Traditional Chinese medicine for rehabilitation treatment of pressure sores as well as preparation method and application of traditional Chinese medicine

Abstract

The invention relates to the technical field of medical drugs, in particular to a traditional Chinese medicine for pressure sore rehabilitation treatment and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 2 parts of honeysuckle flowers, 2 parts of fructus forsythiae, 2 parts of purslane, 1 part of radix isatidis, 1 part of polygonum cuspidatum, 1 part of indigo naturalis, 2 parts of rehmannia glutinosa libosch, 2 parts of prepared rehmannia roots and 1 part of donkey-hide gelatin. The traditional Chinese medicine composition further comprises the following auxiliary materials in parts by weight: 2 parts of tung oil, 1 part of alcohol and 1 part of erythromycin. According to the traditional Chinese medicine for pressure sore rehabilitation treatment and the preparation method and application thereof, inflammation can be effectively reduced, inflammation is one of important factors of pressure sore development, the medicine for clearing away heat and toxic materials can help relieve inflammatory response and improve blood circulation, and sufficient nutrition and oxygen can be provided by promoting local blood circulation; the medicine for clearing away heat and toxic materials has the antibacterial effect, infection can be prevented or controlled, the healing quality is improved, and the healing period is shortened.

Description

Technical Field

[0001] The present invention relates to the technical field of medical drugs, and in particular to a traditional Chinese medicine for the rehabilitation treatment of pressure sores, and a preparation method and application thereof. Background Art

[0002] Pressure sores, also known as bedsores and pressure ulcers, are a type of skin and / or tissue injury limited to the body surface. Due to prolonged pressure on the tissue, insufficient blood supply occurs, causing skin damage, ulcers, and even necrosis. It usually occurs in people who are bedridden or sitting for a long time, especially those who have limited mobility and limited local nerve and blood supply. According to the classification of pressure sores, there are four common stages. Currently, the treatment for pressure sores mainly includes debridement, local wound care, infection control, pain relief, and systemic nutritional support. Surgical treatment is required when necessary, including debridement and flap repair. Currently, pressure sores are particularly common in people who are bedridden or in wheelchairs for a long time. More than 10% of people who are bedridden or in wheelchairs have developed pressure sores. The mortality rate of elderly patients related to pressure sores is 23% to 37%, and the mortality rate of elderly people with pressure sores is 4 times higher than that of elderly people without pressure sores.

[0003] At present, the existing technical methods for treating pressure sores mostly adopt the method of independent treatment for independent patients, and only treat the symptoms that appear. The use of Western medicine for treatment is mainly through anti-inflammatory and antibacterial methods, waiting for the wound surface of the pressure sore to heal. Traditional Chinese medicine advocates clearing away heat and detoxification in the treatment of pressure sores. Through the method of clearing away heat and detoxification, the pressure sores caused by long-term squeezing and stuffiness can be solved. The current traditional Chinese medicine treatment of pressure sores mostly uses astragalus, codonopsis, angelica, and red peony root to promote blood circulation and remove blood stasis, invigorate qi and nourish blood. The treatment effect is not ideal, which results in the poor effect of traditional Chinese medicine in the treatment of pressure sores. Summary of the invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine for the rehabilitation treatment of pressure sores and its preparation method and application, so as to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the first aspect of the present invention provides a traditional Chinese medicine for the rehabilitation treatment of pressure sores, characterized in that the traditional Chinese medicine composition is made of the following components in parts by weight: 1-5 parts of honeysuckle, 2-4 parts of forsythia, 2-5 parts of purslane, 1-3 parts of isatis root, 1-4 parts of knotweed, 1-2 parts of indigo, 2-4 parts of rehmannia, 1-4 parts of prepared rehmannia and 1-3 parts of donkey-hide gelatin, and the traditional Chinese medicine composition also contains the following auxiliary materials in parts by weight: 1-3 parts of tung oil, 1-3 parts of alcohol and 1 part of erythromycin.

[0006] In a further embodiment, the Chinese medicine composition is made of the following components by weight: 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed, 1 part of indigo, 2 parts of rehmannia, 2 parts of prepared rehmannia and 1 part of donkey-hide gelatin, and the Chinese medicine composition also contains the following excipients by weight: 2 parts of tung oil, 1 part of alcohol and 1 part of erythromycin.

