Method for the preparation of medicinal plant aerosol particles

Abstract

The application provides a preparation method of medicinal plant atomized particles. The preparation method of the medicinal plant atomized particles comprises the following steps: selecting a medicinal part of a medicinal plant for decocting operation, separating a plant liquid and residues after decocting; distilling the plant liquid to obtain medicinal volatile oil and an aqueous solution; distilling and concentrating the aqueous solution to obtain a concentrated aqueous solution; drying the residues, and then grinding the dried residues to obtain medicinal residue powder; mixing the medicinal volatile oil, the concentrated aqueous solution and the medicinal residue powder according to a preset proportion, and performing granulation operation to obtain to-be-atomized particles; and placing the to-be-atomized particles into an atomization device for atomization administration. The preparation method of the medicinal plant atomized particles has the effects of less dosage, faster effect and more convenient use.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of drug delivery methods, in particular to a preparation method of medicinal plant atomized particles. BACKGROUND

[0002] Medicinal plants are also known as Chinese herbal medicines. The efficacy of Chinese herbal medicines is increasingly valued in the world today. Chinese acupuncture and decoction of Chinese herbal medicines have been introduced to many parts of the world. The researchability of Chinese medicines provides us with many different plasticities. Chinese medicines are generally prepared by two methods. One is decoction according to the prescription given by a Chinese medicine expert. The other is the method of medicinal liquor. There are many studies on these two methods in China. China is the birthplace of Chinese herbal medicines. There are about 12000 kinds of medicinal plants in China, which other countries do not have. We have a monopoly advantage in Chinese medicine resources.

[0003] However, modern Chinese herbal medicines and decoctions are not easily accepted by the public. The traditional Chinese herbal medicine delivery technology is inconvenient and slow in effect. The two delivery methods are as follows: 1. Sun-dried decoction for oral administration of aqueous solution, paste, and pill; 2. Extracting effective components and taking carriers for oral administration. Both of the above two delivery methods are absorbed through the digestive system, and the dosage is large, the effect is slow, and the patient's body cannot be improved quickly and conveniently. At the same time, the carrying and taking of the medicine are troublesome, and there is no any portability. SUMMARY

[0004] The purpose of the present application is to overcome the shortcomings of the prior art and provide a preparation method of medicinal plant atomized particles with less dosage, fast effect and more convenient use.

[0005] The purpose of the present application is achieved by the following technical solutions:

[0006] A preparation method of medicinal plant atomized particles, comprising the following steps:

[0007] Selecting medicinal parts of medicinal plants for decoction operation, and separating plant liquid and residue after decoction;

[0008] Distilling the plant liquid to obtain medicinal volatile oil and aqueous solution;

[0009] Concentrating the aqueous solution by distillation to obtain concentrated aqueous solution;

[0010] Drying the residue, and then grinding the dried residue to obtain medicinal residue powder;

[0011] Mixing the medicinal volatile oil, the concentrated aqueous solution and the medicinal residue powder in a predetermined proportion, and performing granulation operation to obtain the to-be-atomized particles;

[0012] The particles to be atomized are placed in an atomizing device for atomization administration.

[0013] In one embodiment, the distillation and concentration operation specifically includes the following steps:

[0014] The aqueous solution is concentrated by distillation under reduced pressure to obtain a preliminary concentrated solution;

[0015] using a sugar-precipitating organic solvent to precipitate sugars from the preliminary concentrated solution;

[0016] The preliminary concentrated liquid is centrifuged to remove the precipitate and obtain the supernatant;

[0017] performing a column sugar removal operation on the supernatant;

[0018] An organic solvent is used to perform a column washing operation to elute the effective medicinal component, namely the concentrated aqueous solution.

[0019] In one embodiment, after the step of performing a column sugar removal operation on the supernatant and before the step of performing a column washing operation with an organic solvent to elute the effective medicinal ingredients, i.e., the step of concentrating the aqueous solution, the distillation concentration operation further includes the following steps:

[0020] The organic solvent is removed by distillation under reduced pressure.

[0021] In one embodiment, the sugar precipitation organic solvent is ethanol.

[0022] In one embodiment, the organic solvent is an ethanol solution.

[0023] In one embodiment, the column sugar removal operation uses a resin precipitation column to remove sugar.

[0024] In one embodiment, before the step of selecting the medicinal part of the medicinal plant for decoction and separating the plant liquid and the residue after decoction, the method for preparing the medicinal plant atomized particles further comprises the following steps:

[0025] The medicinal plants are cleaned by using a low-frequency ultrasonic method.

[0026] In one embodiment, after the step of washing the medicinal plant using a low-frequency ultrasonic method and before the step of decocting the medicinal part of the medicinal plant and separating the plant liquid and the residue after decoction, the method for preparing the medicinal plant atomized particles further includes the following steps:

[0027] The medicinal plants are subjected to a ventilation and odor removal operation.

[0028] In one embodiment, the ventilation and odor removal operation lasts for 10 hours to 24 hours.

[0029] In one embodiment, the mass ratio of the drug volatile oil, the concentrated aqueous solution and the drug residue powder is 2:3:5.

