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76 results about "Uridylic Acids" patented technology

Weaned piglet nucleotide feed additive

The invention discloses a weaned piglet nucleotide feed additive. The weaned piglet nucleotide feed additive comprises, by weight, 0.8 to 1.3 of adenosine monophosphate 5'-AMP, 0.3 to 0.8 of cytidine monophosphate 5'-CMP, 1.1 to 1.5 of guanosine monophosphate 5'-GMP and 0.7 to 1.4 of uridine monophosphate 5'UMP. The invention further discloses a preparation method and an application of the feed additive. According to the weaned piglet nucleotide feed additive, stress reaction of weaned piglets can be effectively relieved, the piglet grazing rate and the feed utilization efficiency are improved, the oxidation resistance and the immune function of weaned piglets are improved apparently, the organic resistance is enhanced, and accordingly, important significances are provided for modern scientific, intensive and large-scale pig production.
Owner:NANJING BIOTOGETHER

New method for synthesizing uridylic acid disodium

The invention discloses a new method for synthesizing uridylic acid disodium. The method comprises the following steps: adding cytidylic acid and sodium nitrite in deionized water, and dropwise adding inorganic or organic acid at the constant temperature of minus 5 DEG C-0 DEG C; stirring the solution and heating to 10-60 DGE C, reacting for 1-12 hours, and introducing steam for steam distillation after the reaction is finished so as to obtain a uridylic acid solution; regulating the pH of the uridylic acid solution to 7.0-8.5 with alkali, distilling at reduced pressure until a liquid is not distilled out; adding 95% ethanol the weight of which is 3-12 times that of cytidylic acid, heating and refluxing for 0.5-6 hours under the condition of stirring, crystallizing, and filtering so as to obtain crude uridylic acid disodium; and dissolving crude uridylic acid disodium in a proper amount of water, recrystallizing with ethanol the weight of which is 1-3.5 times that of the crude uridylic acid disodium, filtering and drying so as to obtain the uridylic acid disodium product. By using the method, the yield of uridylic acid disodium is above 92.75%, the purity of uridylic acid disodium by detection of high performance liquid chromatography (HPLC) is more than 99.50%, and the purity of uridylic acid disodium by detection of ultraviolet (UV) light is above 98.50%. The method has the advantages of simple and reasonable process, good product quality stability, low production cost and the like, and is easy to be applied to massively production.
Owner:宋道淮

Method for separating uridylic acid from biocatalytic conversion solution

The invention discloses a method for separating uridylic acid from biocatalytic conversion solution. The method conducts centrifugation, ultrafiltration, and nanofiltration to the biocatalytic conversion solution. Then, the conversion solution is moved to the anion-exchange column for absorption, deionized water washing, inorganic salt solution elution. The solution after elution is then nanofitrated to demineralise, concentrated and dried to obtain high-yielding, high-purity disodium uridine-5'-monophosphate crystal. The total separation yield rate can reach over 90 percent with the purity of 98 percent. The method of the invention lowers the consumption of resin, and the cost, but improves the yielding rate, the separation performance and the purity of the obtained product. The method is suitable for mass production.
Owner:NANJING UNIV OF TECH +1

Ultrahigh cross-linked resin SX-01 and application thereof

The invention discloses ultrahigh cross-linked resin SX-01 and a preparation method thereof. The ultrahigh cross-linked resin SX-01 is prepared by sufficiently swelling chloromethylated polystyrene resin in nitroethylbenzene the weight of which is 3-8 times that of chloromethylated polystyrene resin; after swelling, adding an amination reagent the weight of which is 2-5 times that of chloromethylated beads, then adding ferric trichloride the weight of which is 10-30% that of the chloromethylated beads to be used as a Friedel catalyst, carrying out Friedel-Crafts and crosslinking reaction at the temperature of 100-150 DEG C, stopping reaction when the content of residual chlorine in the resin is 1-3%, cooling and filtering resin spheres after the reaction is finished, washing with ethanol and distilled water, and carrying out vacuum drying. The invention also discloses a new method for separating pyrimidine nucleotide by utilizing the resin. According to the new method, an adsorption column is adopted for adsorbing and separating uridylic acid, so that dosage of acid and base in an operation process can be reduced, and discharge of waste water can be reduced.
Owner:NANJING UNIV OF TECH

