Method for optimizing micro-nano particle control device based on parting structure

Abstract

The invention discloses a method for optimizing a micro-nano particle control device based on a parting structure. Belongs to the field of ultrasound and control, and comprises a piezoelectric plate driving circuit, micro-nano particles with different particle sizes, a suspension, a substrate, a ceramic piezoelectric plate, an acoustic vortex and a three-dimensional fluid chamber, protruding parts distributed according to a certain rule are arranged on the base plate, the ceramic piezoelectric plates are pasted on the protruding parts of the base plate through epoxy resin glue, a three-dimensional fluid cavity is connected to the base plate, and suspension liquid is contained in the three-dimensional fluid cavity. According to the control method, ultrasonic waves with different frequencies are excited, acoustic vortexes with different intensities are generated in a fluid cavity, and therefore the micro-nano particles with different particle sizes in the fluid cavity are controlled in a partitioned mode, separation of the micro-nano particles can be achieved, and the micro-nano particle control method is rapid, free of contact and free of damage.

Description

Technical Field

[0001] The present invention belongs to the field of ultrasound and manipulation, and relates to a method for optimizing a micro-nano particle manipulation device based on a classification structure; specifically, it relates to a method for optimizing a micro-nano particle manipulation device based on a classification structure control, and the manipulation method is to stimulate ultrasound waves of different frequencies to generate acoustic vortices in a fluid chamber, thereby achieving control of microparticles of different particle sizes. Background Art

[0002] With the rapid development of nanotechnology, acoustics, materials science, biomedicine and other fields, how to manipulate different microparticles mixed in fluids has become an important topic in current scientific and technological research. In the biomedical field, ultrasound can be used to sort different types of cells, such as screening and analysis of cancer cells and normal cells; ultrasound can also be used to manipulate particles for targeted movement of drugs. In the food industry, ultrasound can be used to detect the uniformity of ingredients in food and identify bacteria and contaminants. Therefore, how to efficiently, non-destructively and accurately manipulate these particles is a huge technical difficulty that needs to be overcome.

[0003] Therefore, it is necessary to improve the existing technology to solve the shortcomings of the existing technology. Summary of the invention

[0004] In view of the above problems, the purpose of the present invention is to propose a method for optimizing a micro-nano particle manipulation device based on a typing structure. The method is to stick the excitation part of the ceramic piezoelectric sheet to the protruding part of the substrate. The acoustic flow generated by the ceramic piezoelectric sheet generates an acoustic vortex in the suspension in the three-dimensional fluid chamber. According to the different excitation intensities of the ceramic piezoelectric sheets with protrusions of different sizes, microparticles of different particle sizes in the suspension can be controlled at different points.

[0005] The technical solution of the present invention is: a micro-nano particle manipulation device described in the present invention includes a piezoelectric sheet driving circuit, micro-nano particles of different particle sizes, a suspension, a substrate, a ceramic piezoelectric sheet, an acoustic vortex and a three-dimensional fluid chamber.

[0006] Furthermore, it also includes a substrate, on which protrusions distributed in a certain pattern are arranged, the ceramic piezoelectric sheet is adhered to the protrusions of the substrate by epoxy resin glue, and a three-dimensional fluid chamber is connected to the substrate, and a suspension is contained in the three-dimensional fluid chamber.

[0007] Furthermore, the raised parts on the substrate are arranged in a fractal structure, and different structures can be customized according to the characteristics of the microparticles to be manipulated and the manipulation requirements, and the structures include but are not limited to Sierpinski carpet, Sierpinski triangle, Koch snowflake, etc.

[0008] Furthermore, the ceramic piezoelectric sheet is connected to the piezoelectric sheet driving circuit via a wire.

[0009] Furthermore, micro-nano particles of different sizes are dispersed in the suspension, and the ultrasonic waves excited by the ceramic piezoelectric piece drive the movement of the suspension and generate acoustic vortices around the raised portions of the substrate.

[0010] Furthermore, the three-dimensional acoustic fluid chamber can be prepared into different shapes, including but not limited to: circular, triangular, polygonal, pentagonal, etc.;

[0011] The preparation materials include but are not limited to: ceramics, organic polymer materials, and hydrophilic materials.

[0012] Furthermore, the shapes of the raised portions on the substrate include, but are not limited to, circles, triangles, polygons, pentagons, etc., and the control effects of ultrasound modulation on microparticles of different types and sizes also vary.

