Craniocerebral injury animal model construction equipment and construction method

Abstract

The invention provides craniocerebral injury animal model construction equipment and a construction method, and belongs to the field of medical experiments. Comprising a bottom plate, a platform is fixedly connected to the top end of the bottom plate, side plates are fixedly connected to the left side and the right side of the bottom plate, a top plate is fixedly connected to the top ends of the two side plates, a hollow column is arranged on the top plate, and a first adjusting assembly used for adjusting the hardness degree is arranged on the hollow column. An experimental animal is placed on the platform, the hardness of the impact head is adjusted through the first adjusting assembly, impact objects with different sharpness degrees can be simulated conveniently, when the impact head is adjusted to a proper degree, the angle of the impact head is adjusted and locked through the locking assembly, then the second adjusting assembly is extruded through the extrusion assembly, and the impact objects with different sharpness degrees can be simulated. The gravity center of the impact head is adjusted by the second adjusting assembly, and after adjustment is completed, the falling assembly is moved to enable the hollow column to impact the head of the experimental animal, so that the practicability of the device is improved.

Description

Technical Field

[0001] The present invention relates to the field of medical experiments, and more specifically to a device and method for constructing a craniocerebral injury animal model. Background Art

[0002] Equipment for constructing animal models of craniocerebral injury includes biomedical engineering, neuroscience, animal experimental technology, etc. Equipment for constructing animal models of craniocerebral injury usually simulates different types of craniocerebral injuries by precisely controlling impact parameters (such as impact speed, impact angle, impact force, etc.), providing an important experimental means for studying pathological changes after craniocerebral injury, neural repair, and drug intervention effects;

[0003] During use, the existing equipment for constructing animal models of craniocerebral injury usually sets an impact head to impact the experimental animals. However, the current impact head is fixedly mounted on the equipment. Therefore, the current equipment cannot study the situation of impact heads of different sharpness impacting the animals. The purpose of impacting the animals with impact heads of different sharpness can only be achieved by using different construction equipment in coordination. This operation method is relatively cumbersome, the model construction efficiency is low, and the convenience of use needs to be improved. Summary of the invention

[0004] In view of the fact that the current impact head in the prior art is fixedly installed on the equipment, the current equipment is unable to study the situation where the impact heads of different sharpness impact the animals, which leads to the problem that the impact block is relatively limited during use. The purpose of the present invention is to provide a device and method for constructing an animal model of craniocerebral injury.

[0005] To solve the above problems, the present invention adopts the following technical solutions:

[0006] A device and method for constructing an animal model of craniocerebral injury, comprising a base plate, the top of which is fixedly connected to a platform, the left and right sides of the base plate are fixedly connected to side plates, the tops of the two side plates are fixedly connected to a top plate, a hollow column is arranged on the top plate, a first adjustment component for adjusting the hardness is arranged on the hollow column, a locking component for locking the first adjustment component is arranged on the hollow column, a second adjustment component for adjusting the center of gravity is arranged on the hollow column, a squeezing component is arranged on the hollow column, and a retracting component and a dropping component for retracting and dropping the hollow column are arranged on the top plate.

[0007] Optionally, the first adjustment component includes a circular ring plate, a rotating groove is opened on the hollow column, the circular ring plate is rotatably connected in the rotating groove, and the outer surface of the circular ring plate is fixedly connected with a first impact block, a second impact block, a third impact block and a fourth impact block, the first impact block, the second impact block, the third impact block and the fourth impact block have different sharpness of the tips, and the first impact block is directly below the circular ring plate.

[0008] Optionally, the locking assembly includes a rectangular sleeve, which is fixedly connected to the front end of the hollow column, a sliding block is slidably connected to the inner wall of the rectangular sleeve, a first spring is fixedly connected between the inner wall of the rectangular sleeve and the sliding block, a handle is fixedly connected to one side of the sliding block, the handle slides through one end of the rectangular sleeve, a connecting plate is fixedly connected to the top of the sliding block, the connecting plate slides through the top of the rectangular sleeve, a latch is fixedly connected to the rear end of the connecting plate, the latch slides through the front end of the hollow column, and a plurality of slots that cooperate with the latch are provided on the circular plate, and the plurality of slots are arranged in a circle.

