Rolling valve, switching device and immunoadsorption device

Abstract

The invention provides a rolling valve, a switching device and an immunoadsorption device, and relates to the technical field of blood purification. The rolling valve comprises an annular hose located in the shell, an extrusion rod and a plurality of connectors, the outer wall of the annular hose comprises a proximal outer wall located on one side of the annular center and a distal outer wall opposite to the proximal outer wall, and the connectors are arranged on the distal outer wall around the annular center at intervals and all communicate with the annular hose. The annular hose is arranged on the inner bottom wall of the shell, the telecentric outer wall of the annular hose abuts against the inner side wall of the shell, all the connectors penetrate out of the shell, the extrusion rod is rotationally arranged on the inner bottom wall of the shell, and the two ends of the extrusion rod abut against the proximal outer wall and extrude the proximal outer wall towards the inner side wall of the shell. The inner space of the annular hose is divided into two sub-spaces by the extrusion rod, and all the connectors communicated with the same sub-space are communicated with one another. On the basis, the rolling valve can be applied to an immunoadsorption system with double adsorption columns, so that the operation amount of medical personnel during switching between the double adsorption columns is reduced.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to a rolling valve, a switching device and an immunoadsorption device. Background Art

[0002] Blood purification is a technology that uses extracorporeal circulation to remove certain pathogenic substances from the patient's blood. Specifically, the patient's blood is drawn out of the body, purified through a purification device (i.e., certain pathogenic substances are removed from the blood), and the purified blood is returned to the patient's body, ultimately achieving the purpose of treating diseases, such as kidney disease, poisoning, autoimmune diseases, and liver diseases. There are many ways to purify blood, such as hemodialysis, hemofiltration, hemoperfusion, plasma exchange, and immunoadsorption, but in recent years, immunoadsorption has been used more and more widely.

[0003] Immunoadsorption refers to combining highly specific antigens, antibodies or substances with specific physical and chemical affinity (called ligands) with adsorption materials (called carriers) to form adsorbents, and then loading the adsorbents into columns to form adsorption columns. The adsorption columns selectively or specifically adsorb pathogenic substances in the blood, thereby achieving the purpose of purifying the blood and treating diseases. In addition, the adsorption column has limited adsorption capacity for pathogenic substances, and it is usually necessary to use the adsorption column for multiple adsorptions to achieve the treatment effect, which results in a longer treatment time for patients. After each adsorption, the adsorption column needs to be flushed for a long time (this process is called regeneration). Although this can remove the adsorbed pathogenic substances on the adsorption column and facilitate the next adsorption of the adsorption column, it will also further increase the patient's treatment time.

[0004] In the related art, two adsorption columns are provided in the immunoadsorption system, and a number of pipes are connected between the two adsorption columns. A number of tube clamps are provided on these pipes, and the switching between the two adsorption columns is achieved by controlling the number of tube clamps, so that the immunoadsorption system is always in a working state of "one adsorption column adsorbs pathogenic substances, and the other adsorption column regenerates". Although this can reduce the treatment time of patients, each switching requires the simultaneous control of multiple tube clamps. The medical staff has a large amount of operation and is prone to errors, which may affect the patient's treatment progress at the least and endanger the patient's life at the worst. Summary of the invention

[0005] The present application provides a rolling valve, a switching device and an immunoadsorption device, which aim to solve the problems of large amount of operations and high error rate when medical staff switch between dual adsorption columns in related technologies.

[0006] In order to solve the above-mentioned drawbacks existing in the related art, the first aspect of the present application provides a rolling valve, including an annular hose and a plurality of joints, the outer wall of the annular hose includes a proximal outer wall located on one side of the annular center and an opposite distal outer wall, and a plurality of joints are arranged on the distal outer wall at intervals around the annular center and are all connected to the annular hose. The rolling valve also includes an extrusion rod and a hollow shell, the extrusion rod, the annular hose and the plurality of joints are all located in the shell, the annular hose is arranged on the inner bottom wall of the shell, and the distal outer wall abuts against the inner side wall of the shell, one end of each joint away from the annular hose passes through the shell and is used to connect to an external pipeline, a rotating shaft is arranged on the inner bottom wall of the shell, the extrusion rod is arranged on the rotating shaft and rotates with the rotating shaft, the opposite ends of the extrusion rod abut against the proximal outer wall, and the proximal outer wall is squeezed toward the inner side wall of the shell, so that the internal space of the annular hose is divided into two subspaces by the extrusion rod, and all joints connected to the same subspace are interconnected. The extrusion rod is used to rotate around the rotation axis under the action of external force to adjust the joints connected with each subspace and change the flow direction of the liquid entering the annular hose through the pipeline.

[0007] In some implementations, an operation window connected to the interior is provided on the outer wall of the shell, and the operation window corresponds to the extrusion rod; or, a through hole connected to the interior is provided on the outer wall of the shell, and the through hole corresponds to the extrusion rod, and the rolling valve also includes a knob and a connecting rod, the knob is arranged on one end of the connecting rod, and the other end of the connecting rod enters the shell through the hole and is arranged on the extrusion rod. In one of the implementations, the knob includes a base, one side of the base is connected to the connecting rod, and a hand-held portion is formed on the other side opposite to the base, and the length direction of the hand-held portion is consistent with the axis direction of the extrusion rod; further, a plurality of marking points are arranged around the knob at intervals on the shell, and the marking points at different positions on the shell correspond to different valve states of the rolling valve, and the joints connected to each subspace are different in different valve states, and the marking points are used to indicate to the user the current valve state of the rolling valve when the end of the hand-held portion is aligned with itself.

[0008] In some implementation schemes, the rolling valve also includes two rollers, both of which are rotatably set on the extrusion rod, and the two rollers are respectively located on both sides of the rotating shaft. The rollers are in contact with the inner bottom wall of the shell, and the rollers are used to roll on the inner bottom wall of the shell when the extrusion rod rotates around the rotating shaft.

[0009] In some implementation schemes, an annular groove surrounding the rotating shaft is opened on the inner bottom wall of the shell, and two sliders are slidably arranged in the annular groove. The two sliders are connected to the extrusion rod and are respectively located on both sides of the rotating shaft. The sliders are used to slide in the annular groove when the extrusion rod rotates around the rotating shaft.

[0010] In some implementations, the annular hose is in the shape of a donut.

[0011] The second aspect of the present application provides a switching device, which is applied to an immunoadsorption device. The immunoadsorption device includes a plasma separation device, a flushing device, a left adsorption column, a right adsorption column and a waste liquid bag. The two ends of the plasma separation device are respectively used to connect the patient's artery and vein. The switching device includes a first rolling valve and a second rolling valve. The first rolling valve and the second rolling valve are both the rolling valves mentioned in the first aspect of the present application. The first rolling valve has a first joint, a second joint, a third joint and a fourth joint. The second rolling valve has a fifth joint, a sixth joint, a seventh joint and an eighth joint. The two ends of the left adsorption column are respectively connected to the second joint and the sixth joint. The plasma separation device is connected to the first joint. The fifth joint is used to connect the vein. The two ends of the right adsorption column are respectively connected to the third joint and the seventh joint. The flushing device is connected to the fourth joint, and the waste liquid bag is connected to the eighth joint. Among them, the plasma separation device is used to draw blood from the artery and separate plasma; the flushing device is used to provide flushing fluid; the switching device is used to adjust the working state of the immunoadsorption device by rotating the extrusion rods in the first rolling valve and the second rolling valve.

