The present invention provides methods and compositions for modulating the
phosphorylation of DARPP-32 in a serotonergic
receptor intracellular signaling pathway. The invention provides methods and compositions for modulating the activities of DARPP-32,
casein kinase 1 (CK1),
cyclin-dependent
kinase 5 (Cdk5), AMPA receptors,
protein phosphatase-1 (PP-1),
protein phosphatase 2C (PP2C),
protein phosphatase 2B (PP2B) and / or protein phosphatase 2A (PP2A) in cells or tissues. The invention provides methods of treating serotonergic
intracellular signaling pathway disorders, e.g., depression. The invention provides methods of treating
dopamine-related disorders. The invention provides methods of identifying agents that modulate the activities of serotonergic
receptor intracellular signaling molecules, DARPP-32,
casein kinase 1,
cyclin-dependent kinase 5, AMPA receptors, protein phosphatase-1, protein phosphatase 2C, protein phosphatase 2B and / or protein phosphatase 2A, for use in such treatments. The invention also provides methods of modulating
phosphorylation-dependent activation of AMPA receptors for use in such treatments.