Mixed nucleotide which comes from yeast and contains uridylic acid and preparing method and application thereof

The invention relates to the industrial field of animal feed, in particular to mixed nucleotide which comes from yeast and contains uridylic acid and a preparing method and application thereof. The mixed nucleotide contains, by weight, 43-80 parts of cytidine monophosphate, 116-200 parts of adenylate, 95-150 parts of guanylic acid, 400-800 parts of uridylic acid and 1 part of inosinic acid. The invention further provides a yeast autolysate containing the mixed nucleotide, wherein the weight percentage of the mixed nucleotide in the yeast autolysate is 1.5-2%. By the adoption of the yeast autolysate, the growing speed of piglets can be effectively increased, productivity and feed conversion rate are high, average daily gain of piglets is increased by 9.8-17.4%, and application prospects are broad.
Owner:ANGELYEAST CO LTD

Enzyme preparation for preparing uridylic acid and method for preparing uridylic acid through enzyme catalysis

The invention relates to an enzyme preparation for preparing uridylic acid and a method for preparing the uridylic acid through enzyme catalysis. The method comprises the following steps: taking a material liquid containing uridine as a substrate, adding an escherichia coli cell crushing liquid with activity of uridine kinase and poly-phosphokinase, sodium hexametaphosphate, magnesium sulfate anda small amount of ATP (Adenosintriphosphat), and carrying out an enzymatic reaction under conditions that the pH value is 8.0 and the temperature is 30 DEG C to synthesize the uridylic acid. In a coupling catalysis reaction system, the uridine and the ATP are catalyzed by the uridine kinase to generate the uridylic acid, and ADP (Adenosine Diphosphate) is formed along with the dephosphorylation ofthe ATP. Poly-phosphokinase is in charge of catalyzing the sodium hexametaphosphate and the ADP to generate the ATP, so that the regeneration of the ATP is achieved in reactions. The uridylic acid production method provided by the invention has the advantages of being low in raw material price, short in period, simple and convenient to operate, green and environmentally-friendly and high in yield, and has good industrial application value.
Owner:TIANJIN UNIV OF SCI & TECH

Nucleotide probiotic capsule for delaying senescence

The invention discloses a nucleotide probiotic capsule for delaying senescence, and belongs to the technical field of medicine and health care. The nucleotide probiotic capsule comprises a capsule shell and a content, wherein the content comprises four exogenous nucleotides and five probiotics; the exogenous nucleotides comprise 5'-cytidine monophosphate (5'-CMP), 5'-adenosine monophosphate (5'-AMP), 5'-disodium uridine monophosphate (5'-UMPNa2) and 5'-disodium guanylate (5'-GMPNa2); the probiotics comprise lactobacillus acidophilus, lactobacillus plantarum, lactobacillus casei and the like; and the content of the probiotics is greater than 1 * 10 <7>CFU / g. The nucleotide probiotic capsule for delaying senescence can remove free radicals in a body, inhibit oxidative damage of the free radicals to the body and prolong the cell life, has multiple health care effects of delaying senescence, prolonging life, improving immunity, regulating intestinal flora and the like, is convenient to carry and take, and is a health care food suitable for middle-aged and elderly people.
Owner:陈玉松

Preparation method of uridine triphosphate

The invention provides a preparation method of uridine triphosphate, belonging to the field of biosynthesis and bioconversion. According to the method provided by the invention, high permeability yeast cells which are obtained from wet yeasts at a temperature lower than -20 DEG C for over 72 hours can efficiently convert uridylic acid into uridine triphosphate. The method of preparing the permeable yeast can maintain the integrity of yeast cells without a complex treatment process, so that the method is very applicable to industrialized production on a large scale.
Owner:SHANGHAI HUIYUAN BIOLOGICAL SCI & TECH CO LTD

Nucleotide feed additive for tilapia

The invention discloses a nucleotide feed additive for tilapia. The nucleotide feed additive is characterized in that nucleotide comprises adenylic acid 5'-AMP, cytidylic acid 5'-CMP, guanylic acid 5'-GMP and uridylic acid 5'-UMP in a weight ratio of (0.9-1.5):(0.7-1.2):(1.1-2.0):(0.8-1.5). The nucleotide feed additive has the beneficial effects that the nucleotide feed additive can obviously increase the length of the intestinal tract of tilapia and improve the growth efficiency, feed utilization rate and environment tolerance of tilapia, and at the same time, the non-specific immunity of tilapia is greatly enhanced by adding nucleotide, which have profound significance for the present intensive culture industry of intensive tilapia.
Owner:NANJING BIOTOGETHER