[0012] Specifically, the working states include a left column adsorption state and a right column adsorption state. In the left column adsorption state, the first joint is connected to the second joint, the fifth joint is connected to the sixth joint, the third joint is connected to the fourth joint, and the seventh joint is connected to the eighth joint. The flow path of plasma is the first joint, the second joint, the left adsorption column, the sixth joint, the fifth joint and the vein, and the flow path of the flushing liquid is the fourth joint, the third joint, the right adsorption column, the seventh joint, the eighth joint and the waste liquid bag; in the right column adsorption state, the first joint is connected to the third joint, the fifth joint is connected to the seventh joint, the second joint is connected to the fourth joint, and the sixth joint is connected to the eighth joint. The flow path of plasma is the first joint, the third joint, the right adsorption column, the seventh joint, the fifth joint and the vein, and the flow path of the flushing liquid is the fourth joint, the second joint, the left adsorption column, the sixth joint, the eighth joint and the waste liquid bag.

[0013] The third aspect of the present application provides an immunoadsorption device, including a plasma separation device, a flushing device, a left adsorption column, a right adsorption column, a waste liquid bag and the switching device mentioned in the second aspect of the present application, the two ends of the plasma separation device are respectively used to connect the patient's artery and vein, the first roller valve in the switching device has a first joint, a second joint, a third joint and a fourth joint, the second roller valve in the switching device has a fifth joint, a sixth joint, a seventh joint and an eighth joint, the two ends of the left adsorption column are respectively connected to the second joint and the sixth joint, the plasma separation device is connected to the first joint, the fifth joint is used to connect to the vein, the two ends of the right adsorption column are respectively connected to the third joint and the seventh joint, the flushing device is connected to the fourth joint, and the waste liquid bag is connected to the eighth joint. Among them, the plasma separation device is used to draw blood from the artery and separate plasma; the flushing device is used to provide flushing fluid; the switching device is used to adjust the working state of the immunoadsorption device by rotating the extrusion rods in the first roller valve and the second roller valve;

[0014] Specifically, the working states include a left column adsorption state and a right column adsorption state. In the left column adsorption state, the first joint is connected to the second joint, the fifth joint is connected to the sixth joint, the third joint is connected to the fourth joint, and the seventh joint is connected to the eighth joint. The flow path of plasma is the first joint, the second joint, the left adsorption column, the sixth joint, the fifth joint and the vein, and the flow path of the flushing liquid is the fourth joint, the third joint, the right adsorption column, the seventh joint, the eighth joint and the waste liquid bag; in the right column adsorption state, the first joint is connected to the third joint, the fifth joint is connected to the seventh joint, the second joint is connected to the fourth joint, and the sixth joint is connected to the eighth joint. The flow path of plasma is the first joint, the third joint, the right adsorption column, the seventh joint, the fifth joint and the vein, and the flow path of the flushing liquid is the fourth joint, the second joint, the left adsorption column, the sixth joint, the eighth joint and the waste liquid bag.

[0015] In some implementations, the plasma separation device includes a first blood pump and a plasma separator, one end of the plasma separator is connected to the first blood pump, the first blood pump is used to connect to an artery, the other end of the plasma separator is used to connect to a vein, and the plasma separator is also connected to a first connector. The first blood pump is used to draw blood from the artery and pump it to the plasma separator; the plasma separator is used to separate plasma from the blood.

[0016] In one implementation, the plasma separator further includes an arterial pot and a venous pot, one end of the plasma separator is connected to the first blood pump through the arterial pot, and the other end is used to connect to the vein through the venous pot, and the venous pot is connected to the fifth connector. In one implementation, the plasma separator further includes a second blood pump, which is connected between the plasma separator and the first connector and is used to draw plasma from the plasma separator and pump it to the first connector.

[0017] In some implementation schemes, the flushing liquid includes an elution liquid, a balancing liquid and a pre-flushing liquid, the flushing device includes an elution bag, a balancing bag and a pre-flushing bag, and the elution bag, the balancing bag and the pre-flushing bag are respectively connected to the fourth joint; specifically, the elution bag is used to store the elution liquid, the balancing bag is used to store the balancing liquid, and the pre-flushing bag is used to store the pre-flushing liquid. In one of the implementation schemes, the flushing device also includes a third blood pump, an elution switch, a balance switch and a pre-flushing switch. The elution bag is connected to the third blood pump through the elution switch, the balance bag is connected to the third blood pump through the balance switch, the pre-flushing bag is connected to the third blood pump through the pre-flushing switch, and the third blood pump is connected to the fourth connector. Specifically, the elution switch is used to connect the third blood pump and the elution bag when it is turned on, or to block the third blood pump and the elution bag when it is turned off. The balance switch is used to connect the third blood pump and the balance bag when it is turned on, or to block the third blood pump and the balance bag when it is turned off. The pre-flushing switch is used to connect the third blood pump and the pre-flushing bag when it is turned on, or to block the third blood pump and the pre-flushing bag when it is turned off. The third blood pump is used to draw out eluent from the elution bag and pump it to the fourth connector when the elution switch is turned on, or to draw out balance liquid from the balance bag and pump it to the fourth connector when the balance switch is turned on, or to draw out pre-flushing liquid from the pre-flushing bag and pump it to the fourth connector when the pre-flushing switch is turned on.

[0018] The rolling valve provided in the first aspect of the present application includes a hollow shell and an annular hose, an extrusion rod and multiple joints located in the shell. The outer wall of the annular hose includes a proximal outer wall located on one side of the ring center and an opposite distal outer wall. Multiple joints are arranged on the distal outer wall at intervals around the ring center and are all connected to the annular hose. The annular hose is arranged on the inner bottom wall of the shell and the distal outer wall abuts against the inner wall of the shell. One end of each joint away from the annular hose passes through the shell and is used to connect to an external pipeline. A rotating shaft is provided on the inner bottom wall of the shell, and the extrusion rod is rotatably arranged on the rotating shaft. The opposite ends of the extrusion rod abut against the proximal outer wall and squeeze the proximal outer wall toward the inner wall of the shell, so that the internal space of the annular hose is divided into two sub-spaces by the extrusion rod, and all joints connected to the same sub-space are interconnected. In actual applications, the extrusion rod can be rotated around the rotating axis. Since the annular hose is fixed, the position of the annular hose squeezed by the extrusion rod will change during the rotation of the extrusion rod, which will cause the joint connected to each subspace to change. Then the flow direction of the liquid entering the annular hose through the pipeline will naturally change accordingly. Based on this, at least one roller valve can be applied in an immunoadsorption system including two adsorption columns. Specifically, at least one roller valve can be set in a pipe network connecting the two adsorption columns, and multiple joints of the roller valve can be connected to several pipes in the pipe network respectively. In this way, the flow direction of plasma or flushing fluid entering the roller valve can be adjusted by rotating the extrusion rod in the roller valve, so as to achieve switching between the two adsorption columns for adsorption work (i.e., adsorption of pathogenic substances in plasma), so that when one adsorption column is performing adsorption work, the other adsorption column is performing regeneration work (i.e., flushing the adsorption column with flushing fluid). The switching of the present application only requires rotating the extrusion rod in the roller valve, and there is no need to control multiple tube clamps at the same time as in the traditional solution. This not only reduces the amount of operation for medical staff, but also reduces the error rate of medical staff during operation.

