Blood drug concentration testing method and system based on dynamic thermal analysis and ion migration

Abstract

The invention discloses a blood drug concentration test method and system based on dynamic thermal analysis and ion migration, comprising the following steps: for propofol blood drug mixed liquid, a gas phase state is formed by dynamic thermal analysis sampling; a carrier gas is introduced to drive the propofol blood drug mixture in the gas phase state to reach the ion migration functional area at a specific concentration and flow rate; the propofol blood drug mixture in the gas phase state in the ion migration functional area is ionized and ion migration is performed through a high-voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration. The method solves the technical problem that when the gas phase monitoring of the corresponding blood drug concentration of propofol is performed in the prior art, there is a dynamic deviation between the propofol concentration of the exhaled gas and the actual propofol concentration of the plasma, which is easy to cause data inaccuracy and it is difficult to accurately and timely adjust the dosage and rate of propofol infusion.

Description

Technical Field

[0001] The present invention relates to the technical field of propofol blood concentration testing, and in particular to a blood concentration testing method and system based on dynamic thermal analysis and ion migration. Background Art

[0002] At present, propofol is widely used as a medical intravenous anesthetic for inducing and maintaining anesthesia due to its excellent performance in rapid induction and elimination, short duration of effect, mild recovery after anesthesia, few side effects, and no teratogenic effects. Propofol is volatile and can be metabolized through the respiratory system, that is, propofol directly derived from the lung blood can be detected in the exhaled gas. Existing studies have shown that there is a certain correlation between the propofol concentration in the exhaled gas and the propofol concentration in the plasma. Therefore, the use of exhaled gas can achieve real-time gas phase monitoring of the corresponding blood concentration of propofol to a certain extent.

[0003] However, due to the different respiratory rates and strengths of patients, there will be a dynamic deviation in the correlation coefficient between the real-time monitored exhaled gas propofol concentration and the plasma propofol concentration, resulting in inaccurate blood drug concentration data inferred from the exhaled gas drug concentration, making it difficult to accurately and timely adjust the intravenous infusion dose and rate of propofol, and thus difficult to achieve the expected actual blood drug concentration and anesthetic sedation depth. Summary of the invention

[0004] To this end, the present invention provides a blood drug concentration testing method and system based on dynamic thermal analysis and ion migration to solve the technical problem that when the propofol corresponding blood drug concentration is monitored by gas phase in the prior art, there is a dynamic deviation between the propofol concentration directly monitored in the exhaled gas and the actual propofol concentration in the plasma, which can easily lead to data inaccuracy and makes it difficult to accurately and timely adjust the propofol infusion dosage and rate.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] A blood drug concentration testing method based on dynamic thermal analysis and ion migration comprises the following steps:

[0007] The propofol blood drug mixed liquid is sampled by dynamic thermal desorption to form a gas phase state;

[0008] The carrier gas is introduced at a specific concentration and flow rate to drive the propofol-blood drug mixture in the gas phase to the ion migration functional area;

[0009] The propofol blood drug mixture in the gas phase state in the ion migration functional area is ionized and ion migration is carried out through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration.

[0010] On the basis of the above technical solution, the present invention is further described as follows:

[0011] As a further solution of the present invention, the method of subjecting the propofol blood drug mixed liquid to a gas phase state through dynamic thermal analysis injection specifically includes:

[0012] The mixed liquid sample in the propofol blood drug mixed liquid injection pool is heated and analyzed by the injection thermal analysis component, so that the propofol blood drug mixed liquid is analyzed into a gas phase state.

[0013] As a further solution of the present invention, the introduction of carrier gas at a specific concentration and flow rate drives the propofol blood-drug mixture in the gas phase to reach the ion migration functional area, specifically including:

[0014] Outputting air and / or oxygen and / or nitrogen with impurities and humidity lower than a specific value after being filtered by a molecular sieve drying tube through a carrier gas delivery component;

[0015] Air and / or oxygen and / or nitrogen are used as carrier gas to drive the propofol blood drug mixture in the gas phase state inside the injection thermal analysis component into the gas phase ionization zone of the ion migration functional area.