[0013] Furthermore, the suspension in the three-dimensional fluid chamber includes but is not limited to pure water, alkaline suspension, acidic suspension, colloid, emulsion, etc.

[0014] Furthermore, the ceramic piezoelectric sheet can be replaced with any device capable of exciting an ultrasonic device, and the operating frequency f of the ceramic piezoelectric sheet is continuously adjustable within the range of 20-200 kHz.

[0015] Furthermore, the method for optimizing the micro-nano particle manipulation device based on the classification structure has the following operating steps:

[0016] Step (1), uniformly dispersing micro-nano particles of different particle sizes in a three-dimensional fluid chamber containing a suspension;

[0017] Step (2), when the ceramic piezoelectric piece 2 is working, the generated sound waves are transmitted to the suspension through the protrusions on the substrate, and some acoustic vortices are generated around the protrusions. At this time, the acoustic vortex speed generated is relatively low and can only drive the smallest micro-nano particles to move. At this time, the particles with the smallest particle size are captured around the small protrusions;

[0018] Step (3), when the ceramic piezoelectric piece is working, the generated sound waves are transmitted to the suspension through the protrusions on the substrate, and some acoustic vortices are generated around the protrusions. At this time, the acoustic vortex speed that can be generated is relatively large, and micro-nano particles with medium particle sizes can be captured;

[0019] Step (4), when the ceramic piezoelectric piece 3 is working, the generated sound waves are transmitted to the suspension through the raised parts on the substrate, and some acoustic vortices are generated around the raised parts. At this time, the acoustic vortex speed generated is the largest, and micro-nano particles with large particle sizes can be captured;

[0020] Step (5), by using ceramic piezoelectric sheets of different strengths, acoustic vortices of different strengths can be generated in the suspension, and acoustic vortices of different strengths can capture micro-nanoparticles of different sizes, thereby achieving manipulation of the micro-nanoparticles.

[0021] The beneficial effects of the present invention are as follows: the method introduces a fractal structure to generate acoustic vortices of different intensities in the flow field, thereby sorting the particles; specifically, (1) the method of the present invention for optimizing the micro-nano particle manipulation device based on fractal structure control has no requirements on the type of particles, and therefore has good compatibility with biological cells; (2) the manipulation method can manipulate the particles at multiple frequency points, and by customizing different fractal structures, the manipulation requirements for particles of different sizes can be met; (3) the use of fractal structures improves the applicability of materials, reduces weight while ensuring structural strength, and makes it suitable for weight-sensitive application scenarios. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0023] Figure 2 yes Figure 1 Finite element software simulation diagram of the structure;

[0024] In the figure, 1 is a piezoelectric film driving circuit, 2 is micro-nano particles of different sizes, 3 is a suspension, 4 is a substrate, 51 is a ceramic piezoelectric film 1, 52 is a ceramic piezoelectric film 2, 53 is a ceramic piezoelectric film 3, 6 is an acoustic vortex, and 7 is a three-dimensional fluid chamber. DETAILED DESCRIPTION

[0025] The specific technical scheme of the present invention is further described in detail below with reference to specific examples.

[0026] As shown in the figure, a method for optimizing a micro-nano particle manipulation device based on a classification structure according to the present invention comprises a piezoelectric sheet driving circuit 1, micro-nano particles of different particle sizes 2, a suspension 3, a substrate 4, a ceramic piezoelectric sheet (a ceramic piezoelectric sheet 1 51, a ceramic piezoelectric sheet 2 52, a ceramic piezoelectric sheet 3 53), an acoustic vortex 6, and a three-dimensional fluid chamber 7;

[0027] The piezoelectric sheet driving circuit 1 drives the ceramic piezoelectric sheet to perform high-frequency excitation, and the excitation part of the ceramic piezoelectric sheet is adhered to the protruding part of the substrate 4 for zoned excitation. The acoustic flow generated by the ceramic piezoelectric sheet generates a plurality of acoustic vortices 6 of different strengths in the suspension 3 in the three-dimensional fluid chamber 7. The acoustic vortices 6 of different strengths can effectively sort out micro-nano particles 2 of different particle sizes in the suspension 3;

[0028] According to the different excitation strengths of the ceramic piezoelectric sheets with protrusions of different sizes, it is possible to achieve point-by-point control of the micro-nano particles 2 of different particle sizes in the suspension 3.

