Traditional Chinese medicine composition for treating rheumatic arthritis and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating rheumatic arthritis. The traditional Chinese medicine composition is prepared from pubescent holly root, bighead atractylodes rhizome, Japanese inula leaf, rhizoma drynariae, entada phaseoloides, obscured homalomena rhizome, cinnamon, pseudo-ginseng, divaricate saposhnikovia root, radix angelicae pubescentis, notopterygium root, gastrodia elata, salvia miltiorrhiza, old ginger, Chinese lobelia, chrysanthemum, garden balsam stem and liquidambar formosana hance. According to the traditional Chinese medicine, all the medicines are compatible, the effects of dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis, clearing and activating the channels and collaterals, dissipating blood stasis to subdue swelling, resisting inflammation and relieving pain are achieved by taking the effects of removing pathogenic qi of arthralgia and promoting blood circulation to dredge vessels as symptoms and reinforcing qi and nourishing blood as root causes, the root causes of pain are eliminated, both symptoms and root causes are treated, and a good treatment effect on rheumatic arthritis is achieved; meanwhile, the medicine has the effects of promoting blood circulation to remove blood stasis, dissipating blood stasis to subdue swelling, and dredging channels and activating collaterals, so that the medicine also has the effects of relieving and treating unfavorable joints, aching waist and legs, numbness of hands and feet, bone spur pain and the like caused by new and old pains of traumatic injuries and rheumatic arthralgia.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating rheumatoid arthritis and application thereof. Background Art

[0002] Rheumatoid arthritis is a common acute or chronic inflammatory disease of connective tissue, mainly affecting joints, muscles, tendons and other parts. The symptoms of rheumatoid arthritis are joint pain, joint swelling, joint stiffness, fatigue, joint friction sound, etc. Rheumatoid arthritis is also known as Bi syndrome in traditional Chinese medicine. Traditional Chinese medicine believes that this disease refers to the blockage of meridians and poor circulation of qi and blood after a person is invaded by wind, cold, dampness or heat. Symptoms such as redness, swelling, burning, and pain in joints, muscles, tendons and other parts may occur.

[0003] In the treatment of rheumatoid arthritis, Western medicine usually uses aspirin, Voltaren, naproxen or other non-hormonal anti-inflammatory drugs for treatment, but most Western medicines can only relieve pain, and some drugs have certain toxic side effects. Although there are many traditional Chinese medicine compositions for the treatment of rheumatoid arthritis, they have more or less disadvantages, such as unclear efficacy and poor therapeutic effect. Summary of the invention

[0004] Therefore, based on the above background, the present invention provides a Chinese medicine composition for treating rheumatoid arthritis and its application, which can be reasonably combined to effectively treat rheumatoid arthritis and cure both the symptoms and the root cause.

[0005] The technical solution provided by the present invention is:

[0006] A Chinese medicine composition for treating rheumatoid arthritis, comprising the following raw materials by weight:

[0007] 5-30 parts of ilex pubescens, 15-45 parts of atractylodes macrocephala, 10-30 parts of chinensis leaf, 15-35 parts of drynaria, 10-30 parts of rhizoma strychnifoliae, 10-30 parts of herba schizonepetae, 10-30 parts of rhizoma cyrtonemae, 5-25 parts of cassia bark, 10-25 parts of notoginseng, 15-45 parts of siler, 10-25 parts of angelica dahurica, 10-25 parts of notopterygium wilfordii, 15-35 parts of gastrodia elata, 10-25 parts of salvia miltiorrhiza, 10-25 parts of old ginger, 10-30 parts of lobelia, 10-25 parts of chrysanthemum, 10-25 parts of herba speranskiae radix and 10-25 parts of fructus liquidambar formosanae.

[0008] Preferably, it consists of the following raw materials by weight:

[0009] 10 parts of Ilex pubescens, 15 parts of Atractylodes macrocephala, 10 parts of Folium Artemisiae Argyi, 15 parts of Rhizoma Drynariae, 10 parts of Rhizoma Dioscoreae, 10 parts of Rhizoma Cibotii, 10 parts of Rhizoma Cibotii, 10 parts of Cortex Cinnamomi, 10 parts of Notoginseng, 15 parts of Saposhnikovia divaricata, 10 parts of Radix Angelicae Pubescentis, 10 parts of Rhizoma Notopterygii, 15 parts of Rhizoma Gastrodiae, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of Ginger, 10 parts of Herba Lobeliae, 10 parts of Flos Chrysanthemi, 10 parts of Herba Spermatorrhizae Softgels, and 10 parts of F

[0010] Preferably, it consists of the following raw materials by weight:

[0011] 20 parts of Ilex pubescens, 30 parts of Atractylodes macrocephala, 20 parts of Rhizoma Cyperi, 25 parts of Rhizoma Drynariae, 15 parts of Rhizoma Cyperi, 15 parts of Rhizoma Cyperi, 15 parts of Cinnamomum cassia bark, 15 parts of Notoginseng, 25 parts of Saposhnikovia divaricata, 15 parts of Angelica dahurica, 15 parts of Notopterygium wilfordii, 20 parts of Gastrodia elata, 15 parts of Salvia miltiorrhiza, 15 parts of Zingiber officinale, 20 parts of Herba Lobeliae, 20 parts of Flos Chrysanthemi, 15 parts of Herba Schizonepetae, and 20 parts of Fructus Ligustri Lucidi.

[0012] Preferably, 20 parts of Ilex pubescens, 40 parts of Atractylodes macrocephala, 30 parts of Radix Codonopsis pilosulae, 30 parts of Rhizoma Drynariae, 25 parts of Rhizoma Cynomorii, 25 parts of Rhizoma Cibotii, 15 parts of Cassia bark, 20 parts of Panax notoginseng, 30 parts of Saposhnikovia divaricata, 20 parts of Angelica dahurica, 20 parts of Notopterygium wilfordii, 25 parts of Gastrodia elata, 25 parts of Salvia miltiorrhiza, 20 parts of old ginger, 30 parts of Herba Lobeliae, 25 parts of chrysanthemum, 20 parts of Herba Polygoni Multiflori, and 20 parts of Fructus Smilacis Glabrae.

[0013] Preferably, it can be added with medically acceptable adjuvants to prepare an external preparation.

[0014] Preferably, the external agent is a plaster, a spray, a tincture, a powder or a medicated oil.

[0015] Based on the same inventive concept, the present invention also provides a medicinal oil for treating rheumatoid arthritis prepared from the above-mentioned traditional Chinese medicine composition.

[0016] Based on the same inventive concept, the present invention also provides a method for preparing a medicinal oil for treating rheumatoid arthritis, comprising the following steps:

[0017] S1: taking various raw materials according to the amount, crushing them separately, and mixing them into powder;

[0018] S2: Soak the powder in vegetable oil;

[0019] S4: Heat the vegetable oil until it starts to bubble, then cool it down;

[0020] S5: Repeat step S4 4-5 times;

[0021] S6: After cooling the oil and filtering it, the medicinal oil can be obtained.

[0022] Based on the same inventive concept, the present invention also applies the above-mentioned Chinese medicine composition to the preparation of medicines for treating or assisting in the treatment of rheumatoid arthritis.

[0023] The pharmacology of the raw material of the present invention is as follows:

[0024] Ilex hairy mainly refers to the root of the plant Ilex hairy, which can clear away heat and detoxify, promote blood circulation and dredge meridians, and dilate peripheral blood vessels. It can dilate blood vessels by directly acting on the smooth muscles of the blood vessel walls, thereby achieving the effect of promoting blood circulation and removing blood stasis. It is often used in the treatment of cardiovascular and cerebrovascular diseases and various inflammations.

[0025] Atractylodes macrocephala strengthens the spleen, expels dampness and promotes diuresis, replenishes Qi and produces blood. It is mainly used to treat fatigue, diarrhea, edema, colds, aversion to wind, and fetal movement disorder.

[0026] The main functions of Drynaria fortunei are to nourish the kidney and relieve pain, and to promote blood circulation and strengthen tendons. It is mainly used clinically to treat traumatic injuries, especially muscle and ligament injuries and closed fractures, because of its blood circulation and analgesic effects.

[0027] Jinfeicao can reduce qi, resolve phlegm, promote diuresis and eliminate dampness, reduce swelling and relieve pain. It can be used for wind-heat cold, wind in the lung meridian, fullness in the hypochondrium, phlegm-damp cough, sputum retention, chest and diaphragm fullness, or rheumatic pain, cystitis, chronic pharyngitis, mouth and tongue ulcers and other symptoms.

[0028] Guojianglong can dispel wind and dampness, relax muscles and tendons, promote diuresis, and disperse blood stasis. It circulates through the meridians throughout the body and dispels wind, cold and dampness. It is mainly used to treat dampness, numbness, muscle and bone pain, gonorrhea, and injuries from falls.

[0029] It has been used for thousands of years to eliminate rheumatism, dredge meridians, strengthen muscles and bones, and is mainly used to treat wind-cold-dampness arthralgia, cold pain in the waist and knees, cramps and numbness, and weakness of muscles and bones.