[0016] As a further solution of the present invention, the introduction of carrier gas at a specific concentration and flow rate drives the propofol blood-drug mixture in the gas phase to reach the ion migration functional area, further comprising:

[0017] During the heating and decomposition process of the mixed liquid sample by the injection thermal decomposition component, the internal gas phase concentration thereof always shows a dynamic change trend, that is, it increases dynamically in the initial stage of thermal decomposition, and then after being mixed with the carrier gas and driven to be transported to the gas phase ionization zone, the internal gas phase concentration of the injection thermal decomposition component shows a dynamic decrease trend; at the same time, the concentration and flow rate of the carrier gas introduced need to ensure that a gas phase propofol-blood drug mixture of sufficient concentration is stably driven to the gas phase ionization zone within a unit time, and after the carrier gas is introduced and mixed with the gas phase propofol-blood drug mixture and reaches the gas phase ionization zone, the mixed concentration value of the two corresponding to the gas phase ionization zone also needs to ensure the gas phase ionization efficiency and its subsequent migration efficiency;

[0018] The internal initial gas phase concentration of the sample injection thermal desorption component is accurately monitored in real time by a thermal desorption concentration sensor arranged inside the sample injection thermal desorption component. When the internal initial gas phase concentration of the sample injection thermal desorption component reaches a specific threshold range, the carrier gas delivery component is controlled to introduce carrier gas into the sample injection thermal desorption component, and the carrier gas flow rate and concentration control component located in the carrier gas introduction pipeline is used to selectively control the carrier gas introduction rate and concentration according to a specific ratio, so that the mixed concentration of the introduced carrier gas and the propofol blood drug mixture in the gas phase state, which is further monitored in real time by the thermal desorption concentration sensor, is always maintained within the standard concentration threshold range.

[0019] As a further solution of the present invention, the introduction of carrier gas at a specific concentration and flow rate drives the propofol blood-drug mixture in the gas phase to reach the ion migration functional area, further comprising:

[0020] The thermal desorption flow rate sensor inside the sample injection thermal desorption component accurately monitors the overall flow rate of the carrier gas and the propofol blood drug mixture in the gas phase after mixing in real time, and proportionally regulates the carrier gas introduction rate based on the carrier gas flow rate concentration control component until the overall flow rate of the mixed gas is within the standard flow rate threshold range, and the mixed gas that meets the standard concentration and flow rate threshold range is delivered to the gas phase ionization zone.

[0021] As a further solution of the present invention, the method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration specifically includes:

[0022] The propofol-blood drug mixture in the gas phase inside the gas phase ionization zone is ionized by a VUV ultraviolet ionization lamp source, and then the ionization gate located between the gas phase ionization zone and the ion migration zone is periodically opened to push the ions to the ion migration zone. Under the action of the high-voltage electric field corresponding to the ion migration zone, the intensity of the target product ions is measured using a Faraday plate according to the different migration times of the product ions generated by the two different substances, blood and propofol. The current signal is further converted into a digital signal through an analog amplifier and a digital circuit. Finally, the propofol blood concentration is measured based on the standard linear curve.

[0023] As a further solution of the present invention, the method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration also includes:

[0024] Since the product ions generated by blood and propofol have different mobility under the same high voltage electric field, the drift time taken to pass through the entire ion migration zone is also different;

[0025] Therefore, it is assumed that the migration length of the ion migration zone is d, the electric field strength of the high voltage electric field in the ion migration zone is E, and the time taken for the ions to pass through the ion migration zone and reach the Faraday disk is t d , the expression of the ion mobility coefficient K is obtained as follows:

[0026]

[0027] In the above formula, K is the mobility coefficient of the ion (abbreviated as mobility, cm 2 / V·s), which is related to the characteristics of the ion itself and the temperature T and pressure P during concentration detection, so the reduced ion mobility K0 is further introduced to obtain the expression of the reduced ion mobility K0 as follows:

[0028]

[0029] It can be seen from the above formula that at high temperature, the ion mobility will decrease, while at low temperature, the ion mobility will increase; at the same time, under high pressure, the ion mobility and migration number will increase; therefore, the ionization pressure control component and the ionization temperature sensing and control component are respectively connected to the gas phase ionization zone.

