Phenylethyl resorcinol whitening gel and preparation method for improving stability thereof
By preparing phenethyl resorcinol inclusions and combining specific raw materials, the problems of poor instability and water solubility are solved, and a whitening gel with high stability and whitening effect is achieved, which is suitable for cosmetics.
Patent Information
- Application Number
- CN202411575200.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-06
- Publication Date
- 2025-01-14
AI Technical Summary
The application of phenethyl resorcinol in the cosmetics field is limited by its instability and poor water solubility, especially when it is easy to discolor under light, affecting its whitening effect.
By preparing phenethyl resorcinol inclusions and combining raw materials such as disodium ethylenediaminetetraacetate, salicylic acid and sodium metabisulfite, a stable whitening gel is formed, and it is improved in water through ultrasonic and stirring. solubility and stability of the pH value to a slightly acid environment to enhance stability.
It significantly improves the stability and whitening effect of phenethyl resorcinol whitening gel, extends its storage cycle at high temperatures, and is not irritating to the skin, and has good safety.
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of gels, and in particular to a phenethylresorcinol whitening gel and a preparation method for improving the stability of the gel. Background Art
[0002] Phenylethyl resorcinol PR is a new type of highly effective whitening active substance. It was officially approved by the U.S. Food and Drug Administration as a cosmetic raw material in 2012. It is one of the tyrosinase inhibitors with the highest whitening activity reported so far. It can effectively reduce the production of melanin by increasing the activity of inhibiting tyrosinase.
[0003] The chemical name of phenylethyl resorcinol PR is 4-(1-phenylethyl)-1,3-benzenediol. It is a white or beige powder with a structure similar to tyrosine and a bisphenol structure similar to hydroquinone. It is slightly soluble in water at room temperature, and easily soluble in propylene glycol and polar oils. It is unstable under light, and its extremely poor water solubility and stability limit its application in the cosmetics field. Its solubility in water can be effectively improved through inclusion technology, but its stability still needs to be further improved. Summary of the invention
[0004] The purpose of the present invention is to provide a preparation method for improving the stability of phenethylresorcinol whitening gel in view of the deficiencies in the prior art.
[0005] The purpose of the present invention is achieved through the following technical solutions: A phenethylresorcinol whitening gel, which is composed of the following raw materials in percentage by weight: Phenethyl resorcinol inclusion compound 5%-10% Disodium EDTA 0.01%-0.1% Salicylic acid 0.1-2% Sodium metabisulfite 0.5%-2% Agarwood essential oil 0.5%-2% Ecdoin 0.05%-0.2% Sodium carboxymethyl cellulose 0.5%-3% Sodium hyaluronate 0.01%-0.1% Glycerin 5%-8% Phenoxyethanol 0.05%-0.1% Ethylhexylglycerin 0.05%-0.3% Citric acid 0.05%-0.1% Sodium citrate 0.2%-2% Purified water balance, Wherein, the phenethyl resorcinol inclusion compound is made from the following raw materials in parts by weight: Phenylethyl resorcinol 0.1-1 part Propylene glycol 0.5-2 parts β-cyclodextrin 0.5-5 parts 3-30 parts of purified water.
[0006] Preferably, it is composed of the following raw materials in parts by weight: Phenethyl resorcinol inclusion compound 8% Disodium EDTA 0.05% Salicylic acid 1% Sodium metabisulfite 1% Agarwood essential oil 1% Ecdoin 0.1% Sodium carboxymethyl cellulose 2% Sodium hyaluronate 0.05% Glycerin 6% Phenoxyethanol 0.08% Ethylhexylglycerin 0.15% Citric acid 0.08% Sodium citrate 1% Purified water balance, Wherein, the phenethyl resorcinol inclusion compound is made from the following raw materials in parts by weight: Phenethyl resorcinol 0.5% Propylene glycol 1% β-Cyclodextrin 2% 12 parts of purified water.
[0007] A preparation method for improving the stability of phenylethylresorcinol whitening gel, comprising the following process steps: Step A: preparing phenethyl resorcinol inclusion compound; Step B: Prepare reserve solutions. Four different reserve solutions form four phases. The preparation process using a combination of four phases further improves the stability of the gel.
