blockers, inhibitors, trifluoroethyl sulfide acaricides, other insecticides and acaricides, etc.; and the active component A has a structure as follows. The composition of the present invention has advantages such as obvious synergistic effects and delayed resistance development, and can be used for controlling a variety of pests.

An aromatic fused ring compound which acts as a sodium channel blocker, and a use thereof. The aromatic fused ring compound has inhibitory activity on sodium ion channel Nav1.8, and may be used as a drug for a wide range of pain treatment.

Provided herein are crystalline solid forms of Compound 1.

The invention discloses a tetrodotoxin conjugate as well as a preparation method and application thereof. The preparation method comprises the following steps: by taking an artificially synthesized carboxyl-containing high-molecular compound and tetrodotoxin as raw materials, adding a catalyst and a solvent, and carrying out coupling reaction, thereby obtaining the tetrodotoxin conjugate. The high-molecular compound containing carboxyl is selected from carboxylated glucan or carboxylated beta-cyclodextrin. The tetrodotoxin conjugate can be applied to preparation of sodium channel blockers and drugs for treating neuropathic pain caused by chemotherapy. The tetrodotoxin conjugate disclosed by the invention has an analgesic curative effect associated with TTX, a drug window is enlarged, and the medication safety is greatly improved.

The present disclosure relates to sulfamide (or sulfuric diamide) compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The invention relates to the unexpected discovery that the oral administration of charged sodium channel blockers, also called “Nocions,” alleviates inflammation in intestinal inflammatory diseases, such as IBD, ulcerative colitis and / or Crohn's Disease, without substantial systemic exposure, as evidenced by low plasma concentrations.

The present disclosure relates to sulfonamide compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present application provides a kind of as sodium channel blocker and cyclophane compound and its use, it has inhibitory activity to sodium ion channel Nav1.8, can be used as the drug for treating a wide range of pain.

Provided herein are compositions comprising (1) a citrate-based anticoagulant (AC), an aldehyde releaser (AR), a calcium channel blocker, and a sodium channel blocker and (2) a citrate-based anticoagulant (AC), an aldehyde releaser (AR), and a sodium channel blocker, and uses of such compositions for stabilizing components in a blood sample.

The present invention relates to the unexpected discovery that the oral administration of charged sodium channel blockers (also known as "Nocions") alleviates inflammation in intestinal inflammatory diseases, such as inflammatory bowel disease (IBD), ulcerative colitis and / or Crohn's disease, without substantial systemic exposure, as proved by low plasma concentrations. The formulations are designed as enteric-coated tablets to release the composition at selected locations of the intestinal tract.

Tetrodoxine conjugate and its preparation method and application. A synthetic carboxyl-containing polymer compound and tetrodoxine are used as raw materials, a catalyst and a solvent are added, and a tetrodoxine conjugate is obtained through a coupling reaction. The carboxyl-containing polymer compound is selected from carboxylated dextran or carboxylated β-cyclodextrin. The tetrodoxine conjugate can be used to prepare sodium channel blockers and drugs for treating neuropathic pain caused by chemotherapy. The tetrodoxine conjugate of the present invention has analgesic efficacy associated with TTX, and the drug window is enlarged, and the safety of medication is greatly improved.

The invention belongs to the field of insecticidal and acaricidal agents, and relates to an insecticidal and acaricidal composition. The composition contains an active component A and an active component B, and the weight part ratio of the active component A to the active component B is (1: 99)-(99: 1); the active component A is selected from a compound I, and the active component B is selected from a sodium channel regulator or a voltage-dependent sodium channel blocker; the composition disclosed by the invention has the advantages of obvious synergism, resistance delay and the like, and can be used for preventing and treating various pests.

Provided are a tetrodotoxin conjugate, a method for preparing same, and use thereof. A carboxyl-containing macromolecular compound and tetrodotoxin are used as the starting materials, and after a catalyst and a solvent are added, the tetrodotoxin conjugate is obtained by means of a coupling reaction. The carboxyl-containing macromolecular compound is selected from carboxylated dextran, carboxylated β-cyclodextrin, alginic acid, and polyacrylic acid. The tetrodotoxin conjugate can be used in the preparation of a sodium channel blocker and a medicament for treating neuropathic pain caused by chemotherapy, and possesses an analgesic effect associated with tetrodotoxin (TTX). In addition, the therapeutic window is increased, thereby greatly improving the safety.

The invention discloses a tetrodotoxin conjugate as well as a preparation method and application thereof. The preparation method comprises the following steps: by taking a carboxyl-containing high-molecular compound and tetrodotoxin as raw materials, adding a catalyst and a solvent, and carrying out coupling reaction to obtain the tetrodotoxin conjugate. The carboxyl-containing high-molecular compound is selected from alginic acid or polyacrylic acid. The tetrodotoxin conjugate can be applied to preparation of sodium channel blockers and drugs for treating neuropathic pain caused by chemotherapy. The tetrodotoxin conjugate disclosed by the invention has an analgesic curative effect associated with TTX, a drug window is enlarged, and the medication safety is greatly improved.

The invention provides compounds that are useful for treatment of conditions associated with aberrant activity of voltage gated sodium channel Nav1.8, and methods of treating a subject with those compounds for conditions such as pain, itch, and cough.

The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which is effective as a sodium channel blocker, and a method of using the compound.

The present invention relates to compounds having an inhibitory effect on multiple types of sodium ion channels, or pharmaceutically acceptable derivatives thereof, and pharmaceutical compositions thereof, as well as their use as pansodium ion channel blockers.

The present disclosure relates to sulfonamide compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

Provided herein are crystalline solid forms of Compound 1 :

Relates to a compound with an inhibition effect on various sodium ion channels or a pharmaceutically acceptable derivative and a pharmaceutical composition thereof, and application of the compound or the pharmaceutically acceptable derivative and the pharmaceutical composition as a sodium ion channel blocker.

Disclosed herein are methods of treating diseases and disorders using (i) dual N-type and L-type calcium channel blockers selective for the N-type calcium channel and / or (ii) Nav 1.7 sodium channel blockers, including cilnidipine.

The present disclosure provides a novel salt of 5-chloro-2-fluoro-4-((4-fluoro-2-(methyl(2-(methylamino)ethyl)amino)phenyl)amino)-N-(thiazol-4-yl)benzenesulfonamide and a method for preparing the same. The mesylate salt of 5-chloro-2-fluoro-4-((4-fluoro-2-(methyl(2-(methylamino)ethyl)amino)phenyl)amino)-N-(thiazol-4-yl)benzenesulfonamide, which may be prepared using methanesulfonic acid and, without wishing to be bound by theory, can exhibit reduced hygroscopicity and improved physicochemical stability and solubility. In some aspects, the present disclosure provides a pharmaceutical composition for preventing or treating a sodium channel blocker-related disease, comprising the mesylate salt of 5-chloro-2-fluoro-4-((4-fluoro-2-(methyl(2-(methylamino)ethyl)amino)phenyl)amino)-N-(thiazol-4-yl)benzenesulfonamide.

Disclosed herein are methods for treating or reducing symptoms of a gastrointestinal motility disorder in a subject. The methods include administering to the subject a therapeutically effective amount of a sodium channel blocker compound.

The present disclosure relates to sulfonamide compounds, the use thereof for modulat- ing the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present disclosure relates to sulfamide (or sulfuric diamide) compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present disclosure provides deuterated compounds and their use as sodium channel blockers in the treatment or prevention of various diseases or disorders associated with sodium channels.