279 results about "Isopropyl acetate" patented technology

The object of the present invention is to discover a combination of preventive or therapeutic drugs for glaucoma or ocular hypertension, which is useful as a preventive or therapeutic agent for glaucoma or ocular hypertension. By combining isopropyl(6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate with other preventive or therapeutic drug for glaucoma or ocular hypertension, their intraocular pressure lowering effects are complemented and/or enhanced each other. As for the administration form, these drugs may be administered concomitantly or may be administered as a combination drug.

A photoresist stripper composition is made up of a mixture of an acetic acid ester, gamma-butyrolactone (GBL), and a non-acetate ester or a poly alkyl alcohol derivative. The acetic acid ester may be at least one of n-butyl acetate, amyl acetate, ethyl aceto-acetate, and isopropyl acetate. The non-acetate ester may be at least one of ethyl lactate (EL), ethyl-3-ethoxy propionate (EEP) and methyl-3-methoxy (MMP). The poly alkyl alcohol derivative may be at least one of propylene glycol monomethyl ester (PGME) and propylene glycol monomethyl ester acetate (PGMEA).

The invention relates to a method for recycling acetic acid from diluted acetic acid, and aims at solving the problem that the recycling of acetic acid in the hydrolysis of furfural and methyl acetate as well as the Fischer-Tropsch combined production is difficult. The invention comprises the steps as follows: a) diluted acetic acid is extracted by a pulse filling extracting tower, the extractionphase containing extracting agent, the acetic acid and little water for the tower top is acquired, and the residual extraction phase of water containing micro acetic acid from the tower kettle is acquired; b) the extraction phase in an extracting agent recycling tower is conveyed; c) acetic acid 1 is fed into an azeotropic rectifying tower which utilizes one kind of benzene, cyclohexane, ethyl acetate, isopropyl acetate and butyl acetate as the extrainer, two-phase mixture of the extrainer and the water at a phase separator at the top of the tower is acquired, the water is extracted out from the tower top, and the retrainer returns into the tower. The utility model has the technical proposal of producing pure acetic acid at the tower top, solves the problems above, and adapts the industrial productions including recycling of acetic acid from wasted aldehyde water and extracting and refining acetic acid in the methyl acetate hydrolysis technique.

The invention relates to a method for refining long-carbon chain dicarboxylic acid. A long-chain dicarboxylic acid crude product prepared by a fermentation method is used as a raw material, acetic acid is used as a solvent, and the refining and purification are performed by recrystallization treatment. The method comprises the process steps of bleaching filtration, cooling crystallization, centrifugal separation, centrifugal material washing, secondary centrifugation and drying, and is characterized in that a. the long-chain dicarboxylic acid crude product to be refined does not need to be dried; b. the acetic acid solvent is recycled by an azeotropic distillation method, and isopropyl acetate is used as an azeotropic dehydrating agent; and c. the isopropyl acetate is used as a centrifugal material washing solvent for replacing the acetic acid. The purification method of the long-carbon chain dicarboxylic acid provided by the invention has the advantages of distillation equipment investment conservation, low operating power consumption, good product color, high purity, high refining yield and low production cost, the long-carbon chain dicarboxylic acid to be refined does not need to be dried and dehydrated, and the acetic acid solvent is completely recyclable. The quality of the refined product can meet the technical requirements of use of condensed monomer raw materials used by synthesis of high polymer materials.

The invention belongs to the technical field of tobacco packing box, and in particular relates to a method for detecting contents of 21 volatile organic compounds (VOC), including benzene, methyl benzene, p-xylene, m-xylene, o-xylene, styrene, methanol, ethanol, acetone, isopropyl alcohol, methyl acetate, normal propyl alcohol, ethyl acetate, butanone, acetic acid isopropyl ester, n-butyl alcohol, propylene glycol monomethyl ether, n-propyl acetate, propylene glycol monoethyl ether, 4-methyl-2-pentanone, butyl acetate, cyclohexanone in a tobacco packing box. The method for detecting 21 volatile organic compounds in the tobacco packing box disclosed by the invention comprises the following steps of: sample pretreatment: preparing a piece of hard box packing paper; cutting and reserving a main packing surface by an area of 22.0cm*5.5cm; rolling the printing surface of the sample inwards to obtain a barrel-shaped part; putting the barrel-shaped part in a headspace bottle; adding 1000mu l of glycerol triacetate; sealing, and implementing a headspace-gas chromatography detection. The method disclosed by the invention is high in sensitivity, high in recovery rate, and excellent in precision of detecting result.

