Compound sanitary insecticidal composition and application thereof

Abstract

The invention discloses a compound sanitary insecticidal composition and application thereof, the effective components are an active component A and an active component B, the active component A is oxadiazon, the active component B is a piperic acid derivative compound, and the balance is an auxiliary agent. The weight ratio of the active component A to the active component B is (1: 20)-(20: 1), preferably (1: 5)-(5: 1), and the total weight of the active component A and the active component B accounts for 2-80% of the weight of the composition. The binary composition solves the problem of resistance of sanitary pests to pyrethroids, and has the characteristics of high efficiency, low toxicity, environmental friendliness and the like. The binary composition is suitable for preventing and treating indoor and outdoor sanitary pests including mosquitoes, flies, cockroaches, fleas, bugs, diplods and the like, and is suitable for families, restaurants, hotels, carriages, animal breeding places and the like.

Description

Technical Field

[0001] The invention relates to a binary sanitary insecticide composition and application thereof, in particular to an insecticide composition containing methadone and a piperic acid derivative compound and application thereof, belonging to the technical field of sanitary insecticide. Background Art

[0002] For a long time, the types of preparations used to control public health pests have been relatively single, and most of the residual spraying and space spraying insecticides used for public health pests are single or compound pyrethroids. The long-term use of pyrethroid insecticides has caused health pests such as mosquitoes, flies, and cockroaches to develop varying degrees of resistance to some pyrethroids.

[0003] Methicillin has contact and stomach poisoning effects on pests, and has good knockdown activity. It has the dual characteristics of inhibiting acetylcholinesterase and acting on nerve synapses, and is mainly used as a sanitary insecticide to control houseflies, cockroaches, etc. However, the stability of the original drug of methicillin is poor, it is unstable above 50°C, and it will gradually decompose under light. In addition, the solubility of methicillin in water is 1g / L, and it is easily degraded in aqueous liquid preparations. Therefore, ensuring the stability of methicillin in pesticide formulations is an important way to improve the efficacy.

[0004] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has a novel mechanism of action, has no cross-resistance with existing commonly used insecticides, has a broad insecticide spectrum, and has good lasting effect. The structural formula of the compound is as follows:

[0005]

[0006] At present, the only registered formulation of methadone is aerosol, which is used for sanitary pests. The present invention has found through experiments that the combination of methadone and piperic acid derivatives has a synergistic effect. On the one hand, it has good environmental compatibility and reduces the amount of pesticide used. On the other hand, from the perspective of the mechanism of action, methadone and piperic acid derivatives have different mechanisms of action and do not have cross-resistance, which improves the control effect. The combination of insecticides with different mechanisms of action can also delay pest resistance, which is beneficial to the control of pest resistance. Summary of the invention

[0007] The technical problem to be solved by the present invention is to provide a compound sanitary insecticide composition and its application in view of the deficiencies existing in the prior art. The compound sanitary insecticide composition is a compound of oxadone and compound I-72. After the compound of the two, it has the characteristics of high efficiency, low toxicity and good lasting effect, can reduce the number of applications, reduce costs and is more environmentally friendly; on the other hand, the compound of oxadone and compound I-72 can delay the development of drug resistance in sanitary pests.

[0008] In order to achieve the above object, the present invention adopts the following technical solution:

[0009] The present invention first provides a compound sanitary insecticide composition, wherein the active ingredients are composed of active ingredient A and active ingredient B, the total weight of active ingredient A and active ingredient B accounts for 2-80% of the weight of the entire insecticide composition, and the remainder is an adjuvant;

[0010] The active ingredient A is oxadiazine;

[0011] The active ingredient B is a piperic acid derivative compound shown in formula I (referred to as compound I-72)

[0012]

[0013] In the above technical solution, the weight ratio of the compound of oxadone and the piperic acid derivative compound is 1:20 to 20:1, preferably 1:5 to 5:1.

[0014] In the above technical solution, the auxiliary agent is any one of a dispersant, an emulsifier, a stabilizer, an antifreeze agent, a thickener, a preservative, a defoaming agent, a solvent, a wetting agent, a disintegrant, water and a filler, or a mixture of two or more in any proportion.

[0015] In the above technical scheme, the compound sanitary insecticide composition is in the form of emulsifiable concentrate, aqueous emulsion, microemulsion, soluble liquid, suspension, wettable powder and water dispersible granules; it can be formulated into a preparation according to the needs and the technical methods known in the art.

[0016] In the above technical scheme, the compound sanitary insecticide composition, when in the form of emulsifiable concentrate, comprises the following raw materials in weight percentage: 1% to 10% of mefenacet, 1% to 20% of compound I-72, 7% to 20% of emulsifier, and the solvent is supplemented to 100%.

