41 results about "Tocopherol succinate" patented technology

The present invention relates to a liquid pest control system that includes a synthetic pyrethroid as a pest control active ingredient and an agent selected from the group consisting of purified diethylene glycol monoethyl ether, tocopherol nicotinate and tocopherol succinate, and combinations thereof, to reduce or eliminate paraesthesia of the synthetic pyrethroid. The system releases the synthetic pyrethroid efficiently and uniformly. The pest control system is less irritating to the animal's skin as compared to prior art systems, particularly to the small breeds of dogs. The system is useful for making liquid spot-on treatments, sprays and the like.

The invention provides a nano-micelle drug carrier based on a vitamin E derivative, a nano-micelle drug composition as well as a preparation method and application of the nano-micelle drug composition. The nano-micelle drug carrier based on the vitamin E derivative is a nano-micelle formed by D-alpha-tocopherol polyethylene glycol 1000 succinate, D-alpha-tocopherol polyethylene glycol 2000 succinate and alpha-tocopherol succinate; and the carrier entraps a hydrophobic anti-tumor drug to obtain the nano-micelle drug composition. The D-alpha-tocopherol polyethylene glycol 1000 succinate, D-alpha-tocopherol polyethylene glycol 2000 succinate and alpha-tocopherol succinate are matched with one another and cooperate, so that the formed nano-micelle is good in stability, is small and uniform in grain size, improves drug encapsulation efficiency, has relatively good P-glycoprotein inhibiting ability, has good anti-tumor effect, is small in toxicity to normal cells and has good biocompatibility. The preparation method is simple and is wide in application prospect.

The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using γ-tocotrienol, α-tocopherol succinate or γ-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of γ-tocotrienol; or (2) oral administration of a therapeutically effective amount of α-tocopherol succinate or γ-tocotrienol succinate or both.

The invention discloses a method for synthesizing tocopherol succinate. The method comprises the following steps: by taking tocopherol and succinic acid as raw materials and taking lipase as a catalyst, adding the tocopherol and succinic acid in a mole ratio of (1: 1) to (1: 5) into a double-solvent reaction mixed solvent which is prepared by mixing a halohydrocarbon or alkane solvent and DMSO; reacting at 20-60 DEG C for 24-48h by using a method of generating water through an azeotropic removal reaction system while reacting; cooling to room temperature; washing to be neutral by diluted hydrochloric acid and pure water after the reaction is finished; standing for layering to separate out the lower water phase; removing the solvent of the oil phase under vacuum state; adding normal hexane to crystallize; and drying and grinding to obtain high-purity natural vitamin E monoester succinate.

The invention discloses a method for preparing tocopherol succinate, and a heating system. The method comprises the following steps: carrying out pretreatment, specifically, adding acetone into a rawmaterial containing natural tocopherol, and treating for 40-45h at -20 to -17 DEG C to obtain the pretreated raw material; preparing, specifically, adding succinic anhydride and pyridine into the pretreated raw material, carrying out a reaction at 40-50 DEG C for 2-3h by means of the heating system to obtain a crude product of natural tocopheryl succinate; crystallizing, specifically, crystallizing the crude product of the natural tocopheryl succinate with n-hexane. In the preparation process, almost no tocopherol is lost; furthermore, the method is high in whole reaction yield, esterificationrate and purity, mild and efficient in reaction conditions, and in line with the concept of green chemistry.

The present invention provides methods for culturing primary hepatocytes with improved long term function and improved viability, by plating the hepatocytes in the presence of an anti-oxidants) as well as an agent(s) which is a functional inhibitor of enzymes that generate reactive oxygen and reactive nitrogen species. One preferred embodiment provides a combination of 2-oxo-thizolidine and tocopherol succinate. Another preferred embodiment provides a combination of N^G-methylarginine and mannitol.

The invention discloses an antioxidant essence microcapsule and a preparation method thereof. The microcapsule is a transparent spherical soft capsule of a core-shell structure, wherein the capsule wall is a sericin shell membrane, a capsule core is antioxidant essence, the mass ratio of the capsule wall to the capsule core is (1-2):1, and the diameter of the microcapsule is 1-5 mm. The antioxidant essence comprises, by weight, 12-25 parts of astaxanthin, 11-21 parts of tocopherol, 8-16 parts of tocopherol succinate, 3-11 parts of ascorbyl stearate, 1-8 parts of ascorbyl palmitate, 2-8 parts of jojoba oil, 2-8 parts of retinol, 1-7 parts of propylene glycol propionate, 1-6 parts of glycerol and 2-6 parts of sorbitol. The antioxidant essence microcapsule is slightly influenced by environmental factors such as light and heat, and is not easy to decompose and stable in property; antioxidant essence microcapsule particles are in a regular spherical shape, the capsule wall is uniform in thickness, the microcapsule has stable strength and elasticity, and the embedding effect of the capsule core is ensured.