[0030] Compared with the prior art, the present invention has at least the following advantages:

[0031] 1. In the method for preparing aerosolized medicinal plant particles of the present invention, the medicinal portion of the medicinal plant is first decocted to extract the majority of the medicinal components into a plant liquid, which is then distilled and concentrated to obtain a higher concentration of the medicinal components and effectively remove useless or harmful substances from the medicinal plant, thereby improving the medicinal effect of the medicinal plant. Furthermore, the residue separated after decocting is dried and then ground. The ground medicinal residue powder is mixed with a medicinal volatile oil and a concentrated aqueous solution in a predetermined ratio and granulated. The medicinal residue powder and the concentrated aqueous solution are then aerosolized together, effectively increasing the utilization rate of the medicinal plant and enhancing the medicinal effect of the medicinal plant.

[0032] 2. The preparation method of the medicinal plant atomized particles of the present invention extracts the main active ingredients of the medicinal plants through an atomizing device, which are absorbed through the respiratory tract and directly enter the blood. The dosage is small and the effect is fast, which improves the human body's absorption efficiency of the active ingredients of Chinese herbal medicine and is conducive to quickly improving the body's condition. Moreover, by carrying an atomizing device that stores the atomized particles, it is convenient to take the medicine and the portability of the medicine is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0034] Figure 1 This is a flow chart of a method for preparing aerosolized medicinal plant particles according to one embodiment of the present invention;

[0035] Figure 2 for Figure 1 Flow chart of the distillation and concentration operation in the method for preparing aerosolized particles of medicinal plants;

[0036] Figure 3 for Figure 1 A partial schematic diagram of an atomization device in a method for preparing atomized particles of medicinal plants is shown;

[0037] Figure 4 for Figure 1 A chromatogram showing the detection of components of aerosol release in the preparation method of the medicinal plant aerosol particles shown;

[0038] Figure 5 for Figure 1 A diagram showing the test results of the effect of aerosol release on phagocytes in the preparation method of aerosolized medicinal plant particles;

[0039] Figure 6 for Figure 1 A diagram showing the test results of the effect of aerosol release on bronchial alveolar epithelial cells in the preparation method of the medicinal plant aerosol particles shown;

[0040] Figure 7 for Figure 1 The diagram shows the results of animal testing of aerosol release materials in the preparation method of the medicinal plant aerosol particles shown. DETAILED DESCRIPTION

[0041] To facilitate understanding of the present invention, the present invention will be described more fully below with reference to the accompanying drawings. The accompanying drawings illustrate preferred embodiments of the present invention. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the present disclosure.

[0042] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly attached to the other element or there may be an intermediate element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only implementation methods.

[0043] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used herein in the specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0044] The present application provides a method for preparing aerosolized particles of medicinal plants. The above-mentioned method for preparing aerosolized particles of medicinal plants includes the following steps: selecting the medicinal part of the medicinal plant for decoction, separating the plant liquid and the residue after decoction; distilling the plant liquid to obtain a medicinal volatile oil and an aqueous solution; distilling and concentrating the aqueous solution to obtain a concentrated aqueous solution; drying the residue, and then grinding it after drying to obtain a medicinal residue powder; mixing the medicinal volatile oil, the concentrated aqueous solution and the medicinal residue powder in a preset proportion and granulating them to obtain particles to be aerosolized; placing the particles to be aerosolized into an aerosolizing device for aerosol administration. It should be noted that the materials in the aerosol administration method of the present application are not only medicinal plants, but can also be edible plants and the like.

[0045] In the above-mentioned method for preparing aerosolized particles of medicinal plants, the medicinal part of the medicinal plant is first decocted to extract most of the medicinal ingredients into the plant liquid, and then the plant liquid is distilled and concentrated to obtain a higher concentration of medicinal ingredients and effectively remove useless or harmful substances in the medicinal plant, thereby improving the medicinal effect of the medicinal plant. Furthermore, the residue separated after decoction is dried and then ground. The ground medicinal residue powder is mixed with medicinal volatile oil and concentrated aqueous solution in a preset ratio and granulated. The medicinal residue powder and concentrated aqueous solution are then aerosolized together, thereby effectively improving the utilization rate of the medicinal plant and enhancing the medicinal effect of the medicinal plant. Furthermore, the main active ingredients of the medicinal plant are extracted by an atomizing device and atomized for administration through the respiratory tract, directly entering the blood, with a small dosage and rapid effect, which improves the human body's absorption efficiency of the active ingredients of Chinese herbal medicine and facilitates rapid improvement of physical condition. Moreover, by carrying an atomizing device that stores aerosolized particles, it is convenient to take the medicine and also improves the portability of the medicine.

[0046] See also Figure 1 In order to better understand the preparation method of the medicinal plant atomized particles of the present application, the preparation method of the medicinal plant atomized particles of the present application is further explained below. The preparation method of the medicinal plant atomized particles of one embodiment includes the following steps:

[0047] S100, selecting medicinal parts of medicinal plants for decoction, and separating the decoction to obtain plant fluid and residue.

[0048] In the present embodiment, the medicinal plant selected for cleaning is sheared, and then the sheared medicinal part is placed in a decoction device and decocts, thereby extracting most of the medicinal ingredients into the plant liquid. After decoction is completed, the plant liquid and the residue are separated, so that the plant liquid and the residue are further processed respectively. Further, in the process of decoction, the plant liquid is not boiled before using a high heat, and after boiling, a slow fire-low heat is used to keep a micro-boiling state, so as to avoid the juice overflowing or drying up too quickly, slowing down the evaporation of water, and helping the dissolution of the effective ingredient. As for the control of heat and time, it depends mainly on the property and quality of different medicines. In the decoction process, the pot lid is opened as little as possible to avoid the volatilization of the medicinal taste. In the present embodiment, heat refers to the firepower size and the speed of the fire (high heat and rapid fire are called high heat, and low heat and slow fire are called slow heat).

