Artemisia argyi itching relieving and bacterium inhibiting ointment as well as preparation method and application thereof

Abstract

The invention relates to a folium artemisiae argyi itching-relieving and bacterium-inhibiting ointment and a preparation method and application thereof.The folium artemisiae argyi itching-relieving and bacterium-inhibiting ointment is prepared from, by weight, 4-6 parts of medicinal material extract, 36-42 parts of a water phase, 33-38 parts of an oil phase and 16-22 parts of auxiliary materials; the auxiliary materials comprise soybean peptide powder, glycerol and borneol powder. A medicinal material extract is extracted from raw materials of folium artemisiae argyi, fructus cnidii and golden larch bark compounded with multiple traditional Chinese medicinal materials, and the folium artemisiae argyi itching-relieving and antibacterial ointment is obtained after the medicinal material extract is mixed with milk-white paste obtained after a water-phase and oil-phase saponification reaction, soybean peptide powder, glycerol and borneol powder and can be used for preparing a medicine for treating beriberi caused by dermatophytes. The soybean peptide powder and the glycerol in the folium artemisiae argyi itching-relieving and bacterium-inhibiting ointment are combined together for use and have a synergistic effect, so that the folium artemisiae argyi itching-relieving and bacterium-inhibiting ointment is resistant to high temperature, low temperature and centrifugation and is not liable to oxidize and discolor, antibacterial components are not liable to volatilize under the conditions of high temperature and low temperature, and a relatively good antibacterial effect is kept.

Description

Technical Field

[0001] The invention belongs to the field of beriberi medicines, and particularly relates to an antipruritic and antibacterial ointment of wormwood leaves and a preparation method and application thereof. Background Art

[0002] Tinea pedis, also known as athlete's foot, is a chronic skin disease caused by fungal infection. It is characterized by itching, whitening, ulceration, and rubbing between the toes. Occasionally, there are single or multiple small blisters in groups. After rubbing, a small amount of sticky liquid will flow out. In severe cases, there will even be bleeding, erosion between the toes, odor, cracks, and peeling. Although the symptoms of athlete's foot are not very serious at first, rheumatic toxins can easily attack the abdomen. Once it becomes a serious disease, it is difficult to treat. Therefore, doctors in the Jin and Tang dynasties repeatedly emphasized that tinea pedis should be treated in time when the symptoms first appear, and it should not be delayed.

[0003] Artemisia argyi, also known as mugwort, has been shown in modern experimental studies to have detected a variety of effective ingredients in relevant pharmacological studies of artemisia argyi, among which the analgesic and anti-inflammatory, antibacterial, anti-tumor, antiviral, antioxidant, analgesic and anti-inflammatory, hypoglycemic, and immunomodulatory pharmacological effects are significant.

[0004] Cnidium monnieri is a traditional Chinese medicine with a long history. It comes from the dried mature fruit of the plant Cnidium monnieri of the Umbelliferae family. Its main active ingredients include coumarins, chromones, benzophenones and terpenes. According to traditional Chinese medicine theory, Cnidium monnieri has the effects of dispelling wind and dampness, killing insects and relieving itching, strengthening yang and warming the kidney. Clinically, it has been found that famous doctors have achieved significant results in the treatment of eczema by using Cnidium monnieri as an important medicinal material in their prescriptions.

[0005] Tujingpi, a traditional Chinese medicine, is derived from the dried root bark or near-root bark of the plant Pine Pine of the Pinaceae family. It has good effects in treating ringworm, relieving itching and killing insects. According to ancient documents, Tujingpi is warm in nature, pungent in taste and toxic. It enters the lung and spleen meridians. It has good insecticidal and itchy effects. Because of its toxicity, it is often used as an external medicine in clinical practice to treat various ringworm diseases such as tinea corporis, tinea pedis, tinea capitis, etc.