Rna Capable of Suppressing Expression of Klf5 Gene

An RNA capable of suppressing the expression of KLF5 gene, which comprises a sequence consisting of 15 to 30 contiguous nucleotides of KLF5 mRNA and a sequence complementary to the sequence, and which has been designed from the nucleotide sequence of Kruppel-like factor 5 (KLF5) cDNA. Specifically, a double-stranded RNA having a strand of a sequence shown in any one of SEQ ID NOS: 2 to 16 and a strand of a sequence complementary to the sequence, in which 2 uridylic acids are added to the 3′-terminus of each of the strands. By transfecting the RNA or a vector for expression of the RNA into cells, the expression of KLF5 gene in the cells can be suppressed. The RNA or a vector for expression of the RNA can be used as a therapeutic agent for cardiovascular disease or cancer.
Owner:KYOWA HAKKO KIRIN CO LTD +2

Nucleotide mixture crystalline powder and preparation method thereof

The invention discloses nucleotide mixture crystalline powder and a preparation method thereof. The preparation method comprises the following steps of performing solid-liquid separation on ribonucleic acid enzymatic hydrolysate, decoloring the enzymatic hydrolysate, regulating the pH of decolored enzymatic hydrolysate to 6.5-10.0, performing concentration, performing crystallization, performing filtration, and performing drying so as to obtain the nucleotide mixture crystalline powder containing uridylic acid, guanylic acid, cytidylic acid and adenylic acid. The nucleotide mixture crystallinepowder provided by the invention is high in purity, good in stability and free from moisture absorption, has favorable granularity and mobility, and can be widely applied to feed trade. The preparation method provided by the invention is high in yield, simple to operate and low in cost, and is suitable for industrial production.
Owner:NANJING UNIV OF TECH

Partially reduced graphene oxide, preparation method and application thereof

The invention discloses a preparation method of partially reduced graphene oxide, belonging to the application technical field of graphene oxide. Graphene oxide is dispersed in water, a reducing agentis added and reacted to obtain partially reduced graphene oxide; the reducing agent is one or more of components selected from adenylate, disodium adenylate, dipotassium adenylate, adenosine-5'-diphosphate dipotassium salt, cytidylic acid, cytidine-5'-monohposphate disodium salt, cytidine dipotassium, guanylic acid, disodium guanylate, dipotassium guanylate, uridylic acid, disodium uridine-5'-monophosphate, and dipotassium uridine-5'-monophosphate. Nucleotides have different types of R groups, and can interact with graphene oxide by various forces, such as hydrophobic force, electrostatic force and hydrogen bond force, so as to control the surface properties of graphene oxide.
Owner:NANJING UNIV OF TECH

Escherichia coli mutant strain with high cytidine production and method for fermentation production of cytidine

ActiveCN111321103AEffective deregulation of feedbackDefeedback regulationBacteriaHydrolasesEscherichia coliPhenylalanine
The present invention relates to an escherichia coli mutant strain with high cytidine production and a method for fermentation production of cytidine, and belongs to the technical field of fermentation. The escherichia coli mutant strain is obtained by mutagenic screening and has the following characteristics: 1, alanine at 182nd position of carbamyl phosphate synthetase is mutated to valine, andserine at 948th position is mutated to phenylalanine; 2, isoleucine at 86th position, glycine at 93rd position and cysteine at 109th position of aspartic acid carbamoyl transferase regulatory subunitare deleted; 3, asparagine at 72nd position of uridine kinase is mutated to alanine and aspartic acid at 159th position is mutated to asparagine; and 4, aspartic acid at 147th position of cytidine triphosphate synthase is mutated to glutamic acid, and glutamic acid at 149th position is mutated to alanine. The mutant strain is fermented in a 50-L fermentation tank, cytidine yield reaches (90 plus or minus 2) g / L, sugar-acid conversion rate reaches (30 plus or minus 1)%, and the cytidine yield and sugar-acid conversion rate are both the highest values reported.
Owner:HENAN JULONG BIOLOGICAL ENG CO LTD +1

Primer composition for detecting harmful gene of deficiency of uridine monophosphate synthase of cattle, kit with primer composition and application of kit

