Sanitary insecticidal composition containing cyprosulfuron and propoxur and application thereof

Abstract

The invention discloses a sanitary insecticidal composition containing cyprosulfuron and propoxur and application thereof, the effective components are cyprosulfuron and propoxur, the total content of the cyprosulfuron and propoxur is 2%-70%, and the balance is an auxiliary agent; the weight ratio of the cyprosulfuron to the propoxur is (15: 1)-(1: 15); the dosage form of the sanitary insecticidal composition is a suspending agent, an oil suspending agent, a dry suspending agent, wettable powder and water dispersible granules. According to the sanitary insecticidal composition, on one hand, the environmental compatibility is good, the use amount of pesticides is reduced, on the other hand, from the aspect of the action mechanism, the action mechanisms of the cyprosulfuron and the propoxur are different, cross resistance does not exist, the control effect is improved, and the insecticide resistance of pests can be delayed by compounding the two insecticides with different action mechanisms; the resistance treatment of the pests is facilitated.

Description

Technical Field

[0001] The invention relates to a binary sanitary insecticide composition and application thereof, in particular to a sanitary insecticide composition containing ciprofloxacin and propoxur and application thereof, wherein the active ingredients are ciprofloxacin and propoxur. Background Art

[0002] For a long time, residual spraying agents used against public health pests have mostly been single or compound formulations of pyrethroid products. The long-term use of pyrethroid agents has caused health pests such as mosquitoes, flies, and cockroaches to develop varying degrees of resistance to some pyrethroids, greatly reducing the control effect.

[0003] Cyprodinil belongs to the class of diamide compounds that act on the nicotinic acetylcholine receptors of insects, interfering with the stimulation conduction of the insect nervous system, thereby causing paralysis and death of the insects.

[0004] Propoxur has contact and stomach poisoning effects and good knockdown activity. It has the dual characteristics of inhibiting acetylcholinesterase and acting on nerve axons.

[0005] The present invention finds through experiments that the compounding of ciprofloxacin and propoxur can solve the resistance problem. On the one hand, from the perspective of the action mechanism, since the compounding of the two does not have cross-resistance with the existing sanitary insecticides, the resistance problem of sanitary pests such as mosquitoes, flies and cockroaches is solved, the prevention effect is improved, and the dosage of the medicine is reduced; on the other hand, the irritation of ciprofloxacin and propoxur is small, which improves the safety of the pesticide applicators; furthermore, the compounding of the two insecticides with different action mechanisms can also delay the generation of pest resistance. Summary of the invention

[0006] The technical problem to be solved by the present invention is to provide a sanitary insecticide composition containing ciprofloxacin and propoxur and application thereof in view of the deficiencies in the prior art. The active ingredients are ciprofloxacin and propoxur. On the one hand, the environmental compatibility is good and the amount of pesticide use is reduced. On the other hand, from the perspective of the action mechanism, the action mechanisms of ciprofloxacin and propoxur sanitary insecticides are different, there is no cross-resistance, and the prevention effect is improved. The compounding of the two insecticides with different action mechanisms can also delay the drug resistance of pests, which is beneficial to the resistance control of pests.

[0007] In order to achieve the above object, the present invention adopts the following technical solution:

[0008] The invention firstly provides a sanitary insecticide composition containing ciprofloxacin and propoxur. The active ingredients are ciprofloxacin and propoxur. By weight, the total weight of the active ingredients accounts for 2%-70% of the total weight of the sanitary insecticide composition, and the remainder is adjuvant. The weight ratio of ciprofloxacin to propoxur is 15:1-1:15.

[0009] In the above technical solution, the weight ratio of ciprofloxacin to propoxur is preferably 11:1 to 5:1.

[0010] In the above technical solution, the auxiliary agent is a mixture of three or more of a wetting agent, a dispersant, an antifreeze agent, a preservative, a defoaming agent, a thickener, a disintegrant, an emulsifier, a filler, a solvent and deionized water in any proportion.

[0011] In the above technical solution, the sanitary insecticide composition is in the form of suspension, oil suspension, dry suspension, wettable powder and water dispersible granules.