The invention provides a continuous reaction rectification process that isopropyl acetate and methyl alcohol are taken as raw materials to be synthesized into isopropyl alcohol through a trans-esterification method under the existence of basic catalysts such as sodium methylate. According to the invention, a reaction rectification technology is adopted, so that the isopropyl acetate and methyl alcohol are fed from the upper part and the lower part of a reaction section of a reaction rectifying tower respectively to be reacted and separated so as to realize continuous production; and products at the top and the bottom of the reaction rectifying tower are separated and purified by a methyl ester rectifying tower, a sodium methylate rectifying tower, an evaporator and a isopropyl alcohol refining tower, so that isopropyl alcohol is obtained, and raw material and catalyst which are not reacted are recycled at the same time. The continuous reaction rectification process for synthesizing isopropyl alcohol has the characteristics of continuity in operation, low energy consumption, high reaction conversion rate and isopropyl alcohol purity, stable quality, and the like.

[Summary]

[Problem] Provision of a novel compound which is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, that provides a final product simply by extraction-layer-separating, without crystallization and isolation of each intermediate in each step.

[Solving Means] It has been found that the above-mentioned problems can be solved by a particular branched chain-containing aromatic compound.

The invention relates to a transfer printing ink with a release function. The transfer printing ink comprises, by weight, 16 to 25% of a polymethacrylate resin, 1.5 to 2.5% of a cellulose acetate resin, 7 to 30% of a pigment, 50 to 62.5% of a mixed solvent, 0 to 2% of an auxiliary agent, 0 to 1% of matt powder and 0 to 2% of wax powder, wherein the mixed solvent is a mixture of two or more selected from the group consisting of ethyl acetate, n-propyl acetate, isopropyl acetate, n-butyl acetate, toluene, butanone, methyl isobutyl ketone, isopropanol, propylene glycol monomethyl ether and propylene glycol monomethyl ether acetate mixed at any ratio, the auxiliary agent is one or a mixture of more selected from the group consisting of a dispersant, an antistatic agent and an organosilicon leveling agent, the matt powder is gas phase silica, and the wax powder is polymer micro wax powder. The transfer printing ink provided by the invention has all the properties of a traditional transfer printing ink, e.g., pigment concentration, brilliance and good printability and heat resistance, further has excellent release performance and can be used as a release agent in a transfer printing process.

The present invention relates to a process for synthesizing isopropyl acetate and preparation method of its catalyst. Its process adopts fixed bed reactor, uses solid catalyst, and makes reaction under the condition of gas-liquid-solid three-phase reaction, and its solid catalyst includes modified resin catalyst, silica-gel loaded heteropolyacid catalyst, silica-gel loaded phosphoric acid catalyst and super acidic catalyst, its reaction temp. is 80-125 deg.C, propylene pressure is 0.8-1.4 MPa, acetic acid feeding space velocity is 1.0-2.8 h(-1), propylene feeding space velocity is 80-108 hr(-1), and the mole ratio of acetic acid and propylene is 1:1.15-1.80. Said invention also includes the preparation method of the above-mentioned catalysts.

