Automatic blood viscosity measuring device

Abstract

An automatic blood viscosity measuring device according to an embodiment of the present invention comprises: a housing provided with an opening door; a blood sample attachment unit to which a blood collection tube is attached; a blood sample pretreatment unit that sandwiches a plurality of blood collection tubes, scans the sandwiched blood collection tubes, and separates blood collection tube caps attached to the upper ends of the blood collection tubes; a blood sample transfer unit that moves the blood collection tube held by the blood sample pretreatment unit; a blood viscosity measurement unit having the blood viscosity measurement kit attached thereto and including one or more channels for measuring the viscosity of the blood sample injected into the blood viscosity measurement kit; a kit attachment unit which is disposed inside the housing and which attaches a blood viscosity measurement kit to a blood viscosity measurement unit; and a blood sample post-processing unit that sucks in the blood sample from the blood collection tube transferred by the blood sample transfer unit and injects the blood sample into the mounted blood viscosity measurement kit, whereby viscosity measurement can be performed on one or more blood samples at the same time, and it is possible to reduce the work time and improve the work efficiency. And the use simplicity is improved.

Description

Technical Field

[0001] The present invention relates to an automatic blood viscosity measuring device, and more particularly to an automatic blood viscosity measuring device which can simultaneously measure the viscosity of more than one blood sample by configuring a plurality of modules for transmitting and measuring blood samples, thereby shortening the operation time and improving the ease of use. Background Art

[0002] Blood viscosity is a physical property that indicates the flow resistance caused by the flow of blood in blood vessels. It can be specifically divided into whole blood viscosity and plasma viscosity. An abnormal increase in blood viscosity will increase the shear stress and flow resistance acting on the inner wall of blood vessels, thereby significantly increasing the risk of acute cardiovascular disease and microvascular disease.

[0003] In addition, plasma viscosity is not only used to diagnose the inflammatory state in the body, but is also one of the main reasons for increased whole blood viscosity.

[0004] The viscosity of whole blood shows a flow characteristic that the viscosity changes continuously according to the systole and diastole of the heart. The reason is as follows: due to the complex mutual influence of red blood cells and plasma proteins in whole blood, when the blood flows quickly (when the shear rate is high), the viscosity decreases, and conversely, when the blood flows slowly (when the shear rate is low), the viscosity increases. Fluids that show such flow characteristics are called non-Newtonian fluids. In order to accurately understand the non-Newtonian flow characteristics of blood, it is necessary to accurately measure the entire shear rate (for example: 1-1000s ^ -1) of whole blood viscosity.

[0005] In recent years, blood viscosity measuring devices can measure blood viscosity, blood cell aggregation rate, etc. by passing blood obtained from the body through a flow restrictor tube and measuring the flow characteristics of the blood in the flow restrictor tube.

[0006] As a prior art, Korean Authorized Utility Model No. 20-0331884 (a device for simultaneously measuring blood viscosity and blood cell aggregation rate) is disclosed.

[0007] However, since an operator of the device needs to manually inject blood through a syringe to measure the viscosity of the blood, it is difficult to supply blood at a constant pressure and a constant flow rate, thereby causing a problem that it is difficult to measure the viscosity of the blood under the same conditions.

[0008] Furthermore, since the operation is performed manually, there is a problem that the operation time is long, and since the operation is performed manually, there is also a problem that blood infection often occurs.

[0009] In order to solve these problems, an automated blood viscosity measuring device is currently being developed. However, there is a problem that a lot of work time is required to measure the viscosity of the next blood sample after the viscosity measurement of the previous blood sample is completed.

[0010] Furthermore, when a large number of blood samples are measured, the viscosity of the blood is measured in a state where red blood cells and the like settle over time for the blood samples that are obtained later in the sequence, which causes a problem in that the accuracy of the viscosity measurement is reduced.

[0011] In addition, since the existing blood viscosity measuring device only has one clamp and measuring module, when a clamp module fails, there is a problem that the entire measuring device stops starting. In order to solve these problems, it is necessary to develop an automatic blood viscosity measuring device with multiple clamps and excellent holding force. Summary of the invention

[0012] Problems to be solved by the invention

[0013] The present invention is developed to solve the above-mentioned problem, and its purpose is to provide an automatic blood viscosity measuring device as follows, which can improve the measurement speed and accuracy by unifying the entire process of blood sample input, mixing, aspiration, packaging and disposal through an automated robot system, and improve the ease of use by configuring multiple modules for transmitting and measuring blood samples.

[0014] Solutions for solving problems

[0015] According to an embodiment of the present invention, an automatic blood viscosity measuring device may include: a housing, which is provided with an opening door; a blood sample installation portion, which is provided with a blood sampling tube; a blood sample preprocessing portion, which clamps a plurality of blood sampling tubes, scans the clamped blood sampling tubes, and separates the blood sampling tube caps installed at the upper ends of the blood sampling tubes; a blood sample transferring portion, which moves the blood sampling tubes clamped by the above-mentioned blood sample preprocessing portion; a blood viscosity measuring portion, which is provided with a blood viscosity measuring kit and includes one or more channels for measuring the viscosity of the blood sample injected into the blood viscosity measuring kit; a kit installation portion, which is provided inside the above-mentioned housing and is used to install the blood viscosity measuring kit in the blood viscosity measuring portion; and a blood sample post-processing portion, which sucks the blood sample in the blood sampling tube transferred by the above-mentioned blood sample transferring portion and injects it into the installed blood viscosity measuring kit.

[0016] Among them, the above-mentioned blood sample installation part may include: a blood collection tube insertion plate, on which the blood collection tube is vertically installed; a first sliding part, which exposes the blood collection tube insertion plate to the outside by sliding the above-mentioned blood collection tube insertion plate toward the front of the shell; and a first detection part, which is arranged between the above-mentioned blood collection tube insertion plate and the first sliding part, and is used to detect the placement state of the blood collection tube insertion plate.

[0017] In addition, the blood sample installation part may also include: a motion motor, which is arranged on both sides of the blood collection tube insertion plate, so that the blood collection tube insertion plate tilts left and right at a set angle and moves repeatedly at a set period, thereby preventing the red blood cells in the blood sample in the blood collection tube from settling.

