Application of perilla leaf extract in preparation of medicine for treating hormone resistant asthma (SRA)

Through the preparation and application of perilla leaf extract, the problem of difficult to effectively treat hormone-resistant asthma in the prior art is solved, and the high response to SRA airway and significant inhibition of inflammatory factors is achieved, and a new alternative to hormone therapy is provided.

CN119656221APending Publication Date: 2025-03-21INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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Patent Information

Application Number
CN202311211059.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2023-09-19
Publication Date
2025-03-21

AI Technical Summary

Technical Problem

The prior art is difficult to effectively treat hormone-resistant asthma (SRA) because existing hormone therapy cannot reduce airway hyperresponsiveness, number of airway inflammatory cells and levels of related inflammatory factors.

Method used

Perilla leaf extract is prepared by the preparation method of perilla leaf extract, and the steps of extraction, extraction and alcohol precipitation of water or lower alcohol aqueous solution are obtained, and a pharmaceutical composition with this as an ingredient is administered to treat and prevent SRA.

Benefits of technology

Perilla leaf extract significantly improved the airway hyperresponsiveness of SRA mice at a dose of 50 mg/kg. It can significantly inhibit the production of inflammatory cytokines TNF-α and IFN-γ in alveolar lavage fluid, as well as the recruitment of leukocytes and neutrophils, showing effective anti-inflammatory and anti-allergic effects, making up for the shortcomings of hormone therapy.

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Abstract

The invention belongs to the technical field of medicines, and discloses application of a perilla leaf extract in preparation of a medicine for treating and / or preventing hormone resistant asthma (SRA). The perilla leaf extract disclosed by the invention can be used for remarkably improving the airway hyperreactivity of an SRA mouse; the total number of leukocytes and recruitment of neutrophils in SRA model mouse alveolar lavage fluid are obviously inhibited; the generation of inflammatory cytokines TNF-alpha and IFN-gamma in the SRA mouse alveolar lavage fluid is obviously inhibited; the defect that hormone is ineffective to SRA treatment can be effectively supplemented.
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