[0009] Optionally, the second adjustment component includes a solid column, which is fixedly connected to the inner wall of the hollow column, and an airbag is fixedly connected to the inner wall of the hollow column. The airbag is located on the outside of the solid column, and four partitions are fixedly connected to the inner wall of the airbag. The airbag is provided with a first area, a second area, a third area and a fourth area through the partitions, and the first area is located directly below the solid column. Through holes are provided on the four partitions, and the first area, the second area, the third area and the fourth area are connected through the through holes.

[0010] Optionally, the extrusion assembly includes a connecting shaft, which is rotatably connected to the middle part of the solid column, a top block is fixedly connected to the outer surface of the connecting shaft, a circular groove is opened in the middle part of the solid column, and the top block is rotatably connected in the circular groove, four push rods are slidably connected to the solid column, and the four push rods are fixedly connected to an arc plate on one side away from the connecting shaft, the front end of the connecting shaft is fixedly connected to a connecting rod, the connecting rod rotatably passes through the front end of the hollow column, and the front end of the connecting rod is fixedly connected to a knob.

[0011] Optionally, the outer surface of the connecting rod is slidably connected to a first gear, the rear end of the first gear is fixedly connected to a first magnet, the front end of the hollow column is fixedly connected to a round block, the round block is provided with a tooth groove that cooperates with the first gear, and the round block is fixedly connected to a second magnet.

[0012] Optionally, the retrieval assembly includes four sliding rods, the four sliding rods are fixedly connected to the outer surface of the hollow column, the top ends of the four sliding rods are fixedly connected to the same rectangular plate, the outer surface of one of the sliding rods is fixedly connected to a rack plate, the rack plate and four sliding rods slide through the top plate, the top end of the top plate is slidably connected to a movable plate, the top end of the movable plate is fixedly connected to a fixed plate, the front end of the fixed plate is fixedly connected to a motor, the output end of the motor is fixedly connected to a second gear, and the second gear and the rack plate are meshed with each other.

[0013] Optionally, the falling assembly includes a positioning plate, which is fixedly connected to the top of the top plate, and two second springs are fixedly connected between the right side of the positioning plate and the movable plate, and the second springs are in a stretched state. The top of the top plate is slidably connected to a T-shaped plate, and the movable plate is provided with a limiting groove that cooperates with the T-shaped plate.

[0014] Optionally, two T-shaped sliding blocks are fixedly connected to the inner wall of the circular ring plate, and a T-shaped sliding groove cooperating with the T-shaped sliding blocks is provided on the hollow column.

[0015] A method for constructing an animal model of craniocerebral injury:

[0016] S1: Select a suitable experimental animal and place it on the platform for fixation;

[0017] S2: selecting a suitable impact head through the first adjustment component according to the condition of the experimental animal, and adjusting the center of gravity of the impact head through the second adjustment component;

[0018] S3: releasing the impact head through the falling assembly, so that the impact head impacts the animal's head at a set speed and force;

[0019] S4: Observe and record the animal's reactions, brain injuries, and behavioral changes;

[0020] S5: Perform statistical analysis on the collected data to evaluate the effects of the sharpness of the impact object and the different center of gravity positions of the impacting head on craniocerebral injury.

[0021] Compared with the prior art, the technical solution provided by the present invention has at least the following beneficial effects:

[0022] In the above scheme, when it is necessary to impact the head of the experimental animal, the experimental animal is placed on the platform, and the hardness of the impact head is adjusted by the first adjustment component to facilitate the simulation of impact objects with different sharpness. When the hardness of the impact head is adjusted to an appropriate degree, the first adjustment component is adjusted and locked by the locking component to facilitate the staff to adjust the impact angle of the impact head according to the experimental requirements. Subsequently, the second adjustment component is squeezed by the squeezing component to adjust the center of gravity of the impact head. After the adjustment is completed, the drop component is moved to make the hollow column impact the head of the experimental animal, thereby improving the practicality of the device;

