Micro-capsule acne removal cream and preparation method thereof

Abstract

The invention relates to the field of skin care products, in particular to micro-capsule acne removal cream and a preparation method thereof. The micro-capsule acne-removing cream is prepared from the following components: a humectant, a skin conditioner, a suspending agent, a pH regulator and aloe barbadensis leaf water, behenyl alcohol, arachil alcohol, stearic acid, ethylhexyl hydroxystearate, an artemisia annua extract, pentaerythritol tetrakis (ethylhexanoate) ester, polydimethylsiloxane, tocopheryl acetate and squalane are used as raw materials; and carbomer. The anti-acne cream provided by the invention has the novel appearance of transparent gel and coated particles, can form a micro-capsule structure, and has the advantages of enhancing the anti-acne effect and fully exerting the effects of active substances.

Description

Technical Field

[0001] The present application relates to the field of skin care products, and more specifically, to a microcapsule anti-acne cream and a preparation method thereof. Background Art

[0002] In the skin care industry, acne-removing products have always been the focus of consumers. Traditional acne-removing skin care products are mostly in the form of a uniform mixture, where the acne-removing ingredients are directly dissolved or dispersed in a solvent. The original intention of this design is to expect that when applied to the skin, the acne-removing ingredients can quickly enter the skin along with the solvent and exert their therapeutic effects. However, in actual use, this design has obvious problems.

[0003] As the solvent evaporates quickly, many anti-acne ingredients fail to effectively penetrate the stratum corneum of the skin and are lost along with the solvent, resulting in a large number of active ingredients failing to exert their due effects. This not only wastes the effective ingredients, but also greatly reduces the anti-acne effect of the product, and cannot meet consumers' demand for fast and effective acne removal. Therefore, there is still room for improvement. Summary of the invention

[0004] In order to enhance the acne removal effect and give full play to the role of active substances, the present application provides a microcapsule acne removal cream and a preparation method thereof.

[0005] In the first aspect, the present application provides a microcapsule anti-acne cream, which adopts the following technical solution: A microcapsule anti-acne cream comprises the following components in terms of mass percentage: Component A: 5-15% moisturizer, 0-5% skin conditioner, 0.02-0.1% suspending agent, 0.01-1% thickener, 0.01-1% pH adjuster, aloe barbadensis leaf water; Component B: 1-3% behenyl alcohol, 0.05-0.5% arachidyl alcohol, 0.1-0.3% stearic acid, 0.1-1% ethylhexyl hydroxystearate, 0.1-3% artemisia annua extract, 1-3% pentaerythritol tetra(ethylhexanoate), 0.1-1% dimethicone, 0.1-1% tocopheryl acetate, 0.1-0.5% squalane; Component D: 0.4-0.8% Carbomer.

[0006] The microcapsule anti-acne cream provided in the present application has a novel appearance of transparent gel + encapsulated particles and is a gel-like cream body.

[0007] Conventional acne creams on the market have ordinary appearance and texture, are not breathable, and have little appeal to young consumer groups. The gel-type cream of the present application makes the skin feel more refreshing both subjectively and objectively, and the encapsulated particles are suspended in the gel, and the particles are distinct and visually novel. In addition, the melting point of the prepared microcapsule acne cream is close to the human body temperature, and it melts immediately after being applied, providing a good skin feel.

[0008] Wrapping the Artemisia Annua extract in the particles can effectively improve the penetration of Artemisia Annua into the skin. Artemisia Annua can inhibit Propionibacterium acnes and have an acne-removing effect. When applied, it emits a unique plant smell. This special structure can effectively alleviate the situation where the active ingredients cannot fully act as the solvent evaporates quickly.

[0009] In actual research and development, it is found that the active ingredients for acne removal are prone to lose their activity under specific external environments (such as high temperature, light, etc.), which seriously affects the stability and effect of the product. The structure of transparent gel + encapsulated particles obtained in this application can effectively alleviate the impact of specific external environments on the active ingredients and well maintain the activity of the active ingredients.

