Plant-derived anti-allergy soothing composition and application thereof

Abstract

The invention discloses a plant-sourced anti-allergy soothing composition. The composition is prepared from the following components in parts by mass: 0.01 to 0.1 part of Yunnan rhizoma paridis extract, 0.3 to 5 parts of gymnadenia conopsea extract, 0.01 to 0.1 part of kava extract and 0.01 to 0.05 part of citric acid orange fruit extract. The composition can reduce free radicals, reduce release of inflammatory factors, enhance skin barrier and achieve the effect of reducing sensitive occurrence from external and internal multiple pathways aiming at all stages of sensitive skin allergy, and is very suitable for nursing sensitive skin. In addition, each component is irreplaceable, the addition range of the composition is also an optimal range, and the effect, the safety and the cost of the composition are all the optimal ranges. In conclusion, the composition disclosed by the invention is an economical and effective cosmetic composition with multiple anti-allergy and soothing effects.

Description

Technical Field

[0001] The invention belongs to the field of skin care products, and specifically relates to an anti-allergic soothing composition of plant origin and application thereof. Background Art

[0002] In recent years, with the changes in living environment, lifestyle and skin care awareness / methods, the number of people with sensitive skin in Chinese society has increased. Among them, in addition to congenital sensitive skin, there are also many acquired sensitive skin caused by environmental stimulation, life pressure, excessive skin care, improper medical beauty and other reasons. The results of a large-scale epidemiological survey showed that the proportion of sensitive skin among Chinese women reached 49.6%, among which the incidence of sensitive skin among young women aged 18-30 was as high as 65.7%. "Sensitive skin" has become a hot word on social media and has been discussed at a high level in recent years. After several years of growth, China's "sensitive skin care market" has formed a large volume.

[0003] The continuous development of China's sensitive skin skin care market has led to the continuous deepening and refinement of the sensitive skin care concept. More and more sensitive skin brands have segmented sensitive skin types (such as "dry sensitive skin", "oily sensitive skin", etc.) and launched targeted products. With the continuous education of skin care brands and professionals on the concept of "differentiated treatment for sensitive skin", the penetration rate of this concept among ordinary consumers has increased significantly. According to the survey, 52.5% of consumers know that there are many types of sensitive skin, and 78.3% of sensitive skin consumers will choose corresponding skin care products according to their skin type.

[0004] In addition to natural skin problems, excessive use of skin care products, environmental pollution, lifestyle factors, and unscrupulous merchants adding excessive irritating ingredients in pursuit of effects have led to consumers' sensitive skin problems, which has also brought a lot of trouble to people with sensitive skin. Among people with sensitive skin, moderately sensitive people account for the highest proportion, and young consumers account for a large proportion. When choosing soothing and anti-allergic cosmetics, these consumers also have higher requirements for the efficacy, practicality, and safety of the products. Summary of the invention

[0005] The object of the present invention is to overcome at least one deficiency of the prior art and to provide an anti-allergic soothing composition of plant origin and application thereof.

[0006] The technical solution adopted by the present invention is:

[0007] In a first aspect, the present invention provides a plant-derived anti-allergic soothing composition, comprising the following components: Paris polyphylla extract, Panax ginseng extract, Kava extract, and Lycium wilfordii fruit extract.

[0008] In some examples, the mass ratio of the components of the composition is: 0.01-0.1 parts of Paris polyphylla extract, 0.3-5 parts of Panax ginseng extract, 0.01-0.1 parts of Kava extract, and 0.01-0.05 parts of Lycium wilfordii fruit extract.

[0009] In some examples, the mass ratio of the components of the composition is: 0.01 parts of Paris polyphylla extract, 0.3 parts of Panax ginseng extract, 0.01 parts of Kava extract, and 0.01 parts of Lycium wilfordii fruit extract.

[0010] In some examples, the mass ratio of the components of the composition is: 0.05 parts of Paris polyphylla extract, 3 parts of Panax ginseng extract, 0.05 parts of Kava extract, and 0.03 parts of Lycium wilfordii fruit extract.

