The present invention discloses chewing gum with satiety and a preparation method thereof. The chewing gum comprises the following components in weight percentages: 32%-37% of gum bases, 12%-16% of erythritol, 12%-14% of mannitol, 0.01%-0.03% of acesulfame, 12%-16% of yeast beta-glucan, 5.8%-6.4% of crystalline cellulose, 0.5%-0.7% of lecithin, 0.8%-1% of glycerol, 0.2%-0.4% of citric acid, 1%-2% of spices, 4%-4.5% of titanium dioxide, and 8%-10% of talcum powder. The preparation method comprises the following steps of gum base melting and kneading, material mixing, yeast beta-glucan mixing, cooling, extruding and molding, cutting, polishing, powdered sugar coating and finished product obtaining. High viscosity and gelation property of the yeast beta-glucan are used to increase gastric mucosal barrier effects, inhibit sugar metabolism and alleviate hunger feeling, the other components are combined to prepare the chewing gum, and the chewing gum is convenient to carry, can be chewed at any time, can prevent dizziness, inattention, etc. caused by the hunger feeling, is especially suitable for long-distance drivers to use, and effectively avoids driving risks.