[0010] Specifically, with the cooperation of raw materials such as behenyl alcohol, arachidyl alcohol, stearic acid, and ethylhexyl hydroxystearate, particles with an ideal shape and uniform dispersion can be formed without aggregation, making the particles fuller and more uniform, and preventing the gel matrix and the encapsulated particles from aggregation, thereby ensuring the active ingredients encapsulated in the encapsulated particles.

[0011] The present invention achieves slow release and stable storage of acne-removing ingredients by encapsulating them in tiny capsules. This design can not only effectively improve the penetration and utilization rate of acne-removing ingredients, so that they can better exert their effects, but also protect the acne-removing ingredients from the influence of the external environment and maintain their stability and activity.

[0012] The use of pentaerythritol tetra(ethylhexanoate), polydimethylsiloxane, tocopheryl acetate and squalane can increase the oil concentration in the formula, further making the particles fuller and more uniform, making it less likely for the gel matrix and encapsulated particles to aggregate, and better and more encapsulating the active ingredients.

[0013] If the encapsulated particles are too soft, they will easily break during the mixing and preparation process and merge into the gel base; if the encapsulated particles are too hard, not only will the appearance be poor, but also when applied to the skin, the granular feel will be too strong and it will easily scratch the hands and face, resulting in a poor experience of use.

[0014] Pentaerythritol tetra(ethylhexanoate), polydimethylsiloxane, tocopheryl acetate, squalane, behenyl alcohol and arachidyl alcohol are compounded to make the generated encapsulated particles moderately soft and hard, providing better visual and usage experience.

[0015] Preferably, the mass ratio of behenyl alcohol to arachidyl alcohol is (80-90):(10-20), and the mass ratio of stearic acid to ethylhexyl hydroxystearate is (25-35):(65-75).

[0016] By adopting the above technical scheme, the mass ratio of behenyl alcohol, arachidyl alcohol, stearic acid, and ethylhexyl hydroxystearate is further limited, which is beneficial to ensure that a moderate number of encapsulated particles are formed in the microcapsule anti-acne cream, and the encapsulated particles have good dispersibility and do not aggregate, and can better encapsulate the acne-removing active ingredients, thereby enhancing the effect of the microcapsule anti-acne cream.

[0017] Preferably, the microcapsule anti-acne cream also includes hydrolyzed proanthocyanidins.

[0018] Preferably, based on the mass percentage of the microcapsule anti-acne cream, the hydrolyzed proanthocyanidins is 5-15%.

[0019] By adopting the above technical scheme, with the cooperation of Artemisia annua extract, hydrolyzed proanthocyanidins and aloe barbadensis leaf water, the hydrolyzed proanthocyanidins and aloe barbadensis leaf water first penetrate into all layers of the skin, relieve skin discomfort (such as dryness, tightness, etc.), and at the same time replenish moisture and nutrition for the skin to maintain the water-oil balance of the skin; and can effectively enhance the antioxidant properties of hydrolyzed proanthocyanidins, protect the skin from damage by free radicals, and create a good absorption environment for the skin.

[0020] When the outer layer of the microcapsule is gradually absorbed, the Artemisia annua extract contained in it is released. The pre-action of Artemisia annua extract and Aloe vera leaf water further enhances the antibacterial and anti-inflammatory effects of Artemisia annua extract, effectively inhibiting the root causes of acne - inflammation and bacterial infection, helping to reduce the redness, swelling and pain of acne and promote its disappearance. Acne is often accompanied by skin cell damage and oxidative stress. The combination of the three can also remove free radicals in the body, reduce oxidative stress reactions, protect cells from damage, promote skin cell regeneration and repair, help accelerate the repair process of acne skin, and restore the skin to a healthy state faster.

[0021] Preferably, the microcapsule anti-acne cream also includes yeast fermentation lysate filtrate.