[0030] As a further solution of the present invention, the method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration also includes:

[0031] The internal gas pressure of the gas phase ionization zone is monitored in real time by the ionization pressure sensor in the ionization pressure control component, and when the internal gas pressure of the gas phase ionization zone is too high, the ionization pressure control gas port in the ionization pressure control component cooperates with the ionization pressure control gas valve to perform external discharge control;

[0032] The internal temperature of the gas phase ionization zone is monitored in real time through the ionization temperature sensing and regulating components. When the thermal decomposition temperature inside the gas phase ionization zone accumulates too high, the ionization temperature sensing and regulating components are used to cool the inside of the gas phase ionization zone while being able to continue to stably maintain the gas phase state of the mixed gas.

[0033] As a further solution of the present invention, the method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration also includes:

[0034] A low temperature drift gas transport component is connected corresponding to the ion migration zone;

[0035] Gas is periodically introduced into the ion migration zone through a low-temperature drift gas delivery assembly, and the mixed gas ions are assisted in migration by pressurizing and increasing fluidity of the introduced gas. On the basis of stably maintaining the state of the mixed gas ions, the temperature inside the ion migration zone is further lowered to increase the overall ion mobility.

[0036] A blood drug concentration testing system according to the blood drug concentration testing method based on dynamic thermal analysis and ion migration comprises:

[0037] The injection thermal analysis module is used to inject the propofol blood drug mixed liquid into a gas phase state through dynamic thermal analysis;

[0038] The carrier gas delivery module is used to introduce carrier gas at a specific concentration and flow rate to drive the propofol blood drug mixture in the gas phase to the ion migration functional area;

[0039] The ion migration module is used to ionize the propofol blood drug mixture in the gas phase in the ion migration functional area and perform ion migration through a high-voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration.

[0040] The present invention has the following beneficial effects:

[0041] This method and system can effectively realize gas phase detection based on the anesthetic propofol blood drug mixed liquid by combining dynamic thermal analysis sampling technology and sample molecular ionization technology. It is more efficient and convenient as a whole, with a low operating error rate. At the same time, compared with the exhaled gas phase detection, the dynamic deviation is significantly reduced and the accuracy is higher. In addition, it can also make use of the flexible control of concentration, temperature and flow parameters to further improve the efficiency and accuracy of blood drug concentration detection, and significantly enhance the functional practicality of the overall architecture. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] In order to more clearly illustrate the implementation mode of the present invention or the technical solution in the prior art, the drawings required for the implementation mode or the description of the prior art will be briefly introduced below. The structures, proportions, sizes, etc. illustrated in this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read. Any structural modification, change in proportional relationship or adjustment of size should still fall within the scope of the technical contents disclosed in the present invention without affecting the effects and purposes that can be achieved by the present invention.

[0043] Figure 1 A schematic diagram of the overall process of a blood drug concentration testing method based on ion mobility spectrometry technology provided in an embodiment of the present invention.

[0044] Figure 2 A schematic diagram of the functional architecture principle of a blood drug concentration testing method and system based on dynamic thermal analysis and ion migration provided in an embodiment of the present invention.

[0045] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0046] Sample injection thermal analysis component 1, thermal analysis flow rate sensor 11, thermal analysis concentration sensor 12;

[0047] Carrier gas delivery component 2, carrier gas flow rate concentration control component 21;

[0048] Gas phase ionization zone 3; VUV ultraviolet ionization lamp source 4;

[0049] Ionization pressure regulating component 5: ionization pressure sensor 51, ionization pressure regulating air port 52, ionization pressure regulating air valve 53;

[0050] Ionization temperature sensing and regulating component 6; ionization door 7;

[0051] High voltage electric field 8, ion migration region 81, Faraday disk 82;

[0052] Low temperature drift gas delivery assembly 9. DETAILED DESCRIPTION

[0053] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0054] The terms such as "upper", "lower", "left", "right", and "middle" used in this specification are only for the convenience of description and are not intended to limit the scope of the invention. Changes or adjustments to their relative relationships should be regarded as within the scope of the invention without substantially changing the technical content.

