Chlorhexidine gluconate gargle and production process thereof

Abstract

The invention discloses a chlorhexidine gluconate gargle and a production process thereof. The chlorhexidine gluconate gargle is prepared from chlorhexidine gluconate, glycerol, polysorbate 80, menthol, saccharin sodium salt, a buffer solution, xanthan gum, lactoferrin peptide and a compound extract, according to the invention, by adding the lactoferrin peptide and the compound extract, the inhibition effect on oral bacteria can be enhanced, the overall flavor of the gargle can be improved, meanwhile, good antibacterial and anti-inflammatory effects can be provided, mucous membrane tissues can be helped to be repaired when oral mucosa is damaged, and the practicability of the product is improved; in the process of dissolving chlorhexidine gluconate, ultrasonic-assisted treatment is carried out by using ultrasonic equipment, so that the dissolution of chlorhexidine gluconate is promoted, the dissolution efficiency is improved, and the uniformity of solution mixing is guaranteed; before the gargle is filled, the gargle is sterilized by using cold plasma, and structures such as cell walls, cell membranes and nucleic acids of residual microorganisms are destroyed, so that efficient sterilization is realized, and the storage time of the gargle is prolonged.

Description

Technical Field

[0001] The invention relates to the technical field of medical care, in particular to a chlorhexidine gluconate gargle and a production process. Background Art

[0002] Chlorhexidine gluconate mouthwash is a common oral care product, the main ingredient of which is chlorhexidine gluconate. It is a cationic surfactant with a biguanide structure. Chlorhexidine gluconate can be adsorbed on the surface of bacteria, change the permeability of bacterial cell membranes, and cause cell contents to leak out, thereby playing a bactericidal and bacteriostatic role. Its positively charged molecular structure can attract the negatively charged components of bacterial cell walls (such as phospholipids, etc.), destroy the bacterial cell membrane structure, and then inhibit the growth and reproduction of bacteria. The existing chlorhexidine gluconate mouthwash can basically meet the daily use needs, but the mouthwash is limited by the limitations of raw materials. Although it has the use effect of bactericidal and bacteriostatic, it does not have anti-inflammatory and repair effects, which affects the practicality of the product. At the same time, in the production process of the mouthwash, chlorhexidine gluconate is the main functional component of the liquid, and its slow dissolution efficiency will affect its mixing uniformity in the solution. In addition, the process before filling is simple and lacks a sterilization step. The residual bacteria after filling will shorten the storage time of the mouthwash. Therefore, it is very necessary to design a chlorhexidine gluconate mouthwash and a production process. Summary of the invention

[0003] The object of the present invention is to provide a chlorhexidine gluconate gargle and a production process to solve the problems raised in the above background technology.

[0004] To achieve the above object, the present invention provides the following technical scheme: a chlorhexidine gluconate gargle, the formula of which comprises: chlorhexidine gluconate, glycerol, polysorbate 80, menthol, sodium saccharin, buffer, xanthan gum, lactoferrin peptide and a compound extract; the weight proportions of the components are respectively: 1.2-2.2 parts of chlorhexidine gluconate, 47-55 parts of glycerol, 10-15 parts of polysorbate 80, 0.5-2 parts of menthol, 0.1-0.5 parts of sodium saccharin, 5-15 parts of buffer, 12-18 parts of xanthan gum, 0.1-0.5 parts of lactoferrin peptide and 5-10 parts of the compound extract.

[0005] As a further technical solution of the present invention, the compound extract is formed by mixing tea tree essential oil and propolis extract, and the mixing ratio of tea tree essential oil and propolis extract is 5:1.

[0006] As a further technical solution of the present invention, the buffer solution is prepared from citric acid, sodium citrate and deionized water, and the specific preparation process is: first, citric acid and sodium citrate are added to deionized water in a mass ratio of 1:1, and then stirred at a stirring rate of 30 to 35 r / min for 5 to 6 minutes. After stirring, the pH value of the solution is detected, and then the pH value of the solution is adjusted to 6.0 to 6.5 by adding citric acid or sodium citrate, wherein if the pH value of the solution is detected to be <7, sodium citrate is added, and if the pH value of the solution is detected to be >7, citric acid is added for adjustment, and citric acid or sodium citrate is slowly added during the adjustment process and stirred at a stirring rate of 30 to 35 r / min, and the pH value change of the solution is synchronously monitored during the stirring process until the pH value changes to 6.0 to 6.5.