[0018] In addition, the above-mentioned blood sample preprocessing part may include: a preprocessing clamp, which is configured in multiples and is used to clamp the above-mentioned blood collection tube and clamp the blood collection tube cover for rotation; a first transfer module, which controls the horizontal position of the above-mentioned preprocessing clamp; and a first lifting module, which connects the above-mentioned preprocessing clamp and the first transfer module and controls the height of the preprocessing clamp.

[0019] The blood sample pre-processing unit may further include: a scanning module, which is arranged on the first transfer module and is used to scan whether the blood collection tube is installed on the blood collection tube insertion plate.

[0020] In addition, the above-mentioned blood sample transfer part may include: a holding clamp, which is configured in multiples and places the blood collection tube clamped and transferred by the above-mentioned pretreatment clamp, and clamps the lower part of the blood collection tube; a holding clamp transfer module, which is used to transfer the above-mentioned holding clamp; and a guide plate, which guides the reciprocating movement of the holding clamp transferred by the above-mentioned holding clamp transfer module.

[0021] In addition, the blood sample preprocessing unit also includes: a blood collection tube detection unit, which is used to detect one or more blood collection tubes clamped by the above-mentioned holding clamp. Therefore, the automatic blood viscosity measuring device according to the embodiment of the present invention can automatically measure the viscosity of the blood sample in the blood collection tube based on the detection information of the above-mentioned blood collection tube.

[0022] In addition, the above-mentioned blood viscosity measuring part includes: a measuring part case, a shock-proof pad is provided on the upper part of which; a reagent kit installation shell, which is arranged at the upper end of the above-mentioned measuring part case and is provided with a reagent kit insertion slot for installing a blood viscosity measuring reagent kit; an installation detection sensor, which is arranged inside the above-mentioned reagent kit insertion slot and is used to detect the installation state of the blood viscosity measuring reagent kit; a heat transfer component, which is arranged inside the above-mentioned reagent kit installation shell to apply heat to the blood viscosity measuring reagent kit; and a reagent kit fixing unit, which is arranged inside the above-mentioned reagent kit installation shell and is used to position and fix the blood viscosity measuring reagent kit, and the above-mentioned reagent kit fixing unit may include: a first pushing component, which is arranged along the height direction of the inner surface of the reagent kit insertion slot of the above-mentioned reagent kit installation shell, and is used to push the blood viscosity measuring reagent kit to the other side; and a second pushing component, which is arranged in the length direction of the inner surface of the reagent kit insertion slot of the above-mentioned reagent kit installation shell, and is used to push the blood viscosity measuring reagent kit to the other side.

[0023] In addition, the above-mentioned reagent box installation portion may include: a reagent box insertion tray, on which a reagent box for measuring blood viscosity is vertically installed; a second sliding portion, which exposes the reagent box insertion tray to the outside by sliding the above-mentioned reagent box insertion tray toward the front of the shell; and a second detection portion, which is arranged between the above-mentioned reagent box insertion tray and the second sliding portion, and is used to detect the placement state of the reagent box insertion tray.

[0024] The reagent kit installation portion may further include: a fastening unit, which is disposed between the reagent kit insertion tray and the second sliding portion to fix the reagent kit insertion tray on the upper portion of the reagent kit insertion tray.

[0025] In addition, the above-mentioned reagent box installation part may include: a reagent box clamp, which is configured in multiples and is used to clamp the above-mentioned blood viscosity measurement reagent box; a second transfer module, which controls the horizontal position of the above-mentioned reagent box clamp; and a second lifting module, which connects the above-mentioned reagent box clamp and the second transfer module and controls the height of the reagent box clamp.

[0026] In addition, the blood sample post-processing unit may include: an injection device, which is configured in multiples and connected to the second transfer module to mix and absorb the blood sample in the blood collection tube transferred by the blood sample transfer unit, and inject it into the installed blood viscosity measurement kit.

[0027] In addition, the blood sample post-processing unit may further include: a pipette tip insertion tray on which a pipette tip to be loaded and unloaded from the end of the injection device is installed; and a third sliding unit that slides the pipette tip insertion tray toward the front of the housing, thereby exposing the pipette tip insertion tray to the outside.

[0028] In addition, the interior of the above-mentioned shell includes: a first disposal portion, which is arranged between the above-mentioned blood sample installation portion and the blood viscosity measuring portion, and is used to accommodate used pipette tips; and a second disposal portion, which is arranged between the above-mentioned blood viscosity measuring portion and the reagent kit installation portion, and is used to accommodate a blood viscosity measurement reagent kit for completed measurement, and the first disposal portion and the second disposal portion can slide toward the front of the above-mentioned shell, so as to be exposed to the outside of the shell.

[0029] In addition, the automatic blood viscosity measuring device according to an embodiment of the present invention may also include: a control unit, which controls the operation of the above-mentioned blood sample preprocessing unit, blood sample transfer unit, blood viscosity measuring unit, reagent kit installation unit and blood sample post-processing unit; a notification unit, which detects and notifies errors of the automatic blood viscosity measuring device; an emergency stop switch unit, which is used to emergency stop the automatic blood viscosity measuring device; and a monitoring unit, which is used to monitor the viscosity measurement results measured by the above-mentioned blood viscosity measuring unit.

[0030] Effects of the Invention

[0031] The automatic blood viscosity measuring device according to the embodiment of the present invention adopts a dual system structure, thereby having the advantages of shortening the blood viscosity inspection time and being able to continue the inspection even when a malfunction occurs in the holder module or the injection device.

[0032] Furthermore, in order to prevent the red blood cell sedimentation phenomenon during the test, more accurate blood viscosity measurement can be performed by moving the blood collection tube insertion plate and mixing by pipetting to evenly disperse the red blood cells before aspirating the blood.

[0033] Furthermore, the automatic blood viscosity measuring device according to the embodiment of the present invention can safely and quickly replace blood collection tubes, blood viscosity measuring reagent kits, and pipette tips.