[0055] like Figure 1 to Figure 2 As shown, the embodiment of the present invention provides a blood drug concentration test method based on ion mobility spectrometry technology. This method can effectively realize gas phase detection based on the anesthetic propofol blood drug mixed liquid by combining dynamic thermal analysis sampling technology and sample molecular ionization technology. It is more efficient and convenient as a whole, with a low operating error rate. At the same time, compared with the exhaled gas phase detection, the dynamic deviation is significantly reduced and the accuracy is higher. In addition, the flexible regulation of concentration, temperature and flow parameters can be used to further improve the efficiency and accuracy of blood drug concentration detection, and significantly enhance the overall functional practicality. Specifically including the following steps:

[0056] S1: The propofol blood drug mixed liquid is sampled by dynamic thermal desorption to form a gas phase state;

[0057] The specific process is: the mixed liquid sample in the propofol blood drug mixed liquid injection pool is heated and analyzed by the injection thermal analysis component 1, so that the propofol blood drug mixed liquid is analyzed into a gas phase state;

[0058] S2: Introduce carrier gas at a specific concentration and flow rate to drive the propofol-blood drug mixture in the gas phase to the ion migration functional area;

[0059] The specific process is as follows: the carrier gas delivery component 2 outputs air and / or oxygen and / or nitrogen whose impurities and humidity are lower than a specific value after being filtered by a molecular sieve drying tube, and uses the air and / or oxygen and / or nitrogen as carrier gas to drive the propofol blood drug mixture in the gas phase state inside the injection thermal analysis component 1 into the gas phase ionization zone 3 of the ion migration functional area;

[0060] During the heating and analysis of the mixed liquid sample by the sample injection thermal analysis component 1, the internal gas phase concentration thereof always shows a dynamic change trend, that is, it increases dynamically in the initial stage of thermal analysis, and then after being mixed with the carrier gas and driven to be transported to the gas phase ionization zone 3, the internal gas phase concentration of the sample injection thermal analysis component 1 shows a dynamic decrease trend; at the same time, the concentration and flow rate of the carrier gas introduced need to ensure that a gas phase propofol blood drug mixture of sufficient concentration is stably driven to the gas phase ionization zone 3 per unit time, and after the carrier gas is introduced and mixed with the gas phase propofol blood drug mixture and reaches the gas phase ionization zone 3, the mixed concentration value of the two corresponding to the gas phase ionization zone 3 also needs to ensure the gas phase ionization efficiency and its subsequent migration efficiency;

[0061] Therefore, the internal initial gas phase concentration of the sample injection thermal desorption component 1 is accurately monitored in real time by the thermal desorption concentration sensor 12 disposed inside the sample injection thermal desorption component 1. When the internal initial gas phase concentration of the sample injection thermal desorption component 1 reaches a specific threshold range, the carrier gas delivery component 2 is controlled to introduce carrier gas into the sample injection thermal desorption component 1, and the carrier gas flow rate concentration control component 21 located in the carrier gas introduction pipeline is used to specifically control the introduction rate and concentration of the carrier gas according to a specific ratio, so that the mixed concentration of the introduced carrier gas and the propofol blood drug mixture in the gas phase state further monitored in real time by the thermal desorption concentration sensor 12 is always maintained within the standard concentration threshold range; at the same time, the overall flow rate of the introduced carrier gas and the propofol blood drug mixture in the gas phase state after mixing is accurately monitored in real time by the thermal desorption flow rate sensor 11 inside the sample injection thermal desorption component 1, and the introduction rate of the carrier gas is further specifically controlled in proportion based on the carrier gas flow rate concentration control component 21 until the overall flow rate of the mixed gas is within the standard flow rate threshold range, thereby the mixed gas meeting the standard concentration and flow rate threshold range is introduced into the gas phase ionization zone 3;

[0062] S3: Ionize the propofol blood drug mixture in the gas phase in the ion migration functional area and perform ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration.