The invention discloses a primer composition for detecting a harmful gene of deficiency of uridine monophosphate synthase of cattle, a kit with the primer composition and an application of the kit. The primer composition disclosed by the invention is composed of a primer group A and a primer group B, wherein the primer group A is composed of a primer 1 and a primer 2, the primer group B is composed of a primer 3 and a primer 4, and the nucleotide sequences of the primer 1, the primer 2, the primer 3 and the primer 4 are respectively shown as SEQIDNO. 1-4. The invention also provides the kit with the primer composition. The method for applying the kit disclosed by the invention to the detection of the harmful gene of the deficiency of uridine monophosphate synthase of cattle comprises the steps of extracting the complete set of DNA (Deoxyribonucleic acid) in cattle blood as a template to carry out nested PCR (Polymerase Chain Reaction) amplification to obtain a PCR product, and sequencing the obtained PCR product so as to directly know about the basic group change on a mutation site according to a sequenced result, thereby ensuring the accuracy of the result and meeting the requirements of a detecting technology for characteristics such as high speed, precision, high throughput and the like.
Owner:SOUTH CHINA AGRI UNIV

Biomarker compositions for diagnosing cervicitis and cervical cancer

The invention discloses biomarker compositions, and provides biomarker compositions for diagnosing cervicitis and a cervical cancer. The biomarker compositions are characterized by at least comprising one or a combination of uridine-5'-monophosphate disodium, histamine, 3'-O-methyl-guanosine and phenyllactic acid. The biomarker composition for diagnosing the cervicitis is characterized by comprising one or a combination of uridine-5'-monophosphate disodium, L-cysteine, isocitric acid, uridine diphosphate glucose, adenosine monophosphate, inosine 5'-monophosphate, L-pipecolic acid, N-acetyl putrescine and saccharose. The biomarker composition for diagnosing the cervical cancer is characterized by comprising one or a combination of histamine, phenyllactic acid, citraconic acid, L-2-aminoadipic acid, 3'-O-methyl-guanosine, beta-D-glucosamine, glycerin and cholesterol sulfate.
Owner:上海阿趣生物科技有限公司

Application of yeast containing active polysaccharides and nucleotides in dairy cow feed

The invention discloses the application of a yeast containing active polysaccharides and nucleotides in a dairy cow feed. The yeast containing active polysaccharides and nucleotides contains such active polysaccharide components as glucan, mannan and mannan oligosaccharide, and the total content of the active polysaccharides is 1-20wt% of that of the yeast; the yeast also contains such nucleotides as adenylate, cytidine monophosphate, guanylic acid and uridylic acid, and the total content of the nucleotides is 1-20wt% of that of the yeast. According to the method, the active feed is added to the dairy cow feed, the serum albumin of a calf can be increased by 140mg / dL by use of the methods of optimizing charging and feeding conditions and the like, and the maximum mutation rate of the rotavirus in the colostrum can be 75%. The application of the yeast containing active polysaccharides and nucleotides in the dairy cow feed has the advantages that 1, the yeast feed is capable of increasing the content of the serum albumin of the calf and boosting the immunity of the calf, and 2, the yeast feed is capable of mutating a large amount of rotavirus in the colostrum and preventing the rotavirus from pathopoiesis.
Owner:NANJING BIOTOGETHER

Method for producing disodium uridine-5'-monophosphate by a continuous flow reaction device

The invention discloses a method for producing disodium uridine-5'-monophosphate by a continuous flow reaction device. The method includes the following steps: A, preparing a mixed solution by simultaneously pumping solutions for preparing the mixed solution into a mixer, performing uniform mixing, pumping the mixed solution into a mixed solution storage tank to obtain the mixed solution; B, preparing a uridylic acid reaction solution by mixing a matched reagent and the mixed solution to prepare the uridylic acid reaction solution; and C, preparing the disodium uridine-5'-monophosphate: performing salt formation on the uridylic acid reaction solution, performing crystallization, performing filtration, and performing drying to obtain the disodium uridine-5'-monophosphate. In the preparationmethod for the disodium uridine-5'-monophosphate provided by the invention, the reaction time is shorter, in the reaction process, the mass transfer effect of a microchannel reactor is good, so thatthe selectivity and yield of the reactor are better than those of a previous preparation method, and the yield of the uridylic acid is about 97%.
Owner:美亚药业海安有限公司