[0034] On the other hand, the automatic blood viscosity measuring device according to the embodiment of the present invention is not limited to the above-mentioned effects, and is preferably construed as including advantages that can be clearly derived by the combination of the device and structure of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 is a perspective view of an automatic blood viscosity measuring device according to an embodiment of the present invention.

[0036] Figure 2 It is a schematic diagram showing the appearance of the opening door and a part of the front part of the housing being removed.

[0037] Figure 3It is a perspective view showing the overall structure of a blood sample installation section, a blood sample pre-processing section, a blood sample transfer section, a blood viscosity measurement section, a reagent cartridge installation section, and a blood sample post-processing section built into the housing.

[0038] Figure 4 yes Figure 3 main view.

[0039] Figure 5 yes Figure 3 Rear view of.

[0040] Figure 6 1 is a perspective view of a blood sample installation portion and a blood sample transfer portion according to an embodiment of the present invention.

[0041] Figure 7 is a schematic diagram of a blood collection tube insertion plate equipped with a motion motor.

[0042] Figure 8 It is shown Figure 6 Schematic diagram of the state in which the blood collection tube insertion plate and the guide plate are removed.

[0043] Fig. 9 It is a schematic diagram for showing the structure of the first sliding part.

[0044] Fig.10 It is a three-dimensional diagram of the blood sample pre-processing section, blood viscosity measuring section, reagent kit installation section, and blood sample post-processing section.

[0045] Fig.11 It is a perspective view of the blood viscosity measuring unit.

[0046] Fig.12 It is a schematic diagram for showing the form of the measuring unit casing.

[0047] Fig.13 is a schematic diagram of the reagent kit installation housing.

[0048] Fig.14 is a schematic diagram of a test kit installation housing equipped with a heat transfer component and a temperature detection sensor.

[0049] Fig.15 is a schematic diagram of a reagent cartridge installation housing configured with a reagent cartridge retaining unit.

[0050] Fig.16 It is a schematic diagram for showing the structure of the second sliding part.

[0051] Fig.17 It is a perspective view of the reagent cartridge installation portion equipped with the second detection unit.

[0052] Fig.18It is a schematic diagram of the reagent kit holder and injection device installed in the second transfer module.

[0053] Fig.19 It is a schematic diagram for showing the structure of the third sliding part.

[0054] Fig. 20 It is a schematic diagram for illustrating the third detection unit. DETAILED DESCRIPTION

[0055] According to an embodiment of the present invention, an automatic blood viscosity measuring device may include: a housing, which is provided with an opening door; a blood sample installation portion, which is provided with a blood sampling tube; a blood sample preprocessing portion, which clamps a plurality of blood sampling tubes, scans the clamped blood sampling tubes, and separates the blood sampling tube caps installed at the upper ends of the blood sampling tubes; a blood sample transferring portion, which moves the blood sampling tubes clamped by the above-mentioned blood sample preprocessing portion; a blood viscosity measuring portion, which is provided with a blood viscosity measuring kit and includes one or more channels for measuring the viscosity of the blood sample injected into the blood viscosity measuring kit; a kit installation portion, which is provided inside the above-mentioned housing and is used to install the blood viscosity measuring kit in the blood viscosity measuring portion; and a blood sample post-processing portion, which sucks the blood sample in the blood sampling tube transferred by the above-mentioned blood sample transferring portion and injects it into the installed blood viscosity measuring kit.

[0056] Best Mode for Carrying Out the Invention

[0057] The following description of the present invention described with reference to the accompanying drawings is not limited to specific embodiments, and may include multiple changes and various embodiments. In addition, the content described below can be understood to include all changes, equivalents and substitutes within the scope of the idea and technology of the present invention.

[0058] In the following description, the terms "first" and "second" are used to describe various components, and do not have a restrictive meaning by themselves, but are used only to distinguish one component from another.

[0059] The same reference numerals used throughout the specification denote the same constituent elements.

[0060] The singular form used in the present invention includes the plural form unless the context clearly indicates the contrary. In addition, the terms "including", "having" or "having" described below are used to specify the existence of features, numbers, steps, actions, constituent elements, parts or their combinations described in the specification, and are not intended to exclude the existence or addition of one or more other features or numbers, steps, actions, constituent elements, parts or their combinations in advance.

[0061] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as those commonly understood by those skilled in the art. Terms such as commonly used predefined terms are to be understood as having the same meaning as in the context of the relevant technology, and are not to be understood as idealized or overly formalized without explicit definition in this application.

[0062] In addition, when describing with reference to the accompanying drawings, the same components are given the same reference numerals regardless of the reference numerals, and repeated descriptions thereof will be omitted. In the description of the present invention, when it is considered that the specific description of the related conventional technology may unnecessarily obscure the main purpose of the present invention, the detailed description thereof will be omitted.

[0063] The following will be based on Figures 1 to 20 While the automatic blood viscosity measuring device according to the embodiment of the present invention is described in detail, a specific embodiment is described.

[0064] first, Figure 1 is a three-dimensional diagram of an automatic blood viscosity measuring device according to an embodiment of the present invention, Figure 2 is a schematic diagram showing the appearance of the housing with the open door and a portion of the front portion removed. Figure 3 1 is a perspective view showing the overall structure of a blood sample installation section, a blood sample pre-processing section, a blood sample transfer section, a blood viscosity measurement section, a reagent kit installation section, and a blood sample post-processing section built into the housing. Figure 4 yes Figure 3 The main view, Figure 5 yes Figure 3 Rear view of.

[0065] Reference Figures 1 to 5 , an automatic blood viscosity measuring device 1 according to an embodiment of the present invention is briefly described. The device of the present invention may include the following structures: a housing 100, a blood sample installation part 200, a blood sample pre-processing part 300, a blood sample transfer part 400, a blood viscosity measuring part 500, a reagent kit installation part 600 and a blood sample post-processing part 700.

[0066] First, the housing 100 is a housing that forms the appearance of the automatic blood viscosity measuring device 1 and can form a space for housing various mechanical devices described below.

[0067] In addition, the above-mentioned housing 100 can be provided with a cooling unit 101 for discharging heat generated by each mechanical device to the outside. More specifically, the above-mentioned cooling unit 101 can be formed by a combination of an air intake port arranged at the upper part of the housing 100 and sucking air from the outside to the inside of the housing 100, and an air exhaust port arranged at the rear of the housing 100 and discharging the sucked air to the outside.