[0063] The propofol-blood drug mixture in the gas phase state inside the gas phase ionization zone 3 is ionized by a VUV ultraviolet ionization lamp source 4, and then the ionization gate 7 located between the gas phase ionization zone 3 and the ion migration zone 81 is periodically opened to push the ions to the ion migration zone 81. Under the action of the high-voltage electric field 8 corresponding to the ion migration zone 81, the intensity of the target product ions is measured using a Faraday disk 82 according to the different migration times of the product ions generated by the two different substances, blood and propofol, and the current signal is further converted into a digital signal through an analog amplifier and a digital circuit. Finally, the blood drug concentration is measured based on the standard linear curve.

[0064] Since the product ions generated by the two different substances, blood and propofol, have different mobility under the same high voltage electric field 8, the drift time taken to pass through the entire length of the ion migration region 81 is also different;

[0065] Therefore, it is assumed that the migration length of the ion migration region 81 is d, the electric field strength of the high voltage electric field 8 corresponding to the ion migration region 81 is E, and the time taken by the ions to pass through the ion migration region 81 and reach the Faraday disk 82 is t d , the expression of the ion mobility coefficient K is obtained as follows:

[0066]

[0067] In the above formula, K is the mobility coefficient of the ion (abbreviated as mobility, cm 2 / V·s), which is related to the characteristics of the ion itself and the temperature T and pressure P during concentration detection, so the reduced ion mobility K0 is further introduced to obtain the expression of the reduced ion mobility K0 as follows:

[0068]

[0069] Combined with the theory of thermal motion, we can know that ions have faster thermal motion speed and higher kinetic energy at high temperature, making it easier for them to collide with air molecules or other ions, causing collision dissociation or recombination reactions, resulting in a decrease in ion mobility. Therefore, at high temperatures, ion mobility will decrease, while at low temperatures, ion mobility will increase; at the same time, under high pressure, ion mobility and migration number will increase.

[0070] Therefore, an ionization pressure regulating component 5 and an ionization temperature sensing and regulating component 6 are respectively connected to the gas phase ionization zone 3, and the internal gas pressure of the gas phase ionization zone 3 is monitored in real time through the ionization pressure sensor 51 in the ionization pressure regulating component 5. When the internal gas pressure of the gas phase ionization zone 3 is too high, the ionization pressure regulating air port 52 in the ionization pressure regulating component 5 cooperates with the ionization pressure regulating air valve 53 to perform external discharge regulation. At the same time, the internal temperature of the gas phase ionization zone 3 is monitored in real time through the ionization temperature sensing and regulating component 6. When the accumulated thermal decomposition temperature inside the gas phase ionization zone 3 is too high, the ionization temperature sensing and regulating component 6 cools down the inside of the gas phase ionization zone 3 on the basis of being able to continue to stably maintain the gas phase state of the mixed gas.

[0071] As an optional implementation scheme of the present embodiment, a low-temperature floating gas delivery component 9 is connected to the ion migration zone 81, and gas is periodically introduced into the ion migration zone 81 through the low-temperature floating gas delivery component 9. On the one hand, the introduction of gas can be used to increase the pressure and fluidity to assist the migration of the mixed gas ions. On the other hand, on the basis of stably maintaining the state of the mixed gas ions, the inside of the ion migration zone 81 can be further cooled, thereby further increasing the ion mobility under low-temperature conditions and improving the overall blood drug concentration detection efficiency.