[0023] When different impact heads are needed to impact the skull of the experimental animal, the circular plate is rotated, and the circular plate drives the first impact block, the second impact block, the third impact block and the fourth impact block to rotate simultaneously. Through the different sharpness of the tips of the first impact block, the second impact block, the third impact block and the fourth impact block, impact objects with different sharpness can be simulated, so that one of the impact heads of the first impact block, the second impact block, the third impact block and the fourth impact block is directly facing the head of the experimental animal, ensuring that the contact area and impact force of the first impact block, the second impact block, the third impact block and the fourth impact block with the animal's head are evenly distributed during impact, avoiding errors caused by different shapes, ensuring that the impact forces generated by the first impact block, the second impact block, the third impact block and the fourth impact block with different sharpness are consistent under the same conditions, and achieving control of different impact effects produced by the impact heads with different sharpness impacting the head of the experimental animal;

[0024] When the circular plate needs to be locked, the handle is pulled, the handle drives the sliding block to slide, the first spring is compressed, the sliding block drives the connecting plate and the latch, and the latch leaves the slot. Subsequently, the circular plate is rotated, and the circular plate drives the first impact block, the second impact block, the third impact block and the fourth impact block to rotate. When the angle of one of the impact heads is rotated to a position suitable for impacting the head of the experimental animal, the handle is released, the first spring rebounds, the sliding block drives the connecting plate and the latch, and the latch is inserted into the corresponding slot, and the circular plate and the first impact block, the second impact block, the third impact block and the fourth impact block are restricted. The staff can adjust the impact angles of the first impact block, the second impact block, the third impact block and the fourth impact block according to the experimental requirements, test the degree of injury of different experimental animals, and ensure that no error is caused by angle changes during the impact process;

[0025] When the center of gravity of the hollow column needs to be adjusted, one of the four areas in the airbag is squeezed through the extrusion component, and the liquid in the squeezed area enters the other three areas through the through holes, among which the area opposite to the squeezed area has the most liquid flowing in, so that the center of gravity of the hollow column is shifted to the area with the most liquid, which makes it convenient to test different damage effects on the brain by adjusting the center of gravity offset of the impact head. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable those skilled in the relevant art to make and use the invention.

[0027] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0028] Figure 2 For the present invention Figure 1 A is an enlarged schematic diagram of the structure;

[0029] Figure 3 It is a schematic diagram of the structure of the rotating groove and the T-shaped slide groove of the present invention;

[0030] Figure 4 It is a schematic structural diagram of the first regulating component of the present invention;

[0031] Figure 5 It is a schematic diagram of the structures of the first impact block, the second impact block, the third impact block and the fourth impact block of the present invention;

[0032] Figure 6 It is a schematic diagram of the locking assembly structure of the present invention;

[0033] Figure 7 It is a right side cross-sectional structural schematic diagram of the hollow column of the present invention;

[0034] Figure 8 is a schematic structural diagram of a second regulating component of the present invention;

[0035] Fig. 9 It is a schematic diagram of the structure of the extrusion assembly of the present invention;

[0036] Fig.10 It is a schematic diagram of the first gear and tooth groove structure of the present invention;

[0037] Fig.11 It is a schematic diagram of the structure of the retrieving assembly and the falling assembly of the present invention.

[0038] [Reference Signs]

[0039] 101, bottom plate; 102, platform; 103, side plate; 104, top plate; 105, hollow column; 201, annular plate; 202, rotating groove; 203, first impact block; 204, second impact block; 205, third impact block; 206, fourth impact block; 207, rectangular sleeve; 208, sliding block; 209, first spring; 210, handle; 211, connecting plate; 212, latch; 213, slot; 214, solid column; 215, airbag; 216, partition; 217, first area; 218, second area; 219, third area; 220, fourth area; 2 21. through hole; 222. connecting shaft; 223. top block; 224. circular groove; 225. push rod; 226. arc plate; 227. connecting rod; 228. knob; 229. first gear; 230. first magnet; 231. circular block; 232. tooth groove; 233. second magnet; 234. slide bar; 235. rectangular plate; 236. rack plate; 237. moving plate; 238. fixed plate; 239. motor; 240. second gear; 241. positioning plate; 242. second spring; 243. T-shaped plate; 244. limiting groove; 245. T-shaped slider; 246. T-shaped slide groove.