[0019] For the switching device provided in the second aspect of the present application, it includes a first rolling valve and a second rolling valve, and the first rolling valve and the second rolling valve are both rolling valves provided in the first aspect of the present application. The first rolling valve includes four connectors (namely, a first connector, a second connector, a third connector and a fourth connector), and the second rolling valve also includes four connectors (namely, a fifth connector, a sixth connector, a seventh connector and an eighth connector). When the switching device is applied to an immunoadsorption device including a plasma separation device, a flushing device, a waste liquid bag and two adsorption columns (namely, a left adsorption column and a right adsorption column), the two ends of the left adsorption column are respectively connected to the second connector and the sixth connector, the plasma separation device is connected to the first connector, the fifth connector is used to connect to the patient's vein, the two ends of the right adsorption column are respectively connected to the third connector and the seventh connector, the flushing device is connected to the fourth connector, and the waste liquid bag is connected to the eighth connector. In actual applications, the plasma separation device can draw blood from the patient's artery and separate plasma, and the flushing device can provide flushing fluid. When the immunoadsorption device is in the left column adsorption state (that is, the left adsorption column performs adsorption work and the right adsorption column performs regeneration work), the first joint is connected to the second joint, the fifth joint is connected to the sixth joint, the third joint is connected to the fourth joint, and the seventh joint is connected to the eighth joint. The flow path of plasma is the first joint, the second joint, the left adsorption column, the sixth joint, the fifth joint and the vein, and the flow path of the flushing fluid is the fourth joint, the third joint, the right adsorption column, the seventh joint, the eighth joint and the waste liquid. bag; after that, the first joint can be connected to the third joint, the fifth joint can be connected to the seventh joint, the second joint can be connected to the fourth joint, and the sixth joint can be connected to the eighth joint by rotating the squeezing rod in the first rolling valve and the second rolling valve. In this way, the immunoadsorption device changes from the original left column adsorption state to the right column adsorption state (that is, the right adsorption column performs adsorption work and the left adsorption column performs regeneration work). At this time, the flow path of the flushing liquid is the fourth joint, the second joint, the left adsorption column, the sixth joint, the eighth joint and the waste liquid bag, and the flow path of the plasma is the first joint, the third joint, the right adsorption column, the seventh joint, the fifth joint and the vein. It can be seen from this that when the present application switches between the left column adsorption state and the right column adsorption state of the immunoadsorption device, it is only necessary to rotate the squeezing rod in the first rolling valve and the second rolling valve. There is no need to control multiple tube clamps at the same time as in the traditional solution. It can not only reduce the amount of operation of medical staff, but also reduce the error rate of medical staff during operation.

[0020] Regarding the immunoadsorption device provided in the third aspect of the present application, since the immunoadsorption device includes the switching device provided in the second aspect of the present application, the immunoadsorption device has all the advantages of the switching device provided in the second aspect of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the related technologies or the embodiments of the present application, the drawings required for use in the description of the related technologies or the embodiments of the present application will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, not all embodiments. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 A schematic diagram of the structure of a rolling valve provided in an embodiment of the present application;

[0023] Figure 2 A schematic diagram of the structure of a switching device provided in an embodiment of the present application;

[0024] Figure 3 This is a schematic diagram of the structure of the immunoadsorption device provided in an embodiment of the present application.

[0025] The symbols in the above drawings represent:

[0026] 100-rolling valve, 110-annular hose, 120-connector, 130-extrusion rod, 121-first connector, 122-second connector, 123-third connector, 124-fourth connector, 125-fifth connector, 126-sixth connector, 127-seventh connector, 128-eighth connector, 200-switching device, 210-first rolling valve, 220-second rolling valve, 300-immunoadsorption device, 310 -Plasma separation device, 320-flushing device, 330-waste liquid bag, 340-left adsorption column, 350-right adsorption column, 311-first blood pump, 312-plasma separator, 313-arterial pot, 314-venous pot, 315-second blood pump, 321-elution bag, 322-balance bag, 323-pre-flushing bag, 324-elution switch, 325-balance switch, 326-pre-flushing switch, 327-third blood pump. DETAILED DESCRIPTION

[0027] In the related art, two adsorption columns are provided in the immunoadsorption system, and several pipelines are connected between the two adsorption columns. These pipelines are provided with multiple tube clamps. The switching between the two adsorption columns is achieved by controlling the multiple tube clamps, so that the immunoadsorption system is always in a working state of "one adsorption column adsorbs pathogenic substances and the other adsorption column regenerates". Although this can reduce the treatment time of patients, each switch requires simultaneous control of multiple tube clamps. The medical staff has a large amount of operations and is prone to errors, which may affect the patient's treatment progress at the least and endanger the patient's life at the worst. Therefore, the present application proposes a roller valve, a switching device and an immunoadsorption device in the embodiments below. Blood purification can be performed by using the immunoadsorption device to avoid the above-mentioned disadvantages in the related art.

[0028] In order to make the purpose, technical solutions and advantages of the present application more obvious and easy to understand, the present application will be clearly and completely described below in conjunction with the embodiments of the present application and the corresponding drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. It should be understood that the embodiments of the present application described below are only used to explain the present application and are not used to limit the present application, that is, based on the embodiments of the present application, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the scope of protection of the present application. In addition, the technical features involved in the various embodiments of the present application described below can be combined with each other as long as they do not conflict with each other.

[0029] See also Figure 1 , Figure 1 1 is a schematic diagram of the structure of a rolling valve. This embodiment provides a rolling valve 100, which includes an annular hose 110, an extrusion rod 130, a plurality of joints 120 and a hollow shell (not shown in the figure), the outer wall of the annular hose 110 includes a proximal outer wall located on one side of the ring center of the annular hose 110 and a corresponding distal outer wall, and the inner wall of the annular hose 110 includes a proximal inner wall located on one side of the ring center and a corresponding distal inner wall, that is, the proximal outer wall and the proximal inner wall are both close to the ring center, and the distal outer wall and the distal inner wall are both far away from the ring center. In this embodiment, the annular hose 110 can be made of any material commonly used in the art with good elastic properties and recovery ability, such as natural rubber, nitrile rubber, silicone rubber, polyethylene (PE), polyvinyl chloride (PVC) and thermoplastic elastomer (TPE), etc., which can be selected according to actual needs, and this application does not make a sole limitation on this. In addition, it should be noted that the shape of the annular hose 110 is preferably a circular ring, and its ring center is the center of the ring.

[0030] Specifically, the extrusion rod 130, the annular hose 110 and the plurality of joints 120 are all located in the shell, and the plurality of joints 120 are arranged on the distal outer wall of the annular hose 110 at intervals around the annular center, and each joint 120 is communicated with the annular hose 110, and the annular hose 110 is arranged on the inner bottom wall of the shell and its distal outer wall abuts against the inner side wall of the shell, and one end of each joint 120 away from the annular hose 110 passes through the shell and is used to connect to an external pipeline (not shown in the figure), and a rotating shaft (not shown in the figure) is arranged on the inner bottom wall of the shell and is located at the annular hose 110. 0, the extrusion rod 130 is arranged on the rotating shaft and rotates with the rotating shaft, and the opposite ends of the extrusion rod 130 are both in contact with the proximal outer wall of the annular hose 110 and squeeze the proximal outer wall toward the inner wall of the shell, so that the proximal inner wall and the distal inner wall of the annular hose 110 squeezed by the extrusion rod 130 fit together, and at this time, the internal space of the annular hose 110 is divided into two sub-spaces by the extrusion rod 130, and all the joints 120 connected to the same sub-space are interconnected, while the joints 120 connected to different sub-spaces cannot be interconnected. Preferably, the middle part of the extrusion rod 130 is arranged on the rotating shaft.

[0031] In actual application, the squeezing rod 130 can rotate around the rotation axis under the action of external force, so as to adjust the joint 120 connected to each subspace to change the flow direction of the liquid entering the annular hose 110 through the pipeline. In other words, when it is necessary to adjust the flow direction of the liquid entering the annular hose 110 through the pipeline, the user can manipulate the squeezing rod 130 to rotate around the rotation axis. Since the annular hose 110 is fixed, the position squeezed by the squeezing rod 130 on the annular hose 110 will change during the rotation of the squeezing rod 130, which will cause the joint 120 connected to each subspace to change, and the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly. For example, assuming that the roller valve 100 includes four joints 120, which are represented by a, b, x, and y, respectively, and a and b are connected to one subspace, and x and y are connected to another subspace, then the liquid entering the annular hose 110 through a will flow out through b, and the liquid entering the annular hose 110 through y will flow out through x. If the squeeze rod 130 is subsequently rotated to make a and x connected to one subspace, and b and y connected to another subspace, then the liquid entering the annular hose 110 through a will no longer flow out through b, but will flow out through x, and the liquid entering the annular hose 110 through y will no longer flow out through x, but will flow out through b, thus achieving the adjustment of the flow direction of the liquid in the annular hose 110. In addition, it should be noted that the external force in the present application comes from the user, that is, the user applies force to the squeeze rod 130 to cause the squeeze rod 130 to rotate around the axis of rotation.

