13 results about "Stat3 Signaling Pathway" patented technology

The application discloses an azaphilone molecule targeting STAT3 signal pathways, a preparation method and purposes. The structural formula of the azaphilone molecule chaetoviridinol A1 is shown as formula (A). The azaphilone molecule chaetoviridinol A1 or a medicinal salt thereof has the purposes of preparing an antitumor drug.

The invention belongs to the technical field of biological medicines, and provides application of combination of nicotinic acid and metformin in blocking the progress of esophageal squamous carcinoma. The invention discovers that nicotinic acid and metformin inhibit FRMD8 expression through different mechanisms for the first time so as to inhibit a JAK1-STAT3 signal channel. Nicotinic acid and metformin are combined to achieve a more remarkable inhibition effect on the ability of esophageal squamous cell carcinoma cells to subcutaneously grow in mice and generate pulmonary metastasis through caudal veins than a single drug, and a brand new drug direction is provided for prevention and treatment of esophageal squamous cell carcinoma.

This invention provides an application of *Lactobacillus paracasei* IOB413 metabiotic and its composition in gastric cancer, belonging to the field of microbial technology. *Lactobacillus paracasei* IOB413 has the preservation number CGMCC No. 16022. Its metabiotic can inhibit gastric cancer progression by suppressing epithelial-mesenchymal transition in tumor cells and regulating the IL-6 / JAK2 / STAT3 signaling pathway. The composition with folic acid has a synergistic effect, more effectively reducing tumor volume and lowering the levels of pro-inflammatory factors and tumor markers. It has high safety and is suitable as an adjuvant therapy before and after gastric cancer surgery, providing a new approach to gastric cancer treatment.

The invention relates to the technical field of nano-drugs, in particular to a tolbuzumab / lanthanide series metal / nucleic acid nano-composite, a preparation method and application. The mass ratio of the tolbuzumab to the lanthanide series metal to the nucleic acid in the nano-composite is (0.5-5.1): 1: (10-11). The nano compound disclosed by the invention can be used for promoting the activation of a cGAS-STING-STAT1 pathway and blocking an IL6 / IL6R-STAT3 signal pathway at the same time, so that chronic inflammation caused by a CIN phenomenon of tumor cells is converted into anti-tumor immune response.

The invention belongs to the technical field of medicines, and relates to a benzimidazo 2-amino-1, 3, 4-thiadiazole carboxylic ester derivative shown as a formula I, a pharmaceutically acceptable salt and a preparation method thereof, a composition containing one or more compounds, and application of the compounds as an STAT3 signaling pathway inhibitor in treatment of STAT3 high-expression cancer diseases, and particularly relates to a preparation method of the benzimidazo 2-amino-1, 3, 4-thiadiazole carboxylic ester derivative shown as the formula I. The invention also relates to a preparation method of the benzimidazo 2-amino-1, 3, 4-thiadiazole carboxylic ester derivative.

The invention provides a method and system for detecting the malignant degree of endometrial cancer cells, and the method comprises the following steps: judging the influence mechanism of leptin on the malignant degree of cancer cells by detecting parameters such as leptin concentration, JAK2 / STAT3 pathway activation degree, cell proliferation activity, migration and invasion ability and the like; the dynamic association between the leptin concentration change and the activation state of the JAK2 / STAT3 signal channel can be systematically evaluated, the regulation and control effect of the channel on the proliferation, migration and invasion ability of cancer cells is effectively quantified, and a scientific basis is provided for developing treatment schemes and drugs for endometrial cancer.

The present application relates to the technical field of organic synthesis, and particularly provides an indole compound, a preparation method and application thereof. The chemical structural formula of the indole compound is shown as formula I. The provided indole compound can inhibit the growth of Jurkat leukemia cells in combination with dexamethasone at different concentrations, and the indole compound in combination with dexamethasone can activate the phosphorylation level of glucocorticoid, inhibit the PI3K / AKT and JAK2 / STAT3 signal pathways related to glucocorticoid resistance to overcome the drug resistance of glucocorticoid, and make the leukemia cells die.