[0022] Adding yeast fermentation lysate filtrate to microcapsule anti-acne cream can effectively enhance the repair effect.

[0023] Preferably, the moisturizing agent comprises a mixture of one or more of glycerin, butylene glycol, betaine, 1,2-pentanediol, ethylhexylglycerin, and 1,2-hexanediol.

[0024] In a second aspect, the present application provides a method for preparing a microcapsule anti-acne cream, using the following technical solution: A method for preparing a microcapsule anti-acne cream comprises the following steps: Step 1: Disperse the raw materials of component A uniformly and heat to 85±2°C to obtain component A; mix the raw materials of component B at 80±2°C to obtain component B; Step 2: Add component B to component A and stir until uniform; Step 3: Cool down to 45±2°C, add component D, and mix until uniform to obtain a microcapsule anti-acne cream.

[0025] Preferably, when the microcapsule anti-acne cream contains hydrolyzed proanthocyanidins and / or yeast fermentation lysate filtrate, the preparation method comprises the following steps: Step 1: Disperse the raw materials of component A uniformly and heat to 85±2°C to obtain component A; mix the raw materials of component B at 80±2°C to obtain component B; Step 2: Add component B to component A and stir until uniform; Step 3: Cool down to 45±2°C, add hydrolyzed proanthocyanidins and / or yeast fermentation lysate filtrate, and stir until uniform; Step 4: Add component D and mix until uniform to obtain microcapsule anti-acne cream.

[0026] By adopting the above technical solution, the temperature is strictly controlled and no additional emulsifier is needed. At 85±3°C, component B is added to component A by stirring. At high temperature, component B is transparent and fluid. When cooled to 45±2°C, due to the temperature difference and mixing with component A, (after the oil phase solidifies) it automatically forms a state of encapsulated particles.

[0027] In summary, this application has the following beneficial effects: 1. The microcapsule anti-acne cream provided in the present application has a novel appearance of transparent gel + wrapped particles, which makes the skin feel more refreshing both subjectively and objectively. The melting point is close to the human body temperature, and it melts immediately after being applied, providing a good skin feel.

[0028] 2. The present application encapsulates the active ingredients as particles, which effectively improves the permeability of Artemisia annua to the skin. Artemisia annua can inhibit Propionibacterium acnes and play an acne-removing effect.

[0029] 3. With the cooperation of behenyl alcohol, arachidyl alcohol, stearic acid and ethylhexyl hydroxystearate, particles with ideal shape and uniform dispersion can be formed without aggregation. The particles are fuller and more uniform, ensuring that the active ingredients in the particles are encapsulated.

[0030] 4. The combination of Artemisia annua extract, hydrolyzed proanthocyanidins and aloe barbadensis leaf water can exert multiple effects such as antibacterial, anti-inflammatory, antioxidant, repair and soothing, thereby more effectively solving acne problems and restoring the skin to health, smoothness and beauty.

[0031] 5. The preparation process of the present application does not need to rely on emulsifiers, and the morphology of the encapsulated particles is formed by strictly controlling the process parameters. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a comparison picture of the face of volunteer A who used the microcapsule anti-acne cream of Example 1.

[0033] Figure 2 This is a comparison picture of the face of volunteer B who used the microcapsule anti-acne cream of Example 1. DETAILED DESCRIPTION

[0034] The present application is further described in detail below with reference to the accompanying drawings and embodiments.

[0035] All products used in the following examples and comparative examples are commercially available products. Example

[0036] A microcapsule anti-acne cream, comprising, by weight percentage: Component A: 5-15% moisturizer, 0-5% skin conditioner, 0.02-0.1% suspending agent, 0.01-1% pH adjuster and the balance is made up of Aloe barbadensis leaf water.

[0037] The mass percentage of the moisturizer may be any value among 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc.

[0038] The moisturizer may be one or more of glycerin, butylene glycol, and betaine.

[0039] The mass percentage of the skin conditioner can be any value among 0.01%, 0.1%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, etc.