[0032] It can be understood that the roller valve 100 of the present embodiment can be applied to an immunoadsorption system including two adsorption columns. Specifically, at least one roller valve 100 can be set in a pipe network connecting the two adsorption columns, and multiple connectors 120 of the roller valve 100 can be respectively connected to several pipes in the pipe network. In this way, the flow direction of the plasma / flushing fluid entering the roller valve 100 can be adjusted by rotating the squeezing rod 130 in the roller valve 100, thereby realizing switching between the two adsorption columns for adsorption work (i.e., adsorption of pathogenic substances in plasma), so that when one adsorption column is performing adsorption work, the other adsorption column is performing regeneration work (i.e., flushing the adsorption column with flushing fluid), and this switching in the present embodiment only requires rotating the squeezing rod 130 in the roller valve 100, and there is no need to control multiple tube clamps at the same time as in the traditional solution, which not only reduces the amount of operation of medical staff, but also reduces the error rate of medical staff during operation, thereby ensuring the smooth progress of blood purification.

[0033] In some embodiments, an operation window (not shown) communicating with the interior is provided on the outer wall of the housing, and the operation window corresponds to the squeezing rod 130. It is understandable that the squeezing rod 130 is disposed in the housing, so in order to facilitate the user to manipulate the squeezing rod 130 to rotate around the rotation axis, an operation window corresponding to the squeezing rod 130 can be provided on the outer wall of the housing, and when the flow direction of the liquid in the annular hose 110 needs to be adjusted (i.e., the squeezing rod 130 needs to rotate around the rotation axis), the user can extend a finger (such as an index finger and a thumb) into the housing through the operation window to hold the squeezing rod 130 and apply a force to the squeezing rod 130 to rotate it, so that the squeezing rod 130 can rotate around the rotation axis, and the position squeezed by the squeezing rod 130 on the annular hose 110 will change, which will cause the joint 120 connected to each subspace to change, and then the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly, thereby achieving the adjustment of the flow direction of the liquid in the annular hose 110.

[0034] In other embodiments, a through hole (not shown) communicating with the inside of the shell is opened on the outer wall of the shell, and the through hole corresponds to the extrusion rod 130; in addition to the structure given above, the rolling valve 100 also includes a knob (not shown) and a connecting rod (not shown), the knob is arranged on one end of the connecting rod, and the other end of the connecting rod enters the shell through the hole and is arranged on the extrusion rod 130. It can be understood that the squeezing rod 130 is arranged in the shell. In order to facilitate the user to manipulate the squeezing rod 130 to rotate it around the rotation axis, a knob can be set on one end of the connecting rod, and the other end of the connecting rod is inserted into the shell and connected to the squeezing rod 130. When it is necessary to adjust the flow direction of the liquid in the annular hose 110 (that is, the squeezing rod 130 needs to rotate around the rotation axis), the user can hold the knob and apply a force to the knob to rotate it. In this way, the knob will drive the squeezing rod 130 to rotate around the rotation axis through the connecting rod, and the position squeezed by the squeezing rod 130 on the annular hose 110 will change, which will cause the joint 120 connected to each subspace to change, so that the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly, thereby realizing the adjustment of the flow direction of the liquid in the annular hose 110.

[0035] As one or more embodiments, the knob includes a base (not shown), one side of the base is connected to the connecting rod, and a grip portion (not shown) is formed on the other side opposite thereto, and the length direction of the grip portion is consistent with the axial direction of the squeezing rod 130. It can be understood that the portion of the knob for the user to hold is actually the grip portion, that is, when the flow direction of the liquid in the annular hose 110 needs to be adjusted (that is, the squeezing rod 130 needs to rotate around the rotation axis), the user can hold the grip portion on the base and apply a force to the grip portion to rotate the base. In addition, it should be noted that the extrusion rod 130 divides the internal space of the annular hose 110 into two sub-spaces, and the two sub-spaces are respectively located on both sides of the extrusion rod 130. Therefore, when the length direction of the hand-held portion is consistent with the axial direction of the extrusion rod 130, the two sub-spaces are actually also respectively located on both sides of the hand-held portion. Although the user cannot clearly observe the extrusion rod 130 located in the shell, the user can clearly understand the orientation of the extrusion rod 130 in the shell by observing the hand-held portion, and then analyze the positions of the two sub-spaces. In this way, it is more convenient for the user to control the rotation of the extrusion rod 130, and it is also more convenient for the user to adjust the flow direction of the liquid in the annular hose 110.

[0036] As one or more embodiments, a plurality of marking points (not shown) are arranged at intervals around the knob on the housing, and the marking points at different positions on the housing correspond to different valve states of the rolling valve 100, and the joints 120 connected to each subspace are different in different valve states, that is, the flow direction of the liquid in the annular hose 110 is different in different valve states. Specifically, the marking point is used to indicate the current valve state of the rolling valve 100 to the user when the end of the handheld portion is aligned with itself; that is, when the flow direction of the liquid in the annular hose 110 needs to be adjusted to the target flow direction (corresponding to the target valve state), the user can drive the extrusion rod 130 to rotate around the rotating shaft through the knob, and when the end of the handheld portion rotated into the knob is aligned with the target marking point (corresponding to the target valve state), the valve state of the rolling valve 100 is the target valve state, and the flow direction of the liquid in the annular hose 110 is the target flow direction. Here, the example given above is still used. It is assumed that the rolling valve 100 includes four joints 120, a, b, x, and y. The valve state of the rolling valve 100 includes valve state A and valve state B. The marking points include a first marking point corresponding to valve state A and a second marking point corresponding to valve state B. At the current moment, the end of the handheld portion of the knob is aligned with the first marking object, and the rolling valve 100 is in valve state A. In valve state A, a and b are connected to one subspace, and x and y are connected to another subspace. Then, the annular soft The liquid in tube 110 will flow out through b, and the liquid entering the annular hose 110 through y will flow out through x; if the knob is subsequently turned so that the end of the handheld portion is aligned with the second marker, the roller valve 100 will change from the original valve state A to the valve state B. In valve state B, a and x are connected to one subspace, and b and y are connected to another subspace, so the liquid entering the annular hose 110 through a will no longer flow out through b but will flow out through x, and the liquid entering the annular hose 110 through y will no longer flow out through x but will flow out through b.

[0037] In some embodiments, in addition to the structure given above, the rolling valve 100 also includes a support and guide structure (not shown in the figure), which is connected between the extrusion rod 130 and the inner bottom wall of the shell, and is used to support and guide the extrusion rod 130 during the rotation of the extrusion rod 130 around the rotating axis, thereby ensuring the stability of the extrusion rod 130 during the rotation process.

[0038] As one or more embodiments, the support and guide structure includes two rollers (not shown in the figure), both of which are rotatably arranged on the squeeze rod 130, and the two rollers are respectively located on opposite sides of the rotation axis, and each roller is in contact with the inner bottom wall of the shell. Specifically, the rollers are used to roll on the inner bottom wall of the shell when the squeeze rod 130 rotates around the rotation axis; that is, when it is necessary to adjust the flow direction of the liquid in the annular hose 110, the user can manipulate the squeeze rod 130 to rotate around the rotation axis, and because the rollers are rotatably arranged on the squeeze rod 130 and in contact with the inner bottom wall of the shell, each roller will roll on the inner bottom wall of the shell during the rotation of the squeeze rod 130, so that the rotating squeeze rod 130 is supported and guided by the rolling of each roller.