[0011] In some examples, the mass ratio of the components of the composition is: 0.1 parts of Paris polyphylla extract, 5 parts of Panax ginseng extract, 0.1 parts of Kava extract, and 0.05 parts of Lycium wilfordii fruit extract.

[0012] In a second aspect, the composition provided in the first aspect of the present invention is used in a skin care product, wherein the skin care product comprises auxiliary materials and functional ingredients, and the functional ingredients are the anti-allergic and soothing composition derived from the plant.

[0013] In some examples, the plant-derived anti-allergic soothing composition is added in an amount of 0.3 to 6.0% by weight in skin care products.

[0014] In some examples, the skin care product is a cream, lotion, water solution, essence, gel, or mask.

[0015] In some examples, the excipients include solvents, humectants, emulsifiers, chelating agents, and preservatives.

[0016] The beneficial effects of the present invention are:

[0017] Based on the above technical problems, the applicant has successfully designed a plant-derived anti-allergic soothing composition through a large number of experiments. The innovative combination of several natural plant-derived ingredients can achieve excellent anti-allergic and soothing effects at a reasonable concentration. Starting from the causes of sensitive skin, it reduces the damage of free radicals in the external environment, repairs the skin barrier from the inside, reduces the release of inflammatory factors, reduces the occurrence of skin sensitivity, and allows sensitive skin to slowly return to a healthy state. The plant ingredients also meet consumers' expectations for safe and green products.

[0018] The present invention is a plant-derived anti-allergic soothing composition and a preparation method thereof, which comprises a Yunnan Paris extract, a Panax ginseng extract, a Kava extract, and a Lycium wilfordii fruit extract, and is targeted at all stages of allergies in sensitive skin, reduces free radicals, reduces the release of inflammatory factors, and strengthens the skin barrier, achieving the effect of reducing the occurrence of sensitivity through multiple pathways from the outside and inside, and is very suitable for the care of sensitive skin. The present invention proves the effectiveness of the composition of the present invention through a large number of experiments, and each component is irreplaceable. The addition range of the composition of the present invention is also an optimal range, which is an optimal range in terms of effect, safety, and cost. In summary, the composition of the present invention is an economical and effective cosmetic composition with multiple anti-allergic and soothing effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 Comparison of skin redness before use (left) and 28 days after use (right). DETAILED DESCRIPTION

[0020] The following disclosure provides many different embodiments or examples for implementing different solutions of the present invention.

[0021] Yunnan Paris polyphylla extract: Paris polyphylla is recorded in "Shennong's Herbal Classic" and "Compendium of Materia Medica". It is a traditional Chinese medicinal material, the dried rhizome of Paris polyphylla or Paris polyphylla of the Liliaceae family. It is bitter, slightly cold, and belongs to the liver meridian. It contains steroidal saponins, flavonoids, polysaccharides, ecdysone, etc. It has the effects of antibacterial, reducing inflammatory factors IL-1α and TNF-α, inhibiting the inflammatory signaling pathway NF-κB, and inhibiting the TRPV1 channel, and is effectively soothing and anti-inflammatory.

[0022] Ginseng extract: It is derived from the roots of the orchid Ginseng plant Ginseng grown at an altitude of 3400-4550m in Tibet. It uses extraordinary water extraction technology and whole-plant utilization, which is environmentally friendly. Ginseng extract contains more than 50 natural plant active ingredients with a molecular weight distribution between 400,000 and 450,000, mainly Ginseng polysaccharides, Ginseng glycosides, Gastrodin, small molecule peptides and amino acids, which can increase the content of filaggrin and have excellent moisturizing effect. It can also increase the activity of superoxide dismutase (SOD) in liver cells, reduce the generation of reactive oxygen free radicals (ROS) and malondialdehyde (MDA), and at the same time downregulate the mRNA expression levels of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and cyclooxygenase 2 (COX2), and has anti-inflammatory and repair effects.