[0012] In the above technical scheme, when the dosage form of the sanitary insecticide composition is a suspension, it includes the following raw materials in weight percentage: 1-40% of cyfluthrin, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoamer, 0.5-3% of a thickener, and deionized water is added to 100%.

[0013] In the above technical scheme, when the dosage form of the sanitary insecticide composition is an oil suspension, it includes the following raw materials in weight percentage: 1-25% of cyfluthrin, 1-10% of propoxur, 0.2-1% of wetting agent, 0.3-3% of dispersant, 2-6% of emulsifier, 0.2-5% of defoamer, 0.2-5% of thickener, and the solvent is supplemented to 100%.

[0014] In the above technical scheme, when the sanitary insecticide composition is in the form of a dry suspension, it comprises the following raw materials in weight percentage: 1-50% of cyfluthrin, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, and the filler is supplemented to 100%.

[0015] In the above technical scheme, when the dosage form of the sanitary insecticide composition is a wettable powder, it comprises the following raw materials in weight percentage: 1-60% of cyfluthrin, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, and the filler is supplemented to 100%.

[0016] In the above technical scheme, when the dosage form of the sanitary insecticide composition is a water-dispersible granule, it comprises the following raw materials in weight percentage: 1-60% of ciprofloxacin, 1-10% of propoxur, 2-15% of a wetting agent, 5-20% of a dispersant, 2-8% of a disintegrant, and the filler is supplemented to 100%.

[0017] In the above technical scheme, the wetting agent is selected from any one of sodium naphthalenesulfonate, sodium dodecyl sulfate, pull-opening powder BX, alkylphenol polyoxyethylene ether formaldehyde condensate sodium sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sodium sulfate, alkyl sodium sulfonate, and dodecylbenzene sulfonic acid, or a mixture of two or more in any proportion.

[0018] In the above technical scheme, the dispersant is selected from any one of sodium polycarboxylate, sodium lignin sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate, sodium naphthalenesulfonic acid formaldehyde condensate, non-ionic hydroxy polyethylene oxide block copolymer, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, and glycerol fatty acid ester polyoxyethylene ether, or a mixture of two or more in any proportion.

[0019] In the above technical solution, the antifreeze agent is selected from any one of ethylene glycol, propylene glycol, glycerol, glycerin, urea, or a mixture of two or more of them in any proportion.

[0020] In the above technical solution, the preservative is selected from any one of sodium benzoate, benzoic acid, potassium sorbate, and kasone, or a mixture of two or more of them in any proportion.

[0021] In the above technical solution, the defoaming agent is selected from any one of polydimethylsiloxane, silicone oil, glyceryl ricinoleate, distearylethylenediamine, or a mixture of two or more in any proportion.

[0022] In the above technical solution, the thickener is selected from any one of xanthan gum, hydroxymethyl cellulose, hydroxyethyl cellulose, and magnesium aluminum silicate, or a mixture of two or more of them in any proportion.

[0023] In the above technical solution, the disintegrant is selected from any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate, sodium sulfate, or a mixture of two or more of them in any proportion.

[0024] In the above technical scheme, the emulsifier is selected from any one of calcium dodecylbenzene sulfonate, nonylphenol polyoxyethylene ether, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, Span 60, Span 80, Tween 60, Tween 80, fatty alcohol polyoxyethylene ether, styrylphenol polyoxyethylene ether, alkylaryl polyoxyethylene ether polyoxypropylene ether, or a mixture of two or more in any proportion.

[0025] In the above technical solution, the filler is selected from any one of kaolin, white carbon black, corn starch, attapulgite, calcium carbonate, light calcium, diatomaceous earth, bentonite, or a mixture of two or more in any proportion.

[0026] In the above technical scheme, the solvent is selected from any one of N,N-dimethylformamide, N,N-dimethylacetamide, N,N-dimethylbutyl amide, xylene, ethanol, soybean oil, methyl oleate, corn oil, rapeseed oil, and dodecane, or a mixture of two or more in any proportion.