[0017] In the above technical scheme, the compound sanitary insecticide composition, when in the form of an aqueous emulsion, comprises the following raw materials in weight percentage: 1% to 20% of oxadone, 1% to 20% of compound I-72, 2% to 6% of a stabilizer, 5% to 30% of an emulsifier, 10% to 30% of a solvent, 1% to 5% of an antifreeze agent, 0.1% to 0.5% of a defoaming agent, and water is added to 100%.

[0018] In the above technical scheme, the compound sanitary insecticide composition, when in the form of a microemulsion, comprises the following raw materials in weight percentage: 1% to 10% of oxadone, 1% to 10% of compound I-72, 2% to 6% of stabilizer, 10% to 40% of emulsifier, 30% to 50% of solvent, and water to 100%.

[0019] In the above technical scheme, the compound sanitary insecticide composition, when in the form of a soluble liquid, comprises the following raw materials in weight percentage: 1% to 10% of oxadone, 1% to 20% of compound I-72, 2% to 6% of stabilizer, 5% to 20% of emulsifier, and the solvent is supplemented to 100%.

[0020] In the above technical scheme, the compound sanitary insecticide composition, when the dosage form is a suspension, includes the following raw materials in weight percentage: 1% to 20% of mefenamic acid, 1% to 20% of compound I-72, 0.5% to 5% of wetting agent, 1% to 20% of dispersant, 2% to 6% of stabilizer, 0.2% to 2% of thickener, 1% to 10% of antifreeze agent, 0.1% to 0.5% of preservative, 0.1% to 0.5% of defoaming agent, and water is supplemented to 100%.

[0021] In the above technical scheme, the compound sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 1% to 20% of mefenamic acid, 1% to 40% of compound I-72, 2% to 6% of a stabilizer, 0.5% to 5% of a wetting agent, 1% to 15% of a dispersant, and the filler is supplemented to 100%.

[0022] In the above technical scheme, the compound sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 1% to 40% of oxadone, 1% to 40% of compound I-72, 2% to 6% of stabilizer, 1% to 4% of wetting agent, 1% to 10% of dispersant, 1% to 10% of disintegrant, and the filler is supplemented to 100%.

[0023] In the above technical solution, the stabilizer is selected from: any one of benzotriazole and sodium hexametaphosphate or a mixture of the two in any proportion, the purpose of which is to prevent the degradation of mefenamic acid and prevent the weakening of the efficacy.

[0024] In the above technical scheme, the dispersant is selected from: any one of polycarboxylates, alkylphenol polyoxyethylene ether formaldehyde condensates, naphthalenesulfonic acid formaldehyde condensates sodium salts, fatty acid polyoxyethylene ethers, fatty amine polyoxyethylene ethers, lignin sulfonates, and block polyethers, or a mixture of two or more in any proportion.

[0025] In the above technical solution, the wetting agent is selected from: any one of naphthalene sulfonate, alkyl sulfate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfonate, pull-opening powder BX, sodium dodecylbenzene sulfonate, or a mixture of two or more in any proportion.

[0026] In the above technical scheme, the emulsifier is selected from: any one of calcium dodecylbenzene sulfonate, dodecylphenol polyoxyethylene ether, phenethylphenol polyoxyethylene ether, non-ionic hydroxy polyethylene oxide block copolymer, castor oil polyoxyethylene ether, polyoxyethylene ether formaldehyde condensate sulfate, and fatty alcohol polyoxyethylene ether, or a mixture of two or more in any proportion.

[0027] In the above technical solution, the thickener is selected from: any one of xanthan gum, methyl cellulose, and magnesium aluminum silicate, or a mixture of two or more of them in any proportion.

[0028] In the above technical solution, the preservative is selected from: any one of potassium sorbate, sodium benzoate, and kason, or a mixture of two or more of them in any proportion.

[0029] In the above technical solution, the defoaming agent is selected from: any one of silicone compounds, silicone oil, lauric acid, and stearic acid, or a mixture of two or more of them in any proportion.

[0030] In the above technical scheme, the solvent is selected from: any one of isopropyl myristate, tributyl citrate, acetyl tributyl citrate, diisopropyl adipate, N,N-dimethyl decanoate, aromatic solvent oil, dodecylbenzene, N-methyl pyrrolidone, or a mixture of two or more in any proportion.

[0031] The above disintegrant is selected from: one of ammonium sulfate, sodium bicarbonate and sodium sulfate.

[0032] The antifreeze agent is selected from one or more of ethylene glycol, propylene glycol, glycerol, glycerin and urea.