[0007] The production process of chlorhexidine gluconate gargle comprises the following steps: step 1, raw material preparation; step 2, preliminary addition; step 3, seasoning treatment; step 4, functional addition; step 5, dilution and water replenishment; step 6, filtration treatment; step 7, filling treatment;

[0008] Wherein in the above step 1, 1.2-2.2 parts of chlorhexidine gluconate, 47-55 parts of glycerol, 10-15 parts of polysorbate 80, 0.5-2 parts of menthol, 0.1-0.5 parts of saccharin sodium, 5-15 parts of buffer, 12-18 parts of xanthan gum, 0.1-0.5 parts of lactoferrin peptide and 5-10 parts of the composite extract are weighed according to the mass fraction of each group and set aside;

[0009] In the above step 2, the chlorhexidine gluconate prepared in the above step 1 is added to a blender, and then the buffer prepared in the step 1 is added to the blender, and then slowly stirred in the blender to obtain an initial mixed solution for standby use;

[0010] In the above step 3, the glycerin, polysorbate 80, menthol and saccharin sodium prepared in the above step 1 are added to the initial mixed solution prepared in the above step 2, and then stirred at high speed in a blender to obtain an initial gargle solution for standby use;

[0011] In the above step 4, the xanthan gum, lactoferrin peptide and compound extract prepared in the above step 1 are added to the initial gargle solution prepared in the above step 3, and then mixed in a blender to obtain a functional solution for standby use;

[0012] In the step 5, the functional solution prepared in the step 4 is placed in a blender, and then continuously stirred in the blender. Purified water is slowly added to the functional solution during continuous stirring, and the solubility of chlorhexidine gluconate in the solution is continuously detected during stirring. After continuous stirring, a gargle to be tested is obtained for later use.

[0013] In the above step 6, the gargle solution to be tested prepared in the above step 5 is filtered using a microporous filter membrane to obtain a clarified solution for later use;

[0014] In the above step 7, the appearance characteristics of the gargle, such as color and transparency, are observed, and the content of chlorhexidine gluconate is detected by liquid chromatography. After the detection is qualified, the chlorhexidine gluconate gargle is obtained by filling.

[0015] As a further technical solution of the present invention, in the step 2, when slow stirring is performed in the stirrer, the stirring speed of the stirrer is 25 to 45 r / min, and the slow stirring time is 20 to 30 min. During the stirring process, an ultrasonic device is used to perform ultrasonic-assisted treatment on the solution at a power of 20 to 40 kHz and a power of 100 to 160 W.

[0016] As a further technical solution of the present invention, in the step three, when high-speed stirring is performed in the stirrer, the stirring speed of the stirrer is 300 to 350 r / min, and the high-speed stirring time is 10 to 15 min.

[0017] As a further technical solution of the present invention, in the step 4, when the mixing process is carried out in the mixer, the stirring speed of the mixer is 400 to 450 r / min, and the mixing process time is 5 to 15 min.

[0018] As a further technical solution of the present invention, in the step 5, the stirring speed during the continuous stirring process is 45-60 r / min, and the stirring is continued until the concentration of chlorhexidine gluconate is 0.12%-0.2%.

[0019] As a further technical solution of the present invention, in step six, the pore size of the microporous filter membrane used in the filtration process is 0.22 to 0.45 microns.

[0020] As a further technical solution of the present invention, in step seven, the gargle is sterilized using cold plasma before filling.