[0007] The second aspect of the present invention provides a traditional Chinese medicine for the rehabilitation treatment of pressure sores and a preparation method thereof, comprising the following steps:

[0008] 1) Take 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed and 1 part of indigo, mix them according to the above proportions, then add the above raw materials to a crushing device, crush them, and then grind them into fine powder;

[0009] 2) Take 2 grams of Rehmannia root, 2 grams of Rehmannia root prepared, and 1 gram of donkey hide gelatin, cut the Rehmannia root and Rehmannia root prepared into small pieces of uniform size, then add the Rehmannia root and Rehmannia root prepared into the first pot, add appropriate amount of water, then add the donkey hide gelatin into the pot, heat and boil until a gelatinous substance is formed;

[0010] 3) Take 1 part of alcohol and 1 part of erythromycin as raw materials, then add the alcohol into the second pot, heat the alcohol to boiling, add erythromycin while heating, stir evenly, and obtain erythromycin solution;

[0011] 4) adding the fine powder to the first pot and mixing, stirring and mixing evenly, then adding the erythromycin solution to the first pot of the above mixture, and continuing to stir and mix evenly to obtain a Chinese medicine composition;

[0012] 5) adding tung oil to the Chinese medicine composition in the first pot, heating, boiling and stirring at the same time, and continuing heating and stirring after the tung oil is added, and standing and cooling after the heating and stirring are completed to obtain a Chinese medicine cream.

[0013] In a further embodiment, the tung oil is prepared by pretreatment, and the pretreatment preparation method is as follows:

[0014] 1) taking tung oil and sodium hydroxide solution as raw materials, mixing the tung oil and the sodium hydroxide solution, and then heating them, and continuously stirring during the heating process to obtain a tung oil mixed solution;

[0015] 2) filtering the tung oil mixture, and then adding the filtered tung oil mixture to a liquid centrifuge for centrifugation to separate the alkaline solution;

[0016] 3) adding an acidic substance to the centrifuged tung oil mixture and allowing the mixture to stand, so that eleostearic acid in the tung oil mixture is precipitated, and then filtering and centrifuging are performed to separate the precipitate from the tung oil, thereby obtaining tung oil from which eleostearic acid has been removed.

[0017] In a further embodiment, the temperature for mixing and heating the tung oil and the sodium hydroxide solution is 70° C., and the stirring time is 1.5-2 hours.

[0018] In a further embodiment, the acidic substance is one of hydrochloric acid, sulfuric acid, nitric acid and acetic acid, preferably hydrochloric acid.

[0019] 7. A Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof according to claim 1, characterized in that: the heating time of the Rehmannia root and Rehmannia glutinosa in a cooking pot is 0.5-1h, the heating time of the alcohol and erythromycin is until the alcohol is completely volatilized, the heating time of the Chinese medicine composition and tung oil is until the mixture is thick, and stirring is continued for 10 minutes after the heating is completed.

[0020] In a further embodiment, the first pot and the second pot are both common cooking pots.

[0021] In a further embodiment, the fine powder raw materials of honeysuckle, forsythia, purslane, isatis root, knotweed and indigo are ground into 2500 mesh, and the size of the cut pieces of rehmannia and cooked rehmannia is 1-2 cm.

[0022] The third aspect of the present invention provides an application of a traditional Chinese medicine for rehabilitation treatment of pressure sores in the rehabilitation treatment of patients with pressure sores, and a traditional Chinese medicine cream for rehabilitation treatment of pressure sores prepared by using the traditional Chinese medicine for rehabilitation treatment of pressure sores and its preparation method.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The present invention uses honeysuckle, forsythia, purslane, isatis root, knotweed, and indigo as raw materials. These medicinal materials have good heat-clearing and detoxifying effects, can effectively treat carbuncle, swelling and sore, and can effectively reduce inflammation through the above medicinal materials. Inflammation is one of the important factors in the development of pressure sores. Drugs for clearing heat and detoxifying can help alleviate inflammatory reactions, improve blood circulation, and promote local blood circulation. It helps to provide sufficient nutrition and oxygen, accelerate wound healing, and have antibacterial effects. Heat-clearing and detoxifying drugs have antibacterial effects, can prevent or control infections, improve healing quality and shorten healing cycles;

