A local fixed-point irradiation device for small animals and its use method

Abstract

The present invention provides a local fixed-point irradiation device for small animals and a method for using the device, comprising a base and two cover plates, wherein the base is provided with a receiving cavity with an open top, and the two cover plates are relatively slidably installed on the upper side of the base and can completely cover the cavity opening of the receiving cavity; the cover plate is provided with a through hole which is open on one side thereof, and the overlapping area of ​​the through holes of the two cover plates can change with the relative sliding of the cover plates, so as to irradiate different body parts of the anesthetized small animal and cover and protect other parts of the body at the same time.

Description

Technical Field

[0001] The present invention relates to the technical field of small animal irradiation, and in particular to a small animal local fixed-point irradiation device and a use method thereof. Background Art

[0002] In existing small animal irradiation for cancer research, when X-rays are irradiated to local tumors in the body, other parts of the body need to be precisely shielded. In the existing market and in the patents currently queried, the local irradiation small animal containers cannot guarantee the size of the area exposed to ionizing rays in various body positions when the local shielding is performed, which affects the accuracy of the test.

[0003] Application number CN202020800U discloses a drawer-type local irradiation device for tumor-bearing mice. The inner shell can be freely drawn inside the outer shell, so the relative position of the inner shell and the outer shell can be adjusted according to the body shape of the tumor-bearing mouse, and the two are completely fixed by a bolt. The tumor site of the tumor-bearing mouse is passed through a through hole arranged on the inner shell, and its irradiation area cannot be adjusted, the shielding effect is poor, and it is necessary to adjust the placement of the mouse to achieve alignment between the tumor and the through hole, which is inconvenient to operate. Summary of the invention

[0004] The purpose of the present invention is to provide a local fixed-point irradiation device for small animals and a method of using the same, which can irradiate different body parts of an anesthetized small animal while covering and protecting other parts of the body.

[0005] The present invention provides the following technical solutions:

[0006] A local fixed-point irradiation device for small animals and a method for using the same, comprising a base and two cover plates, wherein the base is provided with a containing cavity with an open top, and the two cover plates are relatively slidably installed on the upper side of the base and can completely cover the cavity opening of the containing cavity; the cover plate is provided with a through hole that is open on one side thereof, and the overlapping position and area of ​​the through holes of the two cover plates can change with the relative sliding of the cover plates.

[0007] Preferably, the two cover plates are arranged up and down, the perforation is arranged in the middle position of the side of the cover plate, and the two cover plates with the perforation on one side are slidably installed on the base from both sides of the base respectively, and the length of the window formed by the two perforations changes with the sliding of the two cover plates.

[0008] Preferably, the two cover plates are slidably mounted on the base from two sides of the base opposite to the side provided with the through hole, and the distance between the opposite sides of the two cover plates changes as the two cover plates slide.

[0009] Preferably, the two cover plates are arranged up and down, and the perforations of one of the cover plates are offset, and the offset distance is determined according to the position of the animal's limbs. The window area formed between the offset perforations and the other cover plate changes with the sliding of the two cover plates.

[0010] Preferably, the base comprises a bottom plate, a side plate and two end plates, the number of the side plates is at least two, the side plates are arranged parallel to each other and their bottoms are vertically fixed to the bottom plate, and the two end plates are respectively mounted on the two end surfaces of the side plates;

[0011] U-shaped cover plate grooves are relatively arranged above the side walls opposite to each other of the adjacent side vertical plates, and the two sides of the cover plate can be clamped in the two cover plate grooves and slide along the cover plate grooves. Horizontal support plates are also relatively arranged on the inner walls of the two side vertical plates, and the height difference between the support plate and the cover plate groove is greater than the thickness value of the cover plate, and the horizontal position of the top of the end plate is lower than the horizontal position of the upper surface of the support plate;

[0012] When the number of the side upright plates is greater than two, the cover plate groove and the support plate are provided on both side surfaces of the side upright plates arranged in the middle.

[0013] Preferably, the top surface of the side plate and the upper surface of the cover plate are both provided with scales, the scales on the side plate are arranged along the sliding direction of the cover plate, and the scales on the cover plate are arranged at the edge of the perforation;

[0014] When the number of the side panels is greater than two, the number of scales on the top of the side panels is two and corresponds to the cover plate slots on both sides respectively.