[0021] Compared with the prior art, the invention has the following beneficial effects: the chlorhexidine gluconate gargle and production process can enhance the inhibitory effect of the gargle on oral bacteria by adding lactoferrin peptide and a composite extract mixed with tea tree essential oil and propolis extract into the raw materials; the tea tree essential oil also has a fresh smell, which can improve the overall flavor of the gargle, provide good antibacterial and anti-inflammatory effects for the gargle, and help repair the mucosal tissue when the oral mucosa is damaged, thereby improving the practicality of the product; in the process of dissolving the chlorhexidine gluconate, an ultrasonic device is used to perform ultrasonic auxiliary treatment on the solution at a power of 20 to 40 kHz and a power of 100 to 160 W, so as to promote the dissolution of the chlorhexidine gluconate, improve the dissolution efficiency, and ensure the uniformity of solution mixing; before filling, the gargle is sterilized by using cold plasma to destroy the cell wall, cell membrane, nucleic acid and other structures of the residual microorganisms, thereby achieving efficient sterilization, thereby extending the storage time of the gargle. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a production process flow chart of the present invention. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] Please refer to the attached Figure 1 , a technical solution provided by the present invention:

[0025] Embodiment 1:

[0026] The invention discloses a chlorhexidine gluconate gargle, the formula of which includes: chlorhexidine gluconate, glycerol, polysorbate 80, menthol, sodium saccharin, buffer solution, xanthan gum, lactoferrin peptide and a compound extract; the weight proportions of the components are: 2.2 parts of chlorhexidine gluconate, 55 parts of glycerol, 15 parts of polysorbate 80, 2 parts of menthol, 0.5 parts of sodium saccharin, 15 parts of buffer solution, 18 parts of xanthan gum, 0.5 parts of lactoferrin peptide and 10 parts of the compound extract; the compound extract is prepared by mixing tea tree essential oil and propolis extract, and the mixing ratio of tea tree essential oil and propolis extract is 5:1; the buffer solution is prepared by mixing citric acid, sodium citrate and deionized water. The specific preparation process is as follows: first, citric acid and sodium citrate are added to deionized water in a mass ratio of 1:1, and then the mixture is stirred at a stirring rate of 35 r / min for 6 minutes. After the stirring is completed, the pH value of the solution is detected, and then the pH value of the solution is adjusted to 6.5 by adding citric acid or sodium citrate, wherein sodium citrate is added if the pH value of the solution is detected to be <7, and citric acid is added for adjustment if the pH value of the solution is detected to be >7, during the adjustment process, citric acid or sodium citrate is slowly added and the mixture is stirred at a stirring rate of 35 r / min, and the pH value change of the solution is simultaneously monitored during the stirring process until the pH value changes to 6.5.

[0027] The production process of chlorhexidine gluconate gargle comprises the following steps: step 1, raw material preparation; step 2, preliminary addition; step 3, seasoning treatment; step 4, functional addition; step 5, dilution and water replenishment; step 6, filtration treatment; step 7, filling treatment;

[0028] Wherein in the above step 1, 2.2 parts of chlorhexidine gluconate, 55 parts of glycerol, 15 parts of polysorbate 80, 2 parts of menthol, 0.5 parts of saccharin sodium, 15 parts of buffer, 18 parts of xanthan gum, 0.5 parts of lactoferrin peptide and 10 parts of the composite extract are weighed according to the mass fraction of each group and set aside;

[0029] wherein in the step 2, the chlorhexidine gluconate prepared in the step 1 is added to a stirrer, and then the buffer solution prepared in the step 1 is added to the stirrer, and then slowly stirred in the stirrer to obtain an initial mixed solution for standby use; when slowly stirring in the stirrer, the stirring speed of the stirrer is 45 r / min, and the slow stirring time is 30 min, and during the stirring process, an ultrasonic device is used to perform ultrasonic-assisted treatment on the solution at a power of 40 kHz and a power of 160 W;

[0030] wherein in the step 3, the glycerol, polysorbate 80, menthol and sodium saccharin prepared in the step 1 are added to the initial mixed solution prepared in the step 2, and then stirred at high speed in a blender to obtain an initial gargle solution for standby use; the stirring speed of the blender during high-speed stirring is 350 r / min, and the high-speed stirring time is 15 min;

[0031] In the above step 4, the xanthan gum, lactoferrin peptide and compound extract prepared in the above step 1 are added to the initial gargle solution prepared in the above step 3, and then mixed in a blender to obtain a functional solution for standby use; the stirring speed of the blender during the mixing process is 450 r / min, and the mixing time is 15 min;