[0049] S200, distilling the plant liquid to obtain medicinal volatile oil and aqueous solution.

[0050] It is understood that after decoction, the main components of the medicinal parts of medicinal plants are extracted into the plant liquid. However, only a portion of the plant liquid has effective pharmacological functions, while the rest is useless or harmful substances in the medicinal plant. To further extract the components in the plant liquid, in this embodiment, the plant liquid is transported to a distillation device for distillation. The different boiling points of the mixed liquid, that is, the components in the plant liquid, are utilized to evaporate the low-boiling-point components, which are then condensed to separate the entire components. Compared with other separation methods, such as extraction, filtration and crystallization, the advantage of the distillation operation in this embodiment is that it does not require the use of solvents other than the system components, thereby ensuring that no new impurities are introduced.

[0051] S300, performing a distillation and concentration operation on the aqueous solution to obtain a concentrated aqueous solution.

[0052] It is understood that the purpose of the distillation operation is to collect the volatilized vapor. By performing a distillation operation on the plant liquid, the substances with different volatility in the plant liquid can be separated as thoroughly as possible, and then the vapor is condensed into a liquid, i.e., a medicinal volatile oil. However, after the plant liquid is distilled, not only the medicinal volatile oil is obtained, but also a portion of aqueous solution remains. In the aqueous solution, there may be some medicinal components that have not been volatilized. In order to extract the medicinal components present in the remaining aqueous solution, in this embodiment, after the plant liquid is distilled to obtain the medicinal volatile oil and the aqueous solution, the aqueous solution is then subjected to a distillation and concentration operation, thereby separating the non-volatile or difficult-to-volatilize medicinal components from the volatile solvent to obtain a concentrated aqueous solution with a certain density, that is, the aqueous solution remaining after the distillation is further improved, thereby improving the extraction rate of the medicinal components in the medicinal plant.

[0053] S400, drying the residue, and then grinding it to obtain drug residue powder.

[0054] It is understood that the medicinal parts of the medicinal plants are first decocted to extract most of the medicinal components into the plant liquid, and then the plant liquid is distilled and concentrated to obtain a higher concentration of medicinal components and effectively remove useless or harmful substances in the medicinal plants, thereby improving the medicinal effects of the medicinal plants. After the medicinal plants are decocted, a large amount of residue remains in addition to the plant liquid. Some medicinal components that cannot be separated by decoction remain in the residue. If the residue is directly discarded, it is easy to cause waste and also reduce the efficacy of the medicinal plants. In order to further improve the utilization rate and efficacy of the medicinal plants, in this embodiment, the separated residue is dried to remove some water. At the same time, the drying temperature is controlled at 70°C and the drying time is controlled at 80-90 minutes to control the moisture content of the residue to below 7%. After drying, it is then ground to obtain a medicinal residue powder, which is convenient for subsequent atomization operation, further improving the utilization rate and efficacy of the medicinal plants.

[0055] S500: Mix the drug volatile oil, concentrated aqueous solution and drug residue powder according to a preset ratio and perform a granulation operation to obtain particles to be atomized.

[0056] It is understood that by decocting the medicinal part of the medicinal plant, the plant liquid and the residue are separated after decocting, and then the plant liquid is distilled to obtain the drug volatile oil and the aqueous solution, and then the aqueous solution is evaporated and concentrated to obtain the concentrated aqueous solution, and finally the residue is dried, and then ground after drying to obtain the drug residue powder. The above operation can effectively improve the purity of the medicinal plant, and is also conducive to improving the mixing uniformity of the drug volatile oil, the concentrated aqueous solution and the drug residue powder. In order to facilitate atomization and improve the atomization of the drug components, in this embodiment, the drug volatile oil, the concentrated aqueous solution and the drug residue powder are mixed in a preset ratio and granulated, so that the drug volatile oil, the concentrated aqueous solution and the drug residue powder can be fully and evenly mixed together, which is convenient for subsequent atomization, and effectively improves the atomization of the drug components. Furthermore, by mixing the drug residue powder with the drug volatile oil and the concentrated aqueous solution in a preset proportion and performing a granulation operation, and then placing it in an atomization device for atomization operation, the problem of volatile oil as atomized particles easily leaking in the atomization device in the prior art can be solved. The drug residue powder can reduce the solvent ratio and prevent oil leakage during the atomization process.

[0057] S600: placing the particles to be atomized into an atomization device for atomization administration.

[0058] In the embodiment, the main effective components of medicinal plants are extracted by the atomization device, and are administered by atomization to be absorbed by respiratory tract, directly enter blood, and have less dosage, fast effect, improved absorption efficiency of effective components of Chinese herbal medicine by human body, and benefit to rapidly improve body state; and the atomization device carrying and storing atomized particles improves portability of medicine.