[0040] The skin conditioning agent is preferably niacinamide.

[0041] The mass percentage of the suspending agent can be any value among 0.02%, 0.03%, 0.05%, 0.07%, 0.1% and the like.

[0042] The suspending agent is preferably acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer.

[0043] The pH adjuster is preferably arginine.

[0044] Component B: 1-3% behenyl alcohol, 0.05-0.5% arachidyl alcohol, 0.1-0.3% stearic acid, 0.1-1% ethylhexyl hydroxystearate, 0.1-3% artemisia annua extract, 1-3% pentaerythritol tetra(ethylhexanoate), 0.1-1% polydimethylsiloxane, 0.1-1% tocopheryl acetate, 0.1-0.5% squalane.

[0045] The mass percentage of behenyl alcohol may be any value such as 1, 1.5%, 2%, 2.5%, or 3%.

[0046] The mass percentage of arachidyl alcohol may be any value among 0.05%, 0.07%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% and the like.

[0047] The mass percentage of stearic acid may be any value such as 0.1%, 0.15%, 0.2%, 0.25%, or 0.3%.

[0048] The mass percentage of ethylhexyl hydroxystearate may be any value such as 0.1%, 0.3%, 0.5%, 0.7%, 0.9%, or 1%.

[0049] The mass percentage of the Artemisia annua extract may be any value among 0.1%, 0.3%, 0.5%, 0.7%, 0.9%, 1%, 1.5%, 2%, 2.5%, 3% and the like.

[0050] The mass ratio of behenyl alcohol to arachidyl alcohol is (80-90):(10-20), and the mass ratio of stearic acid to ethylhexyl hydroxystearate is (25-35):(65-75). That is, the mass ratio of behenyl alcohol to arachidyl alcohol can be any mass ratio of 80:20, 82:18, 85:15, 87:13, 90:10, etc.; the mass ratio of stearic acid to ethylhexyl hydroxystearate can be any mass ratio of 25:75, 28:72, 30:70, 32:68, 35:65, etc.

[0051] The mass percentage of pentaerythritol tetra(ethylhexanoate) may be any value such as 1%, 1.5%, 2%, 2.5%, or 3%.

[0052] The mass percentage of polydimethylsiloxane may be any value among 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% and the like.

[0053] The mass percentage of tocopherol acetate may be any value such as 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1%.

[0054] The mass percentage of squalane may be any value such as 0.1%, 0.2%, 0.3%, 0.4%, or 0.5%.

[0055] Component C: 1-3% 1,2-pentanediol, 0.01-0.2% ethylhexylglycerol, 0.1-1% 1,2-hexanediol, 3-6% yeast fermentation lysate filtrate, 5-15% hydrolyzed proanthocyanidins.

[0056] The mass percentage of 1,2-pentanediol may be any value such as 1%, 1.5%, 2%, 2.5%, or 3%.

[0057] The mass percentage of ethylhexylglycerin may be any value such as 0.01%, 0.03%, 0.05%, 0.07%, 0.1%, or 0.2%.

[0058] The mass percentage of 1,2-hexanediol may be any value such as 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1%.

[0059] The mass percentage of the yeast fermentation lysate filtrate can be any value among 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6% and the like.

[0060] The mass percentage of hydrolyzed proanthocyanidins may be any value among 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc.

[0061] Component D: 0.4-0.8% Carbomer.

[0062] The mass percentage of carbomer may be any value among 0.4%, 0.5%, 0.6%, 0.7%, 0.8% and the like.

[0063] A method for preparing a microcapsule anti-acne cream comprises the following steps: Step 1: Disperse the raw materials of component A uniformly, and heat to 85±3°C to obtain component A; mix the raw materials of component B at 80±3°C to obtain component B.

[0064] Step 2: Add component B to component A and stir until well mixed.

[0065] Step 3: Cool down to 45±2°C, add component D, and mix until uniform to obtain a microcapsule anti-acne cream.