[0032] In the step 5, the functional solution prepared in the step 4 is placed in a blender, and then continuously stirred in the blender. Purified water is slowly added to the functional solution during the continuous stirring process, and the solubility of chlorhexidine gluconate in the solution is continuously detected during the stirring process. After continuous stirring, a gargle to be tested is obtained for standby use. The stirring speed during the continuous stirring process is 60 r / min, and the stirring is continued until the concentration of chlorhexidine gluconate is 0.2%;

[0033] In the above step 6, the gargle solution prepared in the above step 5 is filtered using a microporous filter membrane to obtain a clarified solution for later use; the pore size of the microporous filter membrane used in the filtering process is 0.45 microns;

[0034] In the above step seven, the appearance characteristics of the gargle, such as color and transparency, are observed, and the content of chlorhexidine gluconate is detected by liquid chromatography. After the detection is qualified, the chlorhexidine gluconate gargle is obtained by filling; before filling, the gargle is sterilized by using cold plasma.

[0035] Embodiment 2:

[0036] The chlorhexidine gluconate gargle comprises: chlorhexidine gluconate, glycerol, polysorbate 80, menthol, sodium saccharin, buffer, xanthan gum, lactoferrin peptide and compound extract; the weight proportions of the components are: 1.2 parts of chlorhexidine gluconate, 47 parts of glycerol, 10 parts of polysorbate 80, 0.5 parts of menthol, 0.1 parts of sodium saccharin, 5 parts of buffer, 12 parts of xanthan gum, 0.1 parts of lactoferrin peptide and 5 parts of compound extract; the compound extract is prepared by mixing tea tree essential oil and propolis extract, and the mixing ratio of tea tree essential oil and propolis extract is 5:1; the buffer is prepared by mixing citric acid, sodium citrate and deionized water. The specific preparation process is: first, citric acid and sodium citrate are added to deionized water in a mass ratio of 1:1, and then the mixture is stirred at a stirring rate of 30 r / min for 5 minutes. After the stirring is completed, the pH value of the solution is detected, and then the pH value of the solution is adjusted to 6.0 by adding citric acid or sodium citrate; if the pH value of the solution is detected to be <7, sodium citrate is added, and if the pH value of the solution is detected to be >7, citric acid is added for adjustment, and during the adjustment process, citric acid or sodium citrate is slowly added and stirred at a stirring rate of 30 r / min, and the pH value change of the solution is simultaneously monitored during the stirring process until the pH value changes to 6.0.

[0037] The production process of chlorhexidine gluconate gargle comprises the following steps: step 1, raw material preparation; step 2, preliminary addition; step 3, seasoning treatment; step 4, functional addition; step 5, dilution and water replenishment; step 6, filtration treatment; step 7, filling treatment;

[0038] Wherein in the above step 1, 1.2 parts of chlorhexidine gluconate, 47 parts of glycerol, 10 parts of polysorbate 80, 0.5 parts of menthol, 0.1 parts of saccharin sodium, 5 parts of buffer, 12 parts of xanthan gum, 0.1 parts of lactoferrin peptide and 5 parts of the composite extract are weighed according to the mass fraction of each group and set aside;

[0039] wherein in the step 2, the chlorhexidine gluconate prepared in the step 1 is added to a stirrer, and then the buffer solution prepared in the step 1 is added to the stirrer, and then slowly stirred in the stirrer to obtain an initial mixed solution for standby use; when slowly stirring in the stirrer, the stirring speed of the stirrer is 25 r / min, and the slow stirring time is 20 min, and during the stirring process, an ultrasonic device is used to perform ultrasonic-assisted treatment on the solution at a power of 20 kHz and a power of 100 W;

[0040] wherein in the step 3, the glycerol, polysorbate 80, menthol and sodium saccharin prepared in the step 1 are added to the initial mixed solution prepared in the step 2, and then stirred at high speed in a blender to obtain an initial gargle solution for standby use; the stirring speed of the blender during high-speed stirring is 300 r / min, and the high-speed stirring time is 10 min;