[0059] In one of the embodiments, the mass ratio of the medicinal volatile oil, the concentrated aqueous solution and the medicinal residue powder is 2:3:5. In the embodiment, the medicinal residue powder can be used as an enrichment matrix, and the medicinal residue powder, the medicinal volatile oil and the concentrated aqueous solution are from the same medicinal plant, and have good compatibility, so as to improve the enrichment efficiency, and meanwhile, other complex components are not introduced as the matrix, and the safety of the atomized particles is improved. Further, the mass ratio of the medicinal volatile oil, the concentrated aqueous solution and the medicinal residue powder has great influence on the enrichment degree of the effective components in the medicinal plant. When the mass ratio of the medicinal volatile oil, the concentrated aqueous solution and the medicinal residue powder is 2:3:5, the enrichment capacity of the medicinal residue powder is effectively improved, the accumulation of the medicinal effective components in the atomized particles is improved, so as to effectively improve the atomization and the medicinal effect of the atomized particles.

[0060] Further, the cotton and the fiber are added in the atomized mixture of the medicinal volatile oil, the concentrated aqueous solution and the medicinal residue powder. In the embodiment, by dispersing a small amount of the cotton and the fiber in the atomized mixture, the oil conductivity and the flowability of the atomized mixture are improved, so as to improve the atomization sustainability in the atomization process, and prevent the problems of oil leakage or dry burning in the atomization process.

[0061] Further, as shown in FIG. 1, the atomized particles are stored in the atomization device, and the atomization device is provided with a carrying strap, so as to improve the portability of the atomized particles. Figure 3As shown, the atomizing device 10 includes a housing 100 with a receiving space, a heat-conducting component 200 and a heat-insulating member 300, wherein the atomized mixture 400 is placed in the receiving space, and the atomized mixture 400 is in contact with the heat-conducting component 200, the heat-conducting component 200 includes a heat-conducting member 210 and a heat-conducting ceramic 220, the heat-conducting ceramic 220 is sleeved on the heat-conducting member 210, and the heat-insulating member 300 is arranged on the outside of the housing 100. It can be understood that the existing heat-conducting component 200 is generally inserted into the atomized mixture 400 to heat without burning to achieve the atomization effect. However, since this method requires the heating element to be repeatedly inserted into the atomized mixture 400, the heating element is susceptible to wear and tear, and is prone to local overheating and the release of harmful substances. In order to improve the safety and atomization effect during the atomization process, in this embodiment, the atomized mixture 400 is in contact with the heat-conducting component 200. The heat-conducting component 200 includes a heat-conducting part 210 and a heat-conducting ceramic 220. The heat-conducting ceramic 220 is sleeved on the heat-conducting part 210. Since the atomized mixture 400 in this embodiment has good enrichment and oil conductivity, the heat-conducting ceramic 220 generates heat uniformly, and the atomized mixture 400 can be continuously and uniformly atomized, effectively improving the atomization effect. At the same time, the wear of the heating element and the problem of local overheating are avoided, thereby improving the safety of the atomization process.

[0062] In one embodiment, the distillation and concentration operation specifically includes the following steps:

[0063] S310, performing a vacuum distillation and concentration operation on the aqueous solution to obtain a preliminary concentrated solution.

[0064] In this embodiment, vacuum distillation and concentration involve evaporating the solution by applying a vacuum to the interior of a sealed container, thereby lowering the boiling point. This vacuum distillation of an aqueous solution can prevent or reduce the decomposition of heat-sensitive substances; increase the heat transfer temperature difference (Δtm), enhancing the evaporation process; and continuously remove solvent vapor, facilitating smooth evaporation. Furthermore, the boiling point is lowered, allowing heating using low-pressure steam or exhaust gas. The resulting preliminary concentrated solution contains a high content of medicinal ingredients.

[0065] S320, using a sugar precipitation organic solvent to precipitate sugar in the preliminary concentrated solution.

[0066] It is understood that if the sugar content in the preliminary concentrate is too high, the viscosity of the concentrate will increase, thereby affecting the subsequent atomization effect of the concentrate; in addition, sugar compounds cannot be atomized, thereby affecting the atomization effect of the drug. In order to reduce or remove the sugar content in the preliminary concentrate, in this embodiment, a sugar-precipitating organic solvent is used to precipitate the sugar in the preliminary concentrate. By reducing the dielectric constant of the aqueous solution, the polysaccharide is dehydrated to produce a precipitate to separate the polysaccharide, allowing the sugar to be fully precipitated from the preliminary concentrate, thereby achieving the effect of reducing or removing the sugar content in the preliminary concentrate.

[0067] S330, centrifuging the preliminary concentrated solution to remove the precipitate and taking the supernatant.

[0068] It is understood that the non-volatile or hardly volatile medicinal ingredients are separated from the volatile solvent through the vacuum distillation concentration and sugar separation operations, and a partial precipitate is generated. To fully remove the precipitate and obtain a pure concentrate, in this embodiment, the preliminary concentrate is centrifuged using a centrifugal device to effectively separate the concentrate from the precipitate, and then the sediment is removed, and the supernatant is collected for later use.

[0069] S340, performing a column-based sugar removal operation on the supernatant.