[0039] It should be noted that the number of rollers is not limited to two. In other embodiments, the rollers may include one, three or more, which may be set according to actual needs. The present application does not make a sole limitation on this. For example, when the rollers include multiple rollers, the multiple rollers are all rotatably arranged on the extrusion rod 130 and are arranged at intervals along the axis direction of the extrusion rod 130. It should also be noted that, based on the above description, the extrusion rod 130 realizes its own rotation by being rotatably arranged on the rotating shaft, but in fact, the rotating shaft can also be omitted, that is, the extrusion rod 130 is directly arranged on the inner side of the annular hose 110, and the opposite ends of the extrusion rod 130 are made to extrude the annular hose 110. In this case, the extrusion rod 130 can be restricted to the inner side of the annular hose 110 by the inner bottom wall and the inner top wall of the shell, and the rotation of the extrusion rod 130 can be supported and guided by the multiple rollers rotatably arranged on the extrusion rod 130. In this way, the stability of the extrusion rod 130 during rotation can also be ensured.

[0040] As one or more embodiments thereof, the support and guide structure includes an annular chute (not shown) opened on the inner bottom wall of the shell and surrounding the rotating shaft, and two sliders (not shown) are slidably arranged in the annular chute, and the two sliders are connected to the extrusion rod 130 and are respectively located on both sides of the rotating shaft. Specifically, the slider is used to slide in the annular chute when the extrusion rod 130 rotates around the rotating shaft; that is, when it is necessary to adjust the flow direction of the liquid in the annular hose 110, the user can manipulate the extrusion rod 130 to rotate around the rotating shaft, and because the slider is connected to the extrusion rod 130 and slides with the annular chute, each slider will slide in the annular chute during the rotation of the extrusion rod 130, so that the rotating extrusion rod 130 is supported and guided by the sliding of each slider. In addition, it should be noted that the number of annular slides is not limited to one. In other embodiments, the annular slides may also include two or more, which can be specifically set according to actual needs. The present application does not make a sole limitation on this. By way of example, when the annular slides include multiple, the multiple annular slides are radially arranged around the rotating shaft, with the rotation axis pointing in the direction of the proximal outer wall. Any two adjacent annular slides are separated, and each annular slide is provided with two sliders (located on both sides of the rotating shaft respectively), and all the sliders are connected to the extrusion rod 130.

[0041] In some embodiments, the two opposite ends of the extrusion rod 130 are provided with a socket (not shown) that is recessed inward and extends along the axis of the extrusion rod 130; in addition to the structure given above, the rolling valve 100 also includes two plug rods (not shown) and two return springs (not shown), the two return springs are respectively arranged in the two plug holes, the two plug rods are respectively inserted in the two plug holes, and the two ends of each return spring are respectively connected to the extrusion rod 130 and the corresponding plug rod. Specifically, the return spring is used to be compressed when the opposite ends of the extrusion rod 130 abut against the proximal outer wall of the annular hose 110; the plug rod is used to compress the proximal outer wall under the elastic force of the return spring when the opposite ends of the extrusion rod 130 abut against the proximal outer wall of the annular hose 110. That is to say, when the opposite ends of the squeezing rod 130 abut against the proximal outer wall of the annular hose 110, not only the end of the squeezing rod 130 squeezes the annular hose 110, but the insertion rod also squeezes the annular hose 110 under the elastic force of the return spring, thereby enhancing the separation effect of the squeezing rod 130 on the internal space of the annular hose 110, and effectively preventing the liquid in one subspace from penetrating into another subspace through the position squeezed by the squeezing rod 130 in the annular hose 110, that is, preventing the mutual penetration of liquid between the two subspaces.

[0042] See also Figure 2 and Figure 3 , Figure 2 is a schematic diagram of the structure of the switching device. Figure 3This embodiment provides a switching device 200, which is applied to an immunoadsorption device 300. The immunoadsorption device 300 includes a plasma separation device 310, a flushing device 320, a left adsorption column 340, a right adsorption column 350, and a waste liquid bag 330. The two ends of the plasma separation device 310 are respectively used to connect the artery and vein of the patient. The plasma separation device 310 is used to draw blood from the artery and separate plasma. The flushing device 320 is used to provide flushing liquid. Specifically, the switching device 200 includes a first rolling valve 210 and a second rolling valve 220, both of which are the rolling valve 100 described above, the connector 120 in the first rolling valve 210 includes a first connector 121, a second connector 122, a third connector 123 and a fourth connector 124, the connector 120 in the second rolling valve 220 includes a fifth connector 125, a sixth connector 126, a seventh connector 127 and an eighth connector 128, the two ends of the left adsorption column 340 are respectively connected to the second connector 122 and the sixth connector 126, the plasma separation device 310 is connected to the first connector 121, the fifth connector 125 is used to connect to the vein, the two ends of the right adsorption column 350 are respectively connected to the third connector 123 and the seventh connector 127, the flushing device 320 is connected to the fourth connector 124, and the waste liquid bag 330 is connected to the eighth connector 128.

[0043] In this embodiment, the immunoadsorption device 300 has two working states, namely, the left column adsorption state and the right column adsorption state. In the left column adsorption state, the left adsorption column 340 performs adsorption work and the right adsorption column 350 performs regeneration work. The flow path of plasma is the plasma separation device 310, the first joint 121, the second joint 122, the left adsorption column 340, the sixth joint 126, the fifth joint 125 and the vein. The flow path of the flushing liquid is the flushing device 320, the fourth joint 124, the third joint 123, the right adsorption column 350, the seventh joint 126, the fifth joint 125 and the vein. connector 127, the eighth connector 128 and the waste liquid bag 330; in the right column adsorption state, the right adsorption column 350 performs adsorption work and the left adsorption column 340 performs regeneration work, the flow path of plasma is the plasma separation device 310, the first connector 121, the third connector 123, the right adsorption column 350, the seventh connector 127, the fifth connector 125 and the vein, and the flow path of the flushing liquid is the flushing device 320, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128 and the waste liquid bag 330.

[0044] In actual application, the switching device 200 is used to adjust the working state of the immunoadsorption device 300 by rotating the squeezing rod 130 in the first rolling valve 210 and the second rolling valve 220. That is, when the working state of the immunoadsorption device 300 needs to be adjusted, the squeezing rod 130 in the first rolling valve 210 and the second rolling valve 220 can be rotated to adjust the flow direction of the liquid in the first rolling valve 210 and the second rolling valve 220, that is, to adjust the valve state of the first rolling valve 210 and the second rolling valve 220, and then adjust the working state of the immunoadsorption device 300. Specifically, the valve state of the rolling valve 100 includes a first valve state and a second valve state. When the first rolling valve 210 and the second rolling valve 220 are both in the first valve state, the first joint 121 is connected to the second joint 122, the fifth joint 125 is connected to the sixth joint 126, the third joint 123 is connected to the fourth joint 124, and the seventh joint 127 is connected to the eighth joint 128, and the immunoadsorption device 300 is in the left column adsorption state; thereafter, the first rolling valve 210 and the second rolling valve 220 can be rotated to make the first rolling valve 210 and the second rolling valve 220 both in the second valve state, that is, the first joint 121 is connected to the third joint 123, the fifth joint 125 is connected to the seventh joint 127, the second joint 122 is connected to the fourth joint 124, and the sixth joint 126 is connected to the eighth joint 128. At this time, the working state of the immunoadsorption device 300 is changed from the original left column adsorption state to the right column adsorption state, and the working state adjustment of the immunoadsorption device 300 is realized.

