The invention discloses a lifting type sealing and anti-blocking guide chute which comprises a chute body, a material discharging port, a spray nozzle, a buffer board, an adjusting rod, an adjusting bolt, fixing baffles, sliding rails, a movable chute body, a sealing strip, a pull rod, a driving device, a dustproof curtain and a material receiving belt. The top cover of the chute body is of an arc shape, the material discharging port, the spay nozzle and the buffer board are arranged on the top cover of the chute body, the buffer board is supported through the adjusting rod, the adjusting bolt is arranged on the side wall of the chute body, the inclination of the adjusting rod is adjusted through the adjusting bolt to enable materials to be buffered and drop in correct positions, the sliding rails are arranged on the two sides of the chute body, the movable chute body is arranged on the lower portion of the chute body, the movable chute is shaped like a Chinese character 'ji' and formed by the baffles arranged on the two sides and the rear side of the chute body, the pull rod is arranged on the movable chute body, the sealing strip is arranged on the bottom of the movable chute body, and the pull rod is provided with the driving device. The lifting type sealing and anti-blocking guide chute prevents materials from stacking and blocking, is easy and convenient to set, and reduces dust and splashed material dregs brought by falling of materials.