[0070] It is understood that after the sugar separation operation using the sugar separation organic solvent, sugars have been precipitated from the preliminary concentrate, and some of the sugars are dissolved in the supernatant. To further remove sugars from the supernatant, in this embodiment, the supernatant is subjected to a column sugar removal operation, where sugar compounds in the supernatant are separated using a specific chromatographic column, thereby achieving the effect of sugar removal and enrichment of medicinal ingredients.

[0071] S350, using an organic solvent to perform column washing operation to elute to obtain effective medicinal ingredients, i.e., concentrated aqueous solution.

[0072] In this embodiment, the organic solvent is pressure-flowed through a chromatographic column that has separated the carbohydrate compounds and enriched the medicinal components. The residue in the chromatographic column is dissolved in the organic solvent and backflushed out along with the organic solvent, thereby eluting the effective medicinal components, i.e., a concentrated aqueous solution.

[0073] In one embodiment, after the step of performing a column sugar removal operation on the supernatant, and before the step of performing a column washing operation with an organic solvent to elute the effective medicinal ingredients, i.e., the concentrated aqueous solution, the distillation and concentration operation further includes the following steps: performing an organic solvent removal operation by vacuum distillation. It is understandable that by performing a column washing operation with an organic solvent, the effective medicinal ingredients, i.e., the concentrated aqueous solution, can be eluted. However, the organic solvent used in the column washing operation is likely to remain in the concentrated aqueous solution at this time. In order to remove the organic solvent in the concentrated aqueous solution, in this embodiment, the concentrated aqueous solution is subjected to a vacuum distillation operation by a vacuum distillation device to separate and remove the organic solvent in the concentrated aqueous solution, thereby ensuring the effective medicinal ingredients in the concentrated aqueous solution.

[0074] In one embodiment, the sugar analysis organic solvent is ethanol.It is understandable that the sugar in the preliminary concentrated solution is subjected to a precipitation operation using a sugar analysis organic solvent, and the polysaccharide is dehydrated by reducing the dielectric constant of the aqueous solution to produce a precipitate to separate the polysaccharide, so that sugar is fully separated from the preliminary concentrated solution, achieving the effect of reducing or removing sugar in the preliminary concentrated solution. In order to further improve the sugar analysis effect, reduce or remove the carbohydrate compounds in the preliminary concentrated solution, in the present embodiment, the sugar analysis organic solvent is ethanol, and ethanol can play a good dissolution effect in the preliminary concentrated solution. A certain amount of ethanol is added to the aqueous solution containing carbohydrate compounds, thereby reducing the solubility of the solute and allowing it to precipitate and absorb. Specifically, when ethanol is added to the solution, the dielectric constant of the medium is reduced, the electrostatic attraction between the solute molecules increases, and aggregation forms a precipitate, thereby further improving the sugar analysis effect, reducing or removing the carbohydrate compounds in the preliminary concentrated solution.

[0075] In one embodiment, the organic solvent is an ethanol solution. In this embodiment, the organic solvent is mainly used to clean the chromatographic column after sugar analysis. The organic solvent flows through the chromatographic column that has separated the sugar compound and enriched the medicinal ingredients by pressure. The residue in the chromatographic column is dissolved in the organic solvent and is backwashed out along with the organic solvent, thereby eluting to obtain the effective medicinal ingredients, i.e., a concentrated aqueous solution. In order to further improve the elution effect, in this embodiment, the organic solvent is an ethanol solution. Since the surface tension of the ethanol solution is relatively small, it can replace the water adsorbed on the surface of the particles, reduce the effect of hydrogen bonds, reduce the capillary action of the particle aggregation, and make the particles no longer reunite. That is, using an ethanol solution to clean the chromatographic column after sugar analysis can effectively control the reunion of particles, thereby facilitating the subsequent atomization operation of the concentrated aqueous solution and improving the atomization effect.

[0076] In one embodiment, a resin precipitation column is used for sugar removal during the column desugaring process. It is understood that by subjecting the supernatant to column desugaring, sugar compounds in the supernatant are separated using a specific chromatographic column, thereby achieving sugar removal and enrichment of medicinal ingredients. In this embodiment, a resin precipitation column is used for sugar removal, adsorbing the active ingredients, which are then recovered through elution, thereby removing impurities, namely sugar compounds. Furthermore, using a resin precipitation column for sugar removal offers the following advantages: First, it can reduce dosage, improving the intrinsic quality and formulation of traditional Chinese medicine. The refined product obtained through macroporous resin adsorption technology has a highly concentrated concentration of active ingredients and low impurities. The extraction yield is only 2-5% of the original medicinal material, compared to approximately 20-30% using a typical water-boiling method and approximately 15% using an alcohol precipitation method. This reduced dosage, reduced impurities, and improved intrinsic quality facilitate the production of modern dosage forms of traditional Chinese medicine and facilitate quality control. Both pharmacodynamics and clinical studies have confirmed that this process improves the efficacy of the same type of medicine, completing both the impurity removal and concentration steps in one process. For example, ginsenosides are also found in the stems and leaves of ginseng, and can be extracted for medicinal purposes. However, their low content makes extraction by conventional methods cumbersome. However, after purification using macroporous resin adsorption technology, the ginsenoside content can reach over 70%, making extraction very convenient. For another example, Chinese herbal decoction extracts are large in volume and low in active ingredient content. The dosage is too large, making it difficult to select a dosage form, which poses a problem for production. However, using macroporous resin adsorption technology to treat them can better solve this problem. Second, it can reduce the hygroscopicity of the product. Most Chinese patent medicines prepared using traditional processes have strong hygroscopicity, a long-standing problem in the production and storage of Chinese medicines. However, after treatment with macroporous resin adsorption technology, a large amount of hygroscopic components such as sugars, inorganic salts, and mucilage in the decoction can be effectively removed, which is beneficial for the production of various Chinese medicine dosage forms and enhances product stability. Third, resin adsorption technology can shorten the production cycle, requires simple equipment, eliminates time-consuming tasks such as static precipitation and concentration, saves packaging, and reduces costs.