[0025] The present invention has the effects of invigorating qi and nourishing blood and promoting tissue regeneration through the rehmannia root, prepared rehmannia root and donkey-hide gelatin. Therefore, in the later stage of treatment, the wound surface of the pressure sore begins to heal. The above-mentioned medicinal materials can increase the speed of the healing of the pressure sore, further improve the effect of the traditional Chinese medicine ointment on the treatment of the pressure sore, and erythromycin is added to the ointment as an antibiotic to effectively fight bacteria, so that the entire traditional Chinese medicine ointment can safely and efficiently treat the pressure sore. DETAILED DESCRIPTION

[0026] The following will be described clearly and completely in conjunction with the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] A traditional Chinese medicine for rehabilitation treatment of bedsores. The traditional Chinese medicine composition is prepared from the following components by weight: 1-5 parts of honeysuckle, 2-4 parts of forsythia, 2-5 parts of purslane, 1-3 parts of isatis root, 1-4 parts of knotweed, 1-2 parts of indigo, 2-4 parts of rehmannia root, 1-4 parts of prepared rehmannia root and 1-3 parts of donkey-hide gelatin. The traditional Chinese medicine composition also contains the following auxiliary materials by weight: 1-3 parts of tung oil, 1-3 parts of alcohol and 1 part of erythromycin.

[0028] The Chinese medicine composition is made of the following components by weight: 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed, 1 part of indigo, 2 parts of rehmannia, 2 parts of prepared rehmannia and 1 part of donkey-hide gelatin. The Chinese medicine composition also contains the following auxiliary materials by weight: 2 parts of tung oil, 1 part of alcohol and 1 part of erythromycin.

[0029] A traditional Chinese medicine for the rehabilitation treatment of pressure sores and a preparation method thereof, comprising the following steps:

[0030] Take 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed and 1 part of indigo, mix them according to the above proportions, then add the above materials to the crushing equipment to crush them, and then grind them into fine powder; take 2 parts of rehmannia root, 2 parts of rehmannia root prepared and 1 part of donkey-hide gelatin, cut the rehmannia root and rehmannia root prepared into small pieces of uniform size, then add the rehmannia root and rehmannia root prepared into the first pot, add appropriate amount of clean water, then add the donkey-hide gelatin to the pot, heat and boil until a jelly-like substance is formed; take 1 part of alcohol and 1 part of erythromycin, Then, add alcohol into the second pot, heat the alcohol to boiling, add erythromycin while heating, stir evenly, and obtain erythromycin solution; add fine powder into the first pot and mix, stir evenly, then add erythromycin solution into the first pot of the above mixture, continue to stir evenly, and obtain a Chinese medicine composition; add tung oil to the Chinese medicine composition in the first pot, heat, boil and stir at the same time, after the tung oil is added, continue heating and stirring, and after the heating and stirring are completed, let stand and cool to obtain a Chinese medicine cream.

[0031] The relevant experimental data are as follows:

[0032] 1. Animal Experiments

[0033] 1. Experimental Materials

[0034] 1.1 Experimental drugs and reagents

[0035] Main medicinal materials: honeysuckle, forsythia, purslane, isatis root, knotweed, indigo, rehmannia, rehmannia glutinosa and donkey-hide gelatin; auxiliary medicinal materials: tung oil, alcohol and erythromycin; erythromycin, produced by Shanghai Aoji Chemical Co., Ltd., implemented standard GB2006, boric acid zinc oxide borneol ointment, produced by Beijing Shuangji Pharmaceutical Co., Ltd., implemented national medicine standard H11022485, Gram-positive bacteria protein extraction kit BB-3129, produced by Shanghai Beibo Biotechnology Co., Ltd., Gram-negative bacteria protein extraction kit BB-3130, implemented standard YZB / Su 0268-2013, produced by Shanghai Beibo Biotechnology Co., Ltd., implemented standard YZB / Su 0268-2013.

[0036] 1.2 Experimental animals

[0037] The experiment used 40 male SD rats, SPF grade, weighing 300-310 g.

[0038] 1.3 Experimental equipment

[0039] The metallographic microscope XC-200D is produced by Shenzhen Xingchen Optical Instrument Co., Ltd. and the implementation standard is GB / T26600-2024. The fully automatic flow cell counter is produced by Qingdao Huaren Biotechnology Co., Ltd. and the implementation standard is WS / T360-2011. The Sony Alpha 7CR full-frame micro-single camera is equipped with a Sony FE 90mm f / 2.8Macro G OSS (SEL90M28G) macro lens, which is produced by Sony (China) Co., Ltd.