[0072] The embodiment of the present invention also provides a blood drug concentration testing system based on dynamic thermal analysis and ion migration, which specifically includes:

[0073] The injection thermal analysis module is used to inject the propofol blood drug mixed liquid into a gas phase state through dynamic thermal analysis;

[0074] The carrier gas delivery module is used to introduce carrier gas at a specific concentration and flow rate to drive the propofol blood drug mixture in the gas phase to the ion migration functional area;

[0075] The ion migration module is used to ionize the propofol blood drug mixture in the gas phase in the ion migration functional area and perform ion migration through a high-voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration.

[0076] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A blood drug concentration test method based on dynamic thermal analysis and ion migration, characterized in that: The steps include: The propofol blood drug mixed liquid is sampled by dynamic thermal desorption to form a gas phase state; The carrier gas is introduced at a specific concentration and flow rate to drive the propofol-blood drug mixture in the gas phase to the ion migration functional area; The propofol blood drug mixture in the gas phase state in the ion migration functional area is ionized and ion migration is carried out through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration; The method of injecting the propofol blood drug mixed liquid into a gas phase by dynamic thermal analysis specifically includes: The mixed liquid sample in the propofol blood drug mixed liquid injection pool is heated and analyzed by the injection thermal analysis component, so that the propofol blood drug mixed liquid is analyzed into a gas phase state; The introduction of carrier gas at a specific concentration and flow rate drives the propofol blood drug mixture in the gas phase to the ion migration functional area, specifically including: Outputting air and / or oxygen and / or nitrogen with impurities and humidity lower than a specific value after being filtered by a molecular sieve drying tube through a carrier gas delivery component; Air and / or oxygen and / or nitrogen are used as carrier gas to drive the propofol blood drug mixture in the gas phase state inside the injection thermal analysis component into the gas phase ionization zone of the ion migration functional area; The introduction of carrier gas at a specific concentration and flow rate drives the propofol blood-drug mixture in the gas phase to reach the ion migration functional area, and also includes: During the heating and decomposition process of the mixed liquid sample by the injection thermal decomposition component, the internal gas phase concentration thereof always shows a dynamic change trend, that is, it increases dynamically in the initial stage of thermal decomposition, and then after being mixed with the carrier gas and driven to be transported to the gas phase ionization zone, the internal gas phase concentration of the injection thermal decomposition component shows a dynamic decrease trend; at the same time, the concentration and flow rate of the carrier gas introduced need to ensure that a gas phase propofol-blood drug mixture of sufficient concentration is stably driven to the gas phase ionization zone within a unit time, and after the carrier gas is introduced and mixed with the gas phase propofol-blood drug mixture and reaches the gas phase ionization zone, the mixed concentration value of the two corresponding to the gas phase ionization zone also needs to ensure the gas phase ionization efficiency and its subsequent migration efficiency; The internal initial gas phase concentration of the sample injection thermal desorption component is accurately monitored in real time by a thermal desorption concentration sensor arranged inside the sample injection thermal desorption component. When the internal initial gas phase concentration of the sample injection thermal desorption component reaches a specific threshold range, the carrier gas delivery component is controlled to introduce carrier gas into the sample injection thermal desorption component, and the carrier gas flow rate and concentration control component located in the carrier gas introduction pipeline is used to selectively control the carrier gas introduction rate and concentration according to a specific ratio, so that the mixed concentration of the introduced carrier gas and the propofol blood drug mixture in the gas phase state, which is further monitored in real time by the thermal desorption concentration sensor, is always maintained within the standard concentration threshold range.

2. The blood drug concentration test method based on dynamic thermal analysis and ion migration according to claim 1, characterized in that: The introduction of carrier gas at a specific concentration and flow rate drives the propofol blood-drug mixture in the gas phase to reach the ion migration functional area, and also includes: The thermal desorption flow rate sensor inside the sample injection thermal desorption component accurately monitors the overall flow rate of the carrier gas and the propofol blood drug mixture in the gas phase after mixing in real time, and proportionally regulates the carrier gas introduction rate based on the carrier gas flow rate concentration control component until the overall flow rate of the mixed gas is within the standard flow rate threshold range, and the mixed gas that meets the standard concentration and flow rate threshold range is delivered to the gas phase ionization zone.