[0030] Cinnamon bark warms the middle and dispels cold, regulates qi and relieves pain. It can be used for cold pain in the abdomen, vomiting and diarrhea, soreness of the waist and knees, abdominal pain due to cold hernia, pain due to cold and dampness, dysmenorrhea due to blood stasis, bloody dysentery, intestinal wind, swelling and pain due to falls, and bleeding due to trauma. It can also dilate blood vessels to promote blood circulation, and because it can promote blood circulation, it helps to enhance the effectiveness of other medicines.

[0031] Panax notoginseng can promote blood circulation, remove blood stasis, dredge meridians and collaterals, reduce swelling and relieve pain. It is often used for pain caused by blood stasis, such as amenorrhea, irregular menstruation, postpartum blood stasis, dysmenorrhea, etc.

[0032] Fangfeng can dispel wind and relieve exterior symptoms, induce sweating and relieve fever, overcome dampness and relieve pain, and stop spasms. It is often used for external symptoms (wind-cold, wind-heat, rheumatism), urticaria, rheumatic pain, tetanus, and spleen deficiency and dampness.

[0033] Qianghuo can relieve exterior symptoms and dispel cold, dispel wind and dampness, warm the meridians and activate collaterals and relieve pain. It is often used for colds, headaches, stiff necks, rheumatic pain, and shoulder and back pain, and is mainly used to treat upper body pain.

[0034] Duhuo can dispel wind and dampness, dredge meridians and relieve pain. It is often used for wind-cold-dampness arthralgia, pain in the waist and knees, Shaoyin hidden wind headache, wind-cold and dampness headache. It is mainly used to treat rheumatism in the joints of the lower body, pain in the waist, back or hip and knees, and numbness of the feet.

[0035] Gastrodia elata can calm wind and relieve pain, soothe liver yang, dispel wind and dredge meridians. It can treat liver yang, liver wind syndrome, wind-induced dampness and arthralgia (with a stronger focus on dampness and arthralgia), limb numbness and paralysis, and chronic rheumatic arthritis.

[0036] Danshen can promote blood circulation and remove blood stasis, promote menstruation and relieve pain, clear the heart and calm the mind, cool blood and eliminate carbuncle. It is mainly used to treat blood stasis, blood heat, and heat disturbing the mind, and can also treat swelling and pain caused by heat and toxins.

[0037] Old ginger warms the middle and dispels cold, restores yang and unclogs the meridians, warms the lungs and transforms fluid. It is often used for cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, and wheezing and coughing due to cold fluid.

[0038] Lobelia has the functions of clearing away heat, detoxifying, reducing swelling, relieving pain and anti-inflammatory. It is often used for painful swelling, carbuncle, snake and insect bites, ascites, edema, febrile jaundice, warm rash and warm sores.

[0039] Chrysanthemum dispels wind and heat, soothes the liver and improves eyesight, clears away heat and detoxifies. It is often used for wind-heat colds, headaches and dizziness, red and swollen eyes, blurred vision, sores, carbuncles and swelling.

[0040] Radix Polygoni Multiflori has the functions of dispelling wind and dampness, relaxing muscles and activating blood circulation, dispersing blood stasis and relieving swelling, detoxifying and relieving pain. It is often used for rheumatic arthralgia, muscle and bone contracture, beriberi due to cold and dampness, sprained waist, paralysis, amenorrhea, scrotal eczema, and sores, boils and swelling.

[0041] Rhizoma Lulutong has the effects of dispelling wind, activating collaterals, promoting diuresis, promoting menstruation and promoting lactation, and relieving itching. It is commonly used for joint pain, numbness and cramps, edema, oligolactation, and amenorrhea.

[0042] The above technical solution has the following beneficial effects:

[0043] The present invention uses siler, holly and atractylodes as the main drugs, among which siler is mainly used to dispel wind and relieve exterior symptoms, eliminate wind, cold and dampness, and dredge meridians to relieve pain; holly is mainly used to clear away heat and detoxify, dispel heat evil, and promote blood circulation and remove blood stasis; atractylodes invigorates the spleen and dispels dampness, strengthens the transportation and transformation of the middle jiao, promotes the generation of qi and blood, makes qi move and dampness move blood, and relieves pain; siler, holly and atractylodes are compatible to dispel the evil qi that blocks the arteries, dredge meridians and relieve pain, promote blood circulation and remove blood stasis, and invigorate the spleen and dispel dampness, invigorate qi and activate blood circulation, and take into account both dispelling evil and treating symptoms and invigorating qi, nourishing blood and strengthening the body; drynaria, cyperus rotundus, millennium jian, notopterygium, pubescens, scutellaria baicalensis, fennel, lobelia and chrysanthemum are used as the assistant drugs, among which drynaria tonifies the kidney and relieves pain, promotes blood circulation and strengthens tendons, replenishes the innate foundation, strengthens and strengthens The correct function is that Guojianglong, Qiannianjian, Qianghuo, Duhuo, Tougucao and Lulutong work together to regulate wind, cold and dampness, dispel wind, dredge the meridians, relieve numbness and pain, and promote the excretion of water and dampness in the body; Lobelia, Chrysanthemum, and Ilex pubescens are used to clear away heat and detoxify, to help the main medicine dispel heat evil, and have anti-inflammatory and analgesic effects; cinnamon, old ginger, golden leaf, Panax notoginseng, Salvia miltiorrhiza, Gastrodia elata, and cinnamon are used as adjuvants, among which cinnamon and old ginger are used to warm and dredge the meridians, dispel cold and relieve pain, golden leaf is used to promote diuresis and dispel dampness, reduce swelling and relieve pain, to help the main medicine eliminate dampness evil, Panax notoginseng and Salvia miltiorrhiza are used to promote blood circulation and remove blood stasis, dredge menstruation and relieve pain; Gastrodia elata calms wind and relieves pain, dispels wind and dredges the meridians; and cinnamon "dredges the blood vessels" and "promotes all medicines", so cinnamon can also be regarded as a meridian-leading medicine.

[0044] The whole prescription is matched with various medicines to treat the symptoms by removing the evil spirits that cause numbness and promoting blood circulation and unblocking meridians, while taking into account invigorating qi and nourishing blood as a fundamental treatment, so as to achieve the functions of dispelling wind and dampness, promoting blood circulation and removing blood stasis, unblocking meridians and activating collaterals, dispersing blood stasis and reducing swelling, and relieving inflammation and pain, and treating both the symptoms and the root causes to eliminate the root causes of pain. It has a good therapeutic effect on rheumatoid arthritis. At the same time, because the medicine has the functions of promoting blood circulation and removing blood stasis, dispersing blood stasis and reducing swelling, unblocking meridians and activating collaterals, it also has a relieving and therapeutic effect on new and old injuries caused by falls, as well as joint discomfort, low back and leg pain, numbness of hands and feet, bone spur pain, etc. caused by rheumatism and numbness. DETAILED DESCRIPTION

[0045] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0046] Example 1: A Chinese medicine composition for treating rheumatoid arthritis, which is composed of the following raw materials by weight:

[0047] 10 parts of Ilex pubescens, 15 parts of Atractylodes macrocephala, 10 parts of Rhizoma Cyperi, 15 parts of Rhizoma Drynariae, 10 parts of Rhizoma Cyperi, 10 parts of Rhizoma Cyperi, 10 parts of Cinnamomum cassia bark, 10 parts of Notoginseng, 15 parts of Saposhnikovia divaricata, 10 parts of Radix Angelicae Pubescentis, 10 parts of Notopterygium wilfordii, 15 parts of Gastrodia elata, 10 parts of Salvia miltiorrhiza, 10 parts of Zingiber officinale, 10 parts of Herba Lobeliae, 10 parts of Flos Chrysanthemi, 10 parts of Herba Spermatorrhizae Softgels, and 10 parts of Fructus Ligustri Lucidi.

[0048] Specifically, the dosage of one dose in this embodiment is:

[0049] 10g of Ilex tomentosa, 15g of Atractylodes macrocephala, 10g of Radix Codonopsis pilosulae, 15g of Drynaria fortunei, 10g of Rhizoma Cynomorii, 10g of Rhizoma Cibotii, 10g of Cinnamomum cassia bark, 10g of Notoginseng, 15g of Saposhnikovia divaricata, 10g of Angelica dahurica, 10g of Notopterygium incisum, 15g of Gastrodia elata, 10g of Salvia miltiorrhiza, 10g of old ginger, 10g of Lobelia, 10g of Chrysanthemum, 10g of Herba Polygoni Multiflori, and 10g of Rhizoma Smilacis Glabrae.

[0050] Example 2: A Chinese medicine composition for treating rheumatoid arthritis, which is composed of the following raw materials by weight:

[0051] 20 parts of Ilex pubescens, 30 parts of Atractylodes macrocephala, 20 parts of Rhizoma Cyperi, 25 parts of Rhizoma Drynariae, 15 parts of Rhizoma Cyperi, 15 parts of Rhizoma Cyperi, 15 parts of Cinnamomum cassia bark, 15 parts of Notoginseng, 25 parts of Saposhnikovia divaricata, 15 parts of Angelica dahurica, 15 parts of Notopterygium wilfordii, 20 parts of Gastrodia elata, 15 parts of Salvia miltiorrhiza, 15 parts of Zingiber officinale, 20 parts of Herba Lobeliae, 20 parts of Flos Chrysanthemi, 15 parts of Herba Schizonepetae, and 20 parts of Fructus Ligustri Lucidi.

