Premixed calcium silicate / calcium formate self-curing root canal filling material as well as preparation method and application thereof

Abstract

The invention relates to a premixed calcium silicate / calcium formate self-curing root canal filling material as well as a preparation method and application thereof. The premixed root canal filling material which is short in curing time, high in mechanical strength and excellent in injectable performance is prepared by taking the calcium formate powder and the calcium silicate compound as main phases and adding at least one organic phase solvent which can be mixed and dissolved with water and at least one radiation-resistant material. The material keeps fluid under a closed condition, and is hydrated, solidified and hardened after being filled into teeth and contacted with physiological body fluid. The invention combines the advantages of calcium formate and calcium silicate materials, has the advantages of short curing time, good biological activity, good sealing property and antibacterial property, is convenient for clinical use, and can be used as a filling material in the dental restoration fields such as pulp capping, root canal therapy and the like.

Description

Technical Field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to a premixed calcium silicate / calcium formate self-curing root canal filling material and a preparation method and application thereof. Technical Background

[0002] Dental filling materials are substances used to seal the root canal system during root canal treatment. Ideal dental filling materials should meet the following requirements: stable size and structure, non-absorbable, no pollution to tooth structure; good adhesion, strong enough to resist tooth decay repair process; good sealing performance, no dissolution in tissue fluid and leakage; good fluidity and injectability for easy filling; good bactericidal and antibacterial properties; must be X-ray opaque, visible under CT scan and have other excellent physical and chemical properties. Although there are many types and forms of dental filling materials currently used in clinical practice, there is still no product that fully meets the performance requirements of ideal dental filling materials.

[0003] The calcium silicate material most used in dental filling materials at present is tricalcium mineralized material. Mineral trioxide aggregate (MTA) was introduced at Loma Linda University in California in 1990. MTA is composed of inorganic materials such as tricalcium silicate, tricalcium aluminate, tricalcium oxide and silicate oxide, and is used for perforation repair, as a pulp capping agent and to form an apical barrier, and has good biocompatibility and biological activity. Although MTA has these advantages, it also has some limitations, such as tooth discoloration, long curing time, difficult operation, high cost, etc. The Chinese patent "Premixed biological hydraulic cement paste composition and its application" (patent number CN200880011743.1) discloses a premixed paste that can be used for medical or dental purposes. The patent premixes tricalcium silicate, dicalcium silicate and an organic solvent, which is convenient for doctors to use, but the coagulation time is too long, and some require 72 hours to coagulate. The long coagulation time not only prolongs the patient's waiting time, but also makes the surgical process more complicated.

[0004] The Chinese patent "Injectable, High-efficiency, Suspended and Stable Calcium Phosphate Bone Cement and Its Preparation Method and Application" (Patent No. CN200910197934.8) discloses an injectable calcium phosphate bone cement material system, which improves the suspension stability of the calcium phosphate bone cement premix system by adding fumed silica and its modified products. The disadvantage is that calcium phosphate bone cement is not strong enough and is easy to break. Therefore, it is of great significance to further develop dental filling materials with short setting time, good biological activity, high compressive strength and good clinical operation performance.

[0005] Chinese patent CN114099352A relates to a kind of anti-disintegration silicon-calcium-based root canal filling paste, the root canal filling paste comprises a composite solid phase powder and a solidifying liquid, wherein the mass ratio of the composite solid phase powder and the solidifying liquid is 1-3:1; the composite solid phase powder comprises a silicon-calcium-based compound and calcium formate (CF), wherein the mass percentage of the silicon-calcium-based compound is 60-99%, the mass percentage of calcium formate is 1-40%, and the sum of the two mass percentages is 100%; the solidifying liquid is a konjac gluconate solution with a mass percentage concentration of 1-10%, and the solvent in the konjac gluconate solution is water. Because it adopts water as a solvent, it needs on-site stirring when used, which prolongs the operation time and increases the risk of uneven and improper operation damaging the physical and chemical properties of the material. The strength of the product is not related to in the patent at the same time.