[0040] 2. Experimental methods and results

[0041] 2.1 Group establishment and drug administration

[0042] Forty SD rats were randomly divided into four groups, namely, blank control group, model group, boric acid zinc oxide borneol ointment group and Chinese medicine group. Except for the blank group, SD pressure sore models were established in the above three groups. The model group did not receive special treatment, while the boric acid zinc oxide borneol ointment group was given medication three times a day, with 1g / cm2 applied each time. 2 The Chinese medicine group was given 1g / cm3 three times a day 2 , continuous administration, 7 days as a cycle, sterile saline was used to clean the sores during dressing changes to ensure complete coverage of the sore surface, and then covered with medical absorbent gauze dressings, and the pressure sore surface was observed and scored once each cycle, for a total of 3 cycles. On the last day of the 3 cycles, the pressure sore wound tissue of SD rats was taken for bacterial culture and microscopic observation, and blood samples were drawn from SD rats on the first and last days for routine blood tests.

[0043] 2.2 Experimental Results

[0044] The effect of traditional Chinese medicine on the treatment of pressure sores was confirmed by referring to the blood samples, wound extracts and the size of pressure sore wounds of SD rats.

[0045] Table 1 shows the scoring data of Chinese medicine on the healing of pressure ulcer wounds in SD rats

[0046] Group <![CDATA[Dose (g / cm 2 )]]> Rating 1(cm) Rating 2 (cm) Rating 3 (cm) Blank control group — — — — Model Group — 2.2、2.3 2.4、2.4 2.7、2.4 Boric acid zinc oxide borneol ointment group 1 2.3、2.4 1.9、2.2* 1.7、1.9* Chinese Medicine Group 1 2.2、2.5 1.8、2.2* 1.4、1.6**

[0047] Note: Compared with the model group, P*<0.05 indicates a significant difference, and P**<0.01 indicates an extremely significant difference;

[0048] Table 1 measures the maximum horizontal and vertical lengths of the pressure ulcer wounds, and the wound images were taken using the above-mentioned macro SLR camera for comparison;

[0049] As can be seen from Table 1, four groups of data were selected, including blank control group, model group, boric acid zinc oxide borneol ointment group and traditional Chinese medicine group. After experimental measurement: compared with the model group, compared with the boric acid zinc oxide borneol ointment group, the wound healing rate of the traditional Chinese medicine group had significant differences (P<0.05), among which the wound healing rate of the traditional Chinese medicine group had extremely significant differences compared with the model group for two weeks (P<0.01), and the traditional Chinese medicine group had extremely significant differences compared with the boric acid zinc oxide borneol ointment group from the third week (P<0.01).

[0050] Table 2 shows the bacterial culture data of SD rat pressure ulcer wound tissue

[0051] Group <![CDATA[Dose (g / cm 2 )]]> CFU (CFU / ml) Blank control group — — Model Group — 1×5^3 Boric acid zinc oxide borneol ointment group 1 1×4^2* Chinese Medicine Group 1 1×2^2**

[0052] Note: Compared with the model group, P*<0.05 indicates a significant difference, and P**<0.01 indicates an extremely significant difference;

[0053] As can be seen from Table 2, four groups of data were selected, including blank control group, model group, boric acid zinc oxide borneol ointment group and traditional Chinese medicine group. After experimental measurement: compared with the model group, compared with the boric acid zinc oxide borneol ointment group, the number of bacterial colonies in the wound surface of the traditional Chinese medicine group had significant differences (P<0.05), among which the number of bacterial colonies in the bacterial culture of the traditional Chinese medicine group compared with the model group had extremely significant differences (P<0.01), and the traditional Chinese medicine group had significant differences compared with the boric acid zinc oxide borneol ointment group (P<0.05).

[0054] Table 3 shows the blood routine white blood cell data of SD rat blood samples

[0055] Group <![CDATA[Dose (g / cm 2 )]]> WBC (10^9 / L) WBC (10^9 / L) Blank control group — 8.68 9.24 Model Group — 13.66 18.45 Boric acid zinc oxide borneol ointment group 1 12.96 11.48* Chinese Medicine Group 1 13.72 9.84**

[0056] Note: The normal reference range of leukocyte count in SD rats is 2.08-11.78×10^9 / L (male); compared with the model group, P*<0.05 indicates a significant difference, and P**<0.01 indicates an extremely significant difference;

[0057] As can be seen from Table 3, four groups of data were selected, including blank control group, model group, boric acid zinc oxide borneol ointment group and traditional Chinese medicine group. After experimental measurement: compared with the model group, compared with the boric acid zinc oxide borneol ointment group, the white blood cell count of the wound in the traditional Chinese medicine group had significant differences (P<0.05), among which the white blood cell count of the traditional Chinese medicine group had extremely significant differences compared with the model group (P<0.01), and the traditional Chinese medicine group had significant differences compared with the boric acid zinc oxide borneol ointment group (P<0.05).