[0052] Specifically, the dosage of one dose in this embodiment is:

[0053] 20g of Ilex tomentosa, 30g of Atractylodes macrocephala, 20g of Radix Codonopsis pilosulae, 25g of Drynaria fortunei, 15g of Rhizoma Cynomorii, 15g of Rhizoma Cibotii, 15g of Cinnamomum cassia bark, 15g of Notoginseng, 25g of Saposhnikovia divaricata, 15g of Angelica dahurica, 15g of Notopterygium wilfordii, 20g of Gastrodia elata, 15g of Salvia miltiorrhiza, 15g of old ginger, 20g of Lobelia, 20g of Chrysanthemum, 15g of Herba Polygoni Multiflori, and 20g of Rhizoma Smilacis Glabrae.

[0054] Example 3: A Chinese medicine composition for treating rheumatoid arthritis, which is composed of the following raw materials by weight:

[0055] By weight, it consists of the following ingredients:

[0056] 20 parts of Ilex pubescens, 40 parts of Atractylodes macrocephala, 30 parts of Rhizoma Cyperi, 30 parts of Rhizoma Drynariae, 25 parts of Rhizoma Cyperi, 25 parts of Rhizoma Cyperi, 15 parts of Cassia bark, 20 parts of Notoginseng, 30 parts of Saposhnikovia divaricata, 20 parts of Radix Angelicae Pubescentis, 20 parts of Rhizoma Notopterygii, 25 parts of Gastrodia elata, 25 parts of Salvia miltiorrhiza, 20 parts of Zingiber officinale, 30 parts of Herba Lobeliae, 25 parts of Flos Chrysanthemi, 20 parts of Herba Polygoni Multiflori, and 20 parts of Fructus Ligustri Lucidi.

[0057] Specifically, the dosage of one dose in this embodiment is:

[0058] 20g of Ilex tomentosa, 30g of Atractylodes macrocephala, 20g of Radix Codonopsis pilosulae, 25g of Drynaria fortunei, 15g of Rhizoma Cynomorii, 15g of Rhizoma Cibotii, 15g of Cinnamomum cassia bark, 15g of Notoginseng, 25g of Saposhnikovia divaricata, 15g of Angelica dahurica, 15g of Notopterygium wilfordii, 20g of Gastrodia elata, 15g of Salvia miltiorrhiza, 15g of old ginger, 20g of Lobelia, 20g of Chrysanthemum, 15g of Herba Polygoni Multiflori, and 20g of Rhizoma Smilacis Glabrae.

[0059] Examples 1 to 3 are prepared into medicated oils, and the preparation of the medicated oils comprises the following steps:

[0060] S1: According to the dosage of one dose, the raw materials are crushed separately and mixed into powder;

[0061] S2: Soak the powder in 1000ml tea oil;

[0062] S4: Heat the tea oil until it starts to bubble, then cool it down to room temperature;

[0063] S5: Repeat step S4 4-5 times;

[0064] S6: After cooling the tea oil and filtering it, the medicinal oil can be obtained.

[0065] Comparative Example 1: A Chinese medicine composition for treating rheumatoid arthritis, which is composed of the following raw materials by weight:

[0066] By weight, it consists of the following ingredients:

[0067] 30 parts of Atractylodes macrocephala, 20 parts of Folium Artemisiae Argyi, 25 parts of Rhizoma Drynariae, 15 parts of Rhizoma Dioscoreae, 15 parts of Rhizoma Cibotii, 15 parts of Rhizoma Cibotii, 15 parts of Rhizoma Cinnamomi, 15 parts of Rhizoma Panacis, 45 parts of Saposhnikovia divaricata, 15 parts of Radix Angelicae Pubescentis, 15 parts of Rhizoma Notopterygii, 20 parts of Rhizoma Gastrodiae, 15 parts of Salvia miltiorrhizae, 15 parts of Ginger, 20 parts of Herba Lobeliae, 20 parts of Flos Chrysanthemi, 15 parts of Herba Spermatorrhizae Softgels, and 20 parts of Fructus Ligustri Lucidi.