[0045] As can be seen from the above, in this embodiment, when switching between the left column adsorption state and the right column adsorption state of the immunoadsorption device 300, it is only necessary to rotate the squeezing rod 130 in the first rolling valve 210 and the second rolling valve 220. There is no need to control multiple tube clamps at the same time as in the traditional solution. This can not only reduce the amount of operation for medical staff, but also reduce the error rate of medical staff during operation.

[0046] See also Figure 3 The present embodiment provides an immunoadsorption device 300, comprising a plasma separation device 310, a flushing device 320, a left adsorption column 340, a right adsorption column 350, a waste liquid bag 330 and the switching device 200 described above. As for the process of switching the working state of the immunoadsorption device 300 (i.e., the left column adsorption state and the right column adsorption state) using the switching device 200, please refer to the relevant description of the switching device 200 in the above text, and the present application will not elaborate on it here.

[0047] In some embodiments, see Figure 3The plasma separator 310 includes a first blood pump 311, a second blood pump 315 and a plasma separator 312. One end of the plasma separator 312 is connected to the first blood pump 311. The first blood pump 311 is used to connect to the patient's artery. The other end of the plasma separator 312 is used to connect to the patient's vein. The plasma separator 312 is also connected to the first connector 121 through the second blood pump 315. Specifically, the first blood pump 311 is used to draw blood from the artery and pump it to the plasma separator 312; the plasma separator 312 is used to separate plasma from the blood; and the second blood pump 315 is used to draw plasma from the plasma separator 312 and pump it to the first connector 121. That is, in actual application, the first blood pump 311 can draw blood from the patient's artery and pump the drawn blood to the plasma separator 312, the plasma separator 312 can separate plasma from the blood, and the second blood pump 315 can draw plasma from the plasma separator 312 and pump the drawn plasma to the first connector 121.

[0048] As one or more embodiments thereof, the plasma separator 310 includes, in addition to the structure given above, an arterial pot 313 and a venous pot 314. One end of the plasma separator 312 is connected to the first blood pump 311 through the arterial pot 313, and the other end is used to connect to the vein through the venous pot 314. The venous pot 314 is also connected to the fifth connector 125. It can be understood that the arterial pot 313 can filter larger particulate matter to prevent these substances from entering the plasma separator 312 and causing blockage or damage to the plasma separator 312; the arterial pot 313 can also play a certain buffering role, allowing blood to enter the plasma separator 312 at a relatively stable flow rate, avoiding the adverse effects of sudden changes in blood flow rate on the entire treatment process; the arterial pot 313 can be provided with a monitoring port, which can be connected to a pressure monitoring device (such as Figure 3 This helps medical staff to timely understand the state of blood flow and determine whether there are problems such as pipeline blockage and abnormal pressure. In addition, when blood testing is required, blood samples can be conveniently collected from the arterial pot 313 without directly drawing from the patient's blood vessels, reducing the patient's pain and infection risk.

[0049] An important function of the intravenous pot 314 is to prevent air from entering the human blood circulation system. The intravenous pot 314 is usually designed with a certain capacity and a special structure to capture and accumulate tiny bubbles that may be mixed into the blood, thereby avoiding the occurrence of serious complications such as air embolism. Similar to the arterial pot 313, the intravenous pot 314 may also be provided with a monitoring port, which can be connected to a pressure monitoring device (such as Figure 3Pb in the blood) to monitor the pressure at the blood return end. Once an abnormal pressure is detected, an alarm can be issued to remind medical staff to take timely measures; the intravenous pot 314 can be provided with a bubble detector and a liquid level monitoring device. The bubble detector can sensitively detect tiny bubbles and trigger an alarm, thereby ensuring the safety of blood return, and the liquid level monitoring device can monitor the liquid level of the blood in the intravenous pot 314 to prevent excessive filling or emptying of the blood; the intravenous pot 314 is usually provided with a drug addition port. When it is necessary to add drugs to the blood before the blood is returned to the human body, the drug injection operation can be conveniently performed through the drug addition port, so that the drug and blood are fully mixed before being returned to the patient's body.

[0050] In some embodiments, see Figure 3 The flushing device 320 includes an elution bag 321, a balance bag 322, and a pre-flushing bag 323, and the elution bag 321, the balance bag 322, and the pre-flushing bag 323 are respectively connected to the fourth connector 124. Specifically, the flushing liquid includes an elution liquid, a balance liquid, and a pre-flushing liquid, the elution bag 321 is used to store the elution liquid, the balance bag 322 is used to store the balance liquid, and the pre-flushing bag 323 is used to store the pre-flushing liquid. In addition, it should be noted that the eluent can be any solution with an elution function commonly used in the art, such as sodium chloride solution, urea, guanidine hydrochloride solution, etc., which can be selected according to actual needs, and the present application does not make a sole limitation on this; the balancing solution can also be any solution with a balancing function commonly used in the art, such as phosphate buffer, Tris-HCl buffer, buffer containing bovine serum albumin (BSA), etc., which can be selected according to actual needs, and the present application does not make a sole limitation on this; the pre-flushing solution can also be any solution with a flushing function commonly used in the art, such as physiological saline (0.9% sodium chloride solution), etc., which can be selected according to actual needs, and the present application does not make a sole limitation on this.

[0051] It can be understood that the eluent is mainly used to elute the pathogenic substances adsorbed in the adsorption column so that the adsorption column can restore its adsorption capacity; during the use of the adsorption column, the pathogenic substances will be adsorbed on the adsorbent. Over time, the adsorption capacity of the adsorption column will gradually decrease. By using a specific eluent, the interaction between the pathogenic substances and the adsorbent can be destroyed, thereby eluting the pathogenic substances from the adsorption column; different types of adsorption columns may require different eluents, and the selection usually depends on the type of adsorption column, the adsorbed pathogenic substances and the regeneration requirements.

[0052] The function of the balancing solution is to restore the adsorption column to its initial equilibrium state after elution. After the elution process, the internal environment of the adsorption column may have changed, such as pH value, ionic strength, etc. The balancing solution can adjust these parameters to stabilize the performance of the adsorption column and prepare for the next adsorption. The composition of the balancing solution is usually similar to the buffer solution used in the adsorption process, which can ensure the consistency of the adsorption column during the adsorption and regeneration process. At the same time, the balancing solution can also remove the residual eluent and other impurities in the adsorption column, thereby ensuring the cleanliness of the adsorption column.

[0053] The priming liquid can flush out the residual substances in the adsorption column (such as blood, protein, drugs, etc. that may remain after the last use), which helps to reduce the impact of impurities on the regeneration of the adsorption column and improve the regeneration effect of the adsorption column; the priming liquid can expel the air in the adsorption column to ensure that the priming liquid can fully flow through all parts of the adsorption column when the adsorption column is regenerated, and can avoid the appearance of bubbles that affect the adsorption performance of the adsorption column; during the priming process, it is possible to check whether the connection between the adsorption column and the pipeline is tight and whether there is any leakage, so as to ensure the safety of the adsorption column during regeneration; the priming liquid can make the adsorbent of the adsorption column fully moist, thereby preparing for subsequent regeneration; at the same time, the priming liquid can also adjust parameters such as temperature and pressure of the adsorption column to make it better adapt to the regeneration of the adsorption column.