[0033] The filler is selected from one or more of kaolin, diatomaceous earth, bentonite, white carbon black and corn starch.

[0034] The present invention also provides an application of the compound sanitary insecticide composition in the field of preventing and controlling sanitary pests.

[0035] In the above technical solution, the application fields include homes, restaurants, hotels, carriages, animal breeding and other places.

[0036] In the above technical scheme, the sanitary pests include Culex pipiens pallens, Culex pipiens quinquefasciatus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, housefly, city fly, big-headed golden fly, Lucilia sericata, Lucilia cuprina, bright green fly, German cockroach, American cockroach, human flea, bed bug, striped millipede, pink millipede, etc.

[0037] In the above technical scheme, when the compound sanitary insecticide composition is used to control sanitary pests, the insecticide composition is diluted 50-300 times with water and sprayed on surfaces such as walls, doors, windows, ceilings and homes, so that the binary sanitary insecticide remains on the surfaces of the above objects, knocking down and killing the sanitary pests. Its applicable dosage forms are suspensions, wettable powders and water-dispersible granules.

[0038] In the above technical scheme, when the compound sanitary insecticide composition is used to control sanitary pests, the insecticide composition is diluted 50-300 times with water and then evenly sprayed into the space using ultra-low volume, fog machine, constant volume spray and other spray equipment, so that the sanitary pests are exposed to the agent when they are active in the application space, thereby knocking down and killing the sanitary pests, and controlling the sanitary pests. Its applicable dosage forms are emulsifiable concentrates, water emulsions, microemulsions and soluble liquids.

[0039] Compared with the existing technology, it has the following characteristics:

[0040] The sanitary insecticide composition of the present invention has the characteristics of high efficiency, low toxicity, and environmental friendliness, and is mainly used to solve the problem of resistance of sanitary pests to pyrethroids. Through experiments, it was found that the combination of pyrethroid and compound I-72 can not only solve such resistance problems, but also significantly improve the knockdown and lethality of sanitary pests compared with existing sanitary insecticide products. DETAILED DESCRIPTION

[0041] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0042] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0043] The preparation method of the emulsifiable concentrate is as follows: weigh oxadiazine, compound I-72, an emulsifier and a solvent according to a formula, heat and mix them evenly, and then the emulsifiable concentrate can be obtained.

[0044] The preparation method of the aqueous emulsion is as follows: weigh oxadiazine, compound I-72, emulsifier, and solvent according to the ratio, heat and dissolve them as the oil phase, weigh water, stabilizer and antifreeze according to the ratio as the aqueous phase, slowly add the aqueous phase to the oil phase under shear conditions, and finally add the defoaming agent, continue shearing for 5 minutes to obtain the aqueous emulsion.

[0045] The preparation method of the microemulsion is as follows: weigh oxadiazine, compound I-72, stabilizer, emulsifier, solvent and water according to the formula, heat to dissolve and mix evenly to obtain the microemulsion.

[0046] The preparation method of the soluble liquid is as follows: weigh oxadiazine, compound I-72, stabilizer, emulsifier, and solvent according to the formula, heat to fully dissolve and mix evenly, and then the soluble liquid can be obtained.

[0047] The preparation method of the suspension concentrate is: weigh the wetting agent, dispersant, stabilizer, antifreeze, preservative, defoamer and water according to the ratio and mix them evenly, then add oxadiazine and compound I-72, transfer to a sand mill, add an appropriate amount of zirconium oxide beads in the sand mill, grind for 2-3 hours, add a thickener and continue grinding for half an hour, filter to remove the zirconium oxide beads, and the suspension concentrate can be obtained.

[0048] The preparation method of the wettable powder is as follows: the oxadone, compound I-72, stabilizer, wetting agent, dispersant and filler in the said proportion are uniformly mixed, and then crushed by an ultra-fine air flow mill to obtain the wettable powder.

[0049] The preparation method of water-dispersible granules is: mix the said proportion of oxadone, compound I-72, stabilizer, wetting agent, dispersant, disintegrant and filler evenly, crush them with an ultrafine air flow mill, add appropriate amount of water for kneading, and then put them into a granulator for extrusion granulation, and then dry them to obtain water-dispersible granules.

[0050] The present invention will be described below in conjunction with specific embodiments:

[0051] Formulation Example 1: 20% oxadiazine·Compound I-72 Suspension

[0052] 4g of oxadiazine, 6g of compound I-721, 1.5g of benzotriazole, 1.5g of sodium hexametaphosphate, 5g of sodium polycarboxylate, 3g of sodium lignin sulfonate, 1g of block polyether, 2g of sodium naphthalene sulfonate, 5g of ethylene glycol, 1.5g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.5g of potassium sorbate, 0.2g of silicone oil, and water is added to 100g. A suspension is prepared according to the above preparation method.

