26 results about "Sodium channel blocker" patented technology

The present invention relates to a compound having an inhibitory effect on a plurality of sodium ion channels, or a pharmaceutically acceptable derivative thereof, a pharmaceutical composition comprising same, and a use thereof as a pan-sodium ion channel blocker.

The present disclosure relates to sulfonamide compounds, the use thereof for modulat-ing the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present invention relates to an insecticidal and acaricidal composition. The composition contains active component A and active component B, wherein the active component A is selected from compound I; the active component B is selected from one or more of bionic juvenile hormones, chitin biosynthesis inhibitors affecting CHS1, type-1 chitin biosynthesis inhibitors, ecdysone receptor agonists, nicotinic acetylcholine receptor competitive modulators, ryanodine receptor modulators, nicotinic acetylcholine receptor allosteric modulators, glutamate-gated chloride channel allosteric modulators, sodium channel modulators, voltage-dependent sodium channel blockers, inhibitors, trifluoroethyl sulfide acaricides, other insecticides and acaricides, etc.; and the active component A has a structure as follows. The composition of the present invention has advantages such as obvious synergistic effects and delayed resistance development, and can be used for controlling a variety of pests.

Provided herein are crystalline solid forms of Compound 1.

The present disclosure relates to sulfamide (or sulfuric diamide) compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present disclosure relates to sulfonamide compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present application provides a kind of as sodium channel blocker and cyclophane compound and its use, it has inhibitory activity to sodium ion channel Nav1.8, can be used as the drug for treating a wide range of pain.

Provided herein are compositions comprising (1) a citrate-based anticoagulant (AC), an aldehyde releaser (AR), a calcium channel blocker, and a sodium channel blocker and (2) a citrate-based anticoagulant (AC), an aldehyde releaser (AR), and a sodium channel blocker, and uses of such compositions for stabilizing components in a blood sample.

The invention belongs to the field of insecticidal and acaricidal agents, and relates to an insecticidal and acaricidal composition. The composition contains an active component A and an active component B, and the weight part ratio of the active component A to the active component B is (1: 99)-(99: 1); the active component A is selected from a compound I, and the active component B is selected from a sodium channel regulator or a voltage-dependent sodium channel blocker; the composition disclosed by the invention has the advantages of obvious synergism, resistance delay and the like, and can be used for preventing and treating various pests.

Provided are a tetrodotoxin conjugate, a method for preparing same, and use thereof. A carboxyl-containing macromolecular compound and tetrodotoxin are used as the starting materials, and after a catalyst and a solvent are added, the tetrodotoxin conjugate is obtained by means of a coupling reaction. The carboxyl-containing macromolecular compound is selected from carboxylated dextran, carboxylated β-cyclodextrin, alginic acid, and polyacrylic acid. The tetrodotoxin conjugate can be used in the preparation of a sodium channel blocker and a medicament for treating neuropathic pain caused by chemotherapy, and possesses an analgesic effect associated with tetrodotoxin (TTX). In addition, the therapeutic window is increased, thereby greatly improving the safety.

The invention provides compounds that are useful for treatment of conditions associated with aberrant activity of voltage gated sodium channel Nav1.8, and methods of treating a subject with those compounds for conditions such as pain, itch, and cough.

The present invention relates to compounds having an inhibitory effect on multiple types of sodium ion channels, or pharmaceutically acceptable derivatives thereof, and pharmaceutical compositions thereof, as well as their use as pansodium ion channel blockers.

Provided herein are crystalline solid forms of Compound 1 :

Relates to a compound with an inhibition effect on various sodium ion channels or a pharmaceutically acceptable derivative and a pharmaceutical composition thereof, and application of the compound or the pharmaceutically acceptable derivative and the pharmaceutical composition as a sodium ion channel blocker.