[0041] In the above step 4, the xanthan gum, lactoferrin peptide and compound extract prepared in the above step 1 are added to the initial gargle solution prepared in the above step 3, and then mixed in a blender to obtain a functional solution for standby use; the stirring speed of the blender during the mixing process is 400 r / min, and the mixing time is 5 min;

[0042] In the step 5, the functional solution prepared in the step 4 is placed in a blender, and then continuously stirred in the blender, purified water is slowly added to the functional solution during continuous stirring, and the solubility of chlorhexidine gluconate in the solution is continuously detected during stirring; after continuous stirring, a gargle to be tested is obtained for standby use; the stirring speed during continuous stirring is 45 r / min, and stirring is continued until the concentration of chlorhexidine gluconate is 0.12%;

[0043] In the above step 6, the gargle solution prepared in the above step 5 is filtered using a microporous filter membrane to obtain a clarified solution for later use; the pore size of the microporous filter membrane used in the filtering process is 0.22 microns;

[0044] In the above step seven, the appearance characteristics of the gargle, such as color and transparency, are observed, and the content of chlorhexidine gluconate is detected by liquid chromatography. After the detection is qualified, the chlorhexidine gluconate gargle is obtained by filling; before filling, the gargle is sterilized by using cold plasma.

[0045] Embodiment 3:

[0046] The chlorhexidine gluconate gargle comprises: chlorhexidine gluconate, glycerol, polysorbate 80, menthol, sodium saccharin, buffer, xanthan gum, lactoferrin peptide and compound extract; the weight proportions of the components are: 2.2 parts of chlorhexidine gluconate, 47 parts of glycerol, 15 parts of polysorbate 80, 0.5 parts of menthol, 0.5 parts of sodium saccharin, 5 parts of buffer, 18 parts of xanthan gum, 0.1 parts of lactoferrin peptide and 10 parts of compound extract; the compound extract is prepared by mixing tea tree essential oil and propolis extract, and the mixing ratio of tea tree essential oil and propolis extract is 5:1; the buffer is prepared by mixing citric acid, sodium citrate and deionized water. The specific preparation process is as follows: first, citric acid and sodium citrate are added to deionized water in a mass ratio of 1:1, and then the mixture is stirred at a stirring rate of 35 r / min for 5 minutes. After the stirring is completed, the pH value of the solution is detected, and then the pH value of the solution is adjusted to 6.5 by adding citric acid or sodium citrate, wherein sodium citrate is added if the pH value of the solution is detected to be <7, and citric acid is added for adjustment if the pH value of the solution is detected to be >7, during the adjustment process, citric acid or sodium citrate is slowly added and the mixture is stirred at a stirring rate of 30 r / min, and the pH value change of the solution is simultaneously monitored during the stirring process until the pH value changes to 6.5.

[0047] The production process of chlorhexidine gluconate gargle comprises the following steps: step 1, raw material preparation; step 2, preliminary addition; step 3, seasoning treatment; step 4, functional addition; step 5, dilution and water replenishment; step 6, filtration treatment; step 7, filling treatment;

[0048] Wherein in the above step 1, 2.2 parts of chlorhexidine gluconate, 47 parts of glycerol, 15 parts of polysorbate 80, 0.5 parts of menthol, 0.5 parts of saccharin sodium, 5 parts of buffer, 18 parts of xanthan gum, 0.1 parts of lactoferrin peptide and 10 parts of the composite extract are weighed according to the mass fraction of each group and set aside;

[0049] wherein in the step 2, the chlorhexidine gluconate prepared in the step 1 is added to a stirrer, and then the buffer solution prepared in the step 1 is added to the stirrer, and then slowly stirred in the stirrer to obtain an initial mixed solution for standby use; when slowly stirring in the stirrer, the stirring speed of the stirrer is 25 r / min, and the slow stirring time is 30 min, and during the stirring process, an ultrasonic device is used to perform ultrasonic-assisted treatment on the solution at a power of 20 kHz and a power of 160 W;