[0006] Folium Artemisiae Argyi, Fructus Cnidium monnieri, and Rhizoma Cibotii can all be used as Chinese medicinal materials to prepare ointments in combination with other Chinese medicinal materials with antibacterial effects. The ointments are applied to the affected area, can directly contact the lesion, and exert their therapeutic effects through skin administration. They are quickly absorbed, have strong effects, have long action time, are simple in method, and are easy to carry. However, the Chinese medicinal ointments in the prior art are prone to water-oil separation from the low temperature stage in winter to the high temperature stage in summer, are easily oxidized, and the antibacterial components are also easily volatile, thereby reducing the antibacterial effect of the ointment. Summary of the invention

[0007] The purpose of the present invention is to provide an antipruritic and antibacterial ointment of Artemisia argyi and a preparation method and application thereof in order to solve the above problems.

[0008] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0009] An wormwood antipruritic and antibacterial ointment, wherein the preparation materials of the wormwood antipruritic and antibacterial ointment include, by weight, 4-6 parts of medicinal material extract, 36-42 parts of aqueous phase, 33-38 parts of oil phase, and 16-22 parts of auxiliary materials;

[0010] The Chinese medicinal materials used in the preparation of the medicinal extract are composed of wormwood leaf, moutan bark, peach kernel, cassia twig, cnidium monnieri, sophora flavescens, rhubarb, coptis root, scutellaria baicalensis, phellodendron chinense, radix polygoni lobatae, zanthoxylum bungeanum, and thorn bark;

[0011] The oil phase includes stearic acid, lanolin, vaseline, and liquid paraffin;

[0012] The aqueous phase includes triethanolamine, distilled water, and ethylparaben;

[0013] The auxiliary materials include soybean peptide powder, glycerin and borneol powder.

[0014] As a further optimization scheme of the present invention, the mass ratio of the wormwood leaf, moutan bark, peach kernel, cinnamon twig, cnidium monnieri, sophora flavescens, rhubarb, coptis chinensis, scutellaria baicalensis, phellodendron chinense, herba speranskiae, zanthoxylum bungeanum, and thorn bark is 1:2:2:2:1:1.32:1:1:1:1:2:0.66:0.66.

[0015] As a further optimization scheme of the present invention, the oil phase comprises, by mass percentage, 26.7% stearic acid, 8% lanolin, 5.3% vaseline, and 60% liquid paraffin;

[0016] The aqueous phase comprises, by mass percentage, 6.9% of triethanolamine, 92.6% of distilled water, and 0.5% of ethylparaben;

[0017] The auxiliary materials include 35%-62% soybean peptide powder, 35%-62% glycerol and 3% borneol powder by mass percentage.

[0018] As a further optimization scheme of the present invention, the raw materials for preparing the wormwood antipruritic and antibacterial ointment include, by weight, 5 parts of medicinal extract, 39 parts of aqueous phase, 38 parts of oil phase, and 18 parts of auxiliary materials, wherein the auxiliary materials include, by mass percentage, 50% soybean peptide powder, 47% glycerol, and 3% borneol powder.

[0019] A method for preparing an antipruritic and antibacterial ointment of Artemisia argyi comprises the following steps:

[0020] (1) The Chinese medicinal material raw materials for preparing the medicinal material extract are ground into coarse powder, and then soaked in an ethanol solution of 5-6 times the total weight of the Chinese medicinal material raw materials, stirred and turned during the process, and the residues are removed by coarse filtration with a sieve, and then impurities in the liquid medicine are removed by filtering with gauze, and then evaporated and concentrated by a rotary evaporator to obtain the medicinal material extract;

[0021] (2) The water phase and the oil phase are placed in a water bath and heated to dissolve and keep warm. Under the same temperature conditions, the water phase is added to the oil phase to cause a saponification reaction and mixed and ground until a milky white paste is obtained;

[0022] (3) Add the medicinal extract and auxiliary materials to the milky white paste and stir evenly to obtain the wormwood antipruritic and antibacterial ointment.

[0023] As a further optimization scheme of the present invention, the ethanol solution is a 75% medical ethanol solution, and the soaking time is 7-10 days.

[0024] As a further optimization scheme of the present invention, in step (2), the insulation temperature is 80°C-90°C.