Synthetic method of difluoroalkyl substituted uracil, uridine or uridylic acid

The invention discloses a synthetic method of difluoroalkyl substituted uracil, uridine or uridylic acid under a simple and convenient condition. To be specific, simple uracil, uridine or uridylic acid and a halogenated difluoroalkyl compound (chloro, bromo, iodo) are taken as the starting point, and under visible light irradiation, a coordination compound taking iridium and ruthenium as the core is taken as a catalyst, so that the method of obtaining various difluoroalkyl substituted uracil, uridine, uridylic acid and derivatives thereof at the high yield is achieved. According to the synthetic method, the simple and easily available uracil, uridine, uridylic acid, derivatives thereof and the halogenated difluoroalkyl compound (chloro, bromo, iodo) are taken as the raw materials, the advantages that the dosage of the catalyst is small, the application range of the substrate is wide, the operation is simple and convenient, the reaction efficiency is high and the like are achieved; besides, as the obtained structures are similar structures of marketing drugs at present, and are building blocks of novel nucleic acid molecules at the same time, a larger application prospect in the field of biological medicines is achieved.
Owner:ZUNYI MEDICAL UNIVERSITY

Chilled fresh meat freshness marker and screening and prediction model fitting method and application thereof

The invention discloses a metabonomics-based chilled fresh meat freshness marker and a screening and prediction model fitting method and application thereof. The marker is prepared from indole-3-formaldehyde, uridine monophosphate, phenylmercaptouric acid, gluconic acid, tyramine and serine-phenylalanine. The prediction model is: Y=3.964+1.97E<-7>X1- 4.22E<-7>X2-3.37E<-7>X3+8.80E<-8>X4+1.26E<-8>X5-5.57E<-7>X6. According to the method, an Agilent 1290 UHPLC is connected with a Q Exactive Orbitrap high-resolution mass spectrum in series, the method has higher resolution, more substances can be detected more accurately, metabolites in the preservation process of the chilled fresh chicken can be illustrated more comprehensively, and the obtained result is more reliable.
Owner:YANGZHOU UNIV

Method for preparing uridylic acid by enzyme method

The invention, which belongs to the technical field of biological pharmacy and biochemical engineering, discloses an enzyme composition for uridylic acid production and a method for preparing uridylicacid by an enzyme method. The enzyme composition is prepared by cytidine deaminase, polyphosphate kinase and uridine-cytidine kinase. The three enzymes are reasonably combined to efficiently catalyzeand prepare uridylic acid. The enzyme composition disclosed by the invention can be recycled and is low in cost; and energy-saving and environment-friendly effects are realized. According to the invention, the cytidine is used as a substrate and the enzyme composition for uridylic acid production is added, so that the uridylic acid is prepared with low cost and high safety and reliability; the cost of the existing route is reduced; and the large-scale production is realized. The application of uridylic acid in fields of biocatalysis and medicines is guaranteed.
Owner:杭州唯泰生物药业有限公司 +1

Broiler chicken feedstuff additive

The invention discloses a broiler chicken feedstuff additive. The feedstuff additive comprises the following components in parts by weight: 12-33 parts of adenylate, 5-24 parts of guanylic acid, 8-27 parts of uridylic acid, 14-39 parts of cytidine monophosphate, 5-22 parts of glutamine and 6-14 parts of arginine. The invention also discloses a preparation method and application of the broiler chicken feedstuff additive. According to the feedstuff additive disclosed by the invention, the appetite of animals can be boosted, the animals can be promoted to take food actively, the nutrient demand of young chickens in a best immune state is satisfied, the disease resistance and the disease prevention capability of the young chickens are enhanced, and the survival rate of the young chickens obviously increases, so that the feedstuff additive has a positive significance to a livestock culture industry.
Owner:NANJING BIOTOGETHER