[0040] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0041] The following is a detailed description of a device and method for constructing a craniocerebral injury animal model provided by the present invention in conjunction with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for a more specific description of the embodiments, and are not intended to specifically limit the present invention.

[0042] It should be noted that the references to "one embodiment", "embodiment", "exemplary embodiments", "some embodiments" and the like in the specification indicate that the embodiments described may include specific features, structures or characteristics, but not every embodiment may include the specific features, structures or characteristics. In addition, when a specific feature, structure or characteristic is described in conjunction with an embodiment, it should be within the knowledge of a person skilled in the art to implement such feature, structure or characteristic in conjunction with other embodiments (whether or not explicitly described).

[0043] In general, a term can be understood, at least in part, from its use in context. For example, depending, at least in part, on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular sense, or can be used to describe a combination of features, structures, or characteristics in the plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey an exclusive set of factors, but can instead, depending, at least in part, on the context, allow for the presence of other factors that are not necessarily explicitly described.

[0044] It will be understood that the meanings of “on,” “over,” and “above” in the present invention should be interpreted in the broadest manner, so that “on” not only means “directly on” something, but also includes the meaning of being “on” something with intervening features or layers therebetween, and “on” or “over” not only means “on” or “above” something, but also includes the meaning of being “on” or “above” something with no intervening features or layers therebetween.

[0045] Additionally, spatially relative terms such as "under," "beneath," "lower," "above," "upper," and the like may be used herein for descriptive convenience to describe the relationship of one element or feature to another element or features, as shown in the accompanying drawings. Spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the accompanying drawings. The device may be oriented in other ways, and the spatially relative descriptors used herein may be similarly interpreted accordingly.

[0046] like Figures 1 to 11 As shown, an embodiment of the present invention provides a device for constructing an animal model of craniocerebral injury, comprising a base plate 101, a platform 102 being fixedly connected to the top of the base plate 101, side plates 103 being fixedly connected to the left and right sides of the base plate 101, tops of the two side plates 103 being fixedly connected to a top plate 104, a hollow column 105 being arranged on the top plate 104, a first adjusting component for adjusting the hardness being arranged on the hollow column 105, a locking component for locking the first adjusting component being arranged on the hollow column 105, a second adjusting component for adjusting the center of gravity being arranged on the hollow column 105, a squeezing component being arranged on the hollow column 105, and a retracting component and a falling component for retracting and dropping the hollow column 105 being arranged on the top plate 104.

[0047] When it is necessary to impact the head of the experimental animal, the experimental animal is placed on the platform 102, and the hardness of the impact head is adjusted by the first adjusting component to simulate impact objects of different sharpness. When the hardness of the impact head is adjusted to an appropriate degree, the first adjusting component is adjusted and locked by the locking component to facilitate the staff to adjust the impact angle of the impact head according to the experimental requirements. Subsequently, the second adjusting component is squeezed by the squeezing component to adjust the center of gravity of the impact head. After the adjustment is completed, the falling component is moved to make the hollow column 105 impact the head of the experimental animal, thereby improving the practicality of the device.

[0048] like Figures 3 to 5 As shown, the first adjustment component includes a circular plate 201, a rotating groove 202 is opened on the hollow column 105, the circular plate 201 is rotatably connected in the rotating groove 202, and the outer surface of the circular plate 201 is fixedly connected with a first impact block 203, a second impact block 204, a third impact block 205 and a fourth impact block 206, the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 have different degrees of sharpness at the tip, and the first impact block 203 is directly below the circular plate 201.

[0049] When different impact heads are needed to impact the skull of the experimental animal, the annular plate 201 is rotated, and the annular plate 201 drives the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 to rotate simultaneously. The different sharpness of the tips of the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 can simulate impact objects with different sharpness, so that the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 can be used to simulate the impact of objects with different sharpness. One of the impact heads of 6 is directly facing the head of the experimental animal, ensuring that the contact area and impact force of the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 with the animal's head are evenly distributed during impact, avoiding errors caused by different shapes, ensuring that the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 with different sharpness generate the same impact force under the same conditions, and achieving different impact effects when the impact heads with different sharpness impact the head of the experimental animal.