[0029] The aggregation method is to generate multiple acoustic vortices 6 in the flow field by transmitting ultrasonic waves of different frequencies through a phononic crystal plate to simultaneously aggregate micro / nanoparticles (micro / nanoparticles 2 of different particle sizes) in the flow field at multiple points.

[0030] Specifically, the radiation end surface of the ceramic piezoelectric sheet is adhered to the protrusion of the substrate 4, and the ceramic piezoelectric sheet is connected to a piezoelectric sheet driving circuit 1. The piezoelectric sheet driving circuit 1 sends an electrical signal from a signal generator (Tektronix AFG 3022C, 250MS / s, 25MHz) to a power amplifier (Aigtek ATA-4052) for electrical signal power amplification to drive the ceramic piezoelectric sheet, and an oscilloscope (Tektronix TDS2024, 200MHz, 2GS / s) displays the working voltage value and working current value of the ceramic piezoelectric sheet;

[0031] The size of the substrate 4 is 10mm*10mm, wherein the sizes of the raised parts on the substrate 4 are 0.3mm*0.3mm, 1mm*1mm, and 3mm*3mm respectively;

[0032] The sizes of the ceramic piezoelectric sheet 1 (51), the ceramic piezoelectric sheet 2 (52), and the ceramic piezoelectric sheet 3 (53) are 1mm*1mm, 0.3mm*0.3mm, and 3mm*3mm, respectively, and the vibration frequency is at ultrasonic level and is continuously adjustable within the range of 20KHz-200KHz, and the size corresponds to the size of the protrusion of the substrate 4;

[0033] The ceramic piezoelectric sheet 1 (51), the ceramic piezoelectric sheet 2 (52), and the ceramic piezoelectric sheet 3 (53) are piezoelectric sheets of the same size connected in series and are controlled by different piezoelectric sheet driving circuits 1, respectively, so as to excite ultrasound of different intensities.

[0034] The suspension 3 is contained in a three-dimensional fluid chamber 7, and micro-nano particles 2 of different particle sizes are stored in the suspension 3;

[0035] When the ceramic piezoelectric sheet is excited in the three-dimensional fluid chamber 7, acoustic vortices 6 of different strengths are generated. Through these acoustic vortices 6 of different strengths, micro-nano particles 2 of different particle sizes can be sorted and captured;

[0036] The raised parts on the substrate 4 are arranged in a fractal structure, and different structures can be customized according to the characteristics of the microparticles to be manipulated and the manipulation requirements. Here, the Sierpinski carpet arrangement is used.

[0037] Each area and the bottom of the three-dimensional fluid chamber 7 are made of materials that can conduct sound waves, and the excitation part of the ceramic piezoelectric piece is fixed on the raised part of the substrate 4 by an adhesive.

[0038] The three-dimensional fluid chamber 7 is in the shape of a square chamber and is made of acrylic sheet.

[0039] The shape of the raised portion in the substrate 4 of the three-dimensional fluid chamber 7 is a proportionally reduced square.

[0040] The ceramic piezoelectric sheets on the raised part of the pasted substrate 4 are connected in series with the same size of piezoelectric sheets and controlled by the same external circuit. The ceramic piezoelectric sheets are continuously adjustable within the working frequency range.

[0041] The suspension 3 includes but is not limited to pure water, alkaline suspension, acidic suspension, colloid, emulsion, etc.

[0042] like Figure 2 As shown, a two-dimensional plane and a ceramic piezoelectric sheet are used for modeling, wherein a simplified three-dimensional fluid chamber 7 and a substrate 4 are represented by line segments, and the acoustic flow field region is retained, and its size is 4.5 cm*5 cm;

[0043] Driven by different layers of piezoelectric sheets, and numerically studied, it can be calculated that Figure 2 Multiple acoustic vortices 6 are shown; in the present invention, by exciting the protrusions of different levels, the acoustic flow and acoustic pressure generated are different, and micro-nano particles 2 of different particle sizes can be sorted. At the same time, different fractal structures can be customized to meet the requirements for sorting micro-nano particles 2 of different particle sizes;

[0044] This method has a wide range of applications in food processing and biomedicine. For example, in the biomedicine field, it can be used to distinguish cancer cells. Since cancer cells are larger than normal cells, this method can be used to sort cells. Cells distributed at the strongest acoustic flow are all cancer cells. In the field of food processing, it can be used to detect the uniformity of ingredients in food and identify bacteria and contaminants.