[0068] In addition, an open door 110 can be arranged in front of the above-mentioned shell 100. At this time, the above-mentioned open door 110 can be arranged on the front and rear radii of the blood sample installation part 200, the reagent kit installation part 600 and the blood sample post-processing part 700, and can be formed as a transparent material such as acrylic so that the action of the mechanical device can be identified from the outside. In addition, the above-mentioned open door 110 can be provided with a locking device to solve the problem of accidental opening during the operation of the device.

[0069] In addition, the housing 100, the blood sample installation part 200, the blood sample pre-processing part 300, the blood sample transfer part 400, the blood viscosity measurement part 500, the reagent kit installation part 600 and the blood sample post-processing part 700 may be installed inside the above-mentioned housing 100, and a frame 120 for forming a supporting force may be provided.

[0070] At this time, the frame 120 may be a structure that can easily support the load of each mechanical device and also be a vibration damping structure for damping external impact or vibration transmitted from the ground.

[0071] then, Figure 6 is a three-dimensional diagram of a blood sample installation portion and a blood sample transfer portion according to an embodiment of the present invention, Figure 7 is a schematic diagram of a blood collection tube insertion plate equipped with a motion motor. Figure 8 It is shown Figure 6 Schematic diagram of the state where the blood collection tube insertion plate and the guide plate are removed. Fig. 9 It is a schematic diagram for showing the structure of the first sliding part.

[0072] Reference Figures 6 to 9 According to the embodiment of the present invention, the blood sample installation part 200 can be installed with a blood sampling tube T containing a blood sample to be measured. At this time, as shown in the figure, the above-mentioned blood sampling tube T is a container with a length, and a blood sampling tube cap TC can be configured on the upper part to seal the blood sampling tube T from the outside.

[0073] Specifically, the blood sample installation part 200 according to the embodiment of the present invention may include: a blood collection tube insertion plate 210 , a first sliding part 220 and a first detection part 215 .

[0074] First, a blood collection tube T having a length can be vertically mounted on the blood collection tube insertion plate 210, but this is only a structure configured to facilitate the pretreatment clamp 310 described later to clamp the blood collection tube T. According to user requirements, the blood collection tube T can also be installed in a horizontal position.

[0075] Furthermore, the first sliding portion 220 can expose the blood collection tube insertion plate 210 to the outside by sliding the blood collection tube insertion plate 210 toward the front of the housing 100 , and its general shape can be provided in a shape similar to a sliding drawer of a table.

[0076] In addition, a first locking device 221 may be disposed on the side of the first sliding portion 220 to prevent the first sliding portion 220 from accidentally sliding during the startup of the device.

[0077] Furthermore, the first detection unit 215 is disposed between the blood collection tube insertion plate 210 and the first sliding unit 220 , and can detect the placement state of the blood collection tube insertion plate 210 .

[0078] At this time, the blood sample installation part 200 may further include: a motion motor 230, which is arranged on both sides of the blood collection tube insertion plate 210, so that the blood collection tube insertion plate 210 moves at a set period. At this time, the motion motor 230 may be configured to be built into the first sliding part 220 within a range that does not interfere with the sliding movement of the first sliding part 220.

[0079] Therefore, the blood sample installation part 200 according to the embodiment of the present invention has the advantage of preventing the red blood cell sedimentation phenomenon of the blood sample by mixing the blood collection tube insertion plate 210 by shaking it left and right.

[0080] In addition, the blood sample preprocessing unit 300 clamps a plurality of blood collection tubes T, is connected to the blood collection tube detection unit 340, scans the barcode attached to the clamped blood collection tubes T, and can detach the blood collection tube cap TC installed on the upper end of the blood collection tube T.

[0081] In order to perform the above actions, the blood sample preprocessing unit 300 according to the embodiment of the present invention may include a preprocessing clamper 310 , a first transfer module 320 , and a first lifting module 330 .

[0082] First, the pre-processing clamp 310 is arranged in plural numbers, and can clamp the blood collection tube T and the blood collection tube cap TC and rotate it, thereby separating the blood collection tube cap TC from the blood collection tube T.

[0083] In addition, the first transfer module 320 can control the horizontal position of the pre-treatment clamp 310, such as Figure 6As shown, at the rear of the preprocessing holder 310, it may be formed to have a length along the measuring direction.

[0084] At this time, the first transfer module 320 may further include: a scanning module (not shown) for scanning whether the blood collection tube is installed on the blood collection tube insertion plate 210 .

[0085] Specifically, the scanning module (not shown) is configured as an identification device including a laser or optical sensor in the first transfer module 320, so that the blood collection tubes T installed in the holes of the blood collection tube insertion plate 210 can be automatically scanned to determine whether they are installed or not, wherein the first transfer module 320 controls the horizontal position of the pretreatment clamp 310.

[0086] In addition, the first lifting module 330 connects the pre-processing holder 310 and the first transferring module 320 , and can control the height of the pre-processing holder 310 .

[0087] On the other hand, a control motor (not shown) for adjusting the separation distance between the pretreatment clamp 310 and the first lifting module 330 is arranged between the pretreatment clamp 310 and the first lifting module 330. Thus, the pretreatment clamp 310 according to an embodiment of the present invention can be configured to perform horizontal movement and height movement while also being able to work forward and backward.

[0088] In addition, the blood sample transfer unit 400 may transfer the blood collection tube T held by the blood sample pretreatment unit 300 .

[0089] Specifically, the blood sample transfer unit 400 according to the embodiment of the present invention may include a holding clamper 410 , a holding clamper transfer module 420 , and a guide plate 430 .

[0090] First, the holding clamp 410 can be configured in the same number as the pre-processing clamp 310, that is, configured in multiple numbers, and the blood collection tube T clamped and transferred by the pre-processing clamp 310 is placed thereon, and the lower part of the blood collection tube T is clamped or fixed so that the blood collection tube cap TC can be easily separated.