The present disclosure provides a novel salt of 5-chloro-2-fluoro-4-((4-fluoro-2-(methyl(2-(methylamino)ethyl)amino)phenyl)amino)-N-(thiazol-4-yl)benzenesulfonamide and a method for preparing the same. The mesylate salt of 5-chloro-2-fluoro-4-((4-fluoro-2-(methyl(2-(methylamino)ethyl)amino)phenyl)amino)-N-(thiazol-4-yl)benzenesulfonamide, which may be prepared using methanesulfonic acid and, without wishing to be bound by theory, can exhibit reduced hygroscopicity and improved physicochemical stability and solubility. In some aspects, the present disclosure provides a pharmaceutical composition for preventing or treating a sodium channel blocker-related disease, comprising the mesylate salt of 5-chloro-2-fluoro-4-((4-fluoro-2-(methyl(2-(methylamino)ethyl)amino)phenyl)amino)-N-(thiazol-4-yl)benzenesulfonamide.

Disclosed herein are methods for treating or reducing symptoms of a gastrointestinal motility disorder in a subject. The methods include administering to the subject a therapeutically effective amount of a sodium channel blocker compound.

The present disclosure relates to sulfonamide compounds, the use thereof for modulat- ing the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present disclosure relates to sulfamide (or sulfuric diamide) compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

The present disclosure provides deuterated compounds and their use as sodium channel blockers in the treatment or prevention of various diseases or disorders associated with sodium channels.

An insecticidal and acaricidal composition of the present invention comprises an active component A and an active component B, the ratio of weight parts of the active component A to the active component B being 1:100-100:1. The active component B is selected from one or more of bionic juvenile hormones, chitin biosynthesis inhibitors that affect CHS1, type-1 chitin biosynthesis inhibitors, ecdysone receptor agonists, nicotinic acetylcholine receptor competitive modulators, ryanodine receptor modulators, nicotinic acetylcholine receptor allosteric modulators, glutamate-gated chloride channel allosteric modulators, sodium channel modulators, voltage-dependent sodium channel blockers, inhibitors, trifluoroethyl sulfide acaricides and other insecticides and acaricides. The active component A is selected from a compound (I), a compound (II) having the following structures, or stereoisomers thereof. The insecticidal and acaricidal composition of the present invention has the advantages such as obvious synergistic effect and delayed development of drug resistance, and can be used for controlling a variety of pests.

Disclosed herein are methods and kits for treating or preventing a heart condition, e.g., cardiac arrhythmia, e.g., atrial arrhythmia, using potassium channel inhibitors and class I antiarrhythmic agents. Also disclosed herein are methods and kits for treating a heart condition via an intravenously, orally, or inhalationally administered fixed-dose combination of a sodium channel blocker and a class I antiarrhythmic agent.

Compositions and methods for safe and effective treatment for cardiac arrhythmias via increasing [K+]0 and administering a sodium channel blocker are disclosed. In certain embodiments, the method includes administering a composition comprising sodium tablets and flecainide to a subject.

Compositions and methods for controlling pests are disclosed. The compositions comprise a solid particulate of a voltage-dependent sodium channel blocker and methods of using the voltage-dependent sodium channel blocker to control a target pest. The voltage-dependent sodium channel blocker is active in its solid form and provides control of current and future pest generations independent of application timing with respect to insect life stage.

The present disclosure provides a compound represented by Formula (I) or a pharmaceutically acceptable salt which are effective as a sodium channel blocker and a method of using the compound.

The present disclosure provides a compound represented by Formula (I) or a pharmaceutically acceptable salt which are effective as a sodium channel blocker and a method of using the compound: (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are independently selected from hydrogen, halogen, (C1-C4)alkyl, (C1-C4)alkoxy, (C3-C6)cycloalkyl and hetero(C2-C4)cycloalkyl which contains one or more heteroatoms selected from N, O, and S; wherein each (C1-C4)alkyl, (C1-C4)alkoxy and (C3-C6)cycloalkyl are unsubstituted or substituted with one or more substituents selected from halogen and hydroxyl; A and B are each selected from S and CR6, wherein A and B are not identical, and R6 is selected from hydrogen, halogen and (C1-C4)alkyl; and X and Y are independently selected from hydrogen and (C2-C6)alkyl, or taken together with the carbon atom to which they are attached to form (C3-C6)cycloalkyl; wherein (C2-C6)alkyl is unsubstituted or substituted with (C3-C6)cycloalkyl.