[0025] Application of an antipruritic and antibacterial ointment of wormwood in the preparation of a medicine for treating beriberi.

[0026] As a further optimization scheme of the present invention, the wormwood antipruritic and antibacterial ointment has an inhibitory effect on dermatophytes.

[0027] The beneficial effects of the present invention are:

[0028] 1) The present invention obtains a medicinal extract from a raw material of compounding a plurality of Chinese medicinal materials including wormwood leaf, cnidium monnieri, and thorn bark, and the extract is mixed with a milky white paste after saponification reaction of an aqueous phase and an oil phase, soybean peptide powder, glycerin, and borneol powder to prepare a wormwood antipruritic and antibacterial ointment, which has a good antibacterial effect on Trichophyton mentagrophytes and Trichophyton rubrum, and can be used to prepare a drug for treating beriberi caused by dermatophytes;

[0029] 2) The wormwood antipruritic and antibacterial ointment of the present invention has good stability. After heat-resistant treatment, cold-resistant treatment and centrifugal test, oil-water separation still does not occur, and there is no color change after long-term storage, and the quality and performance are stable;

[0030] 3) The soy peptide powder and glycerin in the wormwood antipruritic and antibacterial ointment of the present invention are used together to have a synergistic effect, so that the high temperature resistance, low temperature resistance and centrifugal resistance of the wormwood antipruritic and antibacterial ointment are greatly improved and it is not easy to oxidize and discolor;

[0031] 4) The soy peptide powder and glycerin in the wormwood antipruritic and antibacterial ointment of the present invention are used together to have a synergistic effect, so that the antibacterial components in the wormwood antipruritic and antibacterial ointment are not easy to volatilize under high and low temperature conditions. In practical applications, even after the hot and humid period in summer and the cold and humid period in winter, it can still maintain a good antibacterial effect and is easy to store. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1It is a state diagram of the wormwood antipruritic and antibacterial ointment of Examples 1-9 of the present invention after the heat resistance test.

[0033] Figure 2 It is a state diagram of the wormwood antipruritic and antibacterial ointment of Examples 1-9 of the present invention after being subjected to a cold resistance test.

[0034] Figure 3 It is a state diagram of the wormwood antipruritic and antibacterial ointment of Example 3 of the present invention after centrifugation test.

[0035] Figure 4 It is a state diagram of the wormwood antipruritic and antibacterial ointment of Examples 1-9 of the present invention at room temperature and pressure.

[0036] Figure 5 It is a diagram of the antibacterial test process of the wormwood antipruritic and antibacterial ointment of Example 3 of the present invention after being subjected to a heat resistance test (placed at 50° C. for 24 hours). DETAILED DESCRIPTION

[0037] The present application is further described in detail below in conjunction with the accompanying drawings. It is necessary to point out here that the following specific implementation methods are only used to further illustrate the present application and cannot be understood as limiting the scope of protection of the present application. Technical personnel in this field can make some non-essential improvements and adjustments to the present application based on the above application content.

[0038] 1. Materials

[0039] Artemisia argyi, moutan bark, peach kernel, cinnamon twig, cnidium monnieri, sophora flavescens, rhubarb, coptis chinensis, scutellaria baicalensis, phellodendron chinense, radix polygoni lobatae, zanthoxylum bungeana, thorn bark, and borneol were purchased from Anhui Chengfeng Pharmaceutical Co., Ltd.;

[0040] 75% medical ethanol solution; stearic acid, lanolin, vaseline, liquid paraffin; triethanolamine, distilled water, ethylparaben; glycerol, borneol, purchased from Bozhou Zhixuan Instrument Equipment Co., Ltd.;

[0041] Soy peptide powder is a commercially available product.