[0066] When the microcapsule anti-acne cream comprises component C, the preparation method comprises the following steps.

[0067] Step 1: Disperse the raw materials of component A uniformly, and heat to 85±3°C to obtain component A; mix the raw materials of component B at 80±3°C to obtain component B.

[0068] Step 2: Add component B to component A and stir until well mixed.

[0069] Step 3: Cool down to 45±2°C, add 1,2-pentanediol, ethylhexylglycerol and 1,2-hexanediol of component C under stirring, stir until uniform, then add yeast fermentation lysate filtrate and hydrolyzed proanthocyanidins, and stir evenly.

[0070] Step 4: The material in step 3 is cooled to below 40°C, and then component D (carbomer) which has been dispersed uniformly with a small amount of aloe vera leaf water is added and stirred until uniform to obtain a microcapsule anti-acne cream. There is no strict requirement for the amount of aloe vera leaf water used to disperse component D in this step, as long as component D can be dispersed.

[0071] Example 1 A microcapsule anti-acne cream, comprising: Component A: moisturizer, skin conditioning agent, suspending agent, pH adjuster and Aloe barbadensis leaf water.

[0072] Aloe barbadensis leaf water is commercially available, and in this example, it was purchased from Yunnan Wanlv Biological Co., Ltd.; acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer is commercially available, and in this example, it was purchased from Lubrizol Management (Shanghai) Co., Ltd.

[0073] The moisturizing agents are glycerin, butylene glycol, and betaine, the skin conditioning agent is niacinamide, the suspending agent is acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and the pH adjuster is arginine.

[0074] Component B: Behenyl Alcohol, Arachidyl Alcohol, Stearic Acid, Ethylhexyl Hydroxystearate, Artemisia Annua Extract, Pentaerythrityl Tetraethylhexanoate, Dimethicone, Tocopheryl Acetate, Squalane.

[0075] Artemisia annua extract is commercially available and in this example was purchased from Yangshan Xintu Biotechnology Co., Ltd.

[0076] Component C: 1,2-pentanediol, ethylhexylglycerol, 1,2-hexanediol, yeast fermentation lysate filtrate, hydrolyzed proanthocyanidins.

[0077] Yeast fermentation lysate filtrate was purchased from Jilin Province Ruijin Haoye Biotechnology Co., Ltd., and hydrolyzed proanthocyanidins were purchased from Jilin Province Ruijin Haoye Biotechnology Co., Ltd.

[0078] Component D: Carbomer.

[0079] The specific contents of the above raw materials are shown in Table 1.

[0080] This embodiment also discloses a method for preparing a microcapsule anti-acne cream, comprising the following steps: Step 1: Add part of the aloe vera leaf water, moisturizer, skin conditioner, and suspending agent into an emulsifier, stir and disperse them uniformly, raise the temperature to 85°C, stir evenly, keep warm for 20 minutes, dissolve the pH adjuster in the aloe vera leaf water in advance, add it and stir until uniform. Obtain component A.

[0081] Heat the raw materials of component B to 80°C and stir to dissolve to obtain component B.

[0082] Aloe barbadensis leaf water is used here to dissolve moisturizers, skin conditioners, and suspending agents. Just use an appropriate amount without any special requirements.

[0083] Step 2: Turn on stirring and slowly add component B into the emulsifier. Stir to make the oil droplets small and uniform. Control the size of the oil droplets by controlling the stirring speed according to the actual situation.

[0084] Step 3: Turn on the cooling water in the emulsifier and cool it down to 45°C. Add the pre-dispersed 1,2-pentanediol, ethylhexylglycerol, and 1,2-hexanediol while stirring, stir evenly, add the yeast fermentation lysate filtrate and hydrolyzed proanthocyanidins, and stir evenly.

[0085] Step 4: Cool down to 40°C, add the carbomer pre-dispersed with the remaining aloe vera leaf water, and stir evenly. After passing the test, discharge the material to obtain the microcapsule anti-acne cream.