[0091] In addition, the holding clamp transfer module 420 can transfer the holding clamp 410, such as Figure 8 As shown, below the blood sample installation part 200, it may be formed to have a length along the measuring direction.

[0092] In addition, the guide plate 430 may guide the reciprocating motion of the holding clamp 410 transferred by the holding clamp transfer module 420 . To this end, a guide groove 431 that enables the holding clamp 410 to reciprocate may be disposed on the surface of the guide plate 430 .

[0093] In addition, the blood sample preprocessing unit 300 according to the embodiment of the present invention may include: a blood collection tube detection unit 340 , which is used to detect one or more blood collection tubes T clamped by the holding clamp 410 .

[0094] More specifically, the blood collection tube detection unit 340 may be arranged on a horizontal line or a lifting and lowering movement path of the pretreatment clamp 310 that clamps the blood collection tube T, and may be configured as a bar code reader structure that is capable of identifying bar code data attached to the outer periphery of the blood collection tube T. When the clamped blood collection tube T is rotated by holding the clamp 410, the bar code data attached to the surface of the blood collection tube T may be scanned and detected by the blood collection tube detection unit 340.

[0095] Therefore, the automatic blood viscosity measuring device 1 according to the embodiment of the present invention can automatically measure the viscosity of the blood sample in the blood sampling tube T according to the detection information of the blood sampling tube T mentioned above.

[0096] also, Fig.10 It is a three-dimensional diagram of the blood sample pre-processing section, the blood viscosity measuring section, the reagent kit installation section, and the blood sample post-processing section. Fig.11 This is a three-dimensional diagram of the blood viscosity measurement unit. Fig.12 is a schematic diagram for illustrating the shape of the measuring unit box. Fig.13 This is a schematic diagram of the test kit installation housing. Fig.14 is a schematic diagram of a test kit installation housing equipped with a heat transfer component and a temperature detection sensor.

[0097] Reference Fig.10 and Fig.11 The blood viscosity measuring unit 500 according to the embodiment of the present invention is installed with a blood viscosity measuring reagent kit BK, and may include one or more channels for measuring the viscosity of a blood sample injected into the blood viscosity measuring reagent kit BK.

[0098] Specifically, the blood viscosity measuring section 500 according to the embodiment of the present invention may include a measuring section housing 510 , a reagent kit mounting housing 520 , a mounting detection sensor 530 , a heat transfer component 540 , and a reagent kit fixing unit 550 .

[0099] First, a shock-absorbing pad 511 may be provided on the upper portion of the measuring unit box 510. More specifically, Fig.12 As shown, the measuring unit box 510 may be formed to have two levels, and a shock-absorbing pad 511 for preventing vibration may be provided between the two levels.

[0100] At this time, preferably, the shock-absorbing pad 511 may be formed of two or more types of synthetic materials (eg, rubber or silicon) having different elastic coefficients, but is not necessarily limited thereto.

[0101] In addition, refer to Fig.13 and Fig.14 The reagent kit installation housing 520 is disposed at the upper end of the measuring unit housing 510 and may be provided with a reagent kit insertion slot 521 for installing a blood viscosity measuring reagent kit BK.

[0102] At this time, preferably, the above-mentioned reagent box installation shell 520 is set to 14 channels at the upper part of the measuring part box 510, that is, it is set to 14, but it is not necessarily limited to this. According to the size of the shell 100 or the specifications of the power device of the present invention, the number can be expanded to 28 or 56.

[0103] In addition, the above-mentioned installation detection sensor 530 is arranged inside the above-mentioned reagent kit insertion slot 521, and can detect the installation status of the blood viscosity measurement reagent kit BK, and as the above-mentioned installation detection sensor 530, all electronic sensors that can grasp the installation status can be used, such as optical recognition sensors, pressure point recognition sensors or ultrasonic recognition sensors.

[0104] On the other hand, Fig.15 As shown, the installation detection sensor 530 may be disposed at the lower center of the reagent reagent insertion slot 521 , but this is merely an exemplary form and may also be formed on the inner side of the reagent reagent insertion slot 521 .

[0105] In addition, the above-mentioned heat transfer component 540 is arranged inside the above-mentioned reagent kit installation shell 520, and can apply heat to the blood viscosity measuring reagent kit BK. By configuring a temperature sensor inside or outside the heat transfer component 540, while preventing the heat transfer component 540 from overheating, heat can be applied to the blood viscosity measuring reagent kit BK within the temperature range required by the user.

[0106] Specifically, when observed with the flat cross-section of the reagent kit installation shell 520 as a reference, the heat transfer component 540 is bent into a "U" shape, thereby being configured to surround the blood viscosity measuring reagent kit BK, or is formed by arranging a Z-shaped repeated pattern along the outer peripheral surface of the blood viscosity measuring reagent kit BK, that is, a waveform-shaped hot wire.

[0107] Thus, the blood viscosity measuring section 500 according to the embodiment of the present invention can effectively adjust the temperature of the mounted blood viscosity measuring reagent cartridge BK, thereby having the advantage of being able to measure blood viscosity more accurately.

[0108] Furthermore, the reagent cartridge fixing unit 550 is disposed inside the reagent cartridge mounting housing 520 , and can position and fix the blood viscosity measuring reagent cartridge BK to a sensor for measuring blood height disposed inside the reagent cartridge insertion slot 521 .

[0109] At this time, as the sensor for measuring the blood level, a contact image sensor (CIS) which is an LED light sensor can be used, but it is not necessarily limited to this, and all recognition sensors used for measuring the blood level can be used.

[0110] More specifically, the reagent cartridge fixing unit 550 may be provided by a combination of a first pushing member 551 and a second pushing member 552 .

[0111] First, the first pushing member 551 may be arranged along the height direction of the inner surface of the reagent cartridge insertion slot 521 of the reagent cartridge mounting housing 520 and may push the blood viscosity measuring reagent cartridge BK to the other side by the elasticity of the spring built therein.

[0112] Furthermore, the second pushing member 552 is disposed in the longitudinal direction of the inner surface of the reagent cartridge insertion slot 521 of the reagent cartridge mounting housing 520 and can push the blood viscosity measuring reagent cartridge BK to the other side by the elasticity of a spring built therein.