The invention provides a preparation method of isopropanol. The preparation method of isopropanol comprises the following steps: (1) adding conventional strong-acid cation-exchange resin into a low-carbon alcohol solvent, soaking for 8-24 hours at a temperature of 50-150 DEG C, then introducing inert gas in three stages, and obtaining a catalyst applied to hydrolysis reaction of isopropyl acetate after modification is completed; (2) hydrolyzing isopropyl acetate and water in the presence of a strong-acid cation-exchange resin catalyst modified in the step (1) to generate a mixture with isopropyl alcohol and acetic acid, separating the mixture to obtain isopropyl alcohol, and concentrating the acetic acid and then recycling the acetic acid. The method has the advantages of simple processes, high conversion rate and low energy consumption.

Mesitylene is difficult to separate from 1,2,4-Trimethylbenzene because of the proximity of their boiling points. They are readily separated by azeotropic distillation. Effective agents are isopropyl acetate, 2-pentanol and acetonitrile.

The invention provides a preparation method of ethyl acetate and/or isopropyl acetate. Catalytic dry gas from an oil refinery is used as a dilute ethylene and/or dilute propylene raw material and is introduced into a reaction system with a strong solid acidic catalyst to perform an addition esterification reaction so as to produce ethyl acetate and isopropyl acetate. The dry gas required by the method directly comes from a dry gas desulfurization treatment device of the refinery, the addition reaction pressure is low, continuous production of the ethyl acetate and isopropyl acetate can be realized by using dilute ethylene and/or dilute propylene, i.e., low-concentration ethylene and/or propylene, serving as raw material(s), the device investment is saved, the energy consumption is low, and the preparation method belongs to an advanced technology for new utilization of the catalytic dry gas.

The invention relates to a method and apparatus for synthesizing isopropyl acetate by differential thermal coupling reactive distillation. The apparatus comprises: a feeding mixer, a low-pressure reaction column, a high-pressure distillation column, a product refining column, a phase splitter, a separator, a compressor, a thermal coupling heat exchanger, a condenser and an auxiliary reboiler. Theapparatus for synthesizing isopropyl acetate by differential thermal coupling reactive distillation allows synthesis of high-purity isopropyl acetate during distillation process; a traditional reactive distillation column is split into the high-pressure distillation column and the low-pressure reaction column, high-temperature steam at the top of the high-pressure distillation column is used to heat the reboiler of the low-pressure reaction column, the two columns share one heat exchanger, heat of the top steam of the high-pressure distillation column is made full use, and heat efficiency of the process is improved. By synthesizing isopropyl acetate via the differential thermal coupling reactive distillation process, esterification, distillation separation and thermal coupling are integrated; material that is not fully reacted flows back for reuse, so that total conversion rate of a reactant is increased.

The invention discloses a device for preparing isopropyl acetate in a heat pump dividing-wall reactive distillation column, and belongs to the technical field of distillation. The device is the heat pump dividing-wall reactive distillation column for synthesizing isopropyl acetate by taking methyl acetate and isopropanol as raw materials through a transesterification method. According to the process, production of the high-density isopropyl acetate is achieved in the heat pump dividing-wall reactive distillation column, by means of energy coupling of gas-liquid streams in the tower, latent heat of gas on the tower top is fully utilized to supply heat to two bottom reboilers of the dividing-wall reactive distillation tower simultaneously after being subjected to pressurization and temperature rising of a compressor, an external heat source is not needed to supply heat energy, and therefore energy consumption is greatly reduced. Meanwhile, multiple traditional columns for reactive distillation and subsequent separation and purification processes are integrated into one dividing-wall reactive distillation column, and therefore equipment investment is reduced.

The invention discloses a reaction-distillation coupling preparing acetic acid series ester method, which comprises the following steps: using glacial acetic acid and alcohol with lower five carbons (alcohol, optal,alcohol isopropylicum, butanol, isobutanol, amyl alcohol and isoamyl alcohol ) for raw material; adopting modified strong acidic phenylethene series basic ion exchange resin for accelerant; preparing by reaction-distillation coupling; getting acetic acid ethyl ester, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, amyl acetate and iso-amyl acetate; making glacial acetic acid and alcohol with lower five carbons to carry on esterification reaction by solid acid catalysis in trickle bed reactor; adding reaction product (acetic acid ethyl ester, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, amyl acetate and iso-amyl acetate), water and cycle still liquor in fractionating tower; getting acetic acid ethyl ester, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, amyl acetate and iso-amyl acetate by separating at the top of the tower. The conversion rate of alcohol with lower five carbons is more than 96%, the recovery ratio of acetic acid ethyl ester (propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, amyl acetate and iso-amyl acetate) is more than 95%. The invention has high alcohol conversion rate, which simplifies the operation.