[0068] Specifically, the dosage of one dose in this comparative example is:

[0069] 30g of Atractylodes macrocephala, 20g of Radix Codonopsis pilosulae, 25g of Drynaria fortunei, 15g of Polygonum multiflorum, 15g of Rhizoma Cibotii, 15g of Cinnamomum cassia bark, 15g of Panax notoginseng, 45g of Saposhnikovia divaricata, 15g of Angelica dahurica, 15g of Notopterygium wilfordii, 20g of Gastrodia elata, 15g of Salvia miltiorrhiza, 15g of old ginger, 20g of Lobelia, 20g of Chrysanthemum, 15g of Radix Polygonati Smilacis Glabrae, and 20g of Rhizoma Smilacis Glabrae.

[0070] Compared with Example 2, in this comparative example, Ilex tomentosa is replaced with Saposhnikovia divaricata.

[0071] Comparative Example 2: A Chinese medicine composition for treating rheumatoid arthritis, which is composed of the following raw materials by weight:

[0072] 20 parts of Ilex pubescens, 30 parts of Atractylodes macrocephala, 20 parts of Folium Artemisiae Argyi, 25 parts of Rhizoma Drynariae, 15 parts of Rhizoma Dioscoreae, 15 parts of Rhizoma Cimicifugae, 15 parts of Cortex Cinnamomi, 15 parts of Radix Notoginseng, 25 parts of Herba Schizonepetae, 15 parts of Radix Angelicae Pubescentis, 15 parts of Rhizoma Notopterygii, 20 parts of Rhizoma Gastrodiae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of Ginger, 20 parts of Herba Lobeliae, 20 parts of Flos Chrysanthemi, 15 parts of Herba Schizonepetae, and 20 parts of Fructus Ligustri Lucidi.

[0073] Specifically, the dosage of one dose in this comparative example is:

[0074] 20g of Ilex pubescens, 30g of Atractylodes macrocephala, 20g of Radix Codonopsis pilosulae, 25g of Drynaria fortunei, 15g of Rhizoma Cynomorii, 15g of Rhizoma Cibotii, 15g of Cinnamomum cassia bark, 15g of Notoginseng macrocephala, 25g of Schizonepeta tenuifolia, 15g of Angelica dahurica, 15g of Notopterygium wilfordii, 20g of Gastrodia elata, 15g of Salvia miltiorrhiza, 15g of old ginger, 20g of Lobelia, 20g of Chrysanthemum, 15g of Herba Polygoni Multiflori, and 20g of Rhizoma Smilacis Glabrae.

[0075] Compared with Example 2, the Saposhnikovia divaricata in this comparative example is replaced by Schizonepeta tenuifolia which has the effect of dispelling wind and dispersing exterior pathogens.

[0076] Comparative Example 3: A Chinese medicine composition for treating rheumatoid arthritis, which is composed of the following raw materials by weight:

[0077] 20 parts of Ilex pubescens, 30 parts of Codonopsis pilosula, 20 parts of Folium Artemisiae Argyi, 25 parts of Rhizoma Drynariae, 15 parts of Rhizoma Dioscoreae, 15 parts of Rhizoma Cibotii, 15 parts of Rhizoma Cibotii, 15 parts of Cortex Cinnamomi, 15 parts of Radix Notoginseng, 25 parts of Saposhnikoviae, 15 parts of Radix Angelicae Pubescentis, 15 parts of Rhizoma Notopterygii, 20 parts of Rhizoma Gastrodiae, 15 parts of Salvia miltiorrhizae, 15 parts of Zingiber officinale, 20 parts of Herba Lobeliae, 20 parts of Flos Chrysanthemi, 15 parts of Herba Spermatorrhizae Softgels, and 20 parts

[0078] Specifically, the dosage of one dose in this embodiment is:

[0079] 20g of Ilex pubescens, 30g of Codonopsis pilosula, 20g of Radix Codonopsis pilosulae, 25g of Drynaria fortunei, 15g of Rhizoma Cynomorii, 15g of Rhizoma Cibotii, 15g of Cinnamomum cassia bark, 15g of Panax notoginseng, 25g of Saposhnikovia divaricata, 15g of Angelica dahurica, 15g of Notopterygium wilfordii, 20g of Gastrodia elata, 15g of Salvia miltiorrhiza, 15g of old ginger, 20g of Lobelia, 20g of Chrysanthemum, 15g of Herba Polygoni Multiflori, and 20g of Rhizoma Smilacis Glabrae.

[0080] Compared with Example 2, in this comparative example, Atractylodes macrocephala is replaced by Codonopsis pilosula, which has the effects of strengthening the spleen and replenishing the middle qi.

[0081] Comparative Examples 1 to 3 can all be prepared into medicated oils in the same manner as in Examples 1 to 3 above.