[0113] In addition, according to user requirements, the first pushing component 551 and the second pushing component 552 can be configured as a single or multiple components inside the reagent kit installation housing 520, and at least one of the pushing components (551, 552) is preferably configured as multiple components.

[0114] also, Fig.16 is a schematic diagram for illustrating the structure of the second sliding portion, Fig.17 is a three-dimensional diagram of a reagent kit installation portion equipped with a second detection portion, Fig.18 is a schematic diagram of the reagent kit holder and injection device installed in the second transfer module, Fig.19 is a schematic diagram for illustrating the structure of the third sliding portion, Fig. 20 It is a schematic diagram for illustrating the third detection unit.

[0115] In addition, the above-mentioned reagent kit installation part 600 is configured inside the above-mentioned housing 100, and is installed with a blood viscosity measuring reagent kit BK. The blood viscosity measuring reagent kit BK can be installed in the blood viscosity measuring part 500. At this time, the above-mentioned sensor installation structure can also be used in the above-mentioned reagent kit installation part 600, and an identification unit such as a laser or a light sensor can be used to automatically scan whether the blood viscosity measuring reagent kit BK is installed or not.

[0116] More specifically, the reagent kit installation portion 600 may further include: a reagent kit insertion tray 610 , a second sliding portion 620 , a second detection portion 615 , a reagent kit holder 630 , a second transfer module 640 , and a second lifting module 650 .

[0117] First, a blood viscosity measuring reagent kit BK can be vertically installed on the above-mentioned reagent kit insertion tray 610. Similar to the previously described blood collection tube insertion plate 210, this is only a structure configured to make it easy for the reagent kit holder 630 described in detail later to clamp the blood viscosity measuring reagent kit BK. According to the user's requirements, the blood viscosity measuring reagent kit BK can also be installed in a horizontal position.

[0118] In addition, the second sliding portion 620 can slide the reagent cartridge insertion tray 610 toward the front of the housing 100 to expose the reagent cartridge insertion tray 610 to the outside, and can be provided in a sliding drawer configuration similar to the first sliding portion 220 .

[0119] In addition, a second locking device 621 may be disposed on the side of the second sliding portion 620 to prevent the second sliding portion 620 from accidentally sliding during the startup of the device.

[0120] In addition, the second detection unit 615 is disposed between the reagent kit insertion tray 610 and the second sliding unit 620 , and can detect the placement state of the reagent kit insertion tray 610 .

[0121] For this reason, Fig.17 As shown, the second detection portion 615 can be configured as a three-point sensor structure, but this is only one way to effectively detect the horizontal state and installation state of the reagent kit inserted into the tray 610, and all electronic sensors that can effectively detect the horizontal state and installation state of the reagent kit inserted into the tray 610 can be used.

[0122] In addition, a fastening unit 616 for stably fixing the reagent kit insertion tray 610 on the upper portion of the reagent kit insertion tray 610 may be disposed between the reagent kit insertion tray 610 and the second sliding portion 620. More specifically, as shown in FIG. Fig.16 and Fig.17 As shown, the fastening unit 616 may be configured as a rotating bar on the left and right sides of the reagent kit insertion tray 610 , thereby preventing the reagent kit insertion tray 610 from shaking due to the second lifting module 650 .

[0123] In addition, the reagent cartridge holder 630 may be configured in plurality so as to hold a plurality of blood viscosity measuring reagent cartridges BK at a time, and a pair of clamps formed by a power device are brought close to each other to clamp the blood viscosity measuring reagent cartridges BK.

[0124] In addition, the second transfer module 640 may control the horizontal position of the reagent reagent holder 630 , and may have a length along the measuring direction inside the housing 100 , similar to the first transfer module 320 .

[0125] In addition, the second lifting module 650 connects the reagent kit holder 630 and the second transfer module 640 , and can control the height of the reagent kit holder 630 .

[0126] At this time, a control motor (not shown) for adjusting the separation distance between the second transfer module 640 and the second lifting module 650 can be configured between the second transfer module 640 and the second lifting module 650. Thus, the reagent cartridge holder 630 according to an embodiment of the present invention can be configured to perform horizontal movement and height movement while also being able to work forward and backward.

[0127] In addition, the blood sample post-processing unit 700 may suck the blood sample in the blood collection tube T transferred by the blood sample transferring unit 400 and inject the blood sample into the mounted blood viscosity measuring reagent kit BK.

[0128] Specifically, the blood sample post-processing unit 700 may include an injection device 710 , a pipette tip insertion tray 720 , a third sliding unit 730 , and a third detection unit 740 .

[0129] First, the injection device 710 is configured in plural and connected to the second transfer module 640 to mix and suck the blood sample in the blood collection tube T transferred by the blood sample transfer unit 400 and inject it into the installed blood viscosity measurement reagent kit BK.

[0130] In order to prevent red blood cell sedimentation, the red blood cell sedimentation phenomenon can be prevented when the blood sample is sucked in by using the previously described motion motor 230 to shake the blood collection tube insertion plate 210 left and right to mix and the above-mentioned injection device 710 uses micropipette technology to suck and discharge blood while mixing.

[0131] In addition, a pipette tip PT to be loaded and unloaded from the end of the injection device 710 can be vertically installed on the above-mentioned pipette tip insertion tray 720. At this time, the above-mentioned pipette tip PT will be stained with blood during the inspection, so it refers to a disposable pipette tip used for safety and accuracy, and the above-mentioned pipette tip PT can refer to a conductive type disposable pipette tip used to precisely adjust the suction and discharge amounts of blood required for the inspection.

[0132] Furthermore, for the above-mentioned pipette tip PT, a precise volume control technology within ±1.0% according to conductivity change can be applied, or a precise volume control technology according to pressure change using a pressure type disposable tip can be applied.

[0133] In addition, the third sliding portion 730 may slide the pipette tip insertion tray 720 toward the front of the housing 100 , thereby exposing the pipette tip insertion tray 720 to the outside.

[0134] In addition, a third locking device 731 may be disposed on the side of the third sliding portion 730 to prevent the third sliding portion 730 from sliding during operation of the device.