[0053] Formulation Example 2: 10% oxadiazine·Compound I-72 Suspension

[0054] 2g of oxadiazine, 8g of compound I-72, 1g of benzotriazole, 1g of sodium hexametaphosphate, 5g of sodium polycarboxylate, 1g of phenethylphenol polyoxyethylene ether phosphate, 5g of glycerol, 1.5g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.5g of kason, 0.2g of lauric acid, and water to make up to 100g. A suspension was prepared according to the above preparation method.

[0055] Formulation Example 3: 40% oxadiazine·Compound I-72 Suspension

[0056] 20g of oxadiazine, 20g of compound I-72, 2.5g of benzotriazole, 2.5g of sodium hexametaphosphate, 8g of sodium polycarboxylate, 2g of fatty acid polyoxyethylene ether, 2g of sodium dodecyl sulfonate, 2g of urea, 3g of propylene glycol, 1.5g of methylcellulose, 0.3g of xanthan gum, 0.5g of sodium benzoate, 0.2g of silicone oil, and water to 100g. A suspension was prepared according to the above preparation method.

[0057] Formulation Example 4: 18% Methicillin·Compound I-72 Water Dispersible Granules

[0058] 15g of oxadiazine, 3g of compound I-72, 2g of benzotriazole, 2g of sodium hexametaphosphate, 8g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 2g of sodium lignin sulfonate, 2g of pulverized powder BX, 5g of ammonium sulfate, and corn starch to make up to 100g. Water dispersible granules were prepared according to the above preparation method.

[0059] Formulation Example 5: 40% Methicillin·Compound I-72 Water Dispersible Granules

[0060] 10g of oxadiazine, 30g of compound I-72, 1.5g of benzotriazole, 1.5g of sodium hexametaphosphate, 6g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 2g of sodium lignin sulfonate, 3g of sodium dodecyl sulfate, 1g of pulverized powder BX, 5g of sodium sulfate, 20g of corn starch, and the amount of bentonite is made up to 100g. Water dispersible granules are prepared according to the above preparation method.

[0061] Formulation Example 6: 80% Methicillin·Compound I-72 Water Dispersible Granules

[0062] 40g of oxadiazine, 40g of compound I-72, 3g of benzotriazole, 3g of sodium hexametaphosphate, 6g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 4g of sodium lignin sulfonate, 1g of sodium dodecyl sulfate, 2g of pulverized powder BX, 5g of sodium bicarbonate, and corn starch to make up to 100g. Water dispersible granules were prepared according to the above preparation method.

[0063] Formulation Example 7: 24% oxadiazine·Compound I-72 Wettable Powder

[0064] 16g of oxadiazine, 8g of compound I-7, 2g of benzotriazole, 2g of sodium hexametaphosphate, 4g of sodium dodecylbenzenesulfonate, 3g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 3g of white carbon black, and kaolin to make up to 100g. A wettable powder was prepared according to the above preparation method.

[0065] Formulation Example 8: 30% oxadiazine·Compound I-72 Wettable Powder

[0066] 20g of oxadiazine, 10g of compound I-72, 2g of benzotriazole, 2g of sodium hexametaphosphate, 2g of sodium lauryl sulfate, 10g of fatty amine polyoxyethylene ether, 3g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 3g of white carbon black, and diatomaceous earth to make up to 100g. A wettable powder was prepared according to the above preparation method.

[0067] Formulation Example 9: 40% oxadiazine·Compound I-72 Wettable Powder

[0068] 5g of oxadiazine, 5g of compound I-723, 1g of benzotriazole, 1g of sodium hexametaphosphate, 4g of sodium naphthalenesulfonate, 5g of sodium ligninsulfonate, 5g of sodium salt of naphthalenesulfonic acid formaldehyde condensate, 5g of white carbon black, and corn starch to make up to 100g. A wettable powder was prepared according to the above preparation method.

[0069] Formulation Example 10: 8% oxadiazine·Compound I-72 emulsifiable concentrate

[0070] 6g of oxadiazine, 2g of compound I-72, 4g of polyoxyethylene dodecylphenol ether, 3g of calcium dodecylbenzenesulfonate, 10g of tributyl citrate, and aromatic solvent oil S-150# to make up to 100g. Emulsifiable concentrate was prepared according to the above preparation method.

[0071] Formulation Example 11: 15% oxadiazine·Compound I-72 emulsifiable concentrate

[0072] 9g of oxadone, 6g of compound I-72, 8g of castor oil polyoxyethylene ether, 4g of calcium dodecylbenzenesulfonate, 10g of tributyl citrate, and dodecylbenzene is added to make up to 100g. Emulsifiable concentrate is prepared according to the above preparation method.