[0082] Verification of the toxicity of the medicated oil:

[0083] Experimental Animals:

[0084] Twenty male SD rats weighing 105±25 g were randomly divided into two groups, one group was an experimental group and the other group was a control group. Hair removal was performed on the back of the mice, and the hair removal area was (1-2)×(1-2) cm. The mice in the experimental group were smeared with the medicated oil prepared in Example 3 on the hair removal area once in the morning, noon and evening every day, and the mice in the control group were smeared with water on the hair removal area three times a day.

[0085] Mice were fed normally.

[0086] Experimental days: 7 days.

[0087] The skin of the mice in the hair removal area was observed every day. No animal death or abnormal reaction visible to the naked eye was found in either the experimental group or the control group. When the experimental group and the control group were compared, no allergic reaction such as redness, swelling, or rash occurred in the experimental group. After 7 days, three mice from the experimental group were randomly selected for dissection, and no abnormalities were found in their organs.

[0088] 120 patients diagnosed with rheumatoid arthritis and in the attack stage were recruited, including 42 males and 48 females, aged 32-55 years old.

[0089] Inclusion criteria: (1) patients with high treatment compliance; (2) patients with obvious pain sensation; (3) patients who were aware of the medication used and agreed and signed a written agreement.

[0090] Exclusion criteria: (1) women who are breastfeeding, pregnant, or preparing for pregnancy; (2) those with serious organ diseases, blood diseases, malignant tumors, and mental disorders; (3) those with serious illnesses and who find it difficult to make an accurate judgment on the effectiveness of TCM treatment.

[0091] The above patients were randomly divided into 4 groups, 30 people in each group, namely Example 2 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group.

[0092] Medication situation:

[0093] Patients in group 2 of Example 2 were treated with the medicated oil prepared in Example 2 applied to the affected area at least once in the morning, noon and evening, combined with massage for 3-5 minutes.

[0094] Comparative Example 1 to Comparative Example 3 groups respectively use the medicated oils prepared in Comparative Examples 1 to 3 daily, apply them to the affected area at least once in the morning, noon and evening, and massage for 3-5 minutes.

[0095] After 14 consecutive days of treatment, the efficacy was observed on the 1st, 5th and 10th days, and the visual analog pain scale (VAS) was used to evaluate the pain of the patients after the final application treatment on the 1st, 5th and 10th days.

[0096] Efficacy criteria:

[0097] Effective: The VAS value of pain assessed by patients decreased;

[0098] Ineffective: The patient's VAS value of pain assessment had no significant change or even increased;

[0099] Cure: The patient's pain completely disappears;

[0100] Effectiveness = (number of effective patients + number of cured patients) / total number of patients * 100%.

[0101] The treatment status is shown in Table 1.

[0102] Table 1: Treatment statistics

[0103]

[0104] From the table, it is obvious that the patient's symptoms are significantly relieved after using Example 2, and after 10 days of treatment, the pain of most patients disappears. Comparative Examples 1 to 3 are compared with the therapeutic effects of the medicine prepared by the Chinese medicine composition in Example 2. After the corresponding use of Saposhnikovia divaricata to replace Ilex pubescens, Schizonepeta tenuifolia to replace Saposhnikovia divaricata, and Codonopsis pilosula to replace Atractylodes macrocephala, the therapeutic effects are all significantly worse. It can be inferred that the monarch medicine in the replaced composition changes, resulting in changes in the main treatment principles of the medicine, and the interaction between each medicinal material is weakened or disappears, resulting in a worse therapeutic effect. From the above analysis, it is learned that there is an interactive relationship between the medicinal materials of the Chinese medicine composition of the present application, and the composition plays a therapeutic role as a whole. When the medicinal materials change, the overall therapeutic effect of the composition will change.

[0105] And for the cured patients in Example 2 group and Comparative Example 1 to Comparative Example 3 groups, a follow-up was conducted within 30 days. When the medication was not continued, the pain recurred. In Example 2 group, 1 person relapsed and 1 person was missing, which was classified as relapse, and the relapse rate (number of relapses * 100% / total number of people) was 11.1%; 2 people relapsed in Comparative Example 1, and the relapse rate (number of relapses * 100% / total number of people) was 28.5%; 1 person relapsed in Comparative Example 2 group, and the relapse rate was 12.5%; 3 people relapsed in Comparative Example 3 group, and the relapse rate was 27.2%.