[0027] In the above technical scheme, the sanitary insecticide composition, when in the form of suspension concentrate, oil suspension concentrate, dry suspension concentrate, wettable powder and water dispersible granules, can be prepared according to conventional methods or existing methods in the art.

[0028] The present invention also provides an application of the sanitary insecticide composition containing ciprofloxacin and propoxur in preventing and controlling sanitary pests.

[0029] In the above technical scheme, the sanitary pests refer to Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Aedes harassingus, Chironomids, housefly, city fly, Chrysocytidae, Lucilia sericata, Lucilia cuprina, Lucilia luminifera, summer toilet fly, Yuan toilet fly, German cockroach, and American cockroach.

[0030] In the above technical scheme, the sanitary pests are preferably resistant varieties such as Culex pipiens pallens, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Housefly, Cityfly, Lucilia sericata, Lucilia cuprina, German cockroach, and American cockroach.

[0031] In the above technical scheme, when the sanitary insecticide composition containing cyfluthrin and propoxur is used to control sanitary pests, the sanitary insecticide composition is diluted 50-300 times with water and then sprayed on surfaces such as walls, doors and windows, ceilings and homes, so that the sanitary insecticide composition remains on the surfaces of the above objects, thereby knocking down and killing the sanitary pests.

[0032] Compared with the existing technology, it has the following characteristics:

[0033] (1) A diamide compound is applied to the field of sanitary pest retention spraying;

[0034] (2) The synergistic effect of compounding with propoxur is obvious, which improves the lethal effect on sanitary pests;

[0035] (3) Good environmental compatibility, reducing the amount of pesticides used;

[0036] (4) The combination of two active ingredients with different mechanisms of action can effectively reduce the problem of pest resistance that may arise from long-term use of a single agent. DETAILED DESCRIPTION

[0037] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0038] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0039] The laboratory preparation method of the suspension concentrate is as follows: weigh the wetting agent, dispersant, antifreeze agent, preservative, defoamer, thickener, and deionized water according to the ratio, add them into a beaker and mix them evenly, then add cyfluthrin and propoxur into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, add the thickener and continue grinding for 0.5 hours, control the particle size D95 below 5 microns, filter to remove the zirconium oxide beads, and the suspension concentrate can be obtained.

[0040] The laboratory preparation method of the oil suspension concentrate is as follows: dispersant, wetting agent, emulsifier, defoamer, thickener and solvent are weighed according to the proportion, added into a beaker and mixed evenly, then cyfluthrin and propoxur are added into the beaker, and then transferred to a sand mill, zirconium oxide beads are added into the sand mill, and ground for 2-3 hours, and the thickener is added and ground for 0.5 hours, so that the particle size D95 is controlled below 5 microns, and the zirconium oxide beads are removed by filtering to obtain the oil suspension concentrate.

[0041] The laboratory preparation method of the dry suspension concentrate is: weigh the wetting agent, dispersant and filler according to the ratio, add them into a beaker and mix them evenly, then add cyfluthrin and propoxur into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, control the particle size D95 below 5 microns, filter to remove the zirconium oxide beads, and dry the obtained material through a spray dryer to obtain the suspension concentrate.

[0042] The laboratory preparation method of wettable powder is as follows: weigh cyflumitriptyline, propoxur, wetting agent, dispersant and filler according to the proportion, add them into a food processor and mix them evenly, then put them into a jet mill to grind them.

[0043] The laboratory preparation method of water dispersible granules is as follows: ciprofloxacin, propoxur, wetting agent, dispersant, disintegrant and filler are weighed according to the proportion, added into a food processor and mixed evenly, then put into a jet mill for grinding, mixed again with a food processor, added with an appropriate amount of water, extruded into granules with a granulator, and dried in an oven at 45°C.

[0044] The present invention will be described below in conjunction with specific embodiments:

[0045] Formulation Example 1: 18% cyprodinil·propoxur suspension

[0046] 15% cyfluthrin, 3% propoxur, 1% sodium naphthalenesulfonate, 8% sodium polycarboxylate, 3% ethylene glycol, 0.3% sodium benzoate, 0.1% distearyl ethylenediamine, 3% xanthan gum, and deionized water to 100%.