The invention provides an application of an IGFBP5 (Insulin-like Growth Factor Binding Protein 5) gene in preparation of a medicine for improving endometrial receptivity impairment, and the IGFBP5 gene is used for preparing the medicine for improving the endometrial receptivity impairment. The number of embryo implantation sites can be effectively increased, abnormal proliferation of endometrial epithelial cells is reduced, and the relative expression level of estrogen response genes and progestational hormone response genes is improved. The IGFBP5 gene disclosed by the invention is a key downstream effector molecule of an IL-22-STAT3 signal channel, and the endometrial receptivity can be enhanced by supplementing IGFBP5 protein so as to save embryo implantation failure.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating atherosclerosis as well as a preparation method and application thereof. The invention provides a traditional Chinese medicine composition for preventing and / or treating atherosclerosis. The traditional Chinese medicine composition is prepared from the following raw materials: rhizoma zingiberis, cassia twig, radix salviae miltiorrhizae, caulis spatholobi, semen persicae, rhizoma chuanxiong, rhizoma atractylodis macrocephalae, poria cocos, fructus crataegi, medicated leaven, rhizoma atractylodis and rhizoma acori graminei. The traditional Chinese medicine composition provided by the invention has the effects of warming yang, activating blood, tonifying spleen and reducing phlegm, is mainly used for treating atherosclerosis caused by yang deficiency, blood stasis, spleen deficiency and phlegm stagnation, and is preferably suitable for a subclinical stage. Researches find that the traditional Chinese medicine composition regulates polarization of macrophages and inhibits development of an inflammation process by inhibiting a JAK2 / STAT3 signal channel, so that the progress of AS is relieved. The traditional Chinese medicine composition provided by the invention provides a safe and effective traditional Chinese medicine early intervention scheme convenient for long-term application for huge SAS people.

The invention provides a combination capable of efficiently inducing differentiation of hematopoietic stem / progenitor cells to megakaryocyte lineage cells. The combination comprises three components: a first component, a second component and a third component, wherein the first component is an HSE7 gene or protein, mRNA of HSE7, an HSE7 expression cassette or an HSE7 accelerant; the second component is a histone deacetylase inhibitor; and the third component is a gamma-aminobutyric acid agonist. Also provided is a method for efficiently inducing differentiation of hematopoietic stem / progenitor cells into meganuclear lineage cells, comprising overexpressing HSE7, inhibiting HDAC expression and / or activity, and administering a GABA agonist.

The invention belongs to the technical field of traditional Chinese medicine anti-tumor, and discloses insoluble traditional Chinese medicine small molecule icaritin HP (ICT) loaded hydrogel as well as a preparation method and application thereof. The HP-coated ICT hydrogel has the characteristics of good injectability, thermosensitivity, stability, excellent degradation capability, in-vivo biocompatibility and the like, meanwhile, long-acting slow release can be realized, and the drug can be retained in a tumor for one week. The HP (at) ICT can effectively reverse the tumor immunosuppressive microenvironment by inhibiting a JAK2 / STAT3 signal channel. In-vivo experiments prove that the HP (at) ICT can obviously inhibit the growth of residual hepatocellular carcinoma after radiofrequency ablation of mice and the polarization of tumor-related neutrophil (TAN) in residual cancer tissues from N2 type and PMN-MDSC type to N1 type, and meanwhile inhibit Treg cell infiltration, collect CD8 + T cells and promote the functions of the CD8 + T cells, so that the anti-tumor immunity of the organism is enhanced, and the growth and metastasis of tumors are inhibited.

The invention discloses application of moutan bark derived carbon dots in a medicine for treating acute myelogenous leukemia. The moutan bark derived carbon dots obtained by high-temperature heating through a one-step hydrothermal method can significantly inhibit the cell activity of acute myelogenous leukemia, and show excellent oxidative damage resistance and STAT3 signal channel activation inhibition ability in an in-vivo acute myelogenous leukemia resistance experiment. The moutan bark derived carbon dots can significantly inhibit infiltration of acute myelogenous leukemia cells in the liver, spleen and bone marrow, greatly prolong the lifetime of mice with acute myelogenous leukemia, and have no significant toxicity to the weight, main tissue and blood biochemical indexes of the mice. The invention is expected to provide a new technology and a new preparation for acute myelogenous leukemia.

The application discloses tegaserod or a pharmaceutically acceptable salt thereof as a JAK-STAT3 signal pathway inhibitor, an immunomodulator and application thereof in preparation of an antitumor drug. Tegaserod and the pharmaceutically acceptable salt thereof have very good inhibiting effect on the growth of various tumor cells in vivo and in vitro, and are expected to be used in the treatment of various cancers.