[0006] Chinese patent CN118078641A involves a hydrophilic root canal filling tip material and its preparation method. A small amount of polyethylene glycol (PEG) is used as a dispersant in the patent. In the patent, the proportion of ingredients by weight is 20-30 parts of thermoplastic polymer material, 40-50 parts of zinc oxide, 10-15 parts of barium sulfate, 5-10 parts of titanium dioxide, 3-5 parts of antioxidant, 1-3 parts of beeswax, 2-3 parts of hydroxyapatite, 2-3 parts of modified antibacterial agent, 3-5 parts of hydrophilic additive and 1-2 parts of dispersant. The patent does not involve the strength of the product. Summary of the invention

[0007] The object of the present invention is to provide a premixed root canal filling material with short curing time, high mechanical strength and excellent injectability.

[0008] In order to achieve the above object, the present invention adopts the following technical means:

[0009] The present invention discloses a premixed calcium silicate / calcium formate self-curing root canal filling material, comprising the following components: calcium silicate, calcium formate, A, an X-ray radiation blocking material, and a liquid phase component, wherein the liquid phase component is a non-aqueous phase solvent miscible with water;

[0010] In the premixed calcium silicate / calcium formate self-curing root canal filling material, the ratio of liquid phase component to solid phase component is 0.4-0.5 ml / g; the solid phase component is composed of calcium silicate, calcium formate, A and X-ray radiation blocking material;

[0011] Among them, in the solid phase components, the calcium silicate component + the calcium formate component account for 61%-95% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material, preferably 76-95%, and the mass ratio of the calcium silicate component to the calcium formate component is (4-19):1, preferably (14-19):1. The present invention controls the ratio of calcium silicate to calcium formate to be (4-19):1 and controls the calcium silicate + calcium formate to account for 61%-95% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material in order to shorten the curing time as much as possible and ensure the compressive strength of the product. In the present invention, if the ratio of calcium silicate / calcium formate is too large, it will lead to too long a curing time of the material, and if it is too small, it will lead to a decrease in the compressive strength of the material. Among them, the particle size of the calcium silicate powder is 0.1-10μm, and the average particle size is 400nm-1um, and is further preferably 400-600nm

[0012] A accounts for 0%-9% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material, preferably 3%-9%.

[0013] The X-ray blocking material accounts for 0%-30% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material, preferably 15-25%.

[0014] Wherein, preferably, A is selected from at least one of monocalcium phosphate, calcium hydrogen phosphate, α-tricalcium phosphate, and β-tricalcium phosphate. More preferably, it is α-tricalcium phosphate. In the present invention, A is preferably α-tricalcium phosphate and its dosage is controlled to be 3%-9% in order to improve the biological properties of the material. When the dosage of component A is too much, the physical and chemical properties of the material such as compressive strength and curing time will deteriorate, and too little will lead to no obvious improvement in biological properties, so its dosage is optimized to 3-9%.

[0015] Preferably, the X-ray blocking material is selected from at least one of zirconium oxide, bismuth oxide, and calcium tungstate. Zirconium oxide is further preferred. In the present invention, the amount of the X-ray blocking material is controlled at 15%-25% in order to provide anti-blocking properties. When the amount of the X-ray blocking material is too much, the compressive strength of the material will be reduced, and when it is too little, the resistance will be poor, so the amount is optimized to 15-25%.

[0016] Among them, preferably, the liquid phase component is selected from: one or more of glycerol, propylene glycol, ethylene glycol, polyethylene glycol 200, and polyethylene glycol 400. Polyethylene glycol 200 and / or polyethylene glycol 400 are preferred. The reason why the present invention selects non-aqueous organic matter as a solvent is that a root canal filling material that can be stored for a long time after mixing can be obtained, and the reason why the present invention increases the ratio of liquid phase component to solid phase component to 0.4-0.5 ml / g is because the material has good injectability and fluidity. If the ratio is too low, the injectability and fluidity will be deteriorated, and if it is too high, it will increase the curing time and reduce the compressive strength.

[0017] Preferably, 72% tricalcium silicate powder (average particle size of 500nm), 5% calcium formate powder, 20% zirconium oxide powder (particle size of 1-100nm), and 3% α-tricalcium phosphate powder are uniformly mixed by mass percentage, and polyethylene glycol 200 is used as the premixed liquid phase; the solid phase powder and the premixed liquid phase are fully mixed at a liquid-to-solid ratio of 0.5ml / g; the solid phase powder is composed of the prepared tricalcium silicate powder, calcium formate powder, zirconium oxide powder, and α-tricalcium phosphate powder.