[0047] Formulation Example 2: 16% cyprodinil·propoxur suspension

[0048] 15% cyfluthrin, 1% propoxur, 3% sodium lauryl sulfate, 5% sodium lignin sulfonate, 4% propylene glycol, 1% benzoic acid, 0.4% silicone oil, 2.5% hydroxymethyl cellulose, and deionized water to 100%.

[0049] Formulation Example 3: 10% cyprodinil·propoxur suspension

[0050] 5% of cyfluthrin, 5% of propoxur, 5% of lakai powder BX, 3% of alkylphenol polyoxyethylene ether formaldehyde condensate, 6% of glycerol, 1.5% of potassium sorbate, 0.7% of glycerol ricinoleate, 1.5% of hydroxyethyl cellulose, and deionized water is added to 100%.

[0051] Formulation Example 4: 12% cyprodinil·propoxur suspension

[0052] 2% cyprodinil, 10% propoxur, 8% sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 1% sodium naphthalenesulfonic acid formaldehyde condensate, 7% glycerol, 2% kason, 1% polydimethylsiloxane, 0.5% magnesium aluminum silicate, and deionized water is added to 100%.

[0053] Formulation Example 5: 18% cyprodinil·propoxur oil suspension

[0054] 15% of cyfluthrin, 3% of propoxur, 0.2% of alkylbenzene polyoxyethylene ether phosphate, 3% of non-ionic hydroxy polyethylene oxide block copolymer, 6% of calcium dodecylbenzene sulfonate, 0.2% of distearyl ethylenediamine, 5% of xanthan gum, and methyl oleate is supplemented to 100%.

[0055] Formulation Example 6: 27% cyprodinil·propoxur oil suspension

[0056] 25% cyprodinil, 2% propoxur, 0.5% phenethylphenol polyoxyethylene ether phosphate, 1.5% fatty amine polyoxyethylene ether, 5% nonylphenol polyoxyethylene ether, 2% silicone oil, 3% hydroxymethyl cellulose, and corn oil to make up to 100%.

[0057] Formulation Example 7: 20% cyprodinil·propoxur oil suspension

[0058] 10% cyfluthrin, 10% propoxur, 0.8% sodium lauryl sulfate, 1% polyoxyethylene fatty acid esters, 3% alkylphenol polyoxyethylene ethers, 3% glyceryl ricinoleate, 2% hydroxyethyl cellulose, and rapeseed oil makes up to 100%.

[0059] Formulation Example 8: 8% cyprodinil·propoxur oil suspension

[0060] 2% of ciprofloxacin, 6% of propoxur, 1% of sodium alkyl sulfonate, 0.3% of glycerol fatty acid ester polyoxyethylene ether, 2% of castor oil polyoxyethylene ether, 5% of polydimethylsiloxane, 0.2% of magnesium aluminum silicate, and dodecane is supplemented to 100%.

[0061] Formulation Example 9: 18% cyprodinil·propoxur dry suspension

[0062] 15% of cyfluthrin, 3% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of sodium naphthalenesulfonic acid formaldehyde condensate, and kaolin is added to make up to 100%.

[0063] Formulation Example 10: 55% cyprodinil·propoxur dry suspension

[0064] 50% of cyfluthrin, 5% of propoxur, 3% of sodium lauryl sulfate, 5% of alkylphenol polyoxyethylene ether formaldehyde condensate, and corn starch is supplemented to 100%.

[0065] Formulation Example 11: 30% cyprodinil·propoxur dry suspension

[0066] 20% of cyfluthrin, 10% of propoxur, 5% of sodium alkyl sulfonate, 3% of sodium lignin sulfonate, and attapulgite is added to make up to 100%.

[0067] Formulation Example 12: 12% cyprodinil·propoxur dry suspension

[0068] 2% cyfluthrin, 10% propoxur, 8% dodecylbenzenesulfonic acid, 1% sodium polycarboxylate, and calcium carbonate to 100%.