[0058] 2. Clinical Data

[0059] On the basis of ensuring safety in animal experiments, clinical trials have achieved very good beneficial technical results. The relevant clinical data are as follows:

[0060] Observation on the treatment of 20 patients with stage II pressure ulcers with Chinese medicine cream;

[0061] Diagnostic criteria: Refer to the pressure ulcer detection criteria set out in the Pressure Ulcer Care Guidelines;

[0062] Symptoms: Skin color changes, red, purple or black skin discoloration may occur at the pressure site; pain, pain may be felt at the pressure site, especially when pressure is increased; edema, edema may occur at the pressure site, manifested as swollen and shiny skin; damage and ulcers, in severe cases, damage and ulcers may occur at the pressure site; infection, symptoms include redness, swelling, fever, pus secretion, etc.; functional impairment: It will affect the patient's motor function and lead to limited activity;

[0063] Observation of the pressure ulcer wound showed: skin damage and ulcer formation, which were superficial or deep into the muscle layer, accompanied by symptoms such as pain, edema and infection.

[0064] Twenty patients with pressure sores who met the above criteria, aged 40-60 years old, were divided into two groups. One group was treated with boric acid zinc oxide borneol ointment three times a day, 1 g / cm2 each time according to the pressure sore area. 2 , and the other group was treated with Chinese medicine cream three times a day, 1g / cm2 per time according to the area of ​​the pressure sore. 2 , apply continuously for one month;

[0065] Reference standard: The area of ​​the patient's pressure ulcer wound is used as the standard, with a standard score of 1 to 2 points for poor, 3 to 5 for effective, and 5 to 8 for extremely effective;

[0066] Experimental score: One month after applying the boric acid zinc oxide borneol ointment group, 1 case had an index of 5-8 points, 3 cases had an index of 3-5 points, and 6 cases had an index of 1-2 points;

[0067] One month after applying the Chinese medicine, 4 cases had a score of 5-8, 3 cases had a score of 3-5, and 3 cases had a score of 1-2.

[0068] Results: The total effective rate of patients in the boric acid zinc oxide borneol ointment group was 40%, and the total effective rate of patients in the traditional Chinese medicine group was 70%.

[0069] Example

[0070] A traditional Chinese medicine for rehabilitation treatment of bedsores. The traditional Chinese medicine composition is prepared from the following components by weight: 1-5 parts of honeysuckle, 2-4 parts of forsythia, 2-5 parts of purslane, 1-3 parts of isatis root, 1-4 parts of knotweed, 1-2 parts of indigo, 2-4 parts of rehmannia root, 1-4 parts of prepared rehmannia root and 1-3 parts of donkey-hide gelatin. The traditional Chinese medicine composition also contains the following auxiliary materials by weight: 1-3 parts of tung oil, 1-3 parts of alcohol and 1 part of erythromycin.

[0071] The Chinese medicine composition is made of the following components by weight: 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed, 1 part of indigo, 2 parts of rehmannia, 2 parts of prepared rehmannia and 1 part of donkey-hide gelatin. The Chinese medicine composition also contains the following auxiliary materials by weight: 2 parts of tung oil, 1 part of alcohol and 1 part of erythromycin.

[0072] The invention discloses an application of a traditional Chinese medicine for rehabilitation treatment of pressure sores in rehabilitation treatment of patients with pressure sores, and a traditional Chinese medicine cream for rehabilitation treatment of pressure sores prepared by using the traditional Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof.