[0077] In one of the embodiments, before the step of selecting the medicinal part of the medicinal plant for decoction and separating the plant liquid and the residue after decoction, the method for preparing the atomized particles of the medicinal plant further includes the following steps: the medicinal plant is cleaned by low-frequency ultrasound. It is understandable that some impurities are easily adhered to the surface and surface gaps of the medicinal plant. If these impurities are not removed cleanly, it is easy to affect the purification of the medicinal plant, especially the subsequent atomization treatment, and may even affect the efficacy of the drug. In order to improve the purification effect of the medicinal plant, in this embodiment, the medicinal plant is subjected to a low-frequency ultrasonic cleaning operation by an ultrasonic cleaning machine. Compared with the general flushing operation, it can more fully remove the impurities adhered to the surface and surface gaps of the medicinal plant, thereby improving the purification effect of the medicinal plant.

[0078] In one of the embodiments, after the step of cleaning the medicinal plant by using low frequency ultrasonic method, and before the step of selecting the medicinal part of the medicinal plant to decoct, and separating the plant liquid and residue after decocting, the method for preparing the atomized particles of medicinal plant further comprises the step of ventilating and deodorizing the medicinal plant. It can be understood that, after cleaning, the medicinal plant has some water droplets on the surface, and if the water droplets are not removed, the purification rate of the medicinal part of the medicinal plant will be reduced. However, if the drying method of heating is used, the effective components in the medicinal plant will be destroyed. In addition, some medicinal plants have irritating odor after being picked, and if the irritating odor is not removed, it will cause discomfort after taking, especially after atomization, which will cause irritation to the respiratory system. In order to effectively remove the water droplets on the surface of the medicinal plant after cleaning, and eliminate the irritating odor of the medicinal plant, in this embodiment, the medicinal plant is ventilated and deodorized after cleaning, which can remove the water droplets on the surface of the medicinal plant, and the non-heating drying method is beneficial to preserve the medicinal plant and the effective components in the medicinal plant; on the other hand, it can also dissipate and eliminate the irritating odor of the medicinal plant.

[0079] Further, the ventilating and deodorizing time is 10h-24h. It can be understood that, if the ventilating and deodorizing time is too short, the problem of residual water will occur, and the irritating odor may not be effectively removed; if the ventilating and deodorizing time is too long, the preparation efficiency of the atomized particles of medicinal plant will be reduced. In order to effectively remove the water droplets on the surface and surface crevices of the medicinal plant and the irritating odor, in this embodiment, the ventilating and deodorizing time is 10h-24h, so that the water droplets on the surface and surface crevices of the medicinal plant and the irritating odor can be effectively removed, and the preparation efficiency of the atomized particles of medicinal plant is improved.

[0080] In one embodiment, the particle size of the drug residue powder is 50 to 80 mesh. It is understandable that the residue after the decoction of the medicinal plant is dried and ground to form the drug residue powder. The drug residue powder, concentrated aqueous solution and drug volatile oil are mixed in a preset proportion and granulated, so that the drug volatile oil, concentrated aqueous solution and drug residue powder can be fully and evenly mixed together, which is convenient for subsequent atomization, thereby effectively improving the atomization of the drug components. However, if the particle size of the drug residue powder is too large, it is easy to affect the compatibility of the drug residue powder with the concentrated aqueous solution and drug volatile oil; if the particle size of the drug residue powder is too small, it is easy to cause the drug residue powder to stick or agglomerate with the concentrated aqueous solution and drug volatile oil during the mixing process. In order to further improve the uniformity and atomization effect of the drug residue powder, in this embodiment, the particle size of the drug residue powder is controlled to be 50 to 80 mesh, so that the drug residue powder is easier to mix and be compatible with the concentrated aqueous solution and drug volatile oil, thereby further improving the uniformity and atomization effect of the drug residue powder.

[0081] In one embodiment, after drying the residue and then grinding it to obtain drug residue powder, and before mixing the drug volatile oil, concentrated aqueous solution, and drug residue powder in a predetermined ratio and granulating them to obtain particles to be atomized, the method for preparing aerosolized medicinal plant particles further includes the following steps: disinfecting and sterilizing the drug residue powder. It is understood that drug residue powder is obtained by drying and grinding the residue after decoction of medicinal plants. The residue contains the active ingredients of the medicinal plants and may also contain harmful or harmful bacteria. To improve the safety of the drug residue powder, in this embodiment, a microwave drying kiln and ethylene oxide sterilization method are used to disinfect and sterilize the drug residue powder. This method not only preserves the active ingredients in the residue but also effectively kills the pathogens therein, thereby ensuring the safety and effectiveness of the drug residue powder.