[0086] Reference pictures of volunteers who used the microcapsule anti-acne cream of this example Figure 1 , Figure 2 .

[0087] Figure 1 and Figure 2 For different volunteers, the left side is before use, the right side is after use, and the usage time is 14 days.

[0088] Example 2 A microcapsule anti-acne cream, which is different from Example 1 in that: The mass ratio of behenyl alcohol to arachidyl alcohol is 80:20, and the mass ratio of stearic acid to ethylhexyl hydroxystearate is 25:75.

[0089] The amount of pentaerythritol tetra(ethylhexanoate) was 1 kg, the amount of polydimethylsiloxane was 0.1 kg, the amount of tocopheryl acetate was 0.1 kg, and the amount of squalane was 0.1 kg.

[0090] The specific content of each raw material is shown in Table 1.

[0091] Example 3 A microcapsule anti-acne cream, which is different from Example 1 in that: The mass ratio of behenyl alcohol to arachidyl alcohol is 90:10, and the mass ratio of stearic acid to ethylhexyl hydroxystearate is 35:65.

[0092] The amount of pentaerythritol tetra(ethylhexanoate) was 3 kg, the amount of polydimethylsiloxane was 1 kg, the amount of tocopheryl acetate was 1 kg, and the amount of squalane was 0.5 kg.

[0093] The specific content of each raw material is shown in Table 1.

[0094] Table 1 Comparative Example Comparative Example 1 A microcapsule anti-acne cream, which is different from Example 1 in that behenyl alcohol is replaced by arachidyl alcohol.

[0095] Comparative Example 2 A microcapsule anti-acne cream, which is different from Example 1 in that arachidyl alcohol is replaced by behenyl alcohol.

[0096] Comparative Example 3 A microcapsule anti-acne cream, which is different from Example 1 in that stearic acid is replaced by ethylhexyl hydroxystearate.

[0097] Comparative Example 4 A microcapsule anti-acne cream, which is different from Example 1 in that ethylhexyl hydroxystearate is replaced by stearic acid.

[0098] Comparative Example 5 A microcapsule anti-acne cream, which is different from Example 1 in that the Artemisia annua extract is replaced by green tea extract.

[0099] Comparative Example 6 A microcapsule anti-acne cream, which is different from Example 1 in that the aloe vera leaf water is replaced by water.

[0100] Comparative Example 7 A microcapsule anti-acne cream, which is different from Example 1 in that behenyl alcohol is 0.1275 kg, arachidyl alcohol is 0.0225 kg, stearic acid is 0.015 kg, ethylhexyl hydroxystearate is 0.035 kg, and aloe barbadensis leaf water is 62.64 kg.

[0101] Comparative Example 8 A microcapsule anti-acne cream, which is different from Example 1 in that behenyl alcohol is 6.375 kg, arachidyl alcohol is 1.125 kg, stearic acid is 0.75 kg, ethylhexyl hydroxystearate is 1.75 kg, and aloe barbadensis leaf water is 52.84 kg.

[0102] Comparative Example 9 A method for preparing a microcapsule anti-acne cream, which is different from Example 1 in that: In step 1, the raw materials of component A are uniformly dispersed and heated to 78° C. to obtain component A; the raw materials of component B are mixed at 72° C. to obtain component B.

[0103] Comparative Example 10 A microcapsule anti-acne cream, which is different from Example 1 in that pentaerythritol tetra(ethylhexanoate) is 0.1 kg, polydimethylsiloxane is 0.01 kg, tocopherol acetate is 3 kg, and squalane is 0.09 kg.

[0104] The specific content of each raw material is shown in Table 2.

[0105] Comparative Example 11 A microcapsule anti-acne cream, which is different from Example 1 in that pentaerythritol tetra(ethylhexanoate) is 7 kg, polydimethylsiloxane is 5 kg, tocopherol acetate is 0%, and squalane is 0%.