[0135] In addition, the third detection portion 740 may be disposed between the pipette tip insertion tray 720 and the third sliding portion 730. More specifically, the third detection portion 740 may be configured as a two-point mounted sensor structure, wherein the two-point mounted sensors are disposed in a left-right symmetrical manner on the lower surface of the pipette tip insertion tray 720. However, this is only one method for effectively detecting the horizontal state and the installation state of the pipette tip insertion tray 720, and all electronic sensors that can effectively detect the horizontal state and the installation state of the pipette tip insertion tray 720 may be used.

[0136] In addition, the automatic blood viscosity measuring device 1 according to the embodiment of the present invention may further include a first waste part 800 and a second waste part 900 .

[0137] First, the first disposal part 800 is disposed inside the housing 100 and between the blood sample mounting part 200 and the blood viscosity measuring part 500 , so as to accommodate the used pipette tip PT.

[0138] In addition, the second disposal unit 900 is disposed inside the housing 100 and between the blood viscosity measuring unit 500 and the reagent cartridge mounting unit 600, so as to accommodate the blood viscosity measuring reagent cartridge BK after the measurement.

[0139] In addition, the first disposal part 800 and the second disposal part 900 slide toward the front of the shell 100 so as to be exposed to the outside of the shell 100, and are formed into a sliding drawer like the first to third sliding parts 220, 620, 730. A locking device (not shown) may be provided on the side of each disposal part 800, 900 to solve the problem of accidental opening of the disposal parts 800, 900 during operation of the device.

[0140] Furthermore, the automatic blood viscosity measuring device 1 according to the embodiment of the present invention may further include a control section C, a notification section AL, an emergency stop switch section ES, and a monitoring section (not shown).

[0141] First, the control unit C may control the operation of the blood sample pre-processing unit 300 , the blood sample transferring unit 400 , the blood viscosity measuring unit 500 , the reagent kit installing unit 600 , and the blood sample post-processing unit 700 .

[0142] Furthermore, the notification unit AL can detect an error in the automatic blood viscosity measuring device 1 and notify the user of the error through light or sound.

[0143] Furthermore, when the user needs to urgently stop the automatic blood viscosity measuring device 1, the emergency stop switch unit ES can immediately stop the operation of the mechanical device by operating the switch.

[0144] In addition, the monitoring unit (not shown) may monitor the viscosity measurement result measured by the blood viscosity measuring unit 500 through a display device.

[0145] Therefore, the automatic blood viscosity measuring device 1 according to the embodiment of the present invention adopts a dual system structure, which has the advantages of shortening the blood viscosity inspection time and being able to continue the inspection even when the clamp module or the injection device fails. It also has the advantages of preventing the red blood cell sedimentation phenomenon during the inspection and being able to safely and quickly replace the blood collection tube T, the blood viscosity measurement reagent kit BK and the pipette tip PT.

[0146] In summary, the automatic blood viscosity measuring device 1 according to the embodiment of the present invention is not limited to the above-mentioned effects, and is preferably interpreted as including advantages that can be clearly derived from the combination of the devices and structures possessed by the present invention.

[0147] As mentioned above, refer to Figures 1 to 19 The automatic blood viscosity measuring device 1 according to the embodiment of the present invention is described, but those skilled in the art will understand that the technical features of the present invention can be implemented by other specific forms without changing the technical ideas or essential features of the present invention. Therefore, the embodiments described above are exemplary in all aspects and are not restrictive.

[0148] Description of reference numerals:

[0149] 1: Automatic blood viscosity measuring device;

[0150] 100: housing; 101: cooling unit;

[0151] 110: open door; 120: frame;

[0152] 200: blood sample installation part; 210: blood collection tube insertion plate;

[0153] 215: first detection part; 220: first sliding part;

[0154] 221: first locking device; 230: motion motor;

[0155] 300: blood sample pretreatment unit; 310: pretreatment holder;

[0156] 320: first transfer module; 330: first lifting module;

[0157] 340: blood collection tube detection unit; 400: blood sample transfer unit;

[0158] 410: holding the gripper; 420: holding the gripper transfer module;

[0159] 430: guide plate; 431: guide groove;

[0160] 500: blood viscosity measuring unit; 510: measuring unit housing;

[0161] 511: shockproof pad; 520: reagent kit installation shell;

[0162] 521: inserting the reagent kit into the slot; 530: installing the detection sensor;

[0163] 540: heat transfer component; 550: reagent box fixing unit;

[0164] 551: first pushing member; 552: second pushing member;

[0165] 600: reagent kit installation part; 610: reagent kit insertion tray;

[0166] 615: second detection unit; 616: fastening unit;

[0167] 620: second sliding portion; 621: second locking device;

[0168] 630: reagent kit holder; 640: second transfer module;

[0169] 650: second lifting module; 700: blood sample post-processing unit;

[0170] 710: injection device; 720: pipette tip inserted into tray;

[0171] 730: third sliding portion; 731: third locking device;

[0172] 740: third detection unit; 800: first disposal unit;

[0173] 900: Second abandoned section;

[0174] T: blood collection tube; TC: blood collection tube cap;

[0175] BK: kit for blood viscosity measurement; PT: pipette tip;

[0176] C: Control Department; AL: Notification Department;

[0177] ES: Emergency stop switch.

Claims

1. An automatic blood viscosity measuring device, characterized in that: include: an enclosure configured with an opening door; A blood sample installation part, which is equipped with a blood collection tube; A blood sample preprocessing unit, which clamps a plurality of blood collection tubes, scans the clamped blood collection tubes, and separates the blood collection tube caps installed on the upper ends of the blood collection tubes; a blood sample transfer section that moves the blood collection tube held by the blood sample pretreatment section; a blood viscosity measuring section, which is equipped with a blood viscosity measuring kit and includes one or more channels for measuring the viscosity of a blood sample injected into the blood viscosity measuring kit; A reagent kit installation portion, which is disposed inside the housing and is used to install the blood viscosity measurement reagent kit in the blood viscosity measurement portion; as well as The blood sample post-processing unit sucks the blood sample in the blood collection tube transferred by the blood sample transferring unit and injects the blood sample into the installed blood viscosity measurement kit.