3. The blood drug concentration test method based on dynamic thermal analysis and ion migration according to claim 2, characterized in that: The method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration specifically includes: The propofol-blood drug mixture in the gas phase inside the gas phase ionization zone is ionized by a VUV ultraviolet ionization lamp source, and then the ionization gate located between the gas phase ionization zone and the ion migration zone is periodically opened to push the ions to the ion migration zone. Under the action of the high-voltage electric field corresponding to the ion migration zone, the intensity of the target product ions is measured using a Faraday plate according to the different migration times of the product ions generated by the two different substances, blood and propofol. The current signal is further converted into a digital signal through an analog amplifier and a digital circuit. Finally, the propofol blood concentration is measured based on the standard linear curve.

4. The blood drug concentration test method based on dynamic thermal analysis and ion migration according to claim 3, characterized in that: The method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration also includes: Since the product ions generated by blood and propofol have different mobility under the same high voltage electric field, the drift time taken to pass through the entire ion migration zone is also different; Therefore, it is assumed that the migration length of the ion migration zone is d, the electric field strength of the high voltage electric field in the ion migration zone is E, and the time taken for the ions to pass through the ion migration zone and reach the Faraday disk is t d , the expression of the ion mobility coefficient K is obtained as follows: In the above formula, K is the mobility coefficient of the ion (abbreviated as mobility, cm 2 / V·s), which is related to the characteristics of the ion itself and the temperature T and pressure P during concentration detection. Therefore, the reduced ion mobility K0 is further introduced, and the expression of the reduced ion mobility K0 is obtained as follows: It can be seen from the above formula that at high temperature, the ion mobility will decrease, while at low temperature, the ion mobility will increase; at the same time, under high pressure, the ion mobility and migration number will increase; therefore, the ionization pressure control component and the ionization temperature sensing and control component are respectively connected to the gas phase ionization zone.

5. The blood drug concentration test method based on dynamic thermal analysis and ion migration according to claim 4, characterized in that: The method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration also includes: The internal gas pressure of the gas phase ionization zone is monitored in real time by the ionization pressure sensor in the ionization pressure control component, and when the internal gas pressure of the gas phase ionization zone is too high, the ionization pressure control gas port in the ionization pressure control component cooperates with the ionization pressure control gas valve to perform external discharge control; The internal temperature of the gas phase ionization zone is monitored in real time through the ionization temperature sensing and regulating components. When the thermal decomposition temperature inside the gas phase ionization zone accumulates too high, the ionization temperature sensing and regulating components are used to cool the inside of the gas phase ionization zone while being able to continue to stably maintain the gas phase state of the mixed gas.

6. The blood drug concentration test method based on dynamic thermal analysis and ion migration according to claim 5, characterized in that: The method of ionizing the propofol blood drug mixture in the gas phase in the ion migration functional area and performing ion migration through a high voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration also includes: A low temperature drift gas transport component is connected corresponding to the ion migration zone; Gas is periodically introduced into the ion migration zone through a low-temperature drift gas delivery assembly, and the mixed gas ions are assisted in migration by pressurizing and increasing fluidity of the introduced gas. On the basis of stably maintaining the state of the mixed gas ions, the temperature inside the ion migration zone is further lowered to increase the overall ion mobility.

7. A blood drug concentration testing system according to the blood drug concentration testing method based on dynamic thermal analysis and ion migration as claimed in claim 6, characterized in that: include: The injection thermal analysis module is used to inject the propofol blood drug mixed liquid into a gas phase state through dynamic thermal analysis; The carrier gas delivery module is used to introduce carrier gas at a specific concentration and flow rate to drive the propofol blood drug mixture in the gas phase to the ion migration functional area; The ion migration module is used to ionize the propofol blood drug mixture in the gas phase in the ion migration functional area and perform ion migration through a high-voltage electric field until the ions reach the electrode to measure the propofol blood drug concentration.

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