[0073] A traditional Chinese medicine for the rehabilitation treatment of pressure sores and a preparation method thereof, comprising the following steps:

[0074] 1) Take 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed and 1 part of indigo, mix them according to the above proportions, then add the above raw materials to a crushing device, crush them, and then grind them into fine powder;

[0075] 2) Take 2 grams of Rehmannia root, 2 grams of Rehmannia root prepared, and 1 gram of donkey hide gelatin, cut the Rehmannia root and Rehmannia root prepared into small pieces of uniform size, then add the Rehmannia root and Rehmannia root prepared into the first pot, add appropriate amount of water, then add the donkey hide gelatin into the pot, heat and boil until a gelatinous substance is formed;

[0076] 3) Take 1 part of alcohol and 1 part of erythromycin as raw materials, then add the alcohol into the second pot, heat the alcohol to boiling, add erythromycin while heating, stir evenly, and obtain erythromycin solution;

[0077] 4) adding the fine powder to the first pot and mixing, stirring and mixing evenly, then adding the erythromycin solution to the first pot of the above mixture, and continuing to stir and mix evenly to obtain a Chinese medicine composition;

[0078] 5) adding tung oil to the Chinese medicine composition in the first pot, heating, boiling and stirring at the same time, and continuing heating and stirring after the tung oil is added, and standing and cooling after the heating and stirring are completed to obtain a Chinese medicine cream.

[0079] The heating time of Rehmannia root and Rehmannia root prepared in the cooking pot is 0.5-1h, the heating time of alcohol and erythromycin is until the alcohol is completely volatilized, the heating time of the Chinese medicine composition and tung oil is until the mixture is thick, and the stirring is continued for 10 minutes after the heating is completed. The first pot and the second pot are both ordinary cooking pots. The fine powder raw materials ground from honeysuckle, forsythia, purslane, isatis root, knotweed and indigo are 2500 mesh. The size of the cut pieces of Rehmannia root and Rehmannia root prepared is 1-2cm. Through the main medicinal materials: honeysuckle, forsythia, purslane, isatis root, knotweed, indigo, Rehmannia root, Rehmannia root prepared and donkey-hide gelatin, Auxiliary medicinal materials: Tung oil, alcohol and erythromycin are combined to make a traditional Chinese medicine cream, which has the effects of clearing away heat and detoxifying, evacuating wind-heat, cooling blood and stopping bleeding, stopping dysentery, cooling blood and eliminating spots, and purging fire and calming the nerves. It can effectively reduce inflammation. Inflammation is one of the important factors in the development of pressure sores. Drugs that clear heat and detoxify can help alleviate inflammatory responses and improve blood circulation. By promoting local blood circulation, they help provide sufficient nutrition and oxygen, accelerate wound healing, and have antibacterial effects. Drugs that clear heat and detoxify have antibacterial effects, can prevent or control infection, and thus achieve efficient and safe treatment of pressure sores and improve the effect of pressure sore treatment.

[0080] Tung oil pretreatment preparation, the pretreatment preparation method is as follows:

[0081] 1) taking tung oil and sodium hydroxide solution as raw materials, mixing the tung oil and the sodium hydroxide solution, and then heating them, and continuously stirring during the heating process to obtain a tung oil mixed solution;

[0082] 2) filtering the tung oil mixture, and then adding the filtered tung oil mixture to a liquid centrifuge for centrifugation to separate the alkaline solution;

[0083] 3) adding an acidic substance to the centrifuged tung oil mixture and allowing the mixture to stand, so that eleostearic acid in the tung oil mixture is precipitated, and then filtering and centrifuging are performed to separate the precipitate from the tung oil, thereby obtaining tung oil from which eleostearic acid has been removed.

[0084] The temperature of mixing and heating tung oil and sodium hydroxide solution is 70°C, and the stirring time is 1.5-2h. The acidic substance is one of hydrochloric acid, sulfuric acid, nitric acid and acetic acid, and hydrochloric acid is preferred. Tung oil is the main component for the emulsification of traditional Chinese medicine ointment, but it contains eleostearic acid, which has certain toxicity. Therefore, before preparing the traditional Chinese medicine ointment, the tung oil needs to be purified to remove the eleostearic acid to ensure the safety of the use of the tung oil. In addition, the eleostearic acid in the tung oil is removed by alkaline washing method, and then the safe and non-toxic tung oil is purified for use.

[0085] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine for the rehabilitation treatment of bedsores, characterized in that: The Chinese medicine composition is made of the following components by weight: 1-5 parts of honeysuckle, 2-4 parts of forsythia, 2-5 parts of purslane, 1-3 parts of isatis root, 1-4 parts of knotweed, 1-2 parts of indigo, 2-4 parts of rehmannia, 1-4 parts of prepared rehmannia and 1-3 parts of donkey-hide gelatin. The Chinese medicine composition also contains the following auxiliary materials by weight: 1-3 parts of tung oil, 1-3 parts of alcohol and 1 part of erythromycin.