[0042] 2. Methods

[0043] 2.1 Preparation method of wormwood antipruritic and antibacterial ointment

[0044] The raw materials for preparing the wormwood antipruritic and antibacterial ointment include, by weight, 4-6 parts of medicinal material extract, 36-42 parts of water phase, 33-38 parts of oil phase, and 16-22 parts of auxiliary materials;

[0045] (1) The Chinese medicinal material raw materials for preparing the medicinal material extract are ground into coarse powder, added into a 75% ethanol solution of 5 times the total weight of the Chinese medicinal material, and soaked for 8 days, during which the Chinese medicinal material needs to be stirred and turned, and the residue is removed by coarse filtration with a sieve, and then the impurities in the liquid medicine are removed by filtering with gauze, and the liquid medicine is evaporated and concentrated by a rotary evaporator to obtain the medicinal material extract;

[0046] The Chinese medicinal materials used in the preparation of the medicinal extract are composed of wormwood leaf, moutan bark, peach kernel, cassia twig, cnidium monnieri, sophora flavescens, rhubarb, coptis root, scutellaria baicalensis, phellodendron chinense, radix polygoni lobatae, zanthoxylum bungeanum, and thorn bark;

[0047] The mass ratio of wormwood leaf, moutan bark, peach kernel, cassia twig, cnidium monnieri, sophora flavescens, rhubarb, coptis root, scutellaria baicalensis, phellodendron amurense, radix polygoni lobatae, zanthoxylum bungeanum, and thorn bark is 1:2:2:2:1:1.32:1:1:1:1:2:0.66:0.66;

[0048] (2) The water phase and the oil phase are placed in a water bath and heated to dissolve and keep warm. Under the condition of keeping the water bath warm at 85°C, the water phase is slowly added to the oil phase to cause saponification reaction and mixed and ground until a milky white paste is obtained;

[0049] The oil phase comprises, by mass percentage, 26.7% stearic acid, 8% lanolin, 5.3% vaseline, and 60% liquid paraffin;

[0050] The aqueous phase comprises, by mass percentage, 6.9% of triethanolamine, 92.6% of distilled water, and 0.5% of ethylparaben;

[0051] (3) Add the medicinal extract and auxiliary materials to the milky white paste and stir evenly to obtain the wormwood antipruritic and antibacterial ointment.

[0052] The auxiliary materials include 35%-62% soybean peptide powder, 35%-62% glycerol and 3% borneol powder by mass percentage.

[0053] In order to explore the optimal ratio of the wormwood antipruritic and antibacterial ointment, Examples 1-9 were set up, and the specific preparation raw materials of Examples 1-9 are shown in Table 1:

[0054] Table 1 Preparation of Artemisia argyi antipruritic and antibacterial ointment

[0055]

[0056] 2.2 Performance test of wormwood antipruritic and antibacterial ointment

[0057] 2.2.1 Stability test

[0058] The stability test includes heat resistance test, cold resistance test, appearance test, centrifugation test, and scoring. The group with the highest sum of the four test results is used as an indicator for evaluating the quality of the Artemisia argyi antipruritic and antibacterial ointment. The scoring criteria are shown in Table 2, and the scoring data are shown in Table 3.

[0059] The heat resistance test is as follows: 10g of the antipruritic and antibacterial ointment of Artemisia argyi is placed in a dry test tube and placed at 50℃ for 24h to observe whether there is oil-water separation, flocculence, color change and milky stratification. Figure 1 As shown;

[0060] The specific cold resistance test is to take 10g of the antipruritic and antibacterial ointment of Artemisia argyi and place it in a dry test tube, and place it at -20℃ for 24 hours to observe whether there is oil-water separation, flocculence, color change and milky stratification. Figure 2 As shown;

[0061] The centrifugation test is as follows: 10 g of the antipruritic and antibacterial ointment of Artemisia argyi is placed in a dry centrifuge tube and centrifuged at 3000 r / min and 4000 r / min for 30 min to observe whether there is oil-water separation, flocculence, color change and milky stratification. Figure 3 As shown;

[0062] The specific test of appearance properties is to store the wormwood antipruritic and antibacterial ointment at room temperature and pressure to observe the changes in its texture, color and odor, and apply an appropriate amount of the wormwood antipruritic and antibacterial ointment to the skin to observe the ease of application and skin absorption effect.

