3results about How to "Improve exercise tolerance" patented technology

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound for treating pulmonary fibrosis of diabetes and application thereof. The traditional Chinese medicine compound comprises 70-90 parts of Huangqi, 20-40 parts of Danshen, 10-30 parts of Chuanxiong, 20-40 parts of Beishashen and 40-60 parts of Shanyao. The application also discloses application of the traditional Chinese medicine compound in preparation of a medicine for treating pulmonary fibrosis of diabetes of the type of deficiency of both qi and yin and blood stasis. The traditional Chinese medicine compound has reasonable formula, and uses the traditional Chinese medicine theory scientifically. The raw materials are matched according to the principle of monarch, minister, assistant and guide, and the traditional Chinese medicines are synergistically used, so that the traditional Chinese medicine compound can not only supplement deficiency of both qi and yin of diabetes, but also dredge stasis of collaterals of long-term disease, and achieve good clinical test effect by considering both the symptoms and the root cause.

The invention relates to a traditional Chinese medicine composition and medical application thereof, in particular to a yang-warming and qi-tonifying formula and application thereof in chronic heart failure. The traditional Chinese medicine composition is prepared from fructus rosae laevigatae, astragalus membranaceus, kadsura pepper stem, leech, ginseng, semen lepidii, angelica sinensis, schizonepeta, divaricate saposhnikovia root, cassia twig, poria cocos, bighead atractylodes rhizome and liquorice. According to the composition, monarch, minister, assistant and guide are combined, syndrome differentiation is taken as a main part, disease differentiation is taken as an auxiliary part, diseases and syndromes are combined, and deficiency and excess are combined, clinical experiments show that the prescription can obviously prolong the 6WMT distance of a CHF patient, improve the exercise tolerance of the patient, reduce the blood plasma BNP level, improve the heart failure curative effect integral, reduce the traditional Chinese medicine symptom integral and improve the life quality of the patient, and the curative effect is definite; the traditional Chinese medicine composition is suitable for further popularization and application.

The invention belongs to the technical field of biological medicine, a series of differential miRNAs and intestinal strains are innovatively screened out in a patient queue by applying intestinal flora metagenomics and intestinal bacteria source plasma exosome miRNA sequencing, variable screening is carried out by adopting LASSO regression and gradual backward regression, and finally, two miRNAs including miR1403p and miR10a5p and two intestinal strains including AnaliterunusspG32012 are obtained through screening. According to the heart failure early-stage recognition method based on the Bifidobacteriumlonium, Bifidobacteriumlonium is used as a marker combination, meanwhile, a diagnosis model is constructed, high sensitivity and specificity are achieved for recognition of ventricular remodeling, the efficiency of early-stage recognition of heart failure can be improved, ventricular remodeling can be better found, recognized and intervened as soon as possible, heart failure can be better prevented and delayed, the heart failure early-stage recognition method can be applied to children, full-life-cycle screening and monitoring can be achieved, and the heart failure early-stage recognition method based on the Bifidobacteriumlonium can be used for early-stage recognition of heart failure. The method is expected to be applied to clinical examination and has clinical transformation value.