[0008] Weigh 0.01%-0.1% disodium ethylenediaminetetraacetate, 0.1%-2% salicylic acid, and 0.5%-2% sodium metabisulfite, add 30% purified water and stir until uniform, then add 5%-10% phenethyl resorcinol inclusion compound, and ultrasonicate at 40°C for 20-40 minutes to prepare a phenethyl resorcinol inclusion compound dispersion liquid, which is the standby solution 1; Weigh 0.5%-2% of agarwood essential oil, 0.05%-0.2% of ectoine, 0.05%-0.1% of phenoxyethanol, and 0.05%-0.3% of ethylhexylglycerin, add 10% purified water, stir for 5-10 minutes to mix evenly, and prepare reserve solution 2; Weigh 0.01%-0.1% sodium hyaluronate, 0.5%-3% sodium carboxymethyl cellulose, and 5%-8% glycerol, and stir evenly to obtain a milky white dispersed mucus, which is the reserve solution 3; Weigh 0.05%-0.1% citric acid, add 10% purified water, gradually add 0.2%-2% sodium citrate while stirring, adjust the pH value to 6.0-6.5, and prepare reserve solution 4; Step C: The reserve liquid 4 is mixed evenly with the reserve liquid 1 and the reserve liquid 2 in a stirring tank, and then the reserve liquid 3 is added through the feeding port, and the remaining purified water is supplemented, and the stirring tank is turned on for homogenization, the homogenization speed is 2000r / min-2700r / min, and the homogenization time is 30min-60min, so as to obtain a phenylethylresorcinol whitening gel.
[0009] Preferably, the preparation method of the phenethyl resorcinol inclusion compound in step A is specifically as follows: A1: Weigh 0.1-1 part of phenethyl resorcinol, add 0.5-2 parts of propylene glycol and stir for 10-30 minutes to dissolve it, to prepare a phenethyl resorcinol alcohol solution; Weigh 0.5-5 parts of β-cyclodextrin into a 100 ml round-bottom flask, add water to dissolve at a ratio of m (cyclodextrin): m (water) = 1:6, and stir at 80°C for 1 hour to prepare a cyclodextrin saturated solution; A2: Add the phenethylresorcinol alcohol solution dropwise to the saturated cyclodextrin solution, stir at 40°C for 10-30 min to mix evenly, then cool, remove the filtrate by filtration under reduced pressure, collect the filter cake, and dry it in a vacuum drying oven at 60°C for 20-30 h to obtain a phenethylresorcinol inclusion complex.
[0010] Preferably, during cooling in step A2, the mixed solution is first cooled to room temperature and then refrigerated at 4° C. for 20-30 hours.
[0011] The effects of each raw material of the present invention are as follows: Phenylethyl resorcinol reduces the formation of melanin by inhibiting the activity of tyrosinase, a key enzyme in the production of melanin. In addition, it can inhibit the transfer of melanin to the stratum corneum, reduce the deposition of melanin on the skin surface, and make the skin tone more even.
[0012] Disodium EDTA is a good complexing agent in chemistry. It has six coordinated atoms, and the complex formed is called a chelate. Its main function is to coordinate with metal ions to form a highly stable metal complex, which makes the metal ions in a chemically stable state, prevents discoloration, deterioration, turbidity and oxidative loss of vitamin C caused by metals, and can also improve the antioxidant properties of oils and fats.
[0013] Salicylic acid is a natural active ingredient, also known as beta-hydroxy acid (BHA). As a very important natural active ingredient, it exists in many plants such as willow bark, sweet birch bark and white pearl tree. As an acidic whitening substance, salicylic acid has the ability to exfoliate and clean pores. It can dissolve the constituent substances between the cuticles, cause the stratum corneum to fall off, remove the over-thick cuticle, and promote metabolism. The basic structure of salicylic acid is laminar hydroxybenzoic acid. Due to the substitution of the hydroxyl group at the adjacent position of the carboxyl group, it can form an intramolecular hydrogen bond with the carboxyl group, which enhances the polarity of the oxygen-hydrogen bond in the carboxyl group and the acidity. Salicylic acid has the ability to complex metal ions in a weakly acidic environment, delaying the oxidation of phenethyl resorcinol, and at the same time promoting the permeability of phenethyl resorcinol in the stratum corneum, giving full play to its efficacy as an active substance.