[0063] Table 2 Scoring criteria for stability test of Artemisia argyi antipruritic and antibacterial ointment

[0064]

[0065]

[0066] Table 3 Scoring table for stability test of Artemisia argyi antipruritic and antibacterial ointment

[0067]

[0068] Conclusion: It can be seen from the data in Table 3 that the wormwood antipruritic and antibacterial ointment prepared according to the ratio scheme of Example 3 has the best stability. After heat-resistant treatment, cold-resistant treatment and centrifugal test, there is still no oil-water separation, and there is no color change after long-term storage, no special smell, uniform texture, easy to apply, no other discomfort, and stable quality and performance. Therefore, the ratio scheme of Example 3 is the optimal component formula.

[0069] 2.2.2 Antibacterial test

[0070] The antibacterial test is specifically as follows: 10 g of the untreated wormwood antipruritic antibacterial ointment prepared by the ratio schemes of Examples 3, 5, and 8 and 10 g of the wormwood antipruritic antibacterial ointment prepared by the ratio schemes of Examples 3, 5, and 8 after the above-mentioned heat resistance test (placed at 50°C for 24 h) and cold resistance test (placed at -20°C for 24 h) are taken, and a total of nine groups of wormwood antipruritic antibacterial ointment samples are evenly applied in circles on the surfaces of the tricholoma sphaerocephala culture medium and the tricholoma rubrum culture dish, and a group of blank control groups are prepared, and the blank control group is the tricholoma sphaerocephala culture medium and the tricholoma rubrum culture dish to which the wormwood antipruritic antibacterial ointment to be tested is not applied;

[0071] Preparation of Trichophyton balsamiferum culture medium: cut 100g of potato into pieces, add 200ml of water and boil for 5-10min, take the filtrate, add 10g of glucose and 7.5g of agar and boil until melted, stir evenly, make the volume to 500ml, pour into a culture dish after cooling slightly, put the culture medium into a high pressure sterilization box for sterilization, take it out and wait for cooling and solidification;

[0072] Preparation of culture medium for red hair moss fungus: 100g of potato is cut into pieces, added with 200ml of water and boiled for 5-10min, the filtrate is taken, 10g of glucose, 1.5g of potassium dihydrogen phosphate, 0.75g of magnesium sulfate heptahydrate, 0.01g of VB1, and 10g of agar are added and boiled to melt, stirred evenly, fixed to 500ml, the pH value is adjusted to 6.0±0.2, poured into the culture medium, the culture medium is placed in an autoclave for sterilization, and then taken out and waited for cooling and solidification;

[0073] Prepare several of the above two types of culture dishes, use sterilized tweezers to scrape the bacterial moss back and forth on the surface of the original colony and transfer it to sterile water, then absorb the bacterial suspension, put it into the two prepared culture dishes and spread it evenly, place the two culture dishes under the growth condition of 28°C, and after culturing for 5-7 days of proliferation, they can be used to apply the wormwood antipruritic and antibacterial ointment for testing;

[0074] The specific experimental data are shown in Table 4:

[0075] Table 4 Antibacterial test data

[0076]

[0077]

[0078] Conclusion: If Figure 5 As shown, the culture dish is smeared with the sample of the antipruritic and antibacterial ointment of Artemisia argyi after being processed by the heat resistance test (placed at 50°C for 24 hours);

[0079] Figure 5 The No. 1 fungus in the test is Trichophyton mentagrophytes. Figure 5 The No. 2 fungus in the sample is Trichophyton rubrum. Neither Trichophyton mentagrophytes nor Trichophyton rubrum grow on the medicated part. The fungus in the blank control group grows well, indicating that the external growth environment is suitable for fungal growth and can be used as a control reference.

[0080] It can be seen from the above experimental data that the wormwood antipruritic and antibacterial ointment prepared by the ratio scheme of Example 3 can still maintain a good antibacterial effect after high temperature and low temperature treatment, and the wormwood antipruritic and antibacterial ointment prepared by the ratio scheme of Example 3 has the best antibacterial effect.