[0050] wherein in the step 3, the glycerol, polysorbate 80, menthol and sodium saccharin prepared in the step 1 are added to the initial mixed solution prepared in the step 2, and then stirred at high speed in a blender to obtain an initial gargle solution for standby use; the stirring speed of the blender during high-speed stirring is 300 r / min, and the high-speed stirring time is 10 min;

[0051] wherein in the step 4, the xanthan gum, lactoferrin peptide and compound extract prepared in the step 1 are added to the initial gargle solution prepared in the step 3, and then mixed in a blender to obtain a functional solution for standby use; the stirring speed of the blender during the mixing process is 450 r / min, and the mixing time is 5 min;

[0052] In the step 5, the functional solution prepared in the step 4 is placed in a blender, and then continuously stirred in the blender, purified water is slowly added to the functional solution during continuous stirring, and the solubility of chlorhexidine gluconate in the solution is continuously detected during stirring; after continuous stirring, a gargle to be tested is obtained for standby use; the stirring speed during continuous stirring is 60 r / min, and stirring is continued until the concentration of chlorhexidine gluconate is 0.12%;

[0053] In the above step 6, the gargle solution prepared in the above step 5 is filtered using a microporous filter membrane to obtain a clarified solution for later use; the pore size of the microporous filter membrane used in the filtering process is 0.45 microns;

[0054] In the above step seven, the appearance characteristics of the gargle, such as color and transparency, are observed, and the content of chlorhexidine gluconate is detected by liquid chromatography. After the detection is qualified, the chlorhexidine gluconate gargle is obtained by filling; before filling, the gargle is sterilized by using cold plasma.

[0055] The chlorhexidine gluconate gargles obtained in the above examples were tested for performance and compared with common chlorhexidine gluconate gargles on the market. The results are shown in the following table:

[0056] Doping rate Terpinen-4-ol content Example 1 0.14％ 0.015％ Example 2 0.08％ 0.013％ Example 3 0.23％ 0.017％ Comparative Example 1.35％ 0.000％

[0057] Based on the above, the advantages of the present invention are that, when used, the present invention can enhance the inhibitory effect of the gargle on oral bacteria by adding lactoferrin peptide and a composite extract mixed with tea tree essential oil and propolis extract to the raw materials. At the same time, the tea tree essential oil also has a fresh smell, which can improve the overall flavor of the gargle, and at the same time provide a good antibacterial and anti-inflammatory effect for the gargle, and can also help repair the mucosal tissue when the oral mucosa is damaged, thereby improving the practicality of the product; in the process of dissolving chlorhexidine gluconate, an ultrasonic device is used to perform ultrasonic auxiliary treatment on the solution at a power of 20 to 40 kHz and a power of 100 to 160 W, so as to promote the dissolution of chlorhexidine gluconate, improve the dissolution efficiency, and ensure the uniformity of solution mixing; before filling, the gargle is sterilized by using cold plasma to destroy the cell wall, cell membrane, nucleic acid and other structures of the residual microorganisms, thereby achieving efficient sterilization, thereby extending the storage time of the gargle.

[0058] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. Chlorhexidine gluconate gargle, the formula of which includes: Chlorhexidine gluconate, glycerol, polysorbate 80, menthol, sodium saccharin, buffer, xanthan gum, lactoferrin peptide and compound extract; the characteristics are that the weight proportions of the components are: 1.2-2.2 parts of chlorhexidine gluconate, 47-55 parts of glycerol, 10-15 parts of polysorbate 80, 0.5-2 parts of menthol, 0.1-0.5 parts of sodium saccharin, 5-15 parts of buffer, 12-18 parts of xanthan gum, 0.1-0.5 parts of lactoferrin peptide and 5-10 parts of compound extract.

2. The chlorhexidine gluconate gargle according to claim 1, characterized in that: The compound extract is prepared by mixing tea tree essential oil and propolis extract, and the mixing ratio of the tea tree essential oil and the propolis extract is 5:

1.