2. A Chinese medicine for the rehabilitation treatment of pressure sores according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following components by weight: 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed, 1 part of indigo naturalis, 2 parts of rehmannia root, 2 parts of prepared rehmannia root and 1 part of donkey-hide gelatin. The Chinese medicine composition also contains the following auxiliary materials by weight: 2 parts of tung oil, 1 part of alcohol and 1 part of erythromycin.

3. A Chinese medicine for rehabilitation treatment of pressure sores and its preparation method is applied to the Chinese medicine for rehabilitation treatment of pressure sores as claimed in any one of claims 1 to 2, characterized in that: The following steps are involved: 1) Take 2 parts of honeysuckle, 2 parts of forsythia, 2 parts of purslane, 1 part of isatis root, 1 part of knotweed and 1 part of indigo, mix them according to the above proportions, then add the above raw materials to a crushing device, crush them, and then grind them into fine powder; 2) Take 2 grams of Rehmannia root, 2 grams of Rehmannia root prepared, and 1 gram of donkey hide gelatin, cut the Rehmannia root and Rehmannia root prepared into small pieces of uniform size, then add the Rehmannia root and Rehmannia root prepared into the first pot, add appropriate amount of water, then add the donkey hide gelatin into the pot, heat and boil until a gelatinous substance is formed; 3) Take 1 part of alcohol and 1 part of erythromycin as raw materials, then add the alcohol into the second pot, heat the alcohol to boiling, add erythromycin while heating, stir evenly, and obtain erythromycin solution; 4) adding the fine powder to the first pot and mixing, stirring and mixing evenly, then adding the erythromycin solution to the first pot of the above mixture, and continuing to stir and mix evenly to obtain a Chinese medicine composition; 5) adding tung oil to the Chinese medicine composition in the first pot, heating, boiling and stirring at the same time, and continuing heating and stirring after the tung oil is added, and standing and cooling after the heating and stirring are completed to obtain a Chinese medicine cream.

4. A Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof according to claim 1, characterized in that: The tung oil is prepared by pretreatment, and the pretreatment preparation method is as follows: 1) taking tung oil and sodium hydroxide solution as raw materials, mixing the tung oil and the sodium hydroxide solution, and then heating them, and continuously stirring during the heating process to obtain a tung oil mixed solution; 2) filtering the tung oil mixture, and then adding the filtered tung oil mixture to a liquid centrifuge for centrifugation to separate the alkaline solution; 3) adding an acidic substance to the centrifuged tung oil mixture and allowing the mixture to stand, so that eleostearic acid in the tung oil mixture is precipitated, and then filtering and centrifuging are performed to separate the precipitate from the tung oil, thereby obtaining tung oil from which eleostearic acid has been removed.

5. A Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof according to claim 4, characterized in that: The temperature of mixing and heating the tung oil and the sodium hydroxide solution is 70° C., and the stirring time is 1.5-2 hours.

6. A Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof according to claim 4, characterized in that: The acidic substance is one of hydrochloric acid, sulfuric acid, nitric acid and acetic acid, and hydrochloric acid is preferred.

7. A Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof according to claim 1, characterized in that: The heating time of the Rehmannia root and Rehmannia glutinosa in the cooking pot is 0.5-1h, the heating time of the alcohol and erythromycin is until the alcohol is completely volatilized, and the heating time of the Chinese medicine composition and tung oil is until the mixture is thick, and stirring is continued for 10 minutes after the heating is completed.

8. A Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof according to claim 1, characterized in that: The first pot and the second pot are both common cooking pots.

9. A Chinese medicine for rehabilitation treatment of pressure sores and a preparation method thereof according to claim 1, characterized in that: The fine powder raw materials of honeysuckle, forsythia, purslane, isatis root, knotweed and indigo are ground into 2500 meshes, and the size of the cut pieces of rehmannia root and cooked rehmannia root is 1-2 cm.

10. Use of a traditional Chinese medicine for rehabilitation treatment of pressure sores in rehabilitation treatment of patients with pressure sores, characterized in that: A Chinese medicine cream for the rehabilitation treatment of pressure sores prepared by using the Chinese medicine for the rehabilitation treatment of pressure sores and the preparation method thereof as described in any one of claims 3 to 9.