The invention discloses a preparation method of d-alpha-tocopherol polyethylene glycol succinate. The preparation method comprises the following steps: by taking Merrifield resin and PEG1,000 as raw materials and alkali as a catalyst, performing reaction at 45-135 DEG C in an organic solvent to obtain resin loaded with PEG1,000; under the action of the catalyst, enabling the resin loaded with PEG1,000 and d-alpha-tocopherol succinate to be subjected to water diversion reflux reaction to obtain resin loaded with TPGS; and soaking the resin loaded with TPGS in toluene, then adding ethanol, palladium on carbon and phosphopyridoxal, and performing stirring reaction at 100-110 DEG C for 24 hours in hydrogen gas of 0.8-1.5MPa to obtain the d-alpha-tocopherol polyethylene glycol succinate. By adopting the synthetic method disclosed by the invention, the yield of TPGS is as high as 99%, the monoester content of TPGS is 99%, and the diester content of TPGS is 0.

The invention discloses whitening winkle and scar removal restoration skin care cream and a preparation method thereof. The skin care cream is prepared from the following ingredients of allantoin, glycerol, isopropyl myristate, caprylic/capric triglyceride, hydroxyethyl cellulose, alkyl polyglucoside, cetearyl glucoside, tocopherol succinate, plant extracts, lipidosome comprising bioactive factors, okra polysaccharide, gynostemmapolysaccharide, moringa seed oil, evening primrose oil, behenyl alcohol, phenoxyethanol, chlorphenesin and the balance deionized water. The skin care cream has the advantages that all ingredients are mutually cooperated; the scar removal effect is obvious; no skin irritation exists; the safety is high; the effects of preserving the moisture, tendering the skin, andresisting oxidization and aging are also achieved; the pigmentation can be effectively inhibited; the punctum is reduced, so that the skin restores to the natural state; the skin color is uniform; meanwhile, the winkles can be eliminated; the skin tightness is restored.

The present invention relates to the AAAPT bioconjugate of general Formula 1 or 2, wherein

A may be a small molecule such as, but is not limited to α-tocopherol succinate (1), benzamide riboside (2), bortezomib (3), cycloheximide (4), or hispolone (5) or a macromolecule such as, but not limited to TRAIL, or AIF1 Flavoprotein. L is an alkylene or polyoxaalkyene chain selected from the group comprising —OC(CH₂)_aCO—, —HN(CH₂)_bCO—, —OC(CH₂)_cNH—, —HN(CH₂)_dNH—, —HN(CH₂)_e—, —O(CH₂)_f(CH₂CH₂O)_g(CH₂)_hO—, —OC(CH₂)_i(CH₂CH₂O)_j(CH₂)_kCO—, and —HN(CH₂)_i(CH₂CH₂O)_j(CH₂)_kNH—. L may optionally contain acid enzymatically cleavable polypeptide sequences. T is selected from the group comprising somatostatin receptor binding agents, folate receptor binding agents, cathepsin B binding agents, matrix metalloprotein-2 (MMP-2) binding agents, GRP receptors, estrogen receptors, epidermal growth factor receptors (EGFR), and benzodiazepine.

The invention relates to a preparation method of a polyacrylic acid-tocopherol succinate self-assembly drug loading system for slow drug release. The preparation method comprises the following steps:preparing cystamine modified polyacrylic acid, preparing polyacrylic acid-tocopherol succinate and preparing drug-loading polyacrylic acid-tocopherol succinate. The preparation method has the advantages that the polyacrylic acid-tocopherol succinate self-assembly drug loading system is simple to prepare and can be prepared through two-step amidation reaction, the self-assembled drug loading systemhas dual sensitivity of pH and redox, and a drug can be slowly released through stimulation of pH and glutathione.

The invention relates to a concentration method for low-content natural mixed tocopherol. The method comprises: adding succinic anhydride, sodium hydroxide and butanone into natural mixed tocopherols with the mixed tocopherols content of 10%-45%, and stirring at 40-70 DEG C for 3-6 h; after the reaction is finished, performing reduced-pressure distillation to remove butanone, adding cyclohexane, performing water washing to neutral, cooling to 10-15 DEG C, standing for crystallization for 12-24 h, performing solid separation on the crystal and drying to obtain natural tocopherol succinate; adding ethanol and a potassium hydroxide solution with the concentration of 50% into natural tocopherol succinate to perform hydrolysis, controlling the hydrolysis temperature to be 60-70 DEG C and the hydrolysis time to be 4-6 h, after hydrolysis, adding cyclohexane and performing water washing to neutral, separating and performing reduced-pressure distillation on the solvent layer to recover cyclohexane, so as to obtain the mixed tocopherol concentrated liquid with the mixed tocopherol content larger than 90%.