[0073] Formulation Example 12: 30% oxadiazine·Compound I-72 emulsifiable concentrate

[0074] 10g of oxadiazine, 20g of compound I-72, 8g of fatty alcohol polyoxyethylene ether, 8g of phenethylphenol polyoxyethylene ether, 4g of calcium dodecylbenzenesulfonate, 10g of isopropyl myristate, and dodecylbenzene is added to make up to 100g. An emulsifiable concentrate is prepared according to the above preparation method.

[0075] Formulation Example 13: 6% oxadiazine·Compound I-72 aqueous emulsion

[0076] 1g of oxadiazine, 5g of compound I-72, 1g of benzotriazole, 1g of sodium hexametaphosphate, 8g of fatty alcohol polyoxyethylene ether, 2g of phenethylphenol polyoxyethylene ether, 4g of calcium dodecylbenzenesulfonate, 20g of dodecylbenzene, 5g of glycerol, 0.2g of silicone oil, and water to make up to 100g. A water emulsion was prepared according to the above preparation method.

[0077] Formulation Example 14: 15% oxadiazine·Compound I-72 aqueous emulsion

[0078] 3g of oxadiazine, 12g of compound I-72, 1g of benzotriazole, 1g of sodium hexametaphosphate, 8g of fatty alcohol polyoxyethylene ether, 2g of phenethylphenol polyoxyethylene ether, 2g of polyoxyethylene ether formaldehyde condensate sodium sulfate, 8g of calcium dodecylbenzenesulfonate, 20g of dodecylbenzene, 5g of propylene glycol, 0.2g of silicone oil, and water is added to 100g. A water emulsion is prepared according to the above preparation method.

[0079] Formulation Example 15: 31% oxadiazine·Compound I-72 aqueous emulsion

[0080] 20g of oxadiazine, 1g of compound I-72, 2g of benzotriazole, 2g of sodium hexametaphosphate, 8g of fatty alcohol polyoxyethylene ether, 2g of phenethylphenol polyoxyethylene ether, 2g of calcium dodecylbenzenesulfonate, 15g of tributyl citrate, 5g of dodecylbenzene, 5g of ethylene glycol, 0.2g of stearic acid, and water is added to make up to 100g. A water emulsion is prepared according to the above preparation method.

[0081] Formulation Example 16: 8% oxadiazine·Compound I-72 Microemulsion

[0082] 1g of oxadiazine, compound I-727g, 1g of benzotriazole, 1g of sodium hexametaphosphate, 20g of fatty alcohol polyoxyethylene ether, 5g of calcium dodecylbenzenesulfonate, 50g of N,N-dimethylhexylamide, and water to make up to 100g. A microemulsion was prepared according to the above preparation method.

[0083] Formulation Example 17: 13% oxadiazine·Compound I-72 Microemulsion

[0084] 3g of oxadiazine, 10g of compound I-72, 1g of benzotriazole, 1g of sodium hexametaphosphate, 20g of castor oil polyoxyethylene ether, 5g of calcium dodecylbenzenesulfonate, 30g of N,N-dimethyl decanoamide, 15g of acetyl tributyl citrate, and water to make up to 100g. A microemulsion was prepared according to the above preparation method.

[0085] Formulation Example 18: 20% oxadiazine·Compound I-72 Microemulsion

[0086] 10g of oxadiazine, 10g of compound I-72, 1g of benzotriazole, 1g of sodium hexametaphosphate, 20g of dodecylphenol polyoxyethylene ether, 5g of calcium dodecylbenzenesulfonate, 30g of N,N-dimethyl decanoic acid amide, 15g of dodecylbenzene, and water is added to 100g. A microemulsion is prepared according to the above preparation method.

[0087] Formulation Example 19: 2% oxadiazine·Compound I-72 soluble liquid

[0088] 1g of oxadiazine, 1g of compound I-72, 1g of benzotriazole, 1g of sodium hexametaphosphate, 10g of nonionic hydroxy polyethylene oxide block copolymer, 2g of calcium dodecylbenzenesulfonate, and N-methylpyrrolidone to make up to 100g. A soluble liquid is prepared according to the above preparation method.

[0089] Formulation Example 20: 20% oxadiazine·Compound I-72 soluble liquid

[0090] 5g of oxadiazine, 5g of compound I-721, 1g of benzotriazole, 1g of sodium hexametaphosphate, 10g of dodecylphenol polyoxyethylene ether, 5g of calcium dodecylbenzenesulfonate, 25g of diisopropyl adipate, and N-methylpyrrolidone to make up to 100g. A soluble liquid is prepared according to the above preparation method.