[0081] 2.3 In order to explore the effect of the combined use of soybean peptide powder and glycerin on the performance of Artemisia argyi antipruritic and antibacterial ointment, based on the ratio scheme and preparation process of Example 3, comparative examples 1-4 were set up, specifically:

[0082] Comparative Example 1 is to replace an equal amount of soybean peptide powder with distilled water;

[0083] Comparative Example 2 is to replace an equal amount of glycerol with distilled water;

[0084] Comparative Example 3 is to replace the soybean peptide powder with starch in equal amounts;

[0085] Comparative Example 4 is to replace an equal amount of glycerol with olive oil;

[0086] The experimental test was carried out according to the test methods in 2.2.1 and 2.2.2. The test results are shown in Table 5-6:

[0087] Table 5 Scoring table for stability test of Artemisia argyi antipruritic and antibacterial ointment

[0088]

[0089] Conclusion: The only difference between Comparative Example 1 and Example 3 is that soybean peptide powder is not used, and it is replaced by distilled water of equal mass; the only difference between Comparative Example 2 and Example 3 is that glycerol is not used, and it is replaced by distilled water of equal mass;

[0090] According to the data in Table 5, when only soybean peptide powder or glycerin is used, the prepared wormwood antipruritic and antibacterial ointment is prone to oil-water separation after heat-resistant treatment, cold-resistant treatment, and centrifugal test. The stability of the wormwood antipruritic and antibacterial ointment is poor, it is not resistant to high temperature or low temperature, and it is also easy to oxidize and discolor.

[0091] The difference between Comparative Example 3 and Example 3 is that the same mass of starch is used to replace the soybean peptide powder; the difference between Comparative Example 4 and Example 3 is that the same mass of olive oil is used to replace glycerin;

[0092] According to the data in Table 5, the wormwood antipruritic and antibacterial ointments of Comparative Examples 4 and 5, after heat-resistant treatment, cold-resistant treatment and centrifugal test treatment, have various properties close to those when soy peptide powder or glycerin is used alone. It can be seen that there is no synergistic effect between glycerol and starch, and between olive oil and soy peptide powder, while soy peptide powder and glycerin are used together with a synergistic effect, so that the high temperature resistance, low temperature resistance and centrifugal resistance of the wormwood antipruritic and antibacterial ointment are greatly improved and it is not easy to oxidize and discolor.

[0093] Table 6 Antibacterial test data

[0094]

[0095] Conclusion: The only difference between Comparative Example 1 and Example 3 is that soybean peptide powder is not used, and it is replaced by distilled water of equal mass; the only difference between Comparative Example 2 and Example 3 is that glycerol is not used, and it is replaced by distilled water of equal mass;

[0096] According to the data in Table 5, when only soybean peptide powder or glycerin is used, the antibacterial effect of the prepared wormwood antipruritic and antibacterial ointment on Trichophyton mentagrophytes and Trichophyton rubrum is greatly reduced after heat-resistant treatment and cold-resistant treatment;

[0097] The difference between Comparative Example 3 and Example 3 is that the same mass of starch is used to replace the soybean peptide powder; the difference between Comparative Example 4 and Example 3 is that the same mass of olive oil is used to replace glycerin;

[0098] According to the data in Table 5, the antibacterial effects of the wormwood antipruritic and antibacterial ointments of Comparative Examples 4 and 5 on Trichophyton mentagrophytes and Trichophyton rubrum after heat-resistant treatment and cold-resistant treatment are only slightly different from those when soybean peptide powder or glycerol is used alone, which shows that there is no synergistic effect between glycerol and starch, and between olive oil and soybean peptide powder, while the combination of soybean peptide powder and glycerol has a synergistic effect, so that the antibacterial components in the wormwood antipruritic and antibacterial ointment are not easy to volatilize under high and low temperature conditions. In practical applications, even after the hot and humid period in summer and the cold and humid period in winter, it can still maintain a good antibacterial effect;

[0099] After the soybean peptide powder, glycerin and medicinal material extract are mixed, they can be well dispersed in the milky white paste, making it difficult for the milky white paste itself, the medicinal material extract itself, and the milky white paste and the medicinal material extract to separate into water and oil, and the antibacterial components in the medicinal material extract are not easily volatilized and denatured quickly due to high and low temperatures.