[0106] The specific content of each raw material is shown in Table 2.

[0107] Table 2 Performance testing Test 1: The microcapsule anti-acne creams of Examples 1-3 and Comparative Examples 1-11 were observed to check the shape of the encapsulated particles, the color, form, and feel of the microcapsule anti-acne creams, and the dispersibility of the encapsulated particles in the gel.

[0108] The results are recorded in Table 3.

[0109] Table 3 According to Table 3, the products of Examples 1-3 can form full, round, and moderately sized encapsulated particles, and are evenly dispersed in the gel system, ensuring that the active ingredients are encapsulated in the encapsulated particles.

[0110] Test 2: The microcapsule anti-acne creams of Examples 1-3 and Comparative Examples 1-11 were placed in a UV radiation box (450 W / m 2, 45°C) for 8 weeks, observe the microcapsule anti-acne cream, check the shape of the encapsulated particles, the color, form, feel of the microcapsule anti-acne cream, and the dispersibility of the encapsulated particles in the gel, and compare whether there are any changes.

[0111] The results are recorded in Table 4.

[0112] Table 4 According to Table 4, the products of Examples 1-3 can still maintain a good shape under high temperature and light conditions.

[0113] Test 3: 120 volunteers aged 25-35 were selected, with mild or moderate acne on the left and right sides of the face and at least one acne mark on each side. The volunteers were randomly divided into 12 groups, one group had 10 volunteers, and one group corresponded to a microcapsule anti-acne cream in Examples 1-3 and Comparative Examples 2-10.

[0114] During the trial, the volunteers cleansed their faces in the morning and evening, then applied the microcapsule anti-acne cream to the acne and gently massaged until absorbed, for 14 days.

[0115] 1. Efficacy test: (1) Acne treatment: The subjects tested the Visia red zone area ratio (whole face) and took full-face photos before using the test product and after using the product for 14 consecutive days.

[0116] The data on the percentage of red zone area in Visia were collected, the red zone change rate was calculated according to the following formula, and the average value of volunteers in the same group was recorded in Table 5.

[0117] D14: Skin parameter values ​​of the test area after using the product for 14 days.

[0118] D0: Basic values ​​of skin parameters before using the product on the test area.

[0119] (2) Moisturizing: The subjects used a moisture content tester to test the moisture content of the stratum corneum on both sides of their cheeks before using the test product and for 14 consecutive days.

[0120] The moisturizing change rate was calculated according to the following formula, and the average value of the volunteers in the same group was recorded in Table 5.

[0121] (3) Oil control: The subjects used an oil probe to test the skin oil secretion on the forehead before using the test product and for 14 consecutive days.

[0122] The oil control change rate was calculated according to the following formula, and the average values ​​of the volunteers in the same group were recorded in Table 5.

[0123] Table 5 2. Self-assessment: Questionnaires were distributed to volunteers, and scores were given on a scale of 0-10 for acne removal, acne scar removal, moisturizing, freshness, and breathability. The closer the score is to 10, the better the acne removal effect is / the more significant the acne scar removal effect is / the better the moisturizing is / the higher the freshness is / the higher the breathability is.

[0124] The average score of the volunteers in the same group is taken as the result of the group and recorded in Table 6.

[0125] Table 6 Category Acne Acne scar removal Moisturizing Freshness Breathability Example 1 9.5 9.0 9.3 9.6 9.3 Example 2 9.0 8.7 8.8 9.2 9.0 Example 3 9.1 8.6 8.5 9.3 9.0 Comparative Example 1 / / / / / Comparative Example 2 6.0 6.0 5.7 4.8 4.3 Comparative Example 3 6.2 5.7 5.5 5.1 4.5 Comparative Example 4 5.8 5.8 6.0 4.7 4.3 Comparative Example 5 6.3 6.0 7.0 6.9 6.8 Comparative Example 6 7.3 7.6 7.3 7.8 7.5 Comparative Example 7 6.2 6.0 5.8 5.2 4.6 Comparative Example 8 6.5 6.2 6.3 5.0 4.0 Comparative Example 9 4.5 4.1 5.2 4.0 3.8 Comparative Example 10 8.3 8.0 8.2 8.5 8.3 Comparative Example 11 / / / / / According to Tables 5 and 6, the anti-acne creams of Examples 1-3 have significant anti-acne, moisturizing and oil-control effects, can bring a refreshing and breathable use experience to the user, and have good effects.