[0091] Formulation Example 21: 21% oxadiazine·Compound I-72 soluble liquid

[0092] 1g of oxadiazine, 20g of compound I-72, 1g of benzotriazole, 1g of sodium hexametaphosphate, 8g of dodecylphenol polyoxyethylene ether, 2g of calcium dodecylbenzene sulfonate, 10g of nonionic hydroxy polyethylene oxide block copolymer, 10g of N,N-dimethyl oxadiazine, and N-methyl pyrrolidone to make up to 100g. A soluble liquid is prepared according to the above preparation method.

[0093] The products obtained from the various formulation examples of the present invention are subjected to verification tests.

[0094] Control agent 1: 20% chlorpyrifos suspension

[0095] 20g of oxadiazine, 1.5g of benzotriazole, 1.5g of sodium hexametaphosphate, 5g of sodium polycarboxylate, 2g of sodium naphthalenesulfonate, 3g of sodium ligninsulfonate, 1g of block polyether, 5g of ethylene glycol, 1.5g of magnesium aluminum silicate, 0.5g of potassium sorbate, 0.3g of xanthan gum, 0.2g of silicone oil, and water is added to 100g. A suspension is prepared according to the preparation method of Preparation Example 1 of the present invention.

[0096] Control drug 2: 18% compound I-72 water dispersible granules

[0097] Compound I-7218g, benzotriazole 2g, sodium hexametaphosphate 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 8g, sodium lignin sulfonate 2g, pull open powder BX2g, ammonium sulfate 5g, corn starch is supplemented to 100g. Water dispersible granules are prepared according to the preparation method of the preparation example 4 of the present invention.

[0098] Control agent 3: 20% oxadiazine·Compound I-72 suspension (without stabilizer)

[0099] 4g of oxadiazine, 6g of compound I-721, 5g of sodium polycarboxylate, 2g of sodium naphthalenesulfonate, 3g of sodium ligninsulfonate, 1g of block polyether, 5g of ethylene glycol, 1.5g of magnesium aluminum silicate, 0.5g of potassium sorbate, 0.3g of xanthan gum, 0.2g of silicone oil, and water to 100g. A suspension was prepared according to the above preparation method.

[0100] Control agent 4: 8% chlorpyrifos EC

[0101] 8g of oxadiazine, 4g of dodecylphenol polyoxyethylene ether, 3g of calcium dodecylbenzene sulfonate, 10g of tributyl citrate, and dodecylbenzene is added to make up to 100g. An emulsifiable concentrate is prepared by referring to the preparation method of formulation example 10 of the present invention.

[0102] Control drug 5: 6% compound I-72 aqueous emulsion

[0103] Compound I-726g, 1g benzotriazole, 1g sodium hexametaphosphate, 8g fatty alcohol polyoxyethylene ether, 2g phenethylphenol polyoxyethylene ether, 4g calcium dodecylbenzenesulfonate, 20g dodecylbenzene, 5g glycerol, 0.2g silicone oil, water to 100g. Prepare an aqueous emulsion by referring to the preparation method of formulation example 13 of the present invention.

[0104] Control agent 6: 6% oxadiazine·Compound I-72 aqueous emulsion (without stabilizer)

[0105] 1g of oxadiazine, 5g of compound I-72, 8g of fatty alcohol polyoxyethylene ether, 2g of dodecylphenol polyoxyethylene ether, 4g of calcium dodecylbenzene sulfonate, 20g of dodecylbenzene, 5g of glycerol, 0.2g of silicone oil, and water to make up to 100g. A water emulsion was prepared according to the above preparation method.

[0106] Control agent 7: 8% highly effective cypermethrin wettable powder (commercially available)

[0107] Control agent 8: 10% highly effective cyhalothrin wettable powder (commercially available)

[0108] Control agent 9: 4.5% highly effective cypermethrin emulsion in water (commercially available)

[0109] Control agent 10: 10% highly effective cyhalothrin emulsion in water (commercially available)

[0110] Verification test 1: Co-toxicity coefficient of oxadone and compound I-72 to Culex pipiens pallens

[0111] Test subjects: Culex pipiens pallens, female adults that did not feed on blood on the 3rd to 5th day after emergence (laboratory reared);

[0112] Test method: Refer to the Indoor Bioassay Test Guidelines for Pesticides Part 1: Contact Activity Test, and use the spot method NY / T1154.1-2006 to conduct activity assay experiments on Culex pipiens pallens.