[0100] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. An antipruritic and antibacterial ointment of Artemisia argyi, characterized in that: The raw materials for preparing the wormwood antipruritic and antibacterial ointment include, by weight, 4-6 parts of medicinal material extract, 36-42 parts of aqueous phase, 33-38 parts of oil phase, and 16-22 parts of auxiliary materials; The Chinese medicinal materials used in the preparation of the medicinal extract are composed of wormwood leaf, moutan bark, peach kernel, cassia twig, cnidium monnieri, sophora flavescens, rhubarb, coptis root, scutellaria baicalensis, phellodendron chinense, radix polygoni lobatae, zanthoxylum bungeanum, and thorn bark; The oil phase includes stearic acid, lanolin, vaseline, and liquid paraffin; The aqueous phase includes triethanolamine, distilled water, and ethylparaben; The auxiliary materials include soybean peptide powder, glycerin and borneol powder.

2. The antipruritic and antibacterial ointment of Artemisia argyi according to claim 1, characterized in that: The mass ratio of the wormwood leaf, moutan bark, peach kernel, cassia twig, cnidium monnieri, sophora flavescens, rhubarb, coptis chinensis, scutellaria baicalensis, phellodendron chinense, radix polygoni lobatae, zanthoxylum bungeanum, and thorn bark is 1:2:2:2:1:1.32:1:1:1:1:2:0.66:0.

66.

3. The antipruritic and antibacterial ointment of Artemisia argyi according to claim 1, characterized in that: The oil phase comprises, by mass percentage, 26.7% stearic acid, 8% lanolin, 5.3% vaseline, and 60% liquid paraffin; The aqueous phase comprises, by mass percentage, 6.9% of triethanolamine, 92.6% of distilled water, and 0.5% of ethylparaben; The auxiliary materials include 35%-62% soybean peptide powder, 35%-62% glycerol and 3% borneol powder by mass percentage.

4. The antipruritic and antibacterial ointment of Artemisia argyi according to claim 3, characterized in that: The raw materials for preparing the wormwood antipruritic and antibacterial ointment include, by weight, 5 parts of medicinal material extract, 39 parts of aqueous phase, 38 parts of oil phase, and 18 parts of auxiliary materials, wherein the auxiliary materials include, by mass percentage, 50% of soybean peptide powder, 47% of glycerol, and 3% of borneol powder.

5. A method for preparing the wormwood antipruritic and antibacterial ointment as claimed in any one of claims 1 to 4, characterized in that: The following steps are involved: (1) The Chinese medicinal material raw materials for preparing the medicinal material extract are ground into coarse powder, and then soaked in an ethanol solution of 5-6 times the total weight of the Chinese medicinal material raw materials, stirred and turned during the process, and the residues are removed by coarse filtration with a sieve, and then impurities in the liquid medicine are removed by filtering with gauze, and then evaporated and concentrated by a rotary evaporator to obtain the medicinal material extract; (2) The water phase and the oil phase are placed in a water bath and heated to dissolve and keep warm. Under the same temperature conditions, the water phase is added to the oil phase to cause a saponification reaction and mixed and ground until a milky white paste is obtained; (3) Add the medicinal extract and auxiliary materials to the milky white paste and stir evenly to obtain the wormwood antipruritic and antibacterial ointment.

6. The method for preparing the antipruritic and antibacterial ointment of Artemisia argyi according to claim 5, characterized in that: The ethanol solution is a 75% medical ethanol solution, and the soaking time is 7-10 days.

7. The method for preparing the antipruritic and antibacterial ointment of Artemisia argyi according to claim 5, characterized in that: In step (2), the insulation temperature is 80°C-90°C.

8. Use of the wormwood antipruritic and antibacterial ointment as claimed in any one of claims 1 to 4 in the preparation of a medicine for treating beriberi.

9. The use according to claim 8, characterized in that: The wormwood antipruritic and antibacterial ointment has an inhibitory effect on dermatophytes.

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