[0015] Preferably, the end plate and the side plate can be connected by screws, and the end plate is provided with air holes and long grooves.

[0016] A method for using a local fixed-point irradiation device for small animals, when it is necessary to irradiate the spine of the small animal, comprises the following steps:

[0017] S1. First, anesthetize the mouse and place it flat in the accommodating chamber. Use two cover plates with holes in the middle of the side, place the sides of the two cover plates with holes opposite to each other, then slide one cover plate from the cover plate groove on one side of the side stand plate to the top of the bottom plate, and slide the other cover plate from the other side of the side stand plate along the support plate to the top of the bottom plate;

[0018] S2. Push the two cover plates along the cover plate groove and the support plate toward the middle of the accommodating cavity so that the through holes of the two cover plates are arranged vertically opposite to each other;

[0019] S3. According to the length and position of the spine of the small animal to be irradiated, the size and position of the window formed by the perforations of the two cover plates are adjusted so that the rays can irradiate the spine of the small animal through the window.

[0020] A method for using a local fixed-point irradiation device for small animals, when it is necessary to irradiate a part of the trunk of a small animal, comprises the following steps:

[0021] S1. First, anesthetize the mouse and place it flat in the accommodating cavity, place the two cover plates opposite to each other with the sides of the perforation, and then slide the two cover plates from the opposite sides of the side stand plates along the cover plate grooves or the support plates to install them on the top of the bottom plate;

[0022] S2. Push the two cover plates along the cover plate grooves or the support plates toward the middle of the accommodating cavity;

[0023] S3. According to the position of the trunk of the small animal to be irradiated, the distance and position between the two opposite sides of the cover plates are adjusted so that the rays are irradiated from between the two cover plates to the corresponding position on the trunk of the small animal.

[0024] A method for using a local fixed-point irradiation device for small animals, when it is necessary to irradiate the local limbs of the small animal, comprises the following steps:

[0025] S1. First, anesthetize the mouse and place it flat in the accommodating chamber. Use a cover plate with offset perforations, slide the side of the cover plate with offset perforations from the cover plate groove on one side of the side stand plate to the top of the bottom plate, and slide another cover plate from the other side of the side stand plate along the support plate to the top of the bottom plate;

[0026] S2, push the two cover plates toward the middle of the accommodating cavity along the cover plate groove and the support plate respectively, so that the offset perforation is arranged opposite to the other cover plate surface in the upper and lower directions;

[0027] S3. According to the position of the limbs of the small animal to be irradiated, the size and position of the window formed between the offset perforation and the other cover plate are adjusted by sliding the two cover plates so that the rays can pass through the window to irradiate the corresponding position on the limbs of the small animal.

[0028] The beneficial effects of the present invention are as follows: the present invention arranges two cover plates with perforations, and the relative sliding of the two cover plates realizes the change of the area and position of the perforations, so as to realize irradiation of different body parts of anesthetized small animals, while covering and protecting other parts of the body; the setting of the scale can realize precise control of the size of the exposed part and precise shielding of other parts; a plurality of devices can be used in parallel, which is convenient for setting up comparative experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0030] Figure 1 It is a schematic diagram of the structure of the present invention;

[0031] Figure 2 is a schematic diagram of spinal irradiation of the present invention;

[0032] Figure 3 is a schematic diagram of torso irradiation of the present invention;

[0033] Figure 4 This is a schematic diagram of partial irradiation of limbs of the present invention;

[0034] Figure 5 This is a schematic diagram of using multiple small animal local irradiation devices in parallel according to the present invention;

[0035] The markings in the figure are: 1. bottom plate; 2. side plate; 3. end plate; 4. cover plate; 5. scale; 6. perforation; 7. support plate; 8. cover plate groove. DETAILED DESCRIPTION

[0036] like Figure 1 As shown, a local fixed-point irradiation device for small animals includes a base and two cover plates 4, wherein the cover plates 4 are made of two pieces of lead-containing metal that can be pulled left and right, and the metal can be directly a lead-antimony alloy of a certain thickness, or it can be made by inserting a pure lead rectangular plate of a certain thickness in the middle of an aluminum profile; 3. Except for the cover plates 4, other components can be made of metal or organic materials and then connected by screws.