[0054] As one or more embodiments thereof, the flushing device 320, in addition to the structure given above, also includes a third blood pump 327, an elution switch 324, a balance switch 325 and a pre-flushing switch 326. The elution bag 321 is connected to the third blood pump 327 via the elution switch 324, the balance bag 322 is connected to the third blood pump 327 via the balance switch 325, the pre-flushing bag 323 is connected to the third blood pump 327 via the pre-flushing switch 326, and the third blood pump 327 is connected to the fourth connector 124. Specifically, the elution switch 324 is used to connect the third blood pump 327 and the elution bag 321 when it is turned on, or to block the third blood pump 327 and the elution bag 321 when it is turned off; the balance switch 325 is used to connect the third blood pump 327 and the balance bag 322 when it is turned on, or to block the third blood pump 327 and the balance bag 322 when it is turned off; the pre-flushing switch 326 is used to connect the third blood pump 327 and the pre-flushing bag 323 when it is turned on, or to block the third blood pump 327 and the pre-flushing bag 323 when it is turned off; the third blood pump 327 is used to draw out eluent from the elution bag 321 and pump it to the fourth connector 124 when the elution switch 324 is turned on, or to draw out balancing liquid from the balance bag 322 and pump it to the fourth connector 124 when the balance switch 325 is turned on, or to draw out pre-flushing liquid from the pre-flushing bag 323 and pump it to the fourth connector 124 when the pre-flushing switch 326 is turned on.

[0055] That is to say, the connection and disconnection between the third blood pump 327 and the elution bag 321 is controlled by turning the elution switch 324 on / off. Only when the elution switch 324 is on, the third blood pump 327 can pump the eluent in the elution bag 321 to the fourth connector 124; the connection and disconnection between the third blood pump 327 and the balancing bag 322 is controlled by turning the balancing switch 325 on / off. Only when the balancing switch 325 is on, the third blood pump 327 can pump the balancing liquid in the balancing bag 322 to the fourth connector 124; the connection and disconnection between the third blood pump 327 and the priming bag 323 is controlled by turning the pre-flushing switch 326 on / off. Only when the pre-flushing switch 326 is on, the third blood pump 327 can pump the priming liquid in the priming bag 323 to the fourth connector 124.

[0056] In order to facilitate those skilled in the art to clearly understand the working process of the immunoadsorption device 300, an example of switching from the left column adsorption state to the right column adsorption state is given below:

[0057] When the immunosorbent device 300 is in the left column adsorption state, the first roller valve 210 and the second roller valve 220 are both in the first valve state (i.e., the first connector 121 is connected to the second connector 122, the fifth connector 125 is connected to the sixth connector 126, the third connector 123 is connected to the fourth connector 124, and the seventh connector 127 is connected to the eighth connector 128). If the working state of the immunosorbent device 300 is to be switched to the right column adsorption state, the valve state of the first roller valve 210 can be switched from the first valve state to the second valve state (i.e., the first connector 121 is connected to the third connector 123, and the second connector 122 is connected to the fourth connector 124). At this time, the flow path of the plasma is the plasma separator 312, the first connector 121, the third connector 123, the right adsorption column 350, the seventh connector 127, the eighth connector 128 and the waste liquid bag 330.

[0058] After 2 minutes, the valve state of the second rolling valve 220 can be switched from the first valve state to the second valve state (i.e., the fifth connector 125 is connected to the seventh connector 127, and the sixth connector 126 is connected to the eighth connector 128). At this time, the flow path of the plasma is the plasma separator 312, the first connector 121, the third connector 123, the right adsorption column 350, the seventh connector 127, the fifth connector 125 and the vein. The right adsorption column 350 adsorbs the pathogenic substances in the plasma, and the adsorbed plasma is returned to the patient's vein.

[0059] After 2 minutes, the elution switch 324 can be turned on, and the balance switch 325 and the pre-flushing switch 326 can be turned off. The flow path of the eluent is the elution bag 321, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128 and the waste liquid bag 330, and the left adsorption column 340 is eluted with the eluent.

[0060] After 6 minutes, the balance switch 325 can be turned on, and the elution switch 324 and the pre-flushing switch 326 can be turned off. The flow path of the balance liquid is the balance bag 322, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128 and the waste liquid bag 330, and the balance liquid is used to balance the left adsorption column 340.

[0061] After 6 minutes, the pre-flushing switch 326 can be turned on, and the balance switch 325 and the elution switch 324 can be turned off. The flow path of the pre-flushing liquid is the pre-flushing bag 323, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128 and the waste liquid bag 330, and the left adsorption column 340 is flushed with the pre-flushing liquid.

[0062] After 3 minutes, the regeneration of the left adsorption column 340 is completed, the pre-flushing switch 326 is closed, and then the valve state of the first rolling valve 210 is switched from the second valve state to the first valve state (that is, the first connector 121 is connected to the second connector 122, and the third connector 123 is connected to the fourth connector 124). At this time, the flow path of the plasma is the plasma separator 312, the first connector 121, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128 and the waste liquid bag 330, and the next cycle begins.

[0063] The above embodiments are only preferred implementations of the present application. They are not the only limitations on the rolling valve 100, the switching device 200 and the immunoadsorption device 300. In this regard, those skilled in the art can flexibly set them according to the actual application scenarios based on the above embodiments. It can be understood that through the implementation of the above embodiments of the present application, the rolling valve 100 is composed of a hollow shell and an annular hose 110, an extrusion rod 130 and a plurality of joints 120 located in the shell. The plurality of joints 120 are arranged on the distal outer wall of the annular hose 110 around the center of the ring. Each joint 120 is connected to the annular hose 110. The annular hose 110 is arranged on the inner bottom wall of the shell and its distal outer wall is in contact with the inner wall of the shell. The ends of each joint 120 away from the annular hose 110 pass through the shell and are used to connect to external pipes. The inner bottom wall of the shell is provided with The extrusion rod 130 is disposed on the rotating shaft and is in rotational cooperation with the rotating shaft. The opposite ends of the extrusion rod 130 are both in contact with the proximal outer wall of the annular hose 110, and the proximal outer wall is squeezed toward the inner wall of the shell, so that the proximal inner wall of the position squeezed by the extrusion rod 130 on the annular hose 110 fits with the distal inner wall. At this time, the internal space of the annular hose 110 is divided into two sub-spaces by the extrusion rod 130, and all the joints 120 connected to the same sub-space are interconnected, while the joints 120 connected to different sub-spaces cannot be interconnected. In actual application, the extrusion rod 130 can be rotated around the rotating shaft. Since the annular hose 110 is fixed, the position squeezed by the extrusion rod 130 on the annular hose 110 will change during the rotation of the extrusion rod 130, which causes the joint 120 connected to each sub-space to change, so the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly. On this basis, at least one roller valve 100 can be applied to an immunoadsorption system including two adsorption columns. Specifically, at least one roller valve 100 can be set in a pipe network connecting the two adsorption columns, and multiple joints 120 of the roller valve 100 are respectively connected to several pipes in the pipe network. In this way, the flow direction of the plasma / washing fluid entering the roller valve 100 can be adjusted by rotating the squeezing rod 130 in the roller valve 100, so as to switch between the two adsorption columns for adsorption work, so that one adsorption column performs adsorption work while the other adsorption column performs regeneration work, and the present invention This switching only requires rotating the squeezing rod 130 in the rolling valve 100, and there is no need to control multiple tube clamps at the same time as in the traditional solution, which not only reduces the amount of operation for medical staff, but also reduces the error rate of medical staff during operation; in addition, during the entire process of blood purification, there is no need to adjust the operating speeds of the first blood pump 311, the second blood pump 315, the third blood pump 327, etc., and the adsorption work of the adsorption column does not require any operation. It is only necessary to control the regeneration process of the adsorption column, and the adsorption column can complete the regeneration in only 20 minutes. The simultaneous use of dual adsorption columns can greatly shorten the treatment process.

[0064] It should be noted that the several embodiments shown in the present application are described in a progressive manner, and each embodiment focuses on the differences from other embodiments, and the same or similar parts between the various embodiments can refer to each other. It should also be noted that in the text description of the present application, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply that there is such an actual relationship or order between these entities or operations. Further, the terms "include", "comprise" or any other corresponding variants are intended to cover non-exclusive inclusion, so that the process, method, article or equipment including a series of elements includes not only these elements, but also other elements that are not explicitly listed, or may also include elements inherent to such process, method, article or equipment; and, in the absence of more restrictions, the elements defined by the sentence "including one..." do not exclude the existence of other identical elements in the process, method, article or equipment including the elements.