[0018] As a further preferred embodiment, the average particle size of the tricalcium silicate powder is 500 nm, and the particle size of the zirconium oxide powder is 1-100 nm.

[0019] The invention dispenses each raw material according to the designed composition and then mixes them evenly to obtain the product. In practical application, the evenly mixed slurry is transferred to a medical syringe equipped with an injection butterfly needle, and the premixed calcium silicate / calcium formate self-curing root canal filling material is obtained after packaging and sterilization.

[0020] The present invention uniformly mixes calcium silicate powder, a second phase (such as) for improving solidification performance, powder of a radiation-blocking material, calcium phosphate, and a non-aqueous phase solvent miscible with water by manual or mechanical ball milling to obtain a mixed slurry, and then transfers the mixed slurry to a medical syringe equipped with an injection butterfly needle, and after packaging and sterilization, a premixed calcium silicate / calcium formate self-curing root canal filling material is obtained.

[0021] Furthermore, the present invention also proposes the use of the premixed calcium silicate / calcium formate self-curing root canal filling material in dental root canal filling materials.

[0022] The beneficial effects of the present invention are:

[0023] (1) All components of the premixed calcium silicate / calcium formate self-curing root canal filling material of the present invention are non-cytotoxic, have good biocompatibility and high biosafety.

[0024] (2) The composite slurry is in a premixed state and does not require solid-liquid mixing when used. It has good fluidity and injectability and is simple and convenient to use as a filling material. It also contains a radiation-blocking agent to facilitate postoperative observation.

[0025] (3) The premixed calcium silicate / calcium formate self-curing root canal filling material of the present invention can be cured in a short time after contacting with body fluids, and has high compressive strength, which is conducive to achieving rapid and high-quality filling.

[0026] (4) The composite self-curing root canal filling material can form a bond with the surrounding tissue, actively promote the repair and regeneration of dentin, and has antibacterial properties similar to calcium hydroxide. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a graph showing the injectability performance test results of the premixed calcium silicate / calcium formate self-curing root canal filling materials prepared in Comparative Example 1 and Examples 1, 2, 3, and 4 of the present invention;

[0028] Figure 2 (a)(b)(c)(d) are SEM images of apatite deposited on the surface of premixed calcium silicate / calcium formate / α-tricalcium phosphate / zirconium oxide self-curing root canal filling materials prepared in Comparative Example 2 and Examples 5, 6 and 7, respectively. DETAILED DESCRIPTION

[0029] The present invention will be further described below in conjunction with specific embodiments, and the advantages and features of the present invention will become clearer as the description proceeds.

[0030] The tricalcium silicate used in the following examples is synthesized by coprecipitation. Calcium oxalate and tetraethyl orthosilicate are used as raw materials, nitric acid is used as a catalyst, and the initial stoichiometric ratio of CaO / SiO2 is set to 3. First, 0.1 mol of tetraethyl orthosilicate is added to a mixture of 40 ml of deionized water and 29.3 ml of anhydrous ethanol. Then, the mixture is stirred continuously for 10 minutes at room temperature to mix evenly, and the pH value of the solution is adjusted to 1-2 with nitric acid. After the mixed solution is heated to 60°C, 0.3 mol of calcium oxalate is slowly added to the solution as a calcium precursor, stirred at 60°C for about 2 hours with a magnetic stirrer, and then placed in a 60°C drying oven for drying. The precursor powder is compacted and loaded into an alumina sintering boat, and then calcined at a temperature of 1400°C for 6 hours, and tricalcium silicate is obtained after air cooling, and tricalcium silicate powder (average particle size is 500nm) is obtained by grinding, ball milling and sieving.