Synthesis method of 2'-deoxy-beta-uridine

The invention discloses a synthesis method of 2'-deoxy-beta-uridine, and belongs to the technical field of medicinal chemistry. The synthesis method comprises the following steps: preparing 1-chloro-2-deoxy-3, 5-O-bis(4-chlorobenzoyl)-alpha-D- red-furanose from 2'-deoxyribose by a one-pot methylation, acylation and chlorine substitution method, then coupling with 2, 4-bis(trimethylsilyloxy)pyrimidine, and finally deacylating and recrystallizing to obtain the 2'-deoxy-beta-uridine. By the synthesis method, the defects that when uridylic acid is used as a raw material, stereoisomers are difficult to control and the quality is relatively poor are overcome, the reaction condition is simple, the raw materials are easy to obtain, the product is high in yield and purity and the energy consumptionis reduced, so that the industrial application prospect is greatly improved.
Owner:王成宇

Method for evaluating destroy degree on nucleotide of determination method and production technology of free nucleic acid hydrolysate in protein product

The invention discloses a method for determining a free nucleic acid hydrolysate in protein products. The method comprise the following steps: (1) respectively preparing a nucleotide mixed standard solution and a bases mixed standard solution; (2) preparing a solution of a sample to be tested, and using the nucleotide mixed standard solution and the base mixed standard solution described in step 1 as the reference solution, and employing high performance liquid chromatography through washing peak area method comparison to obtain the content of free nucleotides and free base in the sample. According to the invention, high performance liquid chromatography is used for determining 5 kinds of bases in a single-cell protein raw material (cytosine, uracil, guanine, thymine and adenine), 5 kinds of nucleotides (cytidine monophosphate, uridylic acid, guanylic acid, inosinic acid and adenylic acid), and 5 kinds of nucleosides (cytidine, uridine, inosine, guanosine and adenosine); and then the destroy degree on nucleotide of the production process is determined according to t the relationships between the bases and nucleotides, and between the bases and nucleosides.
Owner:江苏征泰饲料有限公司

Low-protein feed for improving growth performance of litopenaeus vannamei and application thereof

The invention belongs to the technical field of aquaculture, and particularly relates to a low-protein feed for improving growth performance of litopenaeus vannamei and application thereof. The low-protein feed comprise nucleotide, and is used for improving the digestion and absorption capacity of the litopenaeus vannamei to nutrient substances in feed, improving growth performance of the litopenaeus vannamei, improving the body composition and serum biochemical indexes of the litopenaeus vannamei and improving immunity of the litopenaeus vannamei. The nucleotide comprises 5'-cytidylate, 5'-adenylate, disodium 5'-inosinate, disodium 5'-uridylate, disodium 5'-guanylate and disodium 5'-thymidylate. The low-protein feed of the present invention is mainly used for improving crude fat content,serum glutamic oxalacetic transaminase and glutamic-pyruvic transaminase, hepatopancreatic glutamic-pyruvic transaminase, blood cell count, serum PO activity and the total protein content in stomachsand intestinal tracts of the litopenaeus vannamei.
Owner:ANIMAL SCI RES INST GUANGDONG ACADEMY OF AGRI SCI

Nucleotide mixture powder and preparation method and application thereof

The invention discloses nucleotide mixture powder and a preparation method and application thereof. The preparation method comprises the following steps of adding a ribonucleic acid solution in nuclease liquid in a fed-batch manner, performing enzymolysis, performing concentration, and performing drying so as to obtain the nucleotide mixture powder containing uridylic acid, guanylic acid, cytidylic acid and adenylic acid. The nucleotide mixture powder provided by the invention is high in purity and good in stability, is favorable in fluidity, and can be widely applied to feed trade. The preparation method provided by the invention is high in yield, simple to operate, low in cost, and suitable for industrial production.
Owner:NANJING BIOTOGETHER

Screening method and application of uridine monophosphate modified protein in mitochondria

The invention discloses a screening method and an application of uridine monophosphate modified protein in mitochondria. The method is characterized in that biotin-labeled UTP (Biotin-16-UTP) is usedas a raw material, under the action of uridine monophosphate transferase SelO, total mitochondrial protein is subjected to UMP modification reaction, and the protein modified by UMP further has a biotin label, subsequently, the modified protein is screened out by using a biotin-streptavidin Pull-down technology, and finally, the modified protein and a modification site are determined by mass spectrometry. The method is advantaged in that a simple and feasible experimental method is developed, proteins which can be modified by UMP are screened from mitochondrial total proteins, and an importantresearch means is provided for signal transduction mediated by SelO proteins and post-translational modification in mitochondria.
Owner:INST OF BASIC MEDICINE OF SAMS