[0065] In addition, by implementing the several embodiments shown above in the present application, professionals and technicians in this field can implement or use the present application. For the several embodiments shown above in the present application, various modifications will be obvious to professionals and technicians in this field, and the general principles defined in the present application can be implemented in other embodiments not shown without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the several embodiments shown above, but will comply with the widest range consistent with the principles and novel features disclosed in the present application.

Claims

1. A rolling valve, characterized in that: It comprises an annular hose and a plurality of connectors, wherein the outer wall of the annular hose comprises a proximal outer wall located on one side of the annular center and an opposite distal outer wall, and the plurality of connectors are arranged on the distal outer wall at intervals around the annular center and are all connected to the annular hose; The rolling valve also includes an extrusion rod and a hollow shell, wherein the extrusion rod, the annular hose and a plurality of the joints are all located in the shell, the annular hose is arranged on the inner bottom wall of the shell, and the distal outer wall abuts against the inner side wall of the shell, and one end of each joint away from the annular hose passes through the shell and is used to connect to an external pipeline, a rotating shaft is arranged on the inner bottom wall of the shell, the extrusion rod is arranged on the rotating shaft and rotatably cooperates with the rotating shaft, the opposite ends of the extrusion rod abut against the proximal outer wall, and the proximal outer wall is squeezed toward the inner side wall of the shell, so that the internal space of the annular hose is divided into two sub-spaces by the extrusion rod, and all the joints connected to the same sub-space are interconnected; The extrusion rod is used to rotate around the rotation axis under the action of external force to adjust the joints connected with each of the subspaces and change the flow direction of the liquid entering the annular hose through the pipeline.

2. The rolling valve according to claim 1, characterized in that: An operating window communicating with the interior is provided on the outer wall of the shell, and the operating window corresponds to the extrusion rod.

3. The rolling valve according to claim 1, characterized in that: A through hole connected to the interior is opened on the outer wall of the shell, and the through hole corresponds to the extrusion rod. The rolling valve also includes a knob and a connecting rod. The knob is arranged on one end of the connecting rod, and the other end of the connecting rod enters the shell through the through hole and is arranged on the extrusion rod.

4. The rolling valve according to claim 3, characterized in that: The knob comprises a base, one side of the base is connected to the connecting rod, and a hand-holding portion is formed on the other opposite side, and the length direction of the hand-holding portion is consistent with the axial direction of the extrusion rod.

5. The rolling valve according to claim 4, characterized in that: A plurality of marking points are arranged on the shell at intervals around the knob, and the marking points at different positions on the shell correspond to different valve states of the rolling valve. The connectors connected to each subspace are different in different valve states, and the marking points are used to indicate to the user the current valve state of the rolling valve when the end of the handheld portion is aligned with itself.

6. The rolling valve according to claim 1, characterized in that: It also includes two rollers, both of which are rotatably arranged on the extrusion rod, and the two rollers are respectively located on both sides of the rotating shaft. Each of the rollers is in contact with the inner bottom wall of the shell, and the rollers are used to roll on the inner bottom wall of the shell when the extrusion rod rotates around the rotating shaft.

7. The rolling valve according to claim 1, characterized in that: An annular groove surrounding the rotating shaft is provided on the inner bottom wall of the shell, and two sliders are slidably arranged in the annular groove. The two sliders are connected to the extrusion rod and are respectively located on both sides of the rotating shaft. The sliders are used to slide in the annular groove when the extrusion rod rotates around the rotating shaft.

8. The rolling valve according to claim 1, characterized in that: The annular hose is in the shape of a ring.

9. A switching device, characterized in that: Applied in an immunoadsorption device, the immunoadsorption device includes a plasma separation device, a flushing device, a left adsorption column, a right adsorption column and a waste liquid bag, the two ends of the plasma separation device are respectively used to connect the patient's artery and vein, the switching device includes a first rolling valve and a second rolling valve, the first rolling valve and the second rolling valve are both rolling valves according to any one of claims 1 to 8, the first rolling valve has a first joint, a second joint, a third joint and a fourth joint, the second rolling valve has a fifth joint, a sixth joint, a seventh joint and an eighth joint, the two ends of the left adsorption column are respectively connected to the second joint and the sixth joint, the plasma separation device is connected to the first joint, the fifth joint is used to connect the vein, the two ends of the right adsorption column are respectively connected to the third joint and the seventh joint, the flushing device is connected to the fourth joint, and the waste liquid bag is connected to the eighth joint, wherein: The plasma separation device is used to draw blood from the artery and separate plasma; The flushing device is used to provide flushing liquid; The switching device is used to adjust the working state of the immunoadsorption device by rotating the squeezing rods in the first rolling valve and the second rolling valve; The working state includes a left column adsorption state, in which the first connector is connected to the second connector, the fifth connector is connected to the sixth connector, the third connector is connected to the fourth connector, and the seventh connector is connected to the eighth connector, the flow path of the plasma is the first connector, the second connector, the left adsorption column, the sixth connector, the fifth connector and the vein, and the flow path of the flushing liquid is the fourth connector, the third connector, the right adsorption column, the seventh connector, the eighth connector and the waste liquid bag; The working state also includes a right column adsorption state. In the right column adsorption state, the first connector is connected to the third connector, the fifth connector is connected to the seventh connector, the second connector is connected to the fourth connector, and the sixth connector is connected to the eighth connector. The flow path of the plasma is the first connector, the third connector, the right adsorption column, the seventh connector, the fifth connector and the vein, and the flow path of the flushing fluid is the fourth connector, the second connector, the left adsorption column, the sixth connector, the eighth connector and the waste liquid bag.

10. An immunoadsorption device, characterized in that: The invention comprises a plasma separation device, a waste liquid bag, a flushing device, a left adsorption column, a right adsorption column and the switching device according to claim 9, wherein the two ends of the plasma separation device are respectively used to connect the patient's artery and vein, the first roller valve in the switching device has a first joint, a second joint, a third joint and a fourth joint, the second roller valve in the switching device has a fifth joint, a sixth joint, a seventh joint and an eighth joint, the two ends of the left adsorption column are respectively connected to the second joint and the sixth joint, the plasma separation device is connected to the first joint, the fifth joint is used to connect to the vein, the two ends of the right adsorption column are respectively connected to the third joint and the seventh joint, the flushing device is connected to the fourth joint, and the waste liquid bag is connected to the eighth joint, wherein: The plasma separation device is used to draw blood from the artery and separate plasma; The flushing device is used to provide flushing liquid; The switching device is used to adjust the working state of the immunoadsorption device by rotating the squeezing rods in the first rolling valve and the second rolling valve; The working state includes a left column adsorption state, in which the first connector is connected to the second connector, the fifth connector is connected to the sixth connector, the third connector is connected to the fourth connector, and the seventh connector is connected to the eighth connector, the flow path of the plasma is the first connector, the second connector, the left adsorption column, the sixth connector, the fifth connector and the vein, and the flow path of the flushing liquid is the fourth connector, the third connector, the right adsorption column, the seventh connector, the eighth connector and the waste liquid bag; The working state also includes a right column adsorption state. In the right column adsorption state, the first connector is connected to the third connector, the fifth connector is connected to the seventh connector, the second connector is connected to the fourth connector, and the sixth connector is connected to the eighth connector. The flow path of the plasma is the first connector, the third connector, the right adsorption column, the seventh connector, the fifth connector and the vein, and the flow path of the flushing fluid is the fourth connector, the second connector, the left adsorption column, the sixth connector, the eighth connector and the waste liquid bag.

Images