[0023] Kava Extract: Kava is a pepper tree that grows in the Oceania Islands (Vanuatu, Polynesia, Tonga, Samoa, Fiji). In the traditional medicine of the islanders, kava is made into a ritual drink and has been used as a relaxant for hundreds of years. The kava extract used in the present invention contains kavalactones, which are the main active molecular group of kava, including capsaicin, dihydrocapsaicin, methoxycapsaicin, anesthesia capsaicin and demethoxycapsaicin. The synergistic effect of multiple kavalactones gives kava extract a complete soothing mechanism: by affecting GABA and GABA A It binds to the TRPV1 receptors, enhances the inhibition of nerve pain transmission, mediates the sedative effect in the body, and can also significantly reduce the production of TRPV1 receptor protein after stimulation and its binding to the CB1 receptor, playing a comprehensive soothing role such as anti-anxiety.

[0024] Citrus aurantium fruit extract: extracted from the fruit of Citrus aurantium, contains more than 5000ppm of citrus aurantium glycosides, has anti-allergic effects, can inhibit the activity of inflammatory factors IL-1α and IL-1β, and can also protect cells against UVB-induced cell death. It is usually used to treat urticaria and allergic dermatitis.

[0025] The types of raw materials prepared in the following examples of the present invention and their mass fraction compositions are as follows:

[0026] Category A: Cetearyl Olivate 1%, Glyceryl Stearate 0.8%, Behenyl Alcohol 1%, Cetyl Ethylhexanoate 5%, Caprylic / Capric Triglyceride 4%, Pentaerythrityl Tetra(Ethylhexanoate) 5%;

[0027] Category B: Carbomer 0.2%, disodium EDTA 0.05%, pentylene glycol 2%, caprylyl glycol 0.2%, glycerin 3%, after removing all the raw materials in categories A, B, C, and D, the remaining is water;

[0028] Category C: triethanolamine 0.15%;

[0029] The specific compositions of the compounds of class D in different examples are shown in Table 1 below:

[0030] Table 1

[0031]

[0032]

[0033] The specific formula composition of the comparative example is as follows:

[0034] 1. Comparative Example 1 is an essence cream made by replacing the D-type composition of the present invention with the purslane extract, a commonly used plant ingredient with good anti-allergic effect;

[0035] 2. Comparative Example 2 is an essence cream made by replacing the D-type composition of the present invention with the plant antiallergic agent Scutellaria baicalensis extract;

[0036] 3. Comparative Examples 3-6 are essence creams prepared by removing any component in Example 1 of the composition of the present invention;

[0037] 4. Comparative Example 7 is an essence cream prepared by making the contents of all components in the composition of the present invention greater than the maximum value of the present invention;

[0038] 5. Comparative Example 8 is a commercially available essence cream with good anti-allergic and soothing effects.

[0039] The preparation method of the essence cream of each example is as follows:

[0040] 1. Weigh Class A raw materials into a container, stir and heat to 85-90℃ until completely dissolved;

[0041] 2. Weigh Class B raw materials into a container, stir and heat to 85-90°C, homogenize evenly and add step 1, homogenize evenly and add Class C raw materials, stir evenly and cool down;

[0042] 3. When the temperature drops below 40°C, add Class D raw materials and stir evenly to obtain the desired essence cream.

[0043] Efficacy verification

[0044] (I) Efficacy test

[0045] 1. Test instruments:

[0046] 1. The present invention uses the Finnish Delfin VapoMeter SWL5201 transepidermal water loss measuring instrument. VapoMeter uses the closed chamber measurement principle, so the measurement is not affected by the indoor airflow. The measurement time is short, ensuring that the blocking of normal evaporation is minimized.

[0047] 2. Take photos using Delfin Antera 3D from Finland. Antera3D uses innovative optical methods and complex mathematical algorithms to obtain three-dimensional images. This allows data to be extracted from images related to the three-dimensional shape of the skin, which will be able to quantify the effects of treatment and monitor changes over time. For example, measure the texture, smoothness, and depth and width of fine lines and wrinkles of the skin. With its multispectral analysis, Antera software can also measure pigmentation and redness, which will provide meaningful information about sun damage, veins, etc.