The invention discloses an environment-friendly refining preparation process of d-alpha-tocopherol succinate, which comprises the following steps: S1, carrying out esterification reaction on d-alpha-tocopherol and succinic anhydride to obtain d-alpha-tocopherol succinate, heating and dissolving the d-alpha-tocopherol succinate with ethanol, cooling, keeping the temperature below 0 DEG C, adding a proper amount of water, and cooling; s2, carrying out solid-liquid separation, adding a proper amount of water into the separated solid, uniformly mixing, and filtering to obtain water-containing d-alpha-tocopherol succinate; and S3, performing freeze drying to obtain d-alpha-tocopherol succinate powder. According to the method, firstly, ethanol-water is adopted as an organic solvent to crystallize and refine the d-alpha-tocopherol succinate, and the toxicity of the solvent is low; after solid-liquid separation, residual ethanol in the solid is replaced by water, so that only water is discharged in the drying process, and no organic solvent is discharged; and a freeze drying technology is subsequently adopted, so that the product can be in a loose powder shape, a subsequent crushing step is not needed, the generation of dust is reduced, and meanwhile, low-temperature drying is beneficial to reducing oxidative deterioration of the product.

The invention belongs to the field of natural tocopherol succinate preparation, and particularly relates to a method for recovering high-content natural d-alpha-tocopherol succinate from leftovers. The method comprises the following steps of adding 2-10 times by weight of methanol into the pretreated leftovers, adding 0.5-5% of acid catalyst, carrying out esterification reaction at 60-70 DEG C to obtain a corresponding methyl ester product, carrying out reduced pressure distillation to recover methanol, washing with water until the methanol is neutral, carrying out secondary molecular distillation to obtain a secondary light phase which is a methyl ester product, hydrolyzing the methyl ester product in a water-organic solvent system under the catalysis of lipase, and carrying out post-treatment to obtain the high-content natural d-alpha-tocopherol succinate. The method is simple in process, environmentally friendly and high in operability, has very good industrial feasibility, can recover the natural alpha-tocopherol succinate from the leftovers, is used for recycling waste resources, and has important economic value and social value.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an oxaliplatin-containing nano-micelle preparation and a medical application thereof. The oxaliplatin-containing nano-micelle preparation contains oxaliplatin and an amphiphilic block copolymer micelle, wherein the hydrophilic segment of the amphiphilic block copolymer micelle is pluronic, and the hydrophobic segment of the amphiphilic block copolymer micelle is tocopherol succinate. The oxaliplatin is effectively loaded through a nano-micelle drug carrier, the drug loading capacity is improved, the impurity content in the product is reduced, meanwhile, product stability is enhanced, and the inhibition effect of the oxaliplatin for cancer cells is remarkably improved.

The invention provides a whitening, moisturizing, wrinkle-resisting and repairing micro-emulsion, which is prepared from the following components in parts by weight: 1 to 5 parts of marine algae extract, 0.5 to 3 parts of panthenol, 3 to 5 parts of hydroxyethyl urea, 1 to 3 parts of sweet almond oil, 1 to 2 parts of sunflower oil, 1 to 2 parts of tocopherol succinate, 1 to 3 parts of jojoba oil, 1to 5 parts of hyaluronic acid, 0.3 to 1 part of calcium gluconate, 0.3 to 1 part of magnesium gluconate and 0.5 to 1 part of glycyrrhizin. All the components of the whitening, moisturizing, wrinkle-resisting and repairing micro-emulsion supplement each other, so that the compatibility and the permeability between a product and skin of a human body are better; the absorption is more facilitated; the elasticity of the skin is increased, and the effects of moisturization, whitening, wrinkle resisting and the like can be achieved.

The invention discloses a nano organic selenium tablet, which is prepared from the following raw materials in parts by weight: 150 to 170 parts of nano organic selenium powder, 75 to 95 parts of L-ascorbic acid C, 25 to 35 parts of vitamin K2 (fermentation method), 20 to 30 parts of D-alpha-tocopherol succinate, 20 to 195 parts of sorbitol, 10 to 70 parts of lactose, 10 to 35 parts of silicon dioxide, microcrystalline cellulose, and 1 to 3 parts of povidone. The preparation method is characterized by comprising the following steps: weighing main and auxiliary materials according to a certain ratio, carrying out primary crushing and primary grinding and secondary fine grinding to guarantee that the particle size after fine grinding is not larger than 20 nanometer, carrying out boiling granulation after fine grinding, adding a lubricant, and carrying out total mixing, tabletting, coating and packaging. The adopted formula is scientific, the adopted nanocrystallization processing method is a pure physical method, no chemical reaction exists, substances in selenium yeast cells cannot be damaged, harmful substances cannot be brought in, and the selenium-enriched yeast is clean and environmentally friendly, so that the selenium-enriched yeast has the characteristics of being safe to eat, high in selenium content, good in taste, high in bioavailability and good in selenium supplementing effect.