[0014] Sodium metabisulfite is a white crystal or powder, soluble in water. It is a blackening inhibitor and antioxidant. It can reduce the blackening intermediate quinone substances, thereby inhibiting the blackening effect. It has excellent antioxidant properties, can resist the influence of free radicals, and reduce the effect of oxidants. Sodium metabisulfite can effectively delay the oxidation of phenylethyl resorcinol.
[0015] Propylene glycol acts as a solvent to dissolve phenethylresorcinol.
[0016] In addition to its unique aroma, which mainly masks the sulfur smell of sodium metabisulfite itself, agarwood essential oil also has extraordinary stability, which can further enhance the stability of the gel system.
[0017] β-cyclodextrin is used to prepare phenylethyl resorcinol inclusion complex to increase stability.
[0018] Ecdoin not only has certain anti-inflammatory and antioxidant effects, which can protect epidermal melanocytes from damage caused by ultraviolet rays to prevent photoaging, but it also has strong stability and can be used in combination with phenylethylresorcinol inclusion complex.
[0019] Sodium carboxymethyl cellulose, a thickener, is used to prepare whitening gel system.
[0020] Sodium hyaluronate, a moisturizer and lubricant, creates a good sense of smoothness and moisture when the whitening gel is used, improving the experience of use.
[0021] Glycerin is used as a dispersant to disperse sodium carboxymethyl cellulose and sodium hyaluronate, preventing the powder from agglomerating and becoming difficult to dissolve during the preparation process, thereby reducing the preparation and mixing time.
[0022] The beneficial effects of the present invention are as follows: in view of the problem of instability of phenethyl resorcinol gel, the present invention first prepares phenethyl resorcinol into a phenethyl resorcinol inclusion compound, then utilizes the chelating effect of EDTA-2Na to chelate the metal ions that cause the discoloration of phenethyl resorcinol, maintains the structural stability of phenethyl resorcinol in the whitening gel through the antioxidant properties of sodium pyrosulfite and salicylic acid, the phenethyl resorcinol inclusion compound and the combination of the three raw materials work together to achieve the goal of maintaining the stable state of phenethyl resorcinol, and finally controls the pH value of the whitening gel to be 6.0-6.5 in a slightly acidic environment through a pH regulator, thereby further improving the stability of the phenethyl resorcinol whitening gel. The whitening gel prepared by the present invention has good whitening effect and high stability, and can effectively extend the storage period of the whitening gel at high temperature. DETAILED DESCRIPTION
[0023] The present invention is further described in conjunction with the following examples. Example 1
[0024] A phenethylresorcinol whitening gel, which is composed of the following raw materials in percentage by weight: Phenethyl resorcinol inclusion compound 5% Disodium EDTA 0.01% Salicylic acid 0.1 Sodium metabisulfite 0.5% Agarwood essential oil 0.5% Ecdoin 0.05% Sodium carboxymethyl cellulose 0.5% Sodium hyaluronate 0.01% Glycerin 5% Phenoxyethanol 0.05% Ethylhexylglycerin 0.05% Citric acid 0.05% Sodium citrate 0.2% Purified water balance, Wherein, the phenethyl resorcinol inclusion compound is made from the following raw materials in parts by weight: Phenethyl resorcinol 0.1 part Propylene glycol 0.5 parts β-cyclodextrin 0.5 parts 3 parts purified water.