[0037] like Figure 1-Figure 4 As shown, a receiving cavity with an open top is provided in the base, and two cover plates 4 can be installed on the upper side of the base in a relatively slidable manner and can completely cover the cavity opening of the receiving cavity; a through hole 6 is provided on the cover plate 4 and is open to one side thereof, and the overlapping position and area of ​​the through holes 6 of the two cover plates 4 can change with the relative sliding of the cover plates 4, so as to realize irradiation of different body parts of the anesthetized small animal, while covering and protecting other parts of the body.

[0038] like Figure 1-Figure 5 As shown, the base includes a bottom plate 1, a side plate 2 and two end plates 3. The number of the side plates 2 is at least two. The side plates 2 are arranged parallel to each other and their bottoms are vertically fixed on the bottom plate 1. The two end plates 3 are respectively installed on the two end surfaces of the side plates 2.

[0039] U-shaped cover grooves 8 are relatively arranged above the opposite side walls of adjacent side vertical plates 2. The two sides of the cover plate 4 can be clamped in the two cover plate grooves 8 and slide along the cover plate grooves 8. Horizontal support plates 7 are also relatively arranged on the inner walls of the two side vertical plates 2. The height difference between the support plate 7 and the cover plate groove 8 is greater than the thickness value of the cover plate 4, ensuring that the cover plate 4 slidably placed on the support plate 7 can be set up vertically opposite to the cover plate 4 slidably installed in the cover plate groove 8. The horizontal position of the top of the end plate 3 is lower than the horizontal position of the upper surface of the support plate 7, ensuring that the cover plate 4 can be slidably installed on the base along the support plate 7.

[0040] When the number of side panels 2 is greater than two, cover plate grooves 8 and support plates 7 are provided on both side surfaces of the side panels 2 in the middle. Multiple small animal partial irradiation containers are used in parallel, which can facilitate the simultaneous irradiation of multiple mice in comparative experiments.

[0041] The top surface of the side plate 2 and the upper surface of the cover plate 4 are both provided with scales 5. The scales 5 on the side plate 2 are arranged along the sliding direction of the cover plate 4. The scales 5 on the cover plate 4 are arranged at the edge of the perforation 6, so that the size of the exposed part can be accurately controlled.

[0042] When the number of the side upright plates 2 is greater than two, the number of the scales 5 on the top of the side upright plates 2 is two and they correspond to the cover plate grooves 8 on both sides respectively.

[0043] The end plate 3 and the side plate 2 can be connected by screws. The end plate 3 is provided with air holes and long grooves. The air holes are used for small animals to breathe, and the long grooves are used for passing the tails of the animals.

[0044] A working process of a small animal local fixed-point irradiation device is as follows Figure 2 As shown:

[0045] The two cover plates 4 are arranged up and down, that is, they are slidably installed in the support plate 7 and the cover plate groove 8 respectively. The through hole 6 is arranged in the middle position of the side of the cover plate 4, opposite to the spine position of the small animal. When installing, the two cover plates 4 are provided with the side of the through hole 6 and are slidably installed on the base from the two sides of the base respectively. The length and position of the window formed by the two through holes 6 change with the sliding of the two cover plates 4 to expose the spine position of the mouse and cover other parts.

[0046] A method for using the above-mentioned small animal local fixed-point irradiation device comprises the following steps:

[0047] S1. First, anesthetize the mouse and place it flat in the accommodating chamber. Use two cover plates 4 with perforations 6 in the middle of the side, place the sides of the two cover plates 4 with perforations 6 opposite to each other, then slide one cover plate 4 from the cover plate groove 8 on one side of the side stand 2 to the top of the bottom plate 1, and slide the other cover plate 4 from the other side of the side stand 2 along the support plate 7 to the top of the bottom plate 1;

[0048] S2, push the two cover plates 4 along the cover plate groove 8 and the support plate 7 toward the middle of the accommodating cavity, so that the through holes 6 of the two cover plates 4 are arranged vertically opposite to each other;

[0049] S3. According to the length and position of the spine of the small animal to be irradiated, the scale 5 on the cover plate 4 is used to adjust the size and position of the window surrounded by the perforations 6 of the two cover plates 4 so that the rays can irradiate the spine of the small animal through the window.