[0082] In one embodiment, the atomizing device atomizes the atomized particles into particles smaller than 4 μm. It is understood that the main active ingredients of the medicinal plants are extracted by the atomizing device and administered by atomization, absorbed through the respiratory tract, and directly enter the bloodstream. This requires a small amount of dosage and has a rapid effect, thereby improving the body's absorption efficiency of the active ingredients of Chinese herbal medicines and facilitating rapid improvement of physical condition. In order to further improve the absorption efficiency of the medicinal plants after atomization, in this embodiment, the atomizing device atomizes the atomized particles into particles smaller than 4 μm, making them easier to absorb through the respiratory tract and entering the bloodstream more quickly, further improving the absorption efficiency of the medicinal plants after atomization.

[0083] The following are some specific examples, where "%" refers to percentages by weight. It should be noted that the following examples are not exhaustive and that the materials used in the following examples are all commercially available unless otherwise specified.

[0084] Example 1

[0085] Medicinal plants are cleaned with low-frequency ultrasonic cleaning using an ultrasonic cleaner. After cleaning, the plants are aired for 10 hours to remove odors. Medicinal parts of the plants are then selected for decoction. After decoction, plant fluid and residue are separated. The plant fluid is distilled to obtain a medicinal volatile oil and an aqueous solution. The aqueous solution is then distilled and concentrated. The distillation and concentration process specifically includes the following steps: a) concentrating the aqueous solution by vacuum distillation to obtain a preliminary concentrate; b) extracting sugars from the preliminary concentrate using a sugar-precipitating organic solvent; c) centrifuging the preliminary concentrate to remove the precipitate and obtain the supernatant; d) subjecting the supernatant to a column for sugar removal; and washing the column with an organic solvent to elute the active medicinal components, i.e., the concentrated aqueous solution. The residue is then dried and then ground to obtain a medicinal residue powder with a particle size of 50 mesh. The medicinal volatile oil, concentrated aqueous solution, and medicinal residue powder are mixed in a predetermined ratio and granulated to obtain particles to be atomized. Place the particles to be aerosolized into the aerosol device for aerosol administration.

[0086] Example 2

[0087] Medicinal plants are cleaned with low-frequency ultrasonic cleaning using an ultrasonic cleaner. After cleaning, the plants are aired for 24 hours to remove odors. The medicinal parts of the plants are then selected for decoction. After decoction, the plant fluid and residue are separated. The plant fluid is distilled to obtain a medicinal volatile oil and an aqueous solution. The aqueous solution is then distilled and concentrated. The distillation and concentration process specifically includes the following steps: a) concentrating the aqueous solution by vacuum distillation to obtain a preliminary concentrate; b) extracting sugars from the preliminary concentrate using a sugar-precipitating organic solvent; c) centrifuging the preliminary concentrate to remove the precipitate and obtain the supernatant; d) subjecting the supernatant to a column for sugar removal; and washing the column with an organic solvent to elute the active medicinal components, i.e., the concentrated aqueous solution. The residue is then dried and then ground to obtain a medicinal residue powder with a particle size of 80 mesh. The medicinal volatile oil, concentrated aqueous solution, and medicinal residue powder are mixed in a predetermined ratio and granulated to obtain particles to be atomized. Place the particles to be aerosolized into the aerosol device for aerosol administration.

[0088] Example 3

[0089] Medicinal plants are cleaned with low-frequency ultrasonic cleaning using an ultrasonic cleaner. After cleaning, the plants are aired for 15 hours to remove odors. Medicinal parts of the plants are then selected for decoction. After decoction, the plant fluid and residue are separated. The plant fluid is distilled to obtain a medicinal volatile oil and an aqueous solution. The aqueous solution is then distilled and concentrated. The distillation and concentration process specifically includes the following steps: a) concentrating the aqueous solution by vacuum distillation to obtain a preliminary concentrate; b) extracting sugars from the preliminary concentrate using a sugar-precipitating organic solvent; c) centrifuging the preliminary concentrate to remove the precipitate and obtain the supernatant; d) subjecting the supernatant to a column for sugar removal; and washing the column with an organic solvent to elute the active medicinal components, i.e., the concentrated aqueous solution. The residue is then dried and then ground to obtain a medicinal residue powder with a particle size of 60 mesh. The medicinal volatile oil, concentrated aqueous solution, and medicinal residue powder are mixed in a predetermined ratio and granulated to obtain particles to be atomized. Place the particles to be aerosolized into the aerosol device for aerosol administration.

[0090] Example 4

[0091] The medicinal part of bergamot is selected for decoction, and plant liquid and residue are separated after decoction; the plant liquid is distilled to obtain medicinal volatile oil and aqueous solution; the aqueous solution is distilled and concentrated to obtain a concentrated aqueous solution; the residue is dried, and then ground to obtain medicinal residue powder; the bergamot volatile oil, the bergamot concentrated aqueous solution and the bergamot residue powder are mixed in a ratio of 2:3:5 and granulated to obtain particles to be atomized; the particles to be atomized are placed in an atomization device for atomization administration.