[0106] The present invention and its implementation methods are described above, and such description is not restrictive, and the actual methods are not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design implementation methods and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating rheumatoid arthritis, characterized in that: By weight, it consists of the following ingredients: 5-30 parts of Ilex pubescens, 15-45 parts of Atractylodes macrocephala, 10-30 parts of Folium Artemisiae Argyi, 15-35 parts of Rhizoma Drynariae, 10-30 parts of Rhizoma Dioscoreae, 10-30 parts of Rhizoma Cibotii, 10-30 parts of Rhizoma Cibotii, 5-25 parts of Cassia bark, 10-25 parts of Notoginseng, 15-45 parts of Saposhnikovia divaricata, 10-25 parts of Radix Angelicae Pubescentis, 10-25 parts of Rhizoma Notopterygii, 15-35 parts of Gastrodia elata, 10-25 parts of Salvia miltiorrhiza, 10-25 parts of Ginger, 10-30 parts of Herba Lobeliae, 10-25 parts of Flos Chrysanthemi, 10-25 parts of Herba Spermatorrhizae Sinensis, and 10-25 parts of Fructus Ligustri Lucidi.

2. A Chinese medicine composition for treating rheumatoid arthritis according to claim 1, characterized in that: By weight, it consists of the following ingredients: 10 parts of Ilex pubescens, 15 parts of Atractylodes macrocephala, 10 parts of Folium Artemisiae Argyi, 15 parts of Rhizoma Drynariae, 10 parts of Rhizoma Dioscoreae, 10 parts of Rhizoma Cibotii, 10 parts of Rhizoma Cibotii, 10 parts of Cortex Cinnamomi, 10 parts of Notoginseng, 15 parts of Saposhnikovia divaricata, 10 parts of Radix Angelicae Pubescentis, 10 parts of Rhizoma Notopterygii, 15 parts of Rhizoma Gastrodiae, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of Ginger, 10 parts of Herba Lobeliae, 10 parts of Flos Chrysanthemi, 10 parts of Herba Spermatorrhizae Softgels, and 10 parts of Fructus Ligustri Lucidi.

3. A Chinese medicine composition for treating rheumatoid arthritis according to claim 1, characterized in that: By weight, it consists of the following ingredients: 20 parts of Ilex pubescens, 30 parts of Atractylodes macrocephala, 20 parts of Folium Artemisiae Argyi, 25 parts of Rhizoma Drynariae, 15 parts of Rhizoma Dioscoreae, 15 parts of Rhizoma Cibotii, 15 parts of Rhizoma Cibotii, 15 parts of Cortex Cinnamomi, 15 parts of Notoginseng, 25 parts of Saposhnikovia divaricata, 15 parts of Radix Angelicae Pubescentis, 15 parts of Rhizoma Notopterygii, 20 parts of Rhizoma Gastrodiae, 15 parts of Salvia miltiorrhizae, 15 parts of Zingiber officinale, 20 parts of Herba Lobeliae, 20 parts of Flos Chrysanthemi, 15 parts of Herba Spermatorrhizae Softgels, and 20 parts of Fructus Ligustri Lucidi.

4. A Chinese medicine composition for treating rheumatoid arthritis according to claim 1, characterized in that: 20 parts of Ilex pubescens, 40 parts of Atractylodes macrocephala, 30 parts of Folium Artemisiae Argyi, 30 parts of Rhizoma Drynariae, 25 parts of Rhizoma Dioscoreae, 25 parts of Rhizoma Cimicifugae, 15 parts of Cortex Cinnamomi, 20 parts of Notoginseng, 30 parts of Saposhnikovia divaricata, 20 parts of Radix Angelicae Pubescentis, 20 parts of Notopterygium incisum, 25 parts of Gastrodia elata, 25 parts of Salvia miltiorrhiza, 20 parts of Ginger, 30 parts of Herba Lobeliae, 25 parts of Flos Chrysanthemi, 20 parts of Herba Spermatorrhizae Softgels, and 20 parts of Fructus Ligustri Lucidi.

5. A Chinese medicine composition for treating rheumatoid arthritis according to any one of claims 1 to 4, characterized in that: The compound can be added with medically acceptable adjuvants to prepare an external preparation.

6. A Chinese medicine composition for treating rheumatoid arthritis according to claim 5, characterized in that: The external preparation is a plaster, a spray, a tincture, a powder or a medicated oil.

7. A medicinal oil for treating rheumatoid arthritis prepared from the Chinese medicine composition according to any one of claims 1 to 4.

8. The method for preparing the medicinal oil for treating rheumatoid arthritis according to claim 7, characterized in that: The steps include: S1: taking various raw materials according to the amount, crushing them separately, and mixing them into powder; S2: Soak the powder in vegetable oil; S4: Heat the vegetable oil until it starts to bubble, then cool to room temperature; S5: Repeat step S4 4-5 times; S6: After cooling the oil to room temperature and filtering, the medicinal oil can be obtained.

9. The Chinese medicine composition according to any one of claims 1 to 4 is used in the preparation of a medicament for treating or assisting in treating rheumatoid arthritis.

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