[0126] Regarding Comparative Example 5, the Artemisia annua extract is replaced with green tea extract, that is, the Artemisia annua extract as an oil-soluble component is missing, and the green tea extract as a water-soluble component is added. This results in an increase in the interfacial tension between the oil phase particles and the water phase gel, and a weakening of the mutual penetration and anchoring effect at the interface, so that when the system is slightly disturbed by the outside world, the oil phase particles are more likely to detach from or displace from the water phase gel, which is likely to affect the overall stability and functionality of the system. Therefore, although Comparative Example 5 can form particles, the green tea extract is located in the gel phase, which makes the overall stability and functionality of the system poor, and further leads to poor acne cream effect.

[0127] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A microcapsule anti-acne cream, characterized in that: According to mass percentage, it includes the following components: Component A: 5-15% moisturizer, 0-5% skin conditioner, 0.02-0.1% suspending agent, 0.3-0.7% pH adjuster, aloe barbadensis leaf water; Component B: 1-3% behenyl alcohol, 0.05-0.5% arachidyl alcohol, 0.01-0.3% stearic acid, 0.05-1% ethylhexyl hydroxystearate, 0.1-3% artemisia annua extract, 1-3% pentaerythritol tetra(ethylhexanoate), 0.1-1% polydimethylsiloxane, 0.1-1% tocopheryl acetate, 0.1-0.5% squalane; Component D: 0.4-0.8% Carbomer.

2. The microcapsule anti-acne cream according to claim 1, characterized in that: The mass ratio of behenyl alcohol to arachidyl alcohol is (80-90):(10-20), and the mass ratio of stearic acid to ethylhexyl hydroxystearate is (25-35):(65-75).

3. The microcapsule anti-acne cream according to claim 1, characterized in that: The microcapsule anti-acne cream also includes hydrolyzed proanthocyanidins.

4. The microcapsule anti-acne cream according to claim 3, characterized in that: Calculated by mass percentage of the microcapsule anti-acne cream, the hydrolyzed proanthocyanidins are 5-15%.

5. The microcapsule anti-acne cream according to claim 1, characterized in that: The microcapsule anti-acne cream also includes yeast fermentation lysate filtrate.

6. The microcapsule anti-acne cream according to claim 1, characterized in that: The moisturizing agent includes a mixture of one or more of glycerin, butylene glycol and betaine.

7. A method for preparing the microcapsule anti-acne cream according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step 1: Disperse the raw materials of component A uniformly, raise the temperature to 85±2°C, and obtain component A; mix the raw materials of component B at 80±2°C, and obtain component B; Step 2: Add component B to component A and stir until uniform; Step 3: Cool down to 45±2°C, add component D, and mix until uniform to obtain a microcapsule anti-acne cream.

8. The method for preparing the microcapsule anti-acne cream according to claim 7, characterized in that: When the microcapsule anti-acne cream contains hydrolyzed proanthocyanidins and / or yeast fermentation lysate filtrate, the preparation method comprises the following steps: Step 1: Disperse the raw materials of component A uniformly and heat to 85±2°C to obtain component A; mix the raw materials of component B at 80±2°C to obtain component B; Step 2: Add component B to component A and stir until uniform; Step 3: Cool down to 45±2°C, add hydrolyzed proanthocyanidins and / or yeast fermentation lysate filtrate, and stir until uniform; Step 4: Add component D and mix until uniform to obtain microcapsule anti-acne cream.

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