[0050] like Figure 6As shown, the locking assembly includes a rectangular sleeve 207, which is fixedly connected to the front end of the hollow column 105, and a sliding block 208 is slidably connected to the inner wall of the rectangular sleeve 207. A first spring 209 is fixedly connected between the inner wall of the rectangular sleeve 207 and the sliding block 208. A handle 210 is fixedly connected to one side of the sliding block 208, and the handle 210 slides through one end of the rectangular sleeve 207. A connecting plate 211 is fixedly connected to the top of the sliding block 208, and the connecting plate 211 slides through the top of the rectangular sleeve 207. A latch 212 is fixedly connected to the rear end of the connecting plate 211, and the latch 212 slides through the front end of the hollow column 105. A plurality of slots 213 cooperating with the latch 212 are provided on the circular plate 201, and the plurality of slots 213 are arranged in a circle.

[0051] When the annular plate 201 needs to be locked, the handle 210 is pulled, and the handle 210 drives the sliding block 208 to slide, the first spring 209 is compressed, and the sliding block 208 drives the connecting plate 211 and the latch 212 to make the latch 212 leave the slot 213. Then, the annular plate 201 is rotated, and the annular plate 201 drives the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 to rotate. When the angle of one of the impact heads is rotated to a position suitable for impacting the head of the experimental animal, the handle 210 is released, and the first spring 209 is compressed. The spring 209 rebounds, and the sliding block 208 drives the connecting plate 211 and the pin 212, so that the pin 212 is inserted into the corresponding slot 213, and the annular plate 201 and the first impact block 203, the second impact block 204, the third impact block 205, and the fourth impact block 206 are restricted. The staff can adjust the impact angles of the first impact block 203, the second impact block 204, the third impact block 205, and the fourth impact block 206 according to the experimental requirements, test the degree of injury of different experimental animals, and ensure that there will be no errors due to angle changes during the impact process.

[0052] like Figure 7 and Figure 8 As shown, the second adjustment component includes a solid column 214, and the solid column 214 is fixedly connected to the inner wall of the hollow column 105. The inner wall of the hollow column 105 is fixedly connected with an airbag 215, and the airbag 215 is located on the outside of the solid column 214. The inner wall of the airbag 215 is fixedly connected with four partitions 216. The airbag 215 is provided with a first area 217, a second area 218, a third area 219 and a fourth area 220 through the partitions 216. The first area 217 is located directly below the solid column 214. The four partitions 216 are all provided with through holes 221. The first area 217, the second area 218, the third area 219 and the fourth area 220 are connected through the through holes 221.

[0053] When the center of gravity of the hollow column 105 needs to be adjusted, one of the four areas in the airbag 215 is squeezed through the extrusion component, and the liquid in the squeezed area enters the other three areas through the through hole 221, among which the area opposite to the squeezed area has the most liquid flowing in, so that the center of gravity of the hollow column 105 is shifted to the area with the most liquid, which makes it convenient to test different damage effects on the brain by adjusting the center of gravity offset of the impact head.

[0054] like Fig. 9 As shown, the extrusion assembly includes a connecting shaft 222, and the connecting shaft 222 is rotatably connected to the middle part of the solid column 214. The outer surface of the connecting shaft 222 is fixedly connected with a top block 223. A circular groove 224 is opened in the middle part of the solid column 214, and the top block 223 is rotatably connected in the circular groove 224. Four push rods 225 are slidably connected to the solid column 214, and the four push rods 225 are fixedly connected with an arc plate 226 on one side away from the connecting shaft 222. The front end of the connecting shaft 222 is fixedly connected with a connecting rod 227, and the connecting rod 227 rotatably passes through the front end of the hollow column 105. The front end of the connecting rod 227 is fixedly connected with a knob 228.