2. The automatic blood viscosity measuring device according to claim 1, characterized in that: The blood sample installation unit comprises: a blood collection tube insertion plate on which the blood collection tube is vertically mounted; a first sliding portion that slides the blood collection tube insertion plate toward the front of the housing to expose the blood collection tube insertion plate to the outside; and The first detection part is arranged between the blood sampling tube insertion plate and the first sliding part, and is used to detect the placement state of the blood sampling tube insertion plate.

3. The automatic blood viscosity measuring device according to claim 2, characterized in that: The blood sample installation unit also includes: The motion motor is arranged on both sides of the blood collection tube insertion plate, so that the blood collection tube insertion plate is tilted left and right at a set angle and repeatedly moves at a set period, thereby preventing the red blood cells of the blood sample in the blood collection tube from settling.

4. The automatic blood viscosity measuring device according to claim 1, characterized in that: The blood sample pre-processing unit comprises: A pretreatment clamp, which is configured in multiples and is used to clamp the blood collection tube and the blood collection tube cover for rotation; A first transfer module, which controls the horizontal position of the pre-processing holder; and The first lifting module connects the pre-processing clamp and the first transfer module and controls the height of the pre-processing clamp.

5. The automatic blood viscosity measuring device according to claim 4, characterized in that: The blood sample pre-processing unit also includes: The scanning module is arranged on the first transfer module and is used for scanning whether the blood collection tube is installed on the blood collection tube insertion plate.

6. The automatic blood viscosity measuring device according to claim 4, characterized in that: The blood sample transfer unit includes: A holding clamp, which is arranged in plural, has the blood collection tube clamped and transferred by the pretreatment clamp placed thereon, and clamps the lower part of the blood collection tube; a holding clamper transfer module, which is used to transfer the holding clamper; and A guide plate guides the reciprocating motion of the holding gripper transferred by the holding gripper transfer module.

7. The automatic blood viscosity measuring device according to claim 6, characterized in that: The blood sample pre-processing unit also includes: a blood collection tube detection unit, which is used to detect one or more blood collection tubes clamped by the holding clamp, Therefore, the automatic blood viscosity measuring device automatically measures the viscosity of the blood sample in the blood sampling tube according to the detection information of the blood sampling tube.

8. The automatic blood viscosity measuring device according to claim 1, characterized in that: The blood viscosity measuring unit comprises: The measuring part box body has a shock-proof pad disposed on the upper part; A reagent box installation housing is arranged at the upper end of the measuring part box and is provided with a reagent box insertion slot for installing a reagent box for measuring blood viscosity; A detection sensor is installed, which is arranged inside the reagent kit insertion slot and is used to detect the installation state of the blood viscosity measurement reagent kit; a heat transfer member disposed inside the reagent cartridge installation housing to apply heat to the blood viscosity measurement reagent cartridge; and The reagent box fixing unit is arranged inside the reagent box installation housing and is used to position and fix the reagent box for measuring blood viscosity. The reagent kit fixing unit comprises: a first pushing member disposed along the height direction of the inner surface of the reagent cartridge insertion slot of the reagent cartridge installation housing and used to push the blood viscosity measurement reagent cartridge to the other side; and The second pushing member is arranged in the length direction of the inner surface of the reagent cartridge insertion groove of the reagent cartridge installation housing and is used to push the blood viscosity measurement reagent cartridge to the other side.

9. The automatic blood viscosity measuring device according to claim 1, characterized in that: The kit installation unit comprises: a reagent cartridge insertion tray on which a reagent cartridge for measuring blood viscosity is vertically mounted; a second sliding portion for exposing the reagent cartridge insertion tray to the outside by sliding the reagent cartridge insertion tray toward the front of the housing; and The second detection part is arranged between the reagent kit insertion tray and the second sliding part, and is used for detecting the placement state of the reagent kit insertion tray.

10. The automatic blood viscosity measuring device according to claim 9, characterized in that: The kit installation unit also includes: A fastening unit is disposed between the reagent cartridge insertion tray and the second sliding portion to fix the reagent cartridge insertion tray to an upper portion of the reagent cartridge insertion tray.

11. The automatic blood viscosity measuring device according to claim 9, characterized in that: The kit installation unit comprises: A reagent box holder, which is configured in multiple pieces and is used to hold the blood viscosity measurement reagent box; A second transfer module, which controls the horizontal position of the reagent cartridge holder; and The second lifting module is connected to the reagent box holder and the second transfer module, and controls the height of the reagent box holder.

12. The automatic blood viscosity measuring device according to claim 11, characterized in that: The blood sample post-processing unit comprises: The injection device is configured in plural and connected to the second transfer module to mix and suck the blood sample in the blood collection tube transferred by the blood sample transfer unit and inject it into the installed blood viscosity measurement kit.

13. The automatic blood viscosity measuring device according to claim 11, characterized in that: The blood sample post-processing unit also includes: a pipette tip insertion tray on which pipette tips to be loaded and unloaded from the end of the injection device are mounted; and The third sliding portion slides the pipette tip insertion tray toward the front of the housing, thereby exposing the pipette tip insertion tray to the outside.

14. The automatic blood viscosity measuring device according to claim 1, characterized in that: The interior of the housing includes: a first waste portion, which is disposed between the blood sample installation portion and the blood viscosity measurement portion and is used to accommodate used pipette tips; and The second waste part is arranged between the blood viscosity measuring part and the reagent kit installation part, and is used to accommodate the blood viscosity measuring reagent kit after the measurement is completed. The first and second discarding parts slide toward the front of the housing to be exposed to the outside of the housing.

15. The automatic blood viscosity measuring device according to claim 1, characterized in that: The automatic blood viscosity measuring device also includes: a control unit, which controls the operation of the blood sample pre-processing unit, the blood sample transferring unit, the blood viscosity measuring unit, the reagent kit installing unit, and the blood sample post-processing unit; a notification section that detects and notifies an error of the automatic blood viscosity measuring device; an emergency stop switch portion for emergency stopping the automatic blood viscosity measuring device; and A monitoring unit is used to monitor the viscosity measurement result measured by the blood viscosity measuring unit.

Images