[0031] Comparative Example 1

[0032] Single tricalcium silicate powder (particle size of 500nm) is used as the solid phase; analytical grade polyethylene glycol 200 is used as the premixed liquid phase; the solid phase and the solidifying liquid are mixed evenly according to the liquid-solid ratio of 0.5ml / g to prepare the premixed slurry. Setting time: 633±26 minutes. Compressive strength: 58MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, with a measuring speed of 1.00mm / min)

[0033] Example 1

[0034] 95% tricalcium silicate powder (average particle size of 500 nm) and 5% calcium formate powder were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was used as a premixed liquid phase;

[0035] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material remains fluid under sealed conditions, and the extruded sample is placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the solidification time is: 352±11 minutes. Compressive strength: 65MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, and the measurement speed is 1.00mm / min).

[0036] Example 2

[0037] 90% tricalcium silicate powder (average particle size of 500 nm) and 10% calcium formate powder were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was used as a premixed liquid phase;

[0038] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material is kept fluid under sealed conditions, extruded and placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the solidification time is: 328±10 minutes. Compressive strength: 44MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, and the measuring speed is 1.00mm / min).

[0039] Example 3

[0040] 85% tricalcium silicate powder (average particle size of 500 nm) and 15% calcium formate powder were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was used as a premixed liquid phase;

[0041] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material remains fluid under sealed conditions, and the extruded sample is placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the solidification time is: 317±8 minutes. Compressive strength: 26MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, and the measuring speed is 1.00mm / min).

[0042] Example 4

[0043] 80% tricalcium silicate powder (average particle size of 500 nm) and 20% calcium formate powder were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was used as a premixed liquid phase;

[0044] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material is kept fluid under sealed conditions, extruded and placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the solidification time is: 297±11 minutes. Compressive strength: 22MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, and the measuring speed is 1.00mm / min).

[0045] Through the exploration of Examples 1-4, it was found that when using tricalcium silicate, calcium formate and polyethylene glycol 200, increasing the relative amount of calcium formate powder (relative to tricalcium silicate) is beneficial to shorten the setting time, but the compressive strength of the product decays too quickly. In order to ensure that the product has sufficient compressive strength, the mass ratio of tricalcium silicate powder to calcium formate powder is controlled at 10:1 to 19:1. In order to avoid adjusting the components again during application, the present invention also attempts to introduce X-ray blocking materials and calcium phosphate series (including α-tricalcium phosphate) gradually or simultaneously, as follows:

[0046] Comparative Example 2

[0047] 75% tricalcium silicate powder (average particle size of 500 nm), 5% calcium formate powder, and 20% zirconium oxide (particle size of 1-100 nm) were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was taken as a premixed liquid phase;

[0048] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material is kept fluid under sealed conditions, extruded and placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the curing time is: 362±16 minutes. Compressive strength: 20MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, and the measuring speed is 1.00mm / min).

[0049] It is found through Comparative Example 2 that the introduction of X-ray blocking material such as 20% of zirconium oxide causes the compressive strength of the product to decrease rapidly.

[0050] Example 5

[0051] 72% tricalcium silicate powder (average particle size of 500 nm), 5% calcium formate powder, 20% zirconium oxide powder (particle size of 1-100 nm), and 3% α-tricalcium phosphate powder were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was used as a premixed liquid phase;

[0052] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material is kept fluid under sealed conditions, extruded and placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the curing time is: 377±16 minutes. Compressive strength: 27MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, and the measuring speed is 1.00mm / min).

[0053] Example 6

[0054] 69% tricalcium silicate powder (average particle size of 500 nm), 5% calcium formate powder, 20% zirconium oxide powder (particle size of 1-100 nm), and 6% α-tricalcium phosphate powder were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was taken as a premixed liquid phase;

[0055] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material is kept fluid under sealed conditions, extruded and placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the curing time is: 395±14 minutes. Compressive strength: 22MPa (the compressive strength sample is a cylindrical sample with a diameter of 6mm and a height of 12mm, measured using an American Instron3369 mechanical testing machine, and the measuring speed is 1.00mm / min).