[0055] When it is necessary to squeeze the airbag 215, turn the knob 228, the knob 228 drives the connecting rod 227 and the connecting shaft 222 to rotate, the connecting shaft 222 drives the top block 223 to rotate, when the top block 223 rotates to contact one of the push rods 225, the top block 223 can push the push rod 225 to move outward, the push rod 225 drives the arc plate 226 to squeeze one of the first area 217, the second area 218, the third area 219 and the fourth area 220, the liquid in the squeezed area enters the other three areas through the through hole 221, among which the area opposite to the squeezed area has the most liquid, so that the center of gravity of the hollow column 105 is shifted to the area with the most liquid, so that different damage effects on the brain can be tested by adjusting the center of gravity offset of the impact head.

[0056] like Fig.10 As shown, the outer surface of the connecting rod 227 is slidably connected to the first gear 229, the rear end of the first gear 229 is fixedly connected to the first magnet 230, the front end of the hollow column 105 is fixedly connected to the round block 231, the round block 231 is provided with a tooth groove 232 that cooperates with the first gear 229, and the round block 231 is fixedly connected to the second magnet 233.

[0057] When it is necessary to lock the top block 223, turn the knob 228, the knob 228 drives the connecting rod 227 and the connecting shaft 222 to rotate, and the connecting shaft 222 drives the top block 223 to rotate, so as to adjust the center of gravity of the hollow column 105. After the adjustment is completed, slide the first gear 229, and the first gear 229 drives the first magnet 230 to slide, and slide the first gear 229 into the tooth groove 232, and attract the first magnet 230 through the second magnet 233 to restrict the first gear 229, so as to prevent the connecting rod 227 and the connecting shaft 222 from rotating at will.

[0058] like Figure 1 and Fig.11 As shown, the retraction assembly includes four slide bars 234, and the four slide bars 234 are fixedly connected to the outer surface of the hollow column 105. The top ends of the four slide bars 234 are fixedly connected to the same rectangular plate 235, and the outer surface of one of the slide bars 234 is fixedly connected to a rack plate 236, and the rack plate 236 and the four slide bars 234 slide through the top plate 104, and the top end of the top plate 104 is slidably connected to a movable plate 237, and the top end of the movable plate 237 is fixedly connected to a fixed plate 238, and the front end of the fixed plate 238 is fixedly connected to a motor 239, and the output end of the motor 239 is fixedly connected to a second gear 240, and the second gear 240 is meshed with the rack plate 236.

[0059] When the device is used up and the hollow column 105 needs to be retracted, the second gear 240 is meshed with the rack plate 236 through the falling assembly, and then the motor 239 is started. The output end of the motor 239 drives the second gear 240 to rotate, and the second gear 240 drives the rack plate 236 to move upward. The rack plate 236 drives one of the rack plates 236 and the rectangular plate 235 to move, and the rectangular plate 235 drives the other three slide bars 234 to move. The four slide bars 234 simultaneously drive the hollow column 105 to move upward, and the hollow column 105 is retracted to facilitate the next use of the hollow column 105.

[0060] like Fig.11 As shown, the falling assembly includes a positioning plate 241, and the positioning plate 241 is fixedly connected to the top of the top plate 104. Two second springs 242 are fixedly connected between the right side of the positioning plate 241 and the movable plate 237. The second springs 242 are in a stretched state. The top of the top plate 104 is slidably connected with a T-shaped plate 243, and the movable plate 237 is provided with a limiting groove 244 that cooperates with the T-shaped plate 243.

[0061] When the hollow column 105 needs to fall, the T-shaped plate 243 is pulled to pull the T-shaped plate 243 out of the limiting groove 244, and the second spring 242 rebounds to drive the movable plate 237 to move toward the positioning plate 241. The movable plate 237 drives the motor 239 and the second gear 240 to move, so that the second gear 240 is not in contact with the rack plate 236. When the second gear 240 is not engaged with the rack plate 236, under the action of gravity, the hollow column 105 moves downward quickly to hit the head of the experimental animal, so as to simulate brain damage caused by external forces such as falling and impact in reality.

[0062] like Figure 3 and Figure 4 As shown, two T-shaped sliding blocks 245 are fixedly connected to the inner wall of the annular plate 201 , and a T-shaped sliding groove 246 cooperating with the T-shaped sliding blocks 245 is provided on the hollow column 105 .