[0050] Another working process of a small animal local fixed-point irradiation device is as follows: Figure 3 As shown:

[0051] The two cover plates 4 are slidably installed on the base from both sides of the base on the side opposite to the through hole 6. They can be installed on the cover plate groove 8 and the support plate 7 at the same time, or they can be installed on the cover plate groove 8 and the support plate 7 respectively. The distance between the opposite sides of the two cover plates 4 changes with the sliding of the two cover plates 4 to expose the torso position of the mouse and cover other positions.

[0052] A method for using the above-mentioned small animal local fixed-point irradiation device comprises the following steps:

[0053] S1. First, anesthetize the mouse and place it flat in the accommodating cavity, place the two cover plates 4 opposite to the sides of the through hole 6, and then slide the two cover plates 4 from the opposite sides of the side stand 2 along the cover plate groove 8 or the support plate 7 to install them on the top of the bottom plate 1;

[0054] S2, push the two cover plates 4 along the cover plate grooves 8 or the support plates 7 toward the middle of the accommodating cavity;

[0055] S3. According to the position of the trunk of the small animal to be irradiated, the distance and position between the opposite sides of the two cover plates 4 are adjusted so that the rays are irradiated from between the two cover plates 4 to the corresponding position on the trunk of the small animal.

[0056] Another working process of a small animal local fixed-point irradiation device is as follows: Figure 4 As shown:

[0057] Two cover plates 4 are arranged up and down, and the perforation 6 of one of the cover plates 4 is offset, and the other cover plate 4 is slidably installed on the base on the side opposite to the perforation 6. The offset distance is determined according to the position of the animal's limbs. The window area formed between the offset perforation 6 and the other cover plate 4 changes with the sliding of the two cover plates 4 to expose the limbs of the small animal and cover other parts.

[0058] A method for using the above-mentioned small animal local fixed-point irradiation device comprises the following steps:

[0059] S1. First, anesthetize the mouse and place it flat in the accommodating chamber. Use a cover plate 4 with an offset perforation 6, slide the side of the cover plate 4 with the offset perforation 6 from the cover plate groove 8 on one side of the side stand 2 to install it on the top of the bottom plate 1, and slide the other cover plate 4 from the other side of the side stand 2 along the support plate 7 to install it on the top of the bottom plate 1;

[0060] S2, push the two cover plates 4 along the cover plate groove 8 and the support plate 7 to the middle of the accommodating cavity, so that the offset perforation 6 is arranged opposite to the other cover plate 4 in the upper and lower directions;

[0061] S3. According to the position of the limbs of the small animal to be irradiated, the two cover plates 4 are slid to adjust the size and position of the window formed between the offset perforation 6 and the other cover plate 4, so that the rays can pass through the window to irradiate the corresponding position on the limbs of the small animal.

[0062] The present invention is provided with two cover plates 4 with perforations 6, and the area and position of the perforations 6 are changed by relative sliding of the two cover plates 4, so as to irradiate different body parts of the anesthetized small animal, while covering and protecting other parts of the body; the setting of the scale 5 can realize precise control of the size of the exposed part and precise shielding of other parts; multiple devices can be used in parallel, which is convenient for setting up comparative experiments.

[0063] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention is described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A local fixed-point irradiation device for experimental small animals, characterized in that: The invention comprises a base and two cover plates, wherein the base is provided with a receiving cavity with an open top, and the two cover plates are relatively slidably mounted on the upper side of the base and can completely cover the cavity opening of the receiving cavity; the cover plate is provided with a through hole with an open top on one side thereof, and the overlapping position and area of ​​the through holes of the two cover plates can change with the relative sliding of the cover plates; When the spine of a small animal needs to be irradiated, the perforation is arranged in the middle position of the side of the cover plate, and the two sides of the cover plates provided with the perforation are slidably installed on the base from the two sides of the base, so that the length of the window formed by the two perforations changes with the sliding of the two cover plates; When it is necessary to irradiate a part of the trunk of the small animal, the through hole is set in the middle position of the side of the cover plate, and the two cover plates are slidably installed on the base from the two sides of the base opposite to the side where the through hole is set, so that the distance between the opposite sides of the two cover plates changes with the sliding of the two cover plates; When local irradiation of the limbs of a small animal is required, the perforation of one of the cover plates is offset, and the offset distance is determined according to the position of the animal's limbs. The window area formed between the offset perforation and the other cover plate changes as the two cover plates slide.