The invention discloses a technology for separating ethylene glycol monomethyl ether and water by use of a continuous azeotropic distillation method. The technology comprises the following steps of: 1) an entrainer is added into a tower kettle of an azeotropic distillation tower, the raw material enters the azeotropic distillation tower from the 28th tower plate, the operation reflux ratio is 1-3, and the reflux flows back from the tower top of the azeotropic distillation tower; and after phase splitting, the ester-rich phase enters the azeotropic distillation tower, the water-rich phase enters an entrainer recycling tower, and the product of the tower kettle of the azeotropic distillation tower is ethylene glycol monomethyl ether; and 2) after the water-rich phase enters the entrainer recycling tower, common distillation is carried out, wherein the operation reflux ratio is 1-2.5, and the reflux flows back from the tower top of the entrainer recycling tower; and after phase splitting of the produced liquid, the water-rich phase enters the entrainer recycling tower, and water is contained in the tower kettle of the entrainer recycling tower. By taking isopropyl acetate as an entrainer, the technology disclosed by the invention has the characteristics of low toxicity, low pollution, low cost, high yield, high product purity and the like, has wide application prospect, and is particularly suitable for the fields of pharmacy and the like.

The invention relates to an azeotropic method used in methyl acetate catalyzing rectification hydrolysis, mainly solving the problems of the prior methyl acetate catalyzing rectification hydrolysis process including complex flows and high energy consumption. The azeotropic method solves the problems better through adopting the technical proposal which comprises the following steps that: water and methyl acetate are mixed and fed in a catalyzing rectification tower from the top of the tower; the top of the tower is of total reflux and a mixture comprising methanol, acetic acid and water is obtained inside a tower bottom; the mixture is fed in a dealcoholization tower, and the distillate at the top of the dealcoholization tower is a methanol aqueous solution, while an acetic aqueous solution is obtained inside a tower bottom; the methanol aqueous solution is fed in an alcohol treating tower, and the distillate at the top of the alcohol treating tower is methanol, while waste water is generated inside a tower bottom; the acetic aqueous solution is fed in an azeotropic rectification tower which takes one sort of benzene, cyclohexane, isopropyl acetate and n-butyl acetate as an azeotropic agent; a biphase mixture of the azeotropic agent and water is obtained inside the top phase splitter of the azeotropic rectification tower with the water collected from the top of the tower and the azeotropic agent returned to the inside of the tower, while pure acetic acid is obtained inside the tower bottom of the azeotropic rectification tower. The azeotropic method can be used in the industrial production for reclaiming byproduct methyl acetate during producing polyvinyl alcohol.

A process is provided for preparing a dipeptidyl peptidase IV inhibitor of the structure

wherein

is treated with TFAA in isopropyl acetate to protect the tertiary hydroxyl group as a trifluoroacetate group to form 4

(which is a novel intermediate)

which is converted to acid chloride compound 5

(which is a novel compound)

using Vilsmeier reagent or other chloro reagent and coupled with compound 6 in a heterogeneous mixture of ethyl acetate and aqueous bicarbonate to give compound 7

The N,O-bis(trifluoroacetyl) groups of compound 7 are deprotected to give free base compound 10.

