Method for synthetizing isopropanol by ester exchange

Abstract

The invention discloses a method for synthetizing isopropanol by ester exchange. Isopropyl acetate and methyl alcohol are used as raw materials to produce the isopropanol with an ester exchange method. The method for synthetizing isopropanol by ester exchange has the characteristics of high reaction conversion ration, high reaction rate, high selectivity, moderate reaction condition, small equipment corrosivity and the like.

Description

technical field

[0001] The invention belongs to the field of organic reactions, and relates to a method for synthesizing isopropanol through transesterification. Background technique

[0002] Isopropanol has a wide range of uses as organic raw materials and solvents, and can generate intermediates of various compounds. As a solvent, it can be used to produce coatings, inks, extractants and aerosols. Isopropanol is also widely used in the electronics industry, medicine and pesticides and other fields.

[0003] The main method of producing isopropanol at home and abroad is the propylene hydration method. According to whether intermediate products are produced, it can be divided into two methods: propylene indirect hydration method and propylene direct hydration method. Indirect hydration is also called sulfated hydrolysis. This method uses concentrated sulfuric acid to absorb propylene, and then hydrolyzes it into isopropanol. This method has the disadvantages of large sulfu...

Examples

Embodiment 1

[0019] A tank reactor is used with a volume of 1m 3 , with sodium methoxide as the catalyst, isopropyl acetate and methanol in a molar ratio of 1:1, the concentration of the catalyst in the reaction material is 0.4% (mass percentage), the temperature of the reactor is controlled at 50 ° C, and the reaction pressure is 1 atm. First, 408.5kg of isopropyl acetate is added into the reactor and heated to a predetermined reaction temperature. Dissolve 2.14 kg of catalyst sodium methoxide in 128 kg of methanol, preheat to the set reaction temperature, and then add the methanol solution into the reactor for reaction. After reacting for 1 h, the conversion rate of isopropyl acetate was 68.5%. The yield of isopropanol was 67.9%.

Embodiment 2

[0021] A tank reactor is used with a volume of 1m 3 , using sodium methoxide as the catalyst, isopropyl acetate and methanol in a molar ratio of 1:1, the concentration of the catalyst in the reaction material is 0.3% (mass percentage), the temperature of the reactor is controlled at 60°C, and the reaction pressure is 1atm. First, 408.5kg of isopropyl acetate is added into the reactor and heated to a predetermined reaction temperature. Dissolve 1.61 kg of catalyst sodium methoxide in 128 kg of methanol, preheat to the set reaction temperature, and then add the methanol solution into the reactor for reaction. After reacting for 1 h, the conversion rate of isopropyl acetate was 58.2%. The yield of isopropanol was 57.8%.

Embodiment 3

[0023] A tank reactor is used with a volume of 1m 3 , using sodium methoxide as the catalyst, isopropyl acetate and methanol in a molar ratio of 1:1.4, the concentration of the catalyst in the reaction material is 0.4% (mass percentage), the temperature of the reactor is controlled at 45 ° C, and the reaction pressure is 1 atm. First, 291.4kg of isopropyl acetate is added into the reactor and heated to a predetermined reaction temperature. Dissolve 1.68 kg of catalyst sodium methoxide in 128 kg of methanol, preheat to the set reaction temperature, and then add the methanol solution into the reactor for reaction. After reacting for 1 h, the conversion rate of isopropyl acetate was 69.8%. The yield of isopropanol was 68.7%.

technical field

[0001] The invention belongs to the field of organic reactions, and relates to a method for synthesizing isopropanol through transesterification. Background technique

[0002] Isopropanol has a wide range of uses as organic raw materials and solvents, and can generate intermediates of various compounds. As a solvent, it can be used to produce coatings, inks, extractants and aerosols. Isopropanol is also widely used in the electronics industry, medicine and pesticides and other fields.

[0003] The main method of producing isopropanol at home and abroad is the propylene hydration method. According to whether intermediate products are produced, it can be divided into two methods: propylene indirect hydration method and propylene direct hydration method. Indirect hydration is also called sulfated hydrolysis. This method uses concentrated sulfuric acid to absorb propylene, and then hydrolyzes it into isopropanol. This method has the disadvantages of large sulfu...

Examples

Embodiment 1

[0019] A tank reactor is used with a volume of 1m 3 , with sodium methoxide as the catalyst, isopropyl acetate and methanol in a molar ratio of 1:1, the concentration of the catalyst in the reaction material is 0.4% (mass percentage), the temperature of the reactor is controlled at 50 ° C, and the reaction pressure is 1 atm. First, 408.5kg of isopropyl acetate is added into the reactor and heated to a predetermined reaction temperature. Dissolve 2.14 kg of catalyst sodium methoxide in 128 kg of methanol, preheat to the set reaction temperature, and then add the methanol solution into the reactor for reaction. After reacting for 1 h, the conversion rate of isopropyl acetate was 68.5%. The yield of isopropanol was 67.9%.

Embodiment 2

[0021] A tank reactor is used with a volume of 1m 3 , using sodium methoxide as the catalyst, isopropyl acetate and methanol in a molar ratio of 1:1, the concentration of the catalyst in the reaction material is 0.3% (mass percentage), the temperature of the reactor is controlled at 60°C, and the reaction pressure is 1atm. First, 408.5kg of isopropyl acetate is added into the reactor and heated to a predetermined reaction temperature. Dissolve 1.61 kg of catalyst sodium methoxide in 128 kg of methanol, preheat to the set reaction temperature, and then add the methanol solution into the reactor for reaction. After reacting for 1 h, the conversion rate of isopropyl acetate was 58.2%. The yield of isopropanol was 57.8%.

Embodiment 3

[0023] A tank reactor is used with a volume of 1m 3 , using sodium methoxide as the catalyst, isopropyl acetate and methanol in a molar ratio of 1:1.4, the concentration of the catalyst in the reaction material is 0.4% (mass percentage), the temperature of the reactor is controlled at 45 ° C, and the reaction pressure is 1 atm. First, 291.4kg of isopropyl acetate is added into the reactor and heated to a predetermined reaction temperature. Dissolve 1.68 kg of catalyst sodium methoxide in 128 kg of methanol, preheat to the set reaction temperature, and then add the methanol solution into the reactor for reaction. After reacting for 1 h, the conversion rate of isopropyl acetate was 69.8%. The yield of isopropanol was 68.7%.