[0056] Example 7

[0057] 66% tricalcium silicate powder (average particle size of 500 nm), 5% calcium formate powder, 20% zirconium oxide powder (particle size of 1-100 nm), and 9% α-tricalcium phosphate powder were uniformly mixed according to mass percentage to obtain 2 g of composite solid phase powder, and analytical grade polyethylene glycol 200 was used as a premixed liquid phase;

[0058] The solid phase powder and the premixed liquid phase are fully mixed at a liquid-solid ratio of 0.5 ml / g, and then the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed calcium silicate / calcium formate root canal filling material. The material is kept fluid under sealed conditions, extruded and placed in a constant temperature and humidity chamber at 37°C and a humidity of more than 95%, hydrated, solidified and hardened, and the curing time is: 407±14 minutes. Compressive strength: 21 MPa (the compressive strength sample is a cylindrical sample with a diameter of 6 mm and a height of 12 mm, measured using an American Instron 3369 mechanical testing machine, and the measuring speed is 1.00 mm / min).

Claims

1. A premixed calcium silicate / calcium formate self-curing root canal filling material, characterized in that: The invention comprises the following components: calcium silicate, calcium formate, A, X-ray blocking material, and liquid phase component, wherein the liquid phase component is a non-aqueous phase solvent miscible with water; In the premixed calcium silicate / calcium formate self-curing root canal filling material, the ratio of liquid phase component to solid phase component is 0.4-0.5 ml / g; the solid phase component is composed of calcium silicate, calcium formate, A and X-ray radiation blocking material; Among them, in the solid phase components, the calcium silicate component + the calcium formate component account for 61%-95% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material, and the mass ratio of the calcium silicate component to the calcium formate component is (4-19):1; the average particle size of the calcium silicate powder is required to be 400nm-1um; Wherein, A accounts for 0%-9% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material; X-ray blocking material accounts for 0%-30% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material; The A is selected from at least one of monocalcium phosphate, dicalcium phosphate, α-tricalcium phosphate, and β-tricalcium phosphate; The X-ray blocking material is selected from at least one of zirconium oxide, bismuth oxide and calcium tungstate; The liquid phase component is selected from: one or more of glycerol, propylene glycol, ethylene glycol, polyethylene glycol 200, and polyethylene glycol 400.

2. A premixed calcium silicate / calcium formate self-curing root canal filling material according to claim 1, characterized in that: The mass ratio of calcium silicate to component calcium formate is (14-19):

1.

3. A premixed calcium silicate / calcium formate self-curing root canal filling material according to claim 1, characterized in that: A accounts for 3%-9% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material.

4. The premixed calcium silicate / calcium formate self-curing root canal filling material according to claim 1, characterized in that: The X-ray blocking material accounts for 15-25% of the total powder mass of the premixed calcium silicate / calcium formate self-curing root canal filling material.

5. The premixed calcium silicate / calcium formate self-curing root canal filling material according to claim 1, characterized in that: A is α-tricalcium phosphate, and its usage is 3%-9%.

6. The premixed calcium silicate / calcium formate self-curing root canal filling material according to claim 1, characterized in that: The amount of X-ray blocking material is controlled at 15%-25%.

7. The premixed calcium silicate / calcium formate self-curing root canal filling material according to claim 1, characterized in that: The liquid phase component is polyethylene glycol 200 and / or polyethylene glycol 400.

8. The premixed calcium silicate / calcium formate self-curing root canal filling material according to claim 1, characterized in that: 72% tricalcium silicate powder, 5% calcium formate powder, 20% zirconium oxide powder and 3% α-tricalcium phosphate powder are uniformly mixed according to mass percentage, and polyethylene glycol 200 is used as a premixed liquid phase; the solid phase powder and the premixed liquid phase are fully and uniformly mixed at a liquid-to-solid ratio of 0.5 ml / g; the solid phase powder is composed of the prepared tricalcium silicate powder, calcium formate powder, zirconium oxide powder and α-tricalcium phosphate powder.

9. A method for preparing a premixed calcium silicate / calcium formate self-curing root canal filling material according to any one of claims 1 to 8, characterized in that: The raw materials are taken according to the designed composition, and then mixed evenly to obtain the product.

10. An application of the premixed calcium silicate / calcium formate self-curing root canal filling material according to any one of claims 1 to 8, characterized in that: Application of the premixed calcium silicate / calcium formate self-curing root canal filling material in dental filling materials.

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