[0069] Formulation Example 13: 18% cyprodinil·propoxur wettable powder

[0070] 15% cyfluthrin, 3% propoxur, 2% sodium naphthalenesulfonate, 18% sodium polycarboxylate, and kaolin to make up to 100%.

[0071] Formulation Example 14: 65% cyprodinil·propoxur wettable powder

[0072] 60% cyfluthrin, 5% propoxur, 3% sodium lauryl sulfate, 14% sodium lignin sulfonate, 10% white carbon black, and corn starch to make up to 100%.

[0073] Formulation Example 15: 30% cyprodinil·propoxur wettable powder

[0074] 20% of cyfluthrin, 10% of propoxur, 5% of lakai powder BX, 11% of alkylphenol polyoxyethylene ether formaldehyde condensate, and attapulgite is supplemented to 100%.

[0075] Formulation Example 16: 13% cyprodinil·propoxur wettable powder

[0076] 3% of cyfluthrin, 9% of propoxur, 6% of sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 7% of sodium naphthalenesulfonic acid formaldehyde condensate, and kaolin is added to make up to 100%.

[0077] Formulation Example 17: 18% cyprodinil·propoxur water dispersible granules

[0078] 15% of cyfluthrin, 3% of propoxur, 2% of alkylbenzene polyoxyethylene ether phosphate, 20% of non-ionic hydroxy polyethylene oxide block copolymer, 2% of sodium sulfate, and bentonite is added to make up to 100%.

[0079] Formulation Example 18: 64% cyprodinil·propoxur water dispersible granules

[0080] 60% of cyfluthrin, 4% of propoxur, 6% of phenethylphenol polyoxyethylene ether phosphate, 15% of fatty amine polyoxyethylene ether, 2% of sodium carbonate, 2% of sodium bicarbonate, and diatomaceous earth to make up to 100%.

[0081] Formulation Example 19: 30% cyprodinil·propoxur water dispersible granules

[0082] 20% ciprofloxacin, 10% propoxur, 10% sodium lauryl sulfate, 10% polyoxyethylene fatty acid esters, 6% ammonium sulfate, and light calcium supplemented to 100%.

[0083] Formulation Example 20: 20% cyprodinil·propoxur water dispersible granules

[0084] 10% cyprodinil, 10% propoxur, 10% sodium alkyl sulfonate, 5% dodecylbenzenesulfonic acid, 4% fatty acid polyoxyethylene ester, 1% glycerol fatty acid ester polyoxyethylene ether, 8% sodium chloride, and calcium carbonate to make up to 100%.

[0085] Formulation Example 21: 50% cyprodinil·propoxur suspension

[0086] 40% cyfluthrin, 10% propoxur, 1% sodium naphthalenesulfonate, 8% sodium polycarboxylate, 3% ethylene glycol, 0.3% sodium benzoate, 0.1% polydimethylsiloxane, 3% xanthan gum, and deionized water to 100%.

[0087] Formulation Example 22: 35% cyprodinil·propoxur oil suspension

[0088] 25% of cyfluthrin, 10% of propoxur, 0.2% of alkylbenzene polyoxyethylene ether phosphate, 3% of non-ionic hydroxy polyethylene oxide block copolymer, 6% of calcium dodecylbenzene sulfonate, 0.2% of polydimethylsiloxane, 5% of xanthan gum, and methyl oleate is supplemented to 100%.

[0089] Formulation Example 23: 60% cyprodinil·propoxur dry suspension

[0090] 50% of cyfluthrin, 10% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of sodium naphthalenesulfonic acid formaldehyde condensate, and kaolin is added to make up to 100%.

[0091] Formulation Example 24: 70% cyprodinil·propoxur wettable powder

[0092] 60% cyfluthrin, 10% propoxur, 2% sodium naphthalenesulfonate, 7% sodium polycarboxylate, and kaolin to make up to 100%.