2. The local fixed-point irradiation device for experimental small animals according to claim 1, characterized in that: The base comprises a bottom plate, a side plate and two end plates, the number of the side plates is at least two, the side plates are arranged parallel to each other and the bottoms thereof are vertically fixed to the bottom plate, and the two end plates are respectively mounted on the two end surfaces of the side plates; U-shaped cover plate grooves are relatively arranged above the side walls opposite to each other of the adjacent side vertical plates, and the two sides of the cover plate can be clamped in the two cover plate grooves and slide along the cover plate grooves. Horizontal support plates are also relatively arranged on the inner walls of the two side vertical plates, and the height difference between the support plate and the cover plate groove is greater than the thickness value of the cover plate, and the horizontal position of the top of the end plate is lower than the horizontal position of the upper surface of the support plate; When the number of the side upright plates is greater than two, the cover plate groove and the support plate are provided on both side surfaces of the side upright plates arranged in the middle.

3. The local fixed-point irradiation device for experimental small animals according to claim 2, characterized in that: The top surface of the side plate and the upper surface of the cover plate are both provided with scales, the scales on the side plate are arranged along the sliding direction of the cover plate, and the scales on the cover plate are arranged at the edge of the perforation; When the number of the side upright plates is greater than two, the number of scales on the top of the side upright plates is two and they respectively correspond to the cover plate grooves on both sides.

4. The local fixed-point irradiation device for experimental small animals according to claim 2, characterized in that: The end plate and the side plate can be connected by screws, and the end plate is provided with air holes and long grooves.

5. A method for using the local fixed-point irradiation device for experimental small animals according to claim 2, characterized in that: When irradiation of the spine of a small animal is required, the following steps are involved: S1. First, anesthetize the mouse and place it flat in the accommodating chamber. Use two cover plates with holes in the middle of the side, place the sides of the two cover plates with holes opposite to each other, then slide one cover plate from the cover plate groove on one side of the side stand plate to the top of the bottom plate, and slide the other cover plate from the other side of the side stand plate along the support plate to the top of the bottom plate; S2. Push the two cover plates along the cover plate groove and the support plate toward the middle of the accommodating cavity so that the through holes of the two cover plates are arranged vertically opposite to each other; S3. According to the length and position of the spine of the small animal to be irradiated, the size and position of the window formed by the perforations of the two cover plates are adjusted so that the rays can irradiate the spine of the small animal through the window.

6. A method for using the local fixed-point irradiation device for experimental small animals according to claim 2, characterized in that: When it is necessary to irradiate a small animal's trunk, the following steps are included: S1. First, anesthetize the mouse and place it flat in the accommodating cavity, place the two cover plates opposite to each other with the sides of the perforation, and then slide the two cover plates from the opposite sides of the side stand plates along the cover plate grooves or the support plates to install them on the top of the bottom plate; S2. Push the two cover plates along the cover plate grooves or the support plates toward the middle of the accommodating cavity; S3. According to the position of the trunk of the small animal to be irradiated, the distance and position between the two opposite sides of the cover plates are adjusted so that the rays are irradiated from between the two cover plates to the corresponding position on the trunk of the small animal.

7. A method for using the local fixed-point irradiation device for experimental small animals according to claim 2, characterized in that: When local irradiation of the limbs of small animals is required, the following steps are included: S1. First, anesthetize the mouse and place it flat in the accommodating chamber. Use a cover plate with offset perforations, slide the side of the cover plate with offset perforations from the cover plate groove on one side of the side stand plate to the top of the bottom plate, and slide another cover plate from the other side of the side stand plate along the support plate to the top of the bottom plate; S2, push the two cover plates toward the middle of the accommodating cavity along the cover plate groove and the support plate respectively, so that the offset perforation is arranged opposite to the other cover plate surface in the upper and lower directions; S3. According to the position of the limbs of the small animal to be irradiated, the size and position of the window formed between the offset perforation and the other cover plate are adjusted by sliding the two cover plates so that the rays can pass through the window to irradiate the corresponding position on the limbs of the small animal.

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