Claims

1. A micro-nano particle manipulation device, characterized in that: It comprises a piezoelectric sheet driving circuit (1), a substrate (4) and a ceramic piezoelectric sheet; A plurality of raised portions are evenly distributed on the substrate (4), and the ceramic piezoelectric sheet is adhered to the raised portions of the substrate (4) by epoxy resin glue; The ceramic piezoelectric sheet is connected to a piezoelectric sheet driving circuit (1) via an arranged wire.

2. The micro-nano particle manipulation device according to claim 1, characterized in that: A three-dimensional fluid chamber (7) is connected to the substrate (4), a suspension (3) is placed in the three-dimensional fluid chamber (7), and micro-nano particles (2) of different particle sizes are dispersed in the suspension (3).

3. The micro-nano particle manipulation device according to claim 2, characterized in that: The ultrasonic wave excited by the ceramic piezoelectric plate drives the movement of the suspension (3) and generates an acoustic vortex (6) around the raised portion of the substrate (4).

4. The micro-nano particle manipulation device according to claim 1, characterized in that: The protrusions on the substrate (4) are arranged in a fractal structure, and different structures can be customized according to the characteristics of the microparticles to be manipulated and the manipulation requirements. The structures include but are not limited to Sierpinski carpet, Sierpinski triangle or Koch snowflake structure.

5. The micro-nano particle manipulation device according to claim 1, characterized in that: The shape of the raised portion includes but is not limited to a circle, a triangle, a polygon or a pentagon.

6. The micro-nano particle manipulation device according to claim 1, characterized in that: The ceramic piezoelectric sheets include a ceramic piezoelectric sheet 1 (51), a ceramic piezoelectric sheet 2 (52) and a ceramic piezoelectric sheet 3 (53), which can be replaced by any sheet capable of exciting an ultrasonic device; The working frequency f of the ceramic piezoelectric piece is continuously adjustable within the range of 20-200 kHz.

7. The micro-nano particle manipulation device according to claim 1, characterized in that: The ceramic piezoelectric sheets are all connected to a piezoelectric sheet driving circuit (1).

8. The micro-nano particle manipulation device according to claim 2, characterized in that: The shape of the three-dimensional acoustic fluid chamber (7) includes but is not limited to: circular, triangular, polygonal or pentagonal, etc.; The preparation materials include but are not limited to ceramics, organic polymer materials or hydrophilic materials.

9. The micro-nano particle manipulation device according to claim 2, characterized in that: The suspension (3) includes but is not limited to pure water, alkaline suspension, acidic suspension, colloid or emulsion.

10. A method for optimizing a micro-nano particle manipulation device based on a classification structure according to any one of claims 1 to 9, characterized in that: The operation steps are as follows: Step 1: Evenly dispersing micro-nano particles (2) of different particle sizes in a three-dimensional fluid chamber (7) containing a suspension (3); Step 2: When the ceramic piezoelectric sheet 2 (52) is working, the generated sound waves are transmitted to the suspension (3) through the protrusions on the substrate (4), and an acoustic vortex (6) is generated around the protrusions. At this time, the acoustic vortex (6) generated has a low speed and can only drive the smallest micro-nano particles to move. At this time, the particles with the smallest particle size are captured around the small protrusions. Step 3: When the ceramic piezoelectric piece 1 (51) is working, the generated sound waves are transmitted to the suspension (3) through the protruding parts on the substrate (4), and some acoustic vortices (6) are generated around the protruding parts. At this time, the acoustic vortex speed that can be generated is relatively large, and micro-nano particles with medium particle sizes can be captured; Step 4: When the ceramic piezoelectric piece 3 (53) is working, the generated sound waves are transmitted to the suspension (3) through the protruding parts on the substrate (4), and some acoustic vortices (6) are generated around the protruding parts. At this time, the acoustic vortex speed generated is the largest, and micro-nanoparticles with large particle sizes can be captured; Step 5: By using ceramic piezoelectric sheets of different strengths, acoustic vortices (6) of different strengths can be generated in the suspension (3). The acoustic vortices (6) of different strengths can capture micro-nanoparticles of different sizes, thereby achieving the manipulation of the micro-nanoparticles.

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