Low-temperature freeze-drying equipment and freeze-drying method for freeze-dried powder production

Abstract

The invention discloses low-temperature freeze-drying equipment and a freeze-drying method for freeze-dried powder production, the low-temperature freeze-drying equipment comprises a freeze-drying box body, an intermittent feeding mechanism and a locking stepping mechanism, and the locking stepping mechanism comprises a placing plate and a stepping assembly for driving the placing plate to slide into the freeze-drying box body. After sliding columns and clamping plates on the two sides of a placement plate are aligned with a locking sliding plate and a U-shaped limiting frame correspondingly, the placement plate is placed on the freeze-drying box body to be clamped, and the placement plate is driven by a stepping assembly on the inner wall of the freeze-drying box body to gradually enter the freeze-drying box body; when the placing plate moves, the intermittent assembly at one end is driven to push the discharging sliding plate to slide on the L-shaped check block in a reciprocating mode, penicillin bottles falling into the discharging groove are intermittently pushed to fall into the placing plate from the L-shaped check block, it can be ensured that the arrangement modes of the penicillin bottles are consistent, uniformity and high efficiency of the freeze-drying process are facilitated, the manual operation time is shortened, and the labor intensity of workers is reduced. Therefore, the overall efficiency of a production line is obviously improved.

Description