The invention discloses a method for producing isopropyl acetate through a heat pump partition-wall reactive distillation tower and belongs to the technical field of rectification. Isopropanol and methyl acetate are respectively fed into a reaction and separation zone of the heat pump partition-wall reactive distillation tower to be in contact with a catalyst for reaction and separation zone, a vapor-phase mixture of methyl alcohol and methyl acetate flows out of a tower top separation zone and is divided into two ways, one way of mixture is compressed by a compressor and then provides reboiling heat for an isopropyl acetate reboiler at the bottom of the reaction and separation zone, then the way of mixture passes through a throttling valve and then is mixed with the other way of mixture, one part flows back to the tower after condensation, the other part is mixed with the raw material methyl acetate, and the mixture returns to the reaction and separation zone again. The target product high-purity isopropyl acetate is extracted from the lower portion of the reaction and separation zone, and the methyl alcohol is extracted from the lower portion of a methyl alcohol recovery zone. Multiple towers for traditional reaction, rectification and follow-up separation and purification processes are integrated to one partition-wall reactive distillation tower, and device investment is saved.

The invention provides a continuous production device and a continuous production method for isopropyl acetate. The continuous production method for the isopropyl acetate comprises the following steps of: continuously feeding acetic acid and isopropanol in a reactor, and carrying out an esterification reaction under the catalysis of concentrated sulfuric acid to obtain a reaction mixture; feeding the reaction mixture to a reaction rectification tower; carrying out an esterification reaction and rectification when the liquid level exceeds 4/5; feeding one part of an obtained tower-bottom mixture to the reactor, returning the rest part of the obtained tower-bottom mixture to a reaction rectification tower, and keeping the circulation; carrying out condensation and phase separation onto the obtained tower-top mixture in sequence to obtain an isopropyl acetate crude product; feeding the isopropyl acetate crude product to a finished product rectification tower for carrying out rectification and condensation to obtain an isopropyl acetate finished product. The continuous production method for the isopropyl acetate can be used for obviously increasing the front esterification reaction time, so that the ternary azeotropy of reaction rectification tower-top isopropanol, isopropyl acetate and water is relatively stable; the layered interface in the phase slitter is clear, so that the generated water can be automatically separated out, and therefore, a qualified product is obtained in thousand-ton level production.

The present invention pertains generally to the field of coolants and medical therapy. More particularly, the present invention relates to certain anti-nociceptive agents, such as [((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester, that are potent and long-acting and selectively cooling for non-keratinized epithelial tissues as compared to keratinized epithelial tissues, and are useful, for example, for the treatment of (e.g., the alleviation of symptoms of; the amelioration of) sensory discomfort of non-keratinized stratified epithelial (NKSE) tissue; and so for treatment of: sensory discomfort of an ocular surface, an eyelid, a margin of an eyelid, an anterior part of an eyeball, a conjunctiva, a lachrymal system, a pre-corneal film, or a cornea, a lining of the oral cavity, an internal portion of the lips, a pharyngeal surface, an esophageal surface, or an anogenital surface; eye discomfort, e.g., caused by extended wear of contact lenses, by eye strain and/or fatigue, by air pollutants, by excessive exposure to the sun, by conjunctivitis, by dry eye syndrome; sensory discomfort associated with oral mucositis; airway (e.g., larynx, trachea, and/or bronchi) tightness, discomfort in the airways (e.g., larynx, trachea, and/or bronchi), choking, cough, and/or dyspnea, e.g., associated with asthma and/or chronic obstructive pulmonary diseases (COPD).

The invention relates to a method for refining a Gefinitib crystal form I. The method comprises the steps of dissolving a Gefinitib crude product into a mixed solution formed by mixing C2-C5 alcohol with any of acetonitrile, acetone, DMF (Dimethyl Formamide), ethyl formate, methyl tert-butyl ether, methyl acetate, ethyl acetate, propyl acetate and isopropyl acetate according to the volume ratio of (10-1): (1-5), lowering the temperature of a reaction solution, then crystallizing, filtering and drying, thereby obtaining the refined Gefinitib crystal form I, wherein the mass/volume ratio of Gefinitib to the mixed solution is 1: (5-30). The Gefinitib crystal form I prepared by the method has the advantages that the yield is high, the chromatographic purity is basically over 99.5%, and the maximum individual impurity is lower than 0.1%; and the method is simple in preparation and stable in process and is very suitable for large-scale production.