[0092] Related indicator detection:

[0093] 1. Detection of aerosol release components

[0094] The composition of the atomized release prepared in Example 4 was detected by gas chromatography. The specific composition is shown in Table 1 and Figure 4 As shown:

[0095]

[0096] Table 1

[0097] 2. Cytotoxicity test

[0098] The aerosolized release prepared in Example 4 was subjected to cytotoxicity tests, and the effects on macrophages and bronchial alveolar epithelial cells were analyzed. The effects on phagocytes were as follows: Figure 5 The effects on bronchial alveolar epithelial cells are shown in Figure 6By examining the effects of different concentrations of release substances on normal alveolar macrophages and normal bronchial alveolar epithelial cells, it was found that each concentration had no significant effect on cell viability.

[0099] 3. Animal testing

[0100] After making the mouse cough model, the mice were placed in the exposure chamber of the same volume. The model group was not given the release agent, while the experimental group was given the release agent (the amount of release agent was 18mg to 30mg). The number of times the mice coughed within 2 minutes was counted. Figure 7 As shown, the test results show that the released substance has a significant effect on relieving cough in mice.

[0101] Compared with the prior art, the present invention has at least the following advantages:

[0102] 1. In the method for preparing aerosolized medicinal plant particles of the present invention, the medicinal portion of the medicinal plant is first decocted to extract the majority of the medicinal components into a plant liquid, which is then distilled and concentrated to obtain a higher concentration of the medicinal components and effectively remove useless or harmful substances from the medicinal plant, thereby improving the medicinal effect of the medicinal plant. Furthermore, the residue separated after decocting is dried and then ground. The ground medicinal residue powder is mixed with a medicinal volatile oil and a concentrated aqueous solution in a predetermined ratio and granulated. The medicinal residue powder and the concentrated aqueous solution are then aerosolized together, effectively increasing the utilization rate of the medicinal plant and enhancing the medicinal effect of the medicinal plant.

[0103] 2. The preparation method of the medicinal plant atomized particles of the present invention extracts the main active ingredients of the medicinal plants through an atomizing device, which are absorbed through the respiratory tract and directly enter the blood. The dosage is small and the effect is fast, which improves the human body's absorption efficiency of the active ingredients of Chinese herbal medicine and is conducive to quickly improving the body's condition. Moreover, by carrying an atomizing device that stores the atomized particles, it is convenient to take the medicine and the portability of the medicine is improved.

[0104] The above embodiments merely illustrate several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the spirit of the present invention, all of which fall within the scope of protection of the present invention. Therefore, the scope of protection of the patent for this invention shall be determined by the appended claims.

Claims

1. A method for preparing atomized particles of medicinal plants, characterized in that: The steps include: The medicinal parts of the medicinal plants are selected for decoction, and the plant liquid and residue are separated after decoction; Distilling the plant liquid to obtain medicinal volatile oil and aqueous solution; performing a distillation and concentration operation on the aqueous solution to obtain a concentrated aqueous solution; Drying the residue, followed by grinding to obtain drug residue powder; The drug volatile oil, the concentrated aqueous solution and the drug residue powder are mixed in a preset ratio and granulated to obtain particles to be atomized; The particles to be aerosolized are placed in an aerosolizing device for aerosol administration.

2. The method for preparing atomized medicinal plant particles according to claim 1, characterized in that: The distillation and concentration operation specifically comprises the following steps: The aqueous solution is concentrated by distillation under reduced pressure to obtain a preliminary concentrated solution; using a sugar-precipitating organic solvent to precipitate sugars from the preliminary concentrated solution; The preliminary concentrated liquid is subjected to a centrifugal separation operation to remove the precipitate and obtain the supernatant; performing a column sugar removal operation on the supernatant; An organic solvent is used to perform column washing operation to elute the effective medicinal components, namely the concentrated aqueous solution.

3. The method for preparing atomized medicinal plant particles according to claim 2, characterized in that: After the step of performing a column sugar removal operation on the supernatant, and before the step of performing a column washing operation with an organic solvent to elute the effective medicinal components, i.e., the step of concentrating the aqueous solution, the distillation concentration operation further comprises the following steps: The organic solvent is removed by distillation under reduced pressure.

4. The method for preparing atomized medicinal plant particles according to claim 2, characterized in that: The sugar precipitation organic solvent is ethanol.

5. The method for preparing atomized medicinal plant particles according to claim 2, characterized in that: The organic solvent is an ethanol solution.

6. The method for preparing atomized medicinal plant particles according to claim 2, characterized in that: In the column desugaring operation, a resin precipitation column is used for desugaring.

7. The method for preparing atomized medicinal plant particles according to claim 1, characterized in that: Before the steps of selecting the medicinal part of the medicinal plant for decoction and separating the plant liquid and the residue after decoction, the method for preparing the medicinal plant atomized particles further comprises the following steps: The medicinal plants are cleaned by using a low-frequency ultrasonic method.

8. The method for preparing atomized medicinal plant particles according to claim 7, characterized in that: After the step of washing the medicinal plant using a low-frequency ultrasonic method and before the step of decocting the medicinal part of the medicinal plant and separating the plant liquid and the residue after decocting, the method for preparing the medicinal plant atomized particles further comprises the following steps: The medicinal plants are subjected to a ventilation and odor removal operation.

9. The method for preparing atomized medicinal plant particles according to claim 8, characterized in that: The ventilation and odor removal operation time is 10h~24h.

10. The method for preparing atomized medicinal plant particles according to claim 1, characterized in that: The mass ratio of the drug volatile oil, the concentrated aqueous solution and the drug residue powder is 2:3:5.

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