[0093] Formulation Example 25: 70% cyprodinil·propoxur water dispersible granules

[0094] 60% of cyfluthrin, 10% of propoxur, 2% of alkylbenzene polyoxyethylene ether phosphate, 7% of non-ionic hydroxy polyethylene oxide block copolymer, 2% of sodium sulfate, and bentonite is added to make up to 100%.

[0095] The following specific tests are used to test the efficacy of the drug:

[0096] Control agent 1: 10% chlorpromazine-propoxur suspension (commercially available)

[0097] Control agent 2: 10% cischlorfenapyr wettable powder (commercially available)

[0098] Experiment 1: Determination of resistance levels of Culex pipiens pallens and housefly in the wild in Nanjing

[0099] (1) Experimental subjects: Culex pipiens pallens reared in the laboratory, the first generation of Culex pipiens pallens reared in the laboratory from the wild in Nanjing, houseflies reared in the laboratory, and the first generation of houseflies reared in the laboratory from the wild in Nanjing

[0100] (2) Test method: Refer to the Guidelines for Indoor Bioassay of Pesticides (Part 1: Contact Activity Test) and use the spot method NY / T1154.1-2006 to conduct activity assay tests on Culex pipiens pallens and housefly.

[0101] (3) Test agent: Propoxur original drug

[0102] (4) Test results:

[0103] Table 1 Activity data of Culex pipiens pallens and housefly in the laboratory and in the wild in Nanjing

[0104]

[0105] From the table above, we can see that the resistance of Culex pipiens pallens in the wild in Nanjing to propoxur is 33 times that of that in the laboratory, and the resistance of houseflies in the wild in Nanjing to propoxur is 29 times that of that in the laboratory. In the following, the Culex pipiens pallens and houseflies collected from the wild in Nanjing are referred to as field resistant strains.

[0106] Verification test 2: Determination of resistance levels of Culex pipiens pallens and housefly in the wild in Nanjing

[0107] (1) Experimental subjects: Culex pipiens pallens reared in the laboratory, the first generation of Culex pipiens pallens reared in the laboratory from the wild in Nanjing, houseflies reared in the laboratory, and the first generation of houseflies reared in the laboratory from the wild in Nanjing

[0108] (2) Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spraying test.

[0109] (3) Test Agent: Example 1

[0110] (4) Test results:

[0111] Table 2 Residual spraying data of Culex pipiens pallens and housefly in the laboratory and in the wild in Nanjing

[0112]

[0113] From the residual spraying test data in Table 2, it can be seen that the KT50 of Culex pipiens pallens and housefly in the wild in Nanjing is significantly higher than that of the laboratory strains, which also confirms that the Nanjing strain has developed resistance to propoxur.

[0114] Verification test 3: Co-toxicity coefficient of ciprofloxacin and propoxur against Culex pipiens pallens

[0115] (1) Test subjects: Culex pipiens (laboratory reared)

[0116] (2) Test method: Refer to the Guidelines for Indoor Bioassay of Pesticides (Part 1: Contact Activity Test) and use the spot test method NY / T1154.1-2006 to conduct activity assay on Culex pipiens pallens.

[0117] (3) Data statistics: The co-toxicity coefficient method was used to evaluate the activity of the combination of the two against Culex pipiens pallens. The toxicity regression equation was then calculated using DPS statistical software to obtain the LD50 value of each drug, and then the toxicity index and co-toxicity coefficient of the agent were calculated according to the Sun Yunpei method. A co-toxicity coefficient greater than 120 indicates a synergistic effect, a co-toxicity coefficient between 80-120 indicates an additive effect, and a co-toxicity coefficient less than 80 indicates an antagonistic effect. The test results are shown in the following table:

[0118] Table 3 Co-toxicity coefficient of cypermethrin and chlorpyrifos to Culex pipiens pallens

[0119]

[0120] It can be seen from Table 3 that the co-toxicity coefficient of ciprofloxacin:propoxur at the ratio of 13:1 to 5:1 is greater than 120, which is a synergistic effect.

