16 results about "Thienopyridines" patented technology

A cosmetic composition comprising: (a) 2-mercaptonicotinoyl glycine; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) reducing agent. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The present invention relates to a composition comprising: (1) at least one thiopyridinone compound; and (2) caffeine. The present invention can provide a composition including (1) thiopyridinone compound(s) with increased photostabilization of the (1) thiopyridinone compound(s).

The present invention relates to a composition comprising: (1) at least one thiopyridinone compound; and (2) at least one compound selected amongst Vitamin B3 and derivatives thereof. The present invention can provide a composition including (1) thiopyridinone compound(s) with increased solubility of the (1) thiopyridinone compound(s) over time.

The application discloses a synthesis method of 1-chlorobenzo[4,5]thieno[2,3-c]pyridine, and relates to the technical field of preparation of heterocyclic organic compounds containing thiophene and pyridine; the application comprises the following steps: taking 5-bromo-2-chloropyridine and phenylboronic acid as raw materials, and preparing 2-chloro-5-phenylpyridine intermediate product through Suzuki coupling; adding sulfur as a cyclization thiophene raw material; under electrocatalysis conditions, sulfur is solidified through nucleophilic addition, sulfur free radicals are generated through single electron transfer, and the cyclization thiophene synthesis under mild conditions is completed; 1-chlorobenzo[4,5]thieno[2,3-c]pyridine is obtained by separating the crude product; the raw materials are cheap and easy to obtain, the cost is low, the reaction process is simple and easy to operate, the reaction period is simplified, the reaction condition is mild, the three wastes are less, the product yield is good, and the method is suitable for large-scale production.

The invention relates to a thienopyridone compound, application thereof and an antituberculosis drug. The thienopyridone compound disclosed by the invention has a structure as shown in a formula (I), wherein-Ar1-(R1) n is a C6-C10 aromatic ring substituted by n R1 or a 4-10-membered heteroaromatic ring, n is selected from 0, 1, 2, 3 or 4, and n R1 is selected from C1-C6 alkyl, C1-C5 alkoxy, C3-C10 cycloalkyl, halogen, C1-C8 acyl, C1-C6 alkyl substituted by hydroxyl, C1-C6 alkyl substituted by halogen, nitro or cyano; -Ar2-(R2) n is a C6-C10 arylene ring substituted by n R2 or a 4-10-membered heteroaromatic ring, n is selected from 0, 1, 2, 3 or 4, and n R2 is respectively selected from C1-C6 alkyl, C1-C5 alkoxy, C3-C10 cycloalkyl, halogen or nitryl; and R3 is selected from the following groups: H or C1-C8 acyl groups. The thienopyridone compound has a novel mother nucleus structure and excellent anti-tubercle bacillus activity, and has a very strong inhibition effect on the growth of tubercle bacillus.

The present invention relates to crystalline forms of N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (Compound 1), pharmaceutical compositions comprising the crystalline form, processes for preparing the crystalline form and methods of use therefore.

The application discloses a preparation method of 4-bromothieno[2,3-c]pyridine-2-carboxylic acid ethyl ester, which comprises the following steps: 5-bromo-4-iodopyridine-3-thiol and propargyl acid ethyl ester are subjected to a Sonogashira coupling and a ring-closing series reaction under the action of a catalyst and an alkali to obtain 4-bromothieno[2,3-c]pyridine-2-carboxylic acid ethyl ester. The raw material adopted by the method is cheap and easy to obtain, the synthesis method is simple to operate, the reaction condition is mild, the requirement for equipment is low, and the method is suitable for the needs of industrial large-scale production.

Composition comprising a thiopyridinone compound and an amino-sulfonic compound The present invention relates to a composition, in particular cosmetic, comprising at least one compound of formula (I), at least one amino-sulfonic compound of formula (II) and strictly less than 0.2% by weight of an alkali salt of thiosulfuric acid and / or its solvates such as hydrates, or totally free from alkali salt of thiosulfuric acid and / or its solvates such as hydrates.

Disclosed herein are dosage and dosage regimens for N-(3-cyano-5-(cyclohexylmethyl)-6,6- dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide (Compound (1)), or a pharmaceutically acceptable salt thereof, for the treatment or prevention of a dengue virus disease or disorder. In addition, the invention provides using such dosage and dosage regimens in methods for the treatment or prevention of a dengue virus disease or disorder: Compound (1).

The present invention relates to a composition, in particular a cosmetic or dermatological composition, comprising at least one aqueous phase, at least one water-soluble organic UV-screening agent and at least one thiopyridinone compound of given formula, and / or the optical isomers or geometric isomers thereof and also the organic or mineral acid or base salts thereof, and / or solvates thereof, such as hydrates.

The application discloses a novel 3-urea-substituted thieno[2,3-b]pyridine compound, a preparation method and application thereof. The preparation method is that 5-bromothieno[2,3-b]pyridine-3-amine is subjected to nucleophilic substitution reaction with phenyl chloroformate or phenyl thiophosphonic chloride to generate an intermediate, the intermediate is subjected to nucleophilic substitution reaction with a substituted amine to generate a key intermediate, then the key intermediate is subjected to palladium-catalyzed Suzuki coupling reaction or Buchwald-Hartwig coupling reaction under alkaline conditions with a substituted aryl boronic acid or borate or a substituted arylamine to obtain a target product, namely the 3-urea-substituted thieno[2,3-b]pyridine compound. The 3-urea-substituted thieno[2,3-b]pyridine compound has a certain prospect as a DRAK2 inhibitor in the development of metabolic syndrome treatment drugs.

The present invention relates to a composition, notably a cosmetic or dermatological composition, comprising palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, and at least one compound of formula (I) or (I'), as described hereinbelow, and / or optical isomers thereof, geometrical isomers thereof, and also organic or mineral acid or base salts thereof, and / or solvates thereof such as hydrates.

The present invention relates to a composition, in particular a cosmetic or dermatological composition, comprising at least one amino-substituted 2-hydroxybenzophenone compound, and at least one compound of formula (I) or (I'), as described hereinbelow, and / or optical isomers thereof, geometrical isomers thereof, and also organic or mineral acid or base salts thereof, and / or solvates thereof such as hydrates.

The present invention relates to a composition comprising: (a) at least one thiopyridinone compound; and (b) at least one compound selected from ergothioneine and derivatives thereof. The present invention can provide a composition including (a) thiopyridinone compound(s) with increased stability of the (a) thiopyridinone compound(s) over time, in particular even when the composition is maintained for a relatively long period of time under elevated temperature.