[0113] Data statistics: The co-toxicity coefficient method was used to evaluate the activity of the combination of the two against Culex pipiens pallens. Then the toxicity regression equation was calculated using DPS statistical software to obtain the LD50 value of each drug, and then the toxicity index and co-toxicity coefficient of the agent were calculated according to the Sun Yunpei method. A co-toxicity coefficient greater than 120 indicates a synergistic effect, a co-toxicity coefficient between 80-120 indicates an additive effect, and a co-toxicity coefficient less than 80 indicates an antagonistic effect. The test results are shown in the following table:

[0114] Table 1 Determination of co-toxicity coefficient (for Culex pipiens pallens)

[0115]

[0116]

[0117] As can be seen from Table 1, the co-toxicity coefficient of mefenamic acid: compound I-72 at a ratio of 1:5 to 5:1 is greater than 120, and there is an obvious synergistic effect.

[0118] Verification test 2: Efficacy test for controlling mosquitoes and flies

[0119] Test subjects: Culex pipiens and housefly (laboratory reared)

[0120] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spraying test.

[0121] Test agents: Preparation Examples 1, 2, 3, 4, 5, 6, 7, 8, and 9 were diluted with water to 1000 ppm, and control agents 1, 2, 3, 7, and 8 were diluted with water to 1000 ppm.

[0122] Statistics:

[0123] Table 2: Efficacy test of formulation examples 1-9 against mosquitoes and flies

[0124]

[0125]

[0126] As can be seen from Table 2, the KT50 values ​​of the above-mentioned embodiments of the compounding of oxadone and compound I-72 for Culex pipiens pallens and houseflies are all less than 5 minutes, and the 24-hour mortality rate exceeds 90%, while the KT50 values ​​of the control agents 1, 2, 7, and 8 for Culex pipiens pallens and houseflies are all greater than 5 minutes, and the 24-hour mortality rate is not greater than 90%. The above-mentioned embodiments of the compounding of oxadone and compound I-72 have obvious synergistic effects on the knockdown and lethality of mosquitoes and flies, and compared with commercially available products, the knockdown and lethality of the present invention for mosquitoes and flies are higher. The knockdown and lethality of control agent 3 are reduced compared to Example 1, which illustrates the improvement of the efficacy of the stabilizer. It can be seen that oxadone and compound I-72 have good control effects on Culex pipiens pallens and houseflies using a residual spraying method.

[0127] Verification test 3: Efficacy test of mosquito and fly control spray

[0128] Test subjects: Culex pipiens and housefly (laboratory reared)

[0129] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, spray test.

[0130] Test agents: Preparation Examples 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, and 21 were diluted with water to 800 ppm, and control agents 4, 5, 6, 9, and 10 were diluted with water to 800 ppm.

[0131] Statistics:

[0132] Table 3 Efficacy test of formulation examples 10-21 against mosquitoes and flies

[0133]

[0134]

[0135] As can be seen from Table 3, the KT50 values ​​of the above-mentioned embodiments of the compounding of oxadone and compound I-72 for Culex pipiens pallens and houseflies are all less than 5 minutes, and the 24-hour mortality rate exceeds 90%, while the KT50 values ​​of control agents 4, 5, 9, and 10 for Culex pipiens pallens and houseflies are all greater than 5 minutes, and the 24-hour mortality rate is not greater than 90%. The above-mentioned embodiments of the compounding of oxadone and compound I-72 have obvious synergistic effects on the knockdown and lethality of mosquitoes and flies, and compared with commercially available products, the knockdown and lethality of the present invention for mosquitoes and flies are higher. The knockdown and lethality of control agent 6 are reduced compared to Example 13, which illustrates the improvement of the efficacy of the stabilizer. It can be seen that oxadone and compound I-72 have good control effects on Culex pipiens pallens and houseflies using space spraying.

[0136] Verification test 4: efficacy test for preventing and controlling millipede retention

[0137] Test subject: Millipede

[0138] Test method: Select 20 millipedes of the same age and in good condition, put them in a transparent tank, place the transparent tank containing millipedes in a 10m2 (2m×5m) field, and spray the test agent evenly in the designated area using a small spray bottle, with the dosage of 15mL / m2. After the spraying, collect all the test insects and transfer them to a clean and transparent plastic box, resume standard feeding, and record the number of test insect deaths at 2 and 24h; set three replicates for each treatment, and calculate the 2 and 24h mortality rates.

[0139] Test agents: Preparation Examples 1, 2, 3, 4, 5, 6, 7, 8, and 9 were diluted with water to 1000 ppm, and control agents 1, 2, 3, 7, and 8 were diluted with water to 1000 ppm.