[0048] 2. Experimental Principle:

[0049] TEWL value, transepidermal water loss (TEWL) measures the change in water vapor pressure near the skin surface. TEWL value indicates the loss of water from the stratum corneum and is an important criterion for evaluating the barrier function of the stratum corneum. The lower the TEWL value of the skin, the better the barrier function of the skin, and vice versa. By testing the value of skin water loss TEWL, the efficacy of moisturizing and repairing cosmetics can be evaluated. It can also be used in allergic patch tests, contact dermatitis, physical therapy, burns and monitoring of new tissue to promptly detect whether the protective function of the skin has been destroyed. The unit of TEWL is: g / hm 3

[0050] 3. Test population:

[0051] There are 8 groups in total, with 28 people in each group, including volunteers aged 18-60 who meet the experimental requirements.

[0052] 4. Test conditions:

[0053] At room temperature of 20±2°C and relative humidity of 50±10%, real-time dynamic monitoring was performed and the subjects sat quietly for 30 minutes before relevant data were tested.

[0054] 5. Experimental process:

[0055] The experiment was divided into 8 groups. The test subjects in groups 1-6 applied Example 1 on the left face and Comparative Examples 1-6 on the right face respectively; the test subjects in group 7 applied Example 3 on the left face and Comparative Example 7 on the right face; the test subjects in group 8 applied Example 2 on the left face and Comparative Example 8 on the right face. The test subjects applied the product to the face twice a day, morning and evening, for 4 weeks, and recorded the TEWL value. Then, one part of each volunteer's left and right cheek was selected for photography with Antera 3D, and the average redness RED value of the skin was recorded and archived.

[0056] 6. Experimental results:

[0057] Transepidermal water loss (TEWL) and skin redness average (RED) test:

[0058] In this test, the TEWL measured by the subject in week 0 is set as TEWL0, and the TEWL in week 4 is set as TEWL4. The TEWL change value is △TEWL, △TEWL = TEWL4-TEWL0, △TEWL is a negative number, and the lower the value, the less water loss of the skin after four weeks, that is, the better the skin barrier function is repaired, and the healthier the skin is;

[0059] The RED of the 0th week is set as RED0, and the RED of the 4th week is set as RED4. The RED change value is △RED, △RED=RED4-RED0, △RED is a negative number, and the lower the value, the less redness of the skin, that is, the less inflammatory reaction of the basal skin, the more comfortable the skin, and the better the soothing and anti-allergic effect of the product. Table 2 shows the average △TEWL value and △RED value of each group of 25 people, as follows:

[0060] Table 2

[0061]

[0062]

[0063] Experimental results:

[0064] From the experimental results in Table 2, we can see that:

[0065] 1. △TEWL value and △RED value, Example 1> Example 2> Example 3. It can be explained that as the addition ratio of the composition of the present invention increases, the △TEWL and △RED values ​​thereof will become smaller accordingly, that is, the less the skin moisture loss is, the better the integrity of the skin barrier is, the better the ability to resist environmental damage is, the less likely it is to produce allergies, and the less redness of the skin is, which means that the inflammatory response at the base of the skin is smaller, and the soothing effect on sensitive skin is better.

[0066] 2. The △TEWL and △RED values ​​of Example 1 are smaller than those of Comparative Example 1 and Comparative Example 2, indicating that when the composition of the present invention is replaced with a commonly used and effective plant antiallergic agent on the market, its soothing and anti-allergic effect will be weakened.

[0067] 3. The △TEWL and △RED values ​​of Example 1 are smaller than those of Comparative Examples 3, 4, 5 and 6, indicating that removing any component in the composition of the present invention will increase the corresponding △TEWL and △RED values, that is, removing any component will weaken the function of the composition of the present invention in soothing sensitive skin and strengthening the skin barrier.