3. The chlorhexidine gluconate gargle according to claim 1, characterized in that: The buffer solution is prepared from citric acid, sodium citrate and deionized water, and the specific preparation process is: first, citric acid and sodium citrate are added to deionized water in a mass ratio of 1:1, and then stirred at a stirring rate of 30 to 35 r / min for 5 to 6 minutes, and the pH value of the solution is detected after the stirring is completed, and then the pH value of the solution is adjusted to 6.0 to 6.5 by adding citric acid or sodium citrate, wherein if the pH value of the solution is detected to be less than 7, sodium citrate is added, and if the pH value of the solution is detected to be greater than 7, citric acid is added for adjustment, and citric acid or sodium citrate is slowly added during the adjustment process and stirred at a stirring rate of 30 to 35 r / min, and the pH value change of the solution is simultaneously monitored during the stirring process until the pH value changes to 6.0 to 6.

5.

4. The production process of chlorhexidine gluconate gargle comprises the following steps: Step 1, raw material preparation; Step 2, preliminary addition; Step 3, seasoning treatment; Step 4, functional addition; Step 5, dilution and water replenishment; Step 6, filtration treatment; Step 7, filling treatment; It is characterized by: Wherein in the above step 1, 1.2-2.2 parts of chlorhexidine gluconate, 47-55 parts of glycerol, 10-15 parts of polysorbate 80, 0.5-2 parts of menthol, 0.1-0.5 parts of saccharin sodium, 5-15 parts of buffer, 12-18 parts of xanthan gum, 0.1-0.5 parts of lactoferrin peptide and 5-10 parts of the composite extract are weighed according to the mass fraction of each group and set aside; In the above step 2, the chlorhexidine gluconate prepared in the above step 1 is added to a blender, and then the buffer prepared in the step 1 is added to the blender, and then slowly stirred in the blender to obtain an initial mixed solution for standby use; In the above step 3, the glycerin, polysorbate 80, menthol and saccharin sodium prepared in the above step 1 are added to the initial mixed solution prepared in the above step 2, and then stirred at high speed in a blender to obtain an initial gargle solution for standby use; In the above step 4, the xanthan gum, lactoferrin peptide and compound extract prepared in the above step 1 are added to the initial gargle solution prepared in the above step 3, and then mixed in a blender to obtain a functional solution for standby use; In the step 5, the functional solution prepared in the step 4 is placed in a blender, and then continuously stirred in the blender. Purified water is slowly added to the functional solution during continuous stirring, and the solubility of chlorhexidine gluconate in the solution is continuously detected during stirring. After continuous stirring, a gargle to be tested is obtained for later use. In the above step 6, the gargle solution to be tested prepared in the above step 5 is filtered using a microporous filter membrane to obtain a clarified solution for later use; In the above step 7, the appearance characteristics of the gargle, such as color and transparency, are observed, and the content of chlorhexidine gluconate is detected by liquid chromatography. After the detection is qualified, the chlorhexidine gluconate gargle is obtained by filling.

5. The production process of the chlorhexidine gluconate gargle according to claim 4, characterized in that: In the step 2, the stirring speed of the stirrer is 25 to 45 r / min when slow stirring is performed in the stirrer, and the slow stirring time is 20 to 30 min. During the stirring process, an ultrasonic device is used to perform ultrasonic-assisted treatment on the solution at a power of 20 to 40 kHz and a power of 100 to 160 W.

6. The production process of the chlorhexidine gluconate gargle according to claim 4, characterized in that: In the step 3, when high-speed stirring is performed in the stirrer, the stirring speed of the stirrer is 300 to 350 r / min, and the high-speed stirring time is 10 to 15 minutes.

7. The production process of the chlorhexidine gluconate gargle according to claim 4, characterized in that: In the step 4, the stirring speed of the stirrer is 400-450 r / min, and the mixing time is 5-15 min.

8. The production process of the chlorhexidine gluconate gargle according to claim 4, characterized in that: In the step 5, the stirring speed during the continuous stirring process is 45-60 r / min, and the stirring is continued until the concentration of chlorhexidine gluconate is 0.12%-0.2%.

9. The production process of the chlorhexidine gluconate gargle according to claim 4, characterized in that: In step six, the pore size of the microporous filter membrane used in the filtration process is 0.22 to 0.45 microns.

10. The production process of the chlorhexidine gluconate gargle according to claim 4, characterized in that: In the step seven, the gargle is sterilized using cold plasma before filling.

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