[0140] Statistics:

[0141] Table 4: Efficacy test of formulation examples 1-9 against millipedes

[0142]

[0143]

[0144] The results in Table 4 show that the above-mentioned examples of the combination of oxadone and compound I-72 have a better lethal effect on millipedes 2 hours and 24 hours after application than the control agent. This shows that the combination of oxadone and compound I-72 has a good control effect on millipedes by residual spraying.

[0145] The percentages in all the formulas of the present invention are weight percentages, and the processing methods and processes of the various preparations of the composition are all existing technologies, which can be adjusted and changed according to different situations. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A compound sanitary insecticide composition, Features: The active ingredients are composed of active ingredient A and active ingredient B, the total weight of active ingredient A and active ingredient B accounts for 2-80% of the weight of the entire insecticide composition, and the remainder is adjuvant; The active ingredient A is oxadiazine; The active ingredient B is a piperic acid derivative compound shown in formula I (referred to as compound I-72) 2. The compound sanitary insecticide composition according to claim 1, Features: The compounding weight ratio of the oxadone and the piperic acid derivative compound is 1:20 to 20:

1.

3. The compound sanitary insecticide composition according to claim 1, Features: The auxiliary agent is any one of a dispersant, an emulsifier, a stabilizer, an antifreeze agent, a thickener, a preservative, a defoamer, a solvent, a wetting agent, a disintegrant, water and a filler, or a mixture of two or more of them in any proportion; the compound sanitary insecticide composition is in the form of an emulsifiable concentrate, an aqueous emulsion, a microemulsion, a soluble liquid, a suspension, a wettable powder and a water-dispersible granule.

4. The compound sanitary insecticide composition according to claim 3, Features: The compound sanitary insecticide composition, when in the form of emulsifiable concentrate, comprises the following raw materials in weight percentage: 1% to 10% of oxadone, 1% to 20% of compound I-72, 7% to 20% of emulsifier, and the solvent is supplemented to 100%; the compound sanitary insecticide composition, when in the form of aqueous emulsion, comprises the following raw materials in weight percentage: 1% to 20% of oxadone, 1% to 20% of compound I-72, 2% to 6% of stabilizer, 5% to 30% of emulsifier, 10% to 30% of solvent, 1% to 5% of antifreeze agent, 0.1% to 0.5% of defoamer, and water is supplemented to 100%.

5. The compound sanitary insecticide composition according to claim 3, Features: The compound sanitary insecticide composition, when in the form of a microemulsion, comprises the following raw materials in weight percentage: 1% to 10% of mefenamic acid, 1% to 10% of compound I-72, 2% to 6% of a stabilizer, 10% to 40% of an emulsifier, 30% to 50% of a solvent, and water makes up to 100%; the compound sanitary insecticide composition, when in the form of a soluble liquid, comprises the following raw materials in weight percentage: 1% to 10% of mefenamic acid, 1% to 20% of compound I-72, 2% to 6% of a stabilizer, 5% to 20% of an emulsifier, and the solvent makes up to 100%.

6. The compound sanitary insecticide composition according to claim 3, Features: The compound sanitary insecticide composition, when in the form of a suspension, comprises the following raw materials in weight percentage: 1% to 20% of mefenamic acid, 1% to 20% of compound I-72, 0.5% to 5% of wetting agent, 1% to 20% of dispersant, 2% to 6% of stabilizer, 0.2% to 2% of thickener, 1% to 10% of antifreeze agent, 0.1% to 0.5% of preservative, 0.1% to 0.5% of defoamer, and water makes up to 100%; the compound sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 1% to 20% of mefenamic acid, 1% to 40% of compound I-72, 2% to 6% of stabilizer, 0.5% to 5% of wetting agent, 1% to 15% of dispersant, and filler makes up to 100%.

7. The compound sanitary insecticide composition according to claim 3, Features: The compound sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 1% to 40% of mefenamic acid, 1% to 40% of compound I-72, 2% to 6% of stabilizer, 1% to 4% of wetting agent, 1% to 10% of dispersant, 1% to 10% of disintegrant, and the filler is supplemented to 100%.

8. The compound sanitary insecticide composition according to any one of claims 4 to 7, Features: The stabilizer is selected from: any one of benzotriazole and sodium hexametaphosphate or a mixture of the two in any proportion.

9. Use of the compound sanitary insecticide composition according to claim 1 in controlling sanitary pests in application fields.

10. The use according to claim 9, It is characterized in that The application fields include homes, restaurants, hotels, carriages and animal breeding places; the sanitary pests include Culex pipiens pallens, Culex pipiens quinquefasciatus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, housefly, city fly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia luminifera, German cockroach, American cockroach, human flea, bed bug, striped millipede, pink millipede and the like.

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