Production method of ribonucleotide sodium salt

As a food additive and a pharmaceutical intermediate, the ribonucleotide sodium salt is very important. The ribonucleotide comprises an adenylic acid, a cytidylic acid, a uridylic acid, a guanylic acid and an inosinic acid. The sodium salt is usually 5'-ribonucleotide disodium. The invention relates to and adopts a special preparation technology for resolving the problem of bad crystal form and can obtain a plurality of types of sodium salt even tetrasodium salt, and the invention has the characteristics of good crystal form, high quality and high yield.
Owner:SHANDONG KAISHENG NEW MATERIALS

Compound fodder additive for gestation period of sows and preparation method and application thereof

The invention discloses a compound fodder premixed additive for the gestation period of sows. The compound fodder premixed additive comprises, by weight, 40-150 parts of uridylic acid disodium, 40-150parts of uridine, 200-920 parts of carrier, 180-300 parts of NCG and 100-200 parts of chelate iron glycine, wherein the carrier is one of or the mixture of maltodextrin, starch, sepiolite and the like. The invention also discloses a preparation method of the compound fodder additive and fodder prepared from the additive for the gestation period of sows. The premixed additive only needs to be slightly added into the fodder, then the reproductive performance can be improved, the stillbirth rate is reduced, the diarrhea rate of piglets is decreased, and the compound fodder additive has a broad application prospect.
Owner:INST OF SUBTROPICAL AGRI CHINESE ACAD OF SCI

Production method of flos traditional Chinese medicine

The invention discloses a production method of a flos traditional Chinese medicine. The production method is characterized in that nutrients are used during the growth of the flos traditional Chinese medicine, wherein the nutrients include the following components in percentage by weight: 30 to 70% of nucleotide salt and 30 to 70% of medium trace element, and exclude glucose or / and amino acids; the nucleotide salt is the sylvite or sodium salt of four 5'-mixed nucleotides and obtained by hydrolyzing ribonucleic acid alkaline, namely, wherein the four 5'-mixed nucleotides are namely 5'-adenylate dipotassium or sodium, 5'-guanylic dipotassium or sodium, 5'-cytidine monophosphate dipotassium or sodium, 5'-uridylic acid dipotassium or sodium; and the medium trace element includes Mn, B and Fe, namely manganese sulfate, borax and ferrous sulfate. The production method of the flos traditional Chinese medicine has the effect reaching and even exceeding the effect of a patent for invention with publication patent number of CN102079666B and patent number of ZL201010514231.6. The method is economic and simple. The obtained flos traditional Chinese medicine is large and uniform in flower, the uniformity is up to 70 to 90%, the output is 20 to 40% higher than that of flos traditional Chinese medicine produced by the traditional method, the main components account for 10 to 25%, the obtained traditional Chinese medicines can be prepared into quality decoction pieces, or active ingredients can be extracted, and the yield is up to 10 to 22%.
Owner:安徽世茂中药股份有限公司

Production method for flower traditional Chinese medicine

The invention discloses a production method of a flos traditional Chinese medicine. The production method is characterized in that nutrients are used during the growth of the flos traditional Chinese medicine, wherein the nutrients include the following components in percentage by weight: 30 to 70% of nucleotide salt and 30 to 70% of medium trace element, and exclude glucose or / and amino acids; the nucleotide salt is the sylvite or sodium salt of four 5'-mixed nucleotides and obtained by hydrolyzing ribonucleic acid alkaline, namely, wherein the four 5'-mixed nucleotides are namely 5'-adenylate dipotassium or sodium, 5'-guanylic dipotassium or sodium, 5'-cytidine monophosphate dipotassium or sodium, 5'-uridylic acid dipotassium or sodium; and the medium trace element includes Mn, B and Fe, namely manganese sulfate, borax and ferrous sulfate. The production method of the flos traditional Chinese medicine has the effect reaching and even exceeding the effect of a patent for invention with publication patent number of CN102079666B and patent number of ZL201010514231.6. The method is economic and simple. The obtained flos traditional Chinese medicine is large and uniform in flower, the uniformity is up to 70 to 90%, the output is 20 to 40% higher than that of flos traditional Chinese medicine produced by the traditional method, the main components account for 10 to 25%, the obtained traditional Chinese medicines can be prepared into quality decoction pieces, or active ingredients can be extracted, and the yield is up to 10 to 22%.
Owner:HEFEI KAIGE INFORMATION TECH
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