[0063] By providing a T-shaped slider 245 and a T-shaped slot 246, when the annular plate 201 is rotating, the annular plate 201 will drive the T-shaped slider 245 to slide in the T-shaped slot 246. The T-shaped slot 246 can limit and guide the T-shaped slider 245 and the annular plate 201, thereby ensuring the stability of the annular plate 201 during rotation.

[0064] The workflow of the technical solution of the present invention is as follows:

[0065] When in use, place the experimental animal on the platform 102, pull the handle 210, the handle 210 drives the sliding block 208 to slide, the first spring 209 is compressed, the sliding block 208 drives the connecting plate 211 and the latch 212, so that the latch 212 leaves the slot 213, rotate the annular plate 201, the annular plate 201 drives the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 to rotate at the same time, so that one of the impact heads is facing the head of the experimental animal, release the handle 210, the first spring 209 rebounds, the sliding block 208 drives the connecting plate 211 and the latch 212, so that the latch 212 is inserted into the slot 213, restricting the annular plate 201 and the impact head, and turning the knob 2 28. The knob 228 drives the connecting rod 227 and the connecting shaft 222 to rotate, and the connecting shaft 222 drives the top block 223 to rotate. When the top block 223 rotates to contact one of the push rods 225, the top block 223 can push the push rod 225 to move outward, and the push rod 225 drives the arc plate 226 to squeeze one of the first area 217, the second area 218, the third area 219 and the fourth area 220. The liquid in the squeezed area enters the other three areas through the through hole 221, and the area opposite to the squeezed area has the most liquid flowing in, so that the center of gravity of the hollow column 105 is shifted to the area with the most liquid, which is convenient for testing different damage effects on the brain by adjusting the center of gravity offset of the impact head.

[0066] Then, the first gear 229 is slid, and the first gear 229 drives the first magnet 230 to slide, and the first gear 229 is slid into the tooth groove 232, and the first magnet 230 is attracted by the second magnet 233 to limit the first gear 229 to prevent the connecting rod 227 and the connecting shaft 222 from rotating at will, and the T-shaped plate 243 is pulled out of the limiting groove 244, and the second spring 242 rebounds to drive the moving plate 237 to move toward the positioning plate 241, and the moving plate 237 drives the motor 239 and the second gear 240 to move, so that the second gear 240 is not in contact with the rack plate 236. When not meshed, under the action of gravity, the hollow column 105 drives the impact head to move downward quickly to impact the head of the experimental animal. After the impact is completed, the moving drop assembly makes the second gear 240 mesh with the rack plate 236. Then, the motor 239 is started, and the output end of the motor 239 drives the second gear 240 to rotate. The second gear 240 drives the rack plate 236 to move upward. The rack plate 236 drives one of the rack plates 236 and the rectangular plate 235 to move. The rectangular plate 235 drives the other three slide bars 234 to move. The four slide bars 234 simultaneously drive the hollow column 105 to move upward, and the hollow column 105 is retracted to facilitate the next impact of the impact head.

[0067] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0068] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A device for constructing a craniocerebral injury animal model, comprising a base plate, characterized in that: The top of the bottom plate is fixedly connected to a platform, the left and right sides of the bottom plate are fixedly connected to side plates, the tops of the two side plates are fixedly connected to a top plate, a hollow column is arranged on the top plate, a first adjusting component for adjusting the hardness is arranged on the hollow column, a locking component for locking the first adjusting component is arranged on the hollow column, a second adjusting component for adjusting the center of gravity is arranged on the hollow column, an extrusion component is arranged on the hollow column, and a retracting component and a falling component for retracting and dropping the hollow column are arranged on the top plate.

2. The device for constructing a craniocerebral injury animal model according to claim 1, characterized in that: The first adjustment component includes a circular ring plate, a rotating groove is opened on the hollow column, the circular ring plate is rotatably connected in the rotating groove, and the outer surface of the circular ring plate is fixedly connected with a first impact block, a second impact block, a third impact block and a fourth impact block, the first impact block, the second impact block, the third impact block and the fourth impact block have different sharpness of the tips, and the first impact block is directly below the circular ring plate.