[0068] 4. The △TEWL and △RED values ​​of Example 3 are smaller than those of Comparative Example 7, indicating that increasing the amount of the composition of the present invention does not increase but decreases the soothing and repairing effect of the product, and an increase in the content of ingredients will cause skin intolerance and increase the burden on the skin, and the effect is much worse than that within the range of the composition of the present invention.

[0069] 5. The ΔTEWL and ΔRED values ​​of Example 2 are smaller than those of Comparative Example 8, indicating that the anti-allergic and soothing effects of the composition of the present invention are superior to those of commercially available products.

[0070] 6. Test picture comparison

[0071] A part of the facial redness images of volunteers using the embodiment of the present invention were selected for comparison before and after use. Figure 1 It can be seen intuitively from the figure that after volunteers with severe facial redness used it for 28 days, the composition of the present invention had excellent effects in anti-allergy, soothing and repairing skin redness.

[0072] (II) Safety test (human skin patch test)

[0073] 1. Number of testers: 40 people in total, 20 males and 20 females, aged between 18 and 30 years old.

[0074] 2. Health status: The subject has healthy skin, no history of skin allergies, and meets the voluntary inclusion criteria.

[0075] 3. Test method: Select a qualified patch tester and use a closed patch test method. Drop about 0.05g of the test product into the patch tester and cover it on the back of the subject with a special adhesive tape. Each subject has 11 application points. Remove the test article after 24 hours and observe the skin reaction 0.5, 24, and 48 hours after removal. Score according to the skin reaction grading standard in the "Cosmetic Hygiene Standards", calculate the average value, and record the results in Table 4.

[0076] 4. The evaluation criteria are shown in Table 3.

[0077] Table 3 Human skin patch test standard table

[0078]

[0079] Table 4 Skin patch test scoring results

[0080]

[0081]

[0082] It can be seen from Table 4 that the various components of the composition of the present invention are very safe within the content range of the present invention, very friendly to the skin, mild and non-irritating.

[0083] The above is a further detailed description of the present invention, which should not be regarded as a limitation on the specific implementation of the present invention. For ordinary technicians in the technical field to which the present invention belongs, simple deduction or replacement without departing from the concept of the present invention is within the protection scope of the present invention.

Claims

1. A plant-derived anti-allergic soothing composition, characterized in that: The composition comprises the following components: Paris polyphylla yunnanensis extract, Panax ginseng extract, Kava extract and Lycium wilfordii fruit extract.

2. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 0.01-0.1 parts of Paris polyphylla extract, 0.3-5 parts of Panax ginseng extract, 0.01-0.1 parts of kava extract, and 0.01-0.05 parts of Lycium wilfordii fruit extract.

3. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 0.01 part of Paris polyphylla extract, 0.3 part of Panax ginseng extract, 0.01 part of Kava extract, and 0.01 part of Lycium wilfordii fruit extract.

4. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 0.05 parts of Paris polyphylla extract, 3 parts of Panax quinquefolius extract, 0.05 parts of kava extract, and 0.03 parts of Lycium wilfordii fruit extract.

5. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 0.1 parts of Paris polyphylla extract, 5 parts of Panax quinquefolius extract, 0.1 parts of kava extract, and 0.05 parts of Lycium wilfordii fruit extract.

6. Use of the composition according to any one of claims 1 to 5 in skin care products, characterized in that: The skin care product comprises auxiliary materials and functional ingredients, and the functional ingredients are the anti-allergic and soothing composition derived from the plant.

7. The use according to claim 6, characterized in that: The mass addition amount of the plant-derived anti-allergic soothing composition in the skin care product is 0.3-6.0%.

8. The use according to claim 6, characterized in that: The skin care products are creams, lotions, water solutions, essences, gels, and facial masks.

9. The use according to claim 6, characterized in that: The auxiliary materials include solvents, moisturizers, emulsifiers, chelating agents and preservatives.

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