[0121] Verification test 4: Efficacy test for controlling mosquitoes and flies

[0122] (1) Test subjects: Culex pipiens pallens and housefly (first generation of resistant strains bred in the field)

[0123] (2) Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spraying test.

[0124] (3) Test agents: Preparation Examples 1, 5, 9, 13, and 17 were diluted with water to 900 ppm, and control agents 1 and 2 were diluted with water to 900 ppm.

[0125] (4) Statistics:

[0126] Table 4 Efficacy test data of several treatments against Culex pipiens and housefly

[0127]

[0128]

[0129] As can be seen from Table 4, the KT50 values ​​of several embodiments of the combination of ciprofloxacin and propoxur against resistant Culex pipiens pallens and houseflies were all less than 8 minutes, and the 24-hour mortality rates were all greater than 95%, while the KT50 values ​​of control agents 1 and 2 against resistant Culex pipiens pallens and houseflies were all greater than 14 minutes, and the 24-hour mortality rates were all less than or equal to 80%. It can be seen that the combination of ciprofloxacin and propoxur has a good control effect on resistant varieties of Culex pipiens pallens and houseflies using a residual spraying method.

[0130] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A sanitary insecticide composition containing ciprofloxacin and propoxur, characterized in that: The active ingredients are ciprofloxacin and propoxur, and the total weight of the active ingredients accounts for 2%-70% of the total weight of the sanitary insecticide composition, and the remainder is adjuvants; the weight ratio of ciprofloxacin to propoxur is 15:1-1:

15.

2. The sanitary insecticidal composition according to claim 1, characterized in that: The auxiliary agent is a mixture of three or more of wetting agent, dispersant, antifreeze agent, preservative, defoamer, thickener, disintegrant, emulsifier, filler, solvent and deionized water in any proportion; the sanitary insecticide composition has the dosage form of suspension, oil suspension, dry suspension, wettable powder and water dispersible granules.

3. The sanitary insecticidal composition according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of a suspension, it comprises the following raw materials in percentage by weight: 1-40% of ciprofloxacin, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoamer, 0.5-3% of a thickener, and deionized water is added to make up to 100%.

4. The sanitary insecticidal composition according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of an oil suspension, it comprises the following raw materials in percentage by weight: 1-25% of cyfluthrin, 1-10% of propoxur, 0.2-1% of a wetting agent, 0.3-3% of a dispersant, 2-6% of an emulsifier, 0.2-5% of a defoamer, and 0.2-5% of a thickener, and the solvent is supplemented to 100%.

5. The sanitary insecticidal composition according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of a dry suspension, it comprises the following raw materials in percentage by weight: 1-50% of cyfluthrin, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, and the filler is supplemented to 100%.

6. The sanitary insecticidal composition according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of a wettable powder, it comprises the following raw materials in percentage by weight: 1-60% of cyfluthrin, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, and the filler is supplemented to 100%.

7. The sanitary insecticidal composition according to claim 1, characterized in that: When the sanitary insecticide composition is in the form of water dispersible granules, it comprises the following raw materials in weight percentage: 1-60% of ciprofloxacin, 1-10% of propoxur, 2-15% of wetting agent, 5-20% of dispersant, 2-8% of disintegrant, and the filler is supplemented to 100%.

8. Use of the sanitary insecticide composition containing cyfluthrin and propoxur as claimed in any one of claims 1 to 7 in controlling sanitary pests.

9. The use according to claim 8, characterized in that: The sanitary pests mentioned herein refer to Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Argus harassingus, Chironomids, Housefly, Cityfly, Chrysocytidae, Lucilia sericata, Lucilia cuprina, Lucilia luminifera, Summer toilet fly, Yuan toilet fly, German cockroach, and American cockroach.

10. The use according to claim 8, characterized in that: When the sanitary insecticide composition containing cyfluthrin and propoxur is used to control sanitary pests, the sanitary insecticide composition is diluted 30-300 times with water and then sprayed on surfaces such as walls, doors and windows, ceilings and homes, so that the sanitary insecticide composition remains on the surfaces of the above objects, thereby knocking down and killing the sanitary pests.

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