3. The device for constructing a craniocerebral injury animal model according to claim 2, characterized in that: The locking assembly includes a rectangular sleeve, which is fixedly connected to the front end of the hollow column, a sliding block is slidably connected to the inner wall of the rectangular sleeve, a first spring is fixedly connected between the inner wall of the rectangular sleeve and the sliding block, a handle is fixedly connected to one side of the sliding block, the handle slides through one end of the rectangular sleeve, a connecting plate is fixedly connected to the top of the sliding block, the connecting plate slides through the top of the rectangular sleeve, a latch is fixedly connected to the rear end of the connecting plate, the latch slides through the front end of the hollow column, and a plurality of slots cooperating with the latch are provided on the circular plate, and the plurality of slots are arranged in a circle.

4. The device for constructing a craniocerebral injury animal model according to claim 3, characterized in that: The second adjustment component includes a solid column, which is fixedly connected to the inner wall of the hollow column. An airbag is fixedly connected to the inner wall of the hollow column. The airbag is located on the outside of the solid column. The inner wall of the airbag is fixedly connected to four partitions. The airbag is provided with a first area, a second area, a third area and a fourth area through the partitions. The first area is located directly below the solid column. Through holes are provided on the four partitions. The first area, the second area, the third area and the fourth area are connected through the through holes.

5. The device for constructing a craniocerebral injury animal model according to claim 4, characterized in that: The extrusion assembly includes a connecting shaft, which is rotatably connected to the middle part of the solid column. A top block is fixedly connected to the outer surface of the connecting shaft. A circular groove is opened in the middle part of the solid column, and the top block is rotatably connected in the circular groove. Four push rods are slidably connected to the solid column, and the four push rods are fixedly connected to an arc plate on one side away from the connecting shaft. The front end of the connecting shaft is fixedly connected to a connecting rod, which rotatably passes through the front end of the hollow column, and the front end of the connecting rod is fixedly connected to a knob.

6. The device for constructing a craniocerebral injury animal model according to claim 5, characterized in that: The outer surface of the connecting rod is slidably connected to a first gear, the rear end of the first gear is fixedly connected to a first magnet, the front end of the hollow column is fixedly connected to a round block, the round block is provided with a tooth groove that cooperates with the first gear, and the round block is fixedly connected to a second magnet.

7. The device for constructing a craniocerebral injury animal model according to claim 6, characterized in that: The retrieval assembly includes four sliding rods, the four sliding rods are fixedly connected to the outer surface of the hollow column, the top ends of the four sliding rods are fixedly connected to the same rectangular plate, the outer surface of one of the sliding rods is fixedly connected to a rack plate, the rack plate and the four sliding rods slide through the top plate, the top end of the top plate is slidably connected to a movable plate, the top end of the movable plate is fixedly connected to a fixed plate, the front end of the fixed plate is fixedly connected to a motor, the output end of the motor is fixedly connected to a second gear, and the second gear and the rack plate are meshed with each other.

8. The device for constructing a craniocerebral injury animal model according to claim 7, characterized in that: The falling assembly includes a positioning plate, which is fixedly connected to the top of the top plate. Two second springs are fixedly connected between the right side of the positioning plate and the movable plate. The second springs are in a stretched state. The top of the top plate is slidably connected to a T-shaped plate. The movable plate is provided with a limiting groove that cooperates with the T-shaped plate.

9. The device for constructing a craniocerebral injury animal model according to claim 2, characterized in that: Two T-shaped sliding blocks are fixedly connected to the inner wall of the circular ring plate, and a T-shaped sliding groove cooperating with the T-shaped sliding blocks is provided on the hollow column.

10. A method for constructing a craniocerebral injury animal model, applicable to the craniocerebral injury animal model construction device according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1: Select a suitable experimental animal and place it on the platform for fixation; S2: selecting a suitable impact head through the first adjustment component according to the condition of the experimental animal, and adjusting the center of gravity of the impact head through the second adjustment component; S3: releasing the impact head through the falling assembly, so that the impact head impacts the animal's head at a set speed and force; S4: Observe and record the animal's reactions, brain injuries, and behavioral changes; S5: Perform statistical analysis on the collected data to evaluate the effects of the sharpness of the impact object and the different center of gravity positions of the impacting head on craniocerebral injury.

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