[0025] A method for preparing a phenethylresorcinol whitening gel comprises the following process steps: Step A: preparing phenethyl resorcinol inclusion compound; Step B: Preparation of stock solution: Weigh 0.01% disodium ethylenediaminetetraacetate, 0.1% salicylic acid, and 0.5% sodium metabisulfite, add 30% purified water and stir until uniform, then add 5% phenethyl resorcinol inclusion compound, and ultrasonicate at 40°C for 20 minutes to prepare a phenethyl resorcinol inclusion compound dispersion, which is the reserve solution 1; Weigh 0.5% agarwood essential oil, 0.05% ectoine, 0.05% phenoxyethanol, 0.05% ethylhexylglycerin, add 10% purified water, stir for 5 minutes to mix well, and prepare reserve solution 2; Weigh 0.01% sodium hyaluronate, 0.5% sodium carboxymethyl cellulose, and 5% glycerol, and stir evenly to obtain a milky white dispersed mucus, which is the reserve solution 3; Weigh 0.05% citric acid, add 10% purified water, gradually add 0.2% sodium citrate while stirring, and adjust the pH value to 6.0 to prepare reserve solution 4; Step C: The reserve solution 4 is mixed evenly with the reserve solution 1 and the reserve solution 2 in a stirring tank, and then the reserve solution 3 is added through the feeding port, and the remaining purified water is supplemented. The stirring tank is turned on for homogenization, and the homogenization speed is 2000r / min and the homogenization time is 30min to obtain a phenylethylresorcinol whitening gel.
[0026] The preparation method of the phenethyl resorcinol inclusion compound in step A is specifically as follows: A1: Weigh 0.1 parts of phenethyl resorcinol, add 0.5 parts of propylene glycol and stir for 10 minutes to dissolve it, to prepare a phenethyl resorcinol alcohol solution; Weigh 0.5 parts of β-cyclodextrin into a 100 ml round-bottom flask, add water to dissolve it at a ratio of m (cyclodextrin): m (water) = 1:6, and stir at 80°C for 1 hour to prepare a cyclodextrin saturated solution; A2: Add phenethylresorcinol alcohol solution dropwise to the saturated cyclodextrin solution, stir at 40°C for 10 min to mix evenly, cool the mixture to room temperature, and then refrigerate it in a refrigerator at 4°C for 20 h. After taking it out, filter and remove the filtrate under reduced pressure, collect the filter cake, and dry it in a vacuum drying oven at 60°C for 20 h to obtain phenethylresorcinol inclusion compound. Example 2
[0027] A phenethylresorcinol whitening gel, which is composed of the following raw materials in percentage by weight: Phenethyl resorcinol inclusion compound 8% Disodium EDTA 0.05% Salicylic acid 1% Sodium metabisulfite 1% Agarwood essential oil 1% Ecdoin 0.1% Sodium carboxymethyl cellulose 2% Sodium hyaluronate 0.05% Glycerin 6% Phenoxyethanol 0.08% Ethylhexylglycerin 0.15% Citric acid 0.08% Sodium citrate 1% Purified water balance, Wherein, the phenethyl resorcinol inclusion compound is made from the following raw materials in parts by weight: Phenylethyl resorcinol 0.5% Propylene glycol 1% β-Cyclodextrin 2% 12 parts of purified water.
[0028] A method for preparing a phenethylresorcinol whitening gel comprises the following process steps: Step A: preparing phenethyl resorcinol inclusion compound; Step B: Preparation of stock solution: Weigh 0.05% disodium ethylenediaminetetraacetate, 1% salicylic acid, and 1% sodium metabisulfite, add 30% purified water and stir until uniform, then add 8% phenethyl resorcinol inclusion compound, and ultrasonicate at 40°C for 30 minutes to prepare a phenethyl resorcinol inclusion compound dispersion liquid, which is the reserve solution 1; Weigh 1% agarwood essential oil, 0.1% ectoine, 0.08% phenoxyethanol, 0.15% ethylhexylglycerin, add 10% purified water, stir for 8 minutes to mix well, and prepare reserve solution 2; Weigh 0.05% sodium hyaluronate, 2% sodium carboxymethyl cellulose, and 6% glycerol, and stir evenly to obtain a milky white dispersed mucus, which is the reserve solution 3; Weigh 0.08% citric acid, add 10% purified water, gradually add 1% sodium citrate while stirring, adjust the pH to 6.2, and prepare reserve solution 4; Step C: The reserve liquid 4 is mixed evenly with the reserve liquid 1 and the reserve liquid 2 in a stirring tank, and then the reserve liquid 3 is added through the feeding port, and the remaining purified water is supplemented. The stirring tank is turned on for homogenization, the homogenization speed is 2400r / min, and the homogenization time is 45min, so as to obtain a phenylethylresorcinol whitening gel.
[0029] The preparation method of the phenethyl resorcinol inclusion compound in step A is specifically as follows: A1: Weigh 0.5 parts of phenethyl resorcinol, and dissolve it in 1 part of propylene glycol after stirring for 20 minutes to prepare a phenethyl resorcinol alcohol solution; Weigh 2 parts of β-cyclodextrin into a 100 ml round-bottom flask, add water to dissolve it at a ratio of m (cyclodextrin): m (water) = 1:6, and stir at 80°C for 1 hour to prepare a saturated cyclodextrin solution; A2: Add phenethylresorcinol alcohol solution dropwise into cyclodextrin saturated solution, stir at 40°C for 20 min to mix evenly, cool the mixture to room temperature, and then refrigerate at 4°C for 25 h. Remove the mixture by vacuum filtration to remove the filtrate, collect the filter cake, and dry it in a vacuum drying oven at 60°C for 25 h to obtain phenethylresorcinol inclusion complex. Example 3
[0030] A phenethylresorcinol whitening gel, which is composed of the following raw materials in percentage by weight: Phenethyl resorcinol inclusion compound 10% Disodium EDTA 0.1% Salicylic acid 2% Sodium metabisulfite 2% Agarwood essential oil 2% Ecdoin 0.2% Sodium carboxymethyl cellulose 3% Sodium hyaluronate 0.1% Glycerin 8% Phenoxyethanol 0.1% Ethylhexylglycerin 0.3% Citric acid 0.1% Sodium citrate 2% Purified water balance, Wherein, the phenethyl resorcinol inclusion compound is made from the following raw materials in parts by weight: 1 part of phenylethyl resorcinol Propylene glycol 2 parts 5 parts of β-cyclodextrin 30 parts of purified water.
[0031] A method for preparing a phenethylresorcinol whitening gel comprises the following process steps: Step A: preparing phenethyl resorcinol inclusion compound; Step B: Preparation of stock solution: Weigh 0.1% disodium ethylenediaminetetraacetate, 2% salicylic acid, and 2% sodium metabisulfite, add 30% purified water and stir until uniform, then add 10% phenethylresorcinol inclusion compound, and ultrasonicate at 40°C for 40 minutes to prepare a phenethylresorcinol inclusion compound dispersion, which is the reserve solution 1; Weigh 2% agarwood essential oil, 0.2% ectoine, 0.1% phenoxyethanol, 0.3% ethylhexylglycerin, add 10% purified water, stir for 10 minutes to mix well, and prepare reserve solution 2; Weigh 0.1% sodium hyaluronate, 3% sodium carboxymethyl cellulose, and 8% glycerol, and stir evenly to obtain a milky white dispersed mucus, which is the reserve solution 3; Weigh 0.1% citric acid, add 10% purified water, gradually add 2% sodium citrate while stirring, adjust the pH value to 6.5, and prepare the reserve solution 4; Step C: The reserve solution 4 is mixed evenly with the reserve solution 1 and the reserve solution 2 in a stirring tank, and then the reserve solution 3 is added through the feeding port, and the remaining purified water is supplemented. The stirring tank is turned on for homogenization, and the homogenization speed is 2700r / min and the homogenization time is 60min to obtain a phenylethylresorcinol whitening gel.
[0032] The preparation method of the phenethyl resorcinol inclusion compound in step A is specifically as follows: A1: Weigh 1 part of phenethyl resorcinol, and dissolve it in 2 parts of propylene glycol after stirring for 30 minutes to prepare a phenethyl resorcinol alcohol solution; Weigh 5 parts of β-cyclodextrin into a 100 ml round-bottom flask, add water to dissolve it at a ratio of m (cyclodextrin): m (water) = 1:6, and stir at 80°C for 1 hour to prepare a cyclodextrin saturated solution; A2: Add phenethylresorcinol alcohol solution dropwise into cyclodextrin saturated solution, stir at 40°C for 30 min to mix evenly, cool the mixture to room temperature, and then refrigerate at 4°C for 30 h. Remove the filtrate by vacuum filtration, collect the filter cake, and dry it in a vacuum drying oven at 60°C for 30 h to obtain phenethylresorcinol inclusion compound.
[0033] Comparative Example 1
[0034] The difference between Comparative Example 1 and Example 2 is that 0.05% disodium ethylenediaminetetraacetate is not used, and the other aspects are the same.
[0035] Comparative Example 2
[0036] The difference between Comparative Example 1 and Example 2 is that 1% salicylic acid and 1% sodium metabisulfite are not added, and the other aspects are the same.
[0037] Comparative Example 3
[0038] The difference between Comparative Example 1 and Example 2 is that 0.05% disodium edetate, 1% salicylic acid and 1% sodium metabisulfite are not used, and the other contents are the same.
[0039] Comparative Example 4
[0040] The difference between Comparative Example 1 and Example 2 is that the addition of reserve solution 4 is omitted, and the other parts are the same.
[0041] Experimental part:
[0042] 1. Whitening gel stability test
[0043] 2 kg of samples of Examples 1-3 and Comparative Examples 1-5 were prepared, and then packaged into glass bottles at 100 g each for stability testing. Test method: The test samples were placed in dry transparent glass bottles, sealed, and placed in a programmable constant temperature and humidity stability testing box. The test results are shown in Table 1 below.
[0044] Table 1
[0045] It can be seen from the results in Table 1 above that after one month of stability study, comparative examples 1-4 showed obvious color changes at high temperature, especially comparative example 3 showed very obvious color changes. This is because the combination of disodium ethylenediaminetetraacetic acid, salicylic acid and sodium metabisulfite was not used at the same time to cooperate with the phenethyl resorcinol inclusion compound, resulting in a significant decrease in stability. Examples 1-3 prepared by the method of the present invention have better stability and no stratification and discoloration occurs.
[0046] 2. Whitening gel whitening effect test
[0047] 2.1 Test method: 79 volunteers with whitening needs were divided into 6 groups, with 19 people in each group. They used the whitening gel of the test sample 5 times a week for 4 weeks. The safety and whitening efficacy were evaluated based on the volunteers' experience. Whitening efficacy standards: (1) The whitening effect is very good, the whitening gel is fine and has good ductility, is not sticky, and does not rub into mud after use; (2) Effective: There is a certain whitening effect, and the whitening gel is fine; (3) Ineffective: There is no change before and after use.
[0048] 2.2 Test results: The whitening test results are shown in Table 2: Table 2
[0049] It can be seen from Table 2 that the whitening gels prepared in Examples 1-3 of the present invention have obvious whitening effects. According to the feedback from volunteers, no irritation problems such as skin redness or stinging were found, and the effective rate was high. According to the feedback from volunteers, the whitening gels prepared in Comparative Examples 1-4 had skin redness or stinging, and the effective rate was low. In particular, the whitening effect of Comparative Example 3 was greatly reduced. This is because the combination of disodium ethylenediaminetetraacetic acid, salicylic acid and sodium pyrosulfite was not used at the same time to cooperate with the phenylethyl resorcinol inclusion compound, resulting in a greatly reduced stability. It can be seen that the present invention improves the stability of the phenylethyl resorcinol whitening gel, and the prepared whitening gel has a good whitening effect, is non-irritating to the skin, and has good safety.
[0050] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.
Claims
1. A phenethylresorcinol whitening gel, characterized in that: It is composed of the following raw materials in weight percentage: Phenethyl resorcinol inclusion compound 5%-10% Disodium EDTA 0.01%-0.1% Salicylic acid 0.1-2% Sodium metabisulfite 0.5%-2% Agarwood essential oil 0.5%-2% Ecdoin 0.05%-0.2% Sodium carboxymethyl cellulose 0.5%-3% Sodium hyaluronate 0.01%-0.1% Glycerin 5%-8% Phenoxyethanol 0.05%-0.1% Ethylhexylglycerin 0.05%-0.3% Citric acid 0.05%-0.1% Sodium citrate 0.2%-2% Purified water balance, Wherein, the phenethyl resorcinol inclusion compound is made from the following raw materials in parts by weight: Phenylethyl resorcinol 0.1-1 part Propylene glycol 0.5-2 parts β-cyclodextrin 0.5-5 parts 3-30 parts of purified water.
2. A phenethylresorcinol whitening gel according to claim 1, characterized in that: It is composed of the following raw materials in parts by weight: Phenethyl resorcinol inclusion compound 8% Disodium EDTA 0.05% Salicylic acid 1% Sodium metabisulfite 1% Agarwood essential oil 1% Ecdoin 0.1% Sodium carboxymethyl cellulose 2% Sodium hyaluronate 0.05% Glycerin 6% Phenoxyethanol 0.08% Ethylhexylglycerin 0.15% Citric acid 0.08% Sodium citrate 1% Purified water balance, Wherein, the phenethyl resorcinol inclusion compound is made from the following raw materials in parts by weight: Phenylethyl resorcinol 0.5% Propylene glycol 1% β-Cyclodextrin 2% 12 parts of purified water.
3. A method for preparing a phenylethylresorcinol whitening gel for improving stability as claimed in claim 1, characterized in that: It includes the following process steps: Step A: preparing phenethyl resorcinol inclusion compound; Step B: Preparation of stock solution: Weigh 0.01%-0.1% disodium ethylenediaminetetraacetate, 0.1%-2% salicylic acid, and 0.5%-2% sodium metabisulfite, add 30% purified water and stir until uniform, then add 5%-10% phenethyl resorcinol inclusion compound, and ultrasonicate at 40°C for 20-40 minutes to prepare a phenethyl resorcinol inclusion compound dispersion liquid, which is the standby solution 1; Weigh 0.5%-2% of agarwood essential oil, 0.05%-0.2% of ectoine, 0.05%-0.1% of phenoxyethanol, and 0.05%-0.3% of ethylhexylglycerin, add 10% purified water, stir for 5-10 minutes to mix evenly, and prepare reserve solution 2; Weigh 0.01%-0.1% sodium hyaluronate, 0.5%-3% sodium carboxymethyl cellulose, and 5%-8% glycerol, and stir evenly to obtain a milky white dispersed mucus, which is the reserve solution 3; Weigh 0.05%-0.1% citric acid, add 10% purified water, gradually add 0.2%-2% sodium citrate while stirring, adjust the pH value to 6.0-6.5, and prepare reserve solution 4; Step C: The reserve liquid 4 is mixed evenly with the reserve liquid 1 and the reserve liquid 2 in a stirring tank, and then the reserve liquid 3 is added through the feeding port, and the remaining purified water is supplemented, and the stirring tank is turned on for homogenization, the homogenization speed is 2000r / min-2700r / min, and the homogenization time is 30min-60min, so as to obtain a phenylethylresorcinol whitening gel.
4. A method for preparing a phenylethylresorcinol whitening gel for improving stability according to claim 3, characterized in that: The preparation method of the phenethyl resorcinol inclusion compound in step A is specifically as follows: A1: Weigh 0.1-1 part of phenethyl resorcinol, add 0.5-2 parts of propylene glycol and stir for 10-30 minutes to dissolve it, to prepare a phenethyl resorcinol alcohol solution; Weigh 0.5-5 parts of β-cyclodextrin into a 100 ml round-bottom flask, add water to dissolve at a ratio of m (cyclodextrin): m (water) = 1:6, and stir at 80°C for 1 hour to prepare a cyclodextrin saturated solution; A2: Add the phenethylresorcinol alcohol solution dropwise to the cyclodextrin saturated solution, stir at 40°C for 10-30 min to mix evenly, cool, and remove the filtrate by vacuum filtration. Collect the filter cake and dry it in a vacuum drying oven at 60°C for 20-30 h to obtain a phenethylresorcinol inclusion complex.
5. A method for preparing a phenylethylresorcinol whitening gel for improving stability according to claim 4, characterized in that: During cooling in step A2, the mixed solution is first cooled to room temperature and then refrigerated at 4° C. for 20-30 hours.