A circular RNA for regulating Huaxi cattle breeding and its application
By identifying and applying novel_circ_0001180 circular RNA and its siRNA preparation, the problem of skeletal muscle development regulation in West China cattle breeding was solved, effective regulation of West China cattle skeletal muscle cell proliferation and cell cycle was achieved, and the process of high-yield meat breeding in West China cattle was promoted.
CN119120480BActive Publication Date: 2025-04-29INST OF ANIMAL SCI & VETERINARY MEDICINE SHANDONG ACADEMY OF AGRI SCI
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Patent Information
- Application Number
- CN202411449571.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-17
- Publication Date
- 2025-04-29
- Estimated Expiration
- 2044-10-17
AI Technical Summary
Technical Problem
The lack of effective circular RNA regulation methods in West China cattle breeding has affected the development of skeletal muscles and meat breeding.
Method used
A circular RNA derived from the SLTM gene, novel_circ_0001180, was identified and used to regulate the proliferation and cell cycle of West China bovine skeletal muscle cells by designing corresponding siRNA preparations.
Benefits of technology
novel_circ_0001180 can significantly regulate the proliferation and cell cycle of bovine skeletal muscle cells, providing a new target for beef cattle breeding, and promoting the high-yield meat breeding process of West China cattle.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention provides a circular RNA for regulating breeding of Huaxi cattle and its application, belonging to the field of breeding technology. The circular RNA is novel_circ_0001180, and its transcript sequence and connection gene sequence are shown as SEQ ID NO.1 and SEQ ID NO.2, respectively. The circular RNA promotes meat quality breeding by regulating the proliferation of skeletal muscle cells of Huaxi cattle. In addition, the present invention also provides the application of siRNA of novel_circ_0001180 in the preparation of a preparation for regulating skeletal muscle development of Huaxi cattle, and the siRNA sequence is as SEQ ID NO.15 and SEQ ID NO.16. The gene preparation is composed of siRNA of novel_circ_0001180 and nuclease-free water, which inhibits the proliferation of skeletal muscle cells of Huaxi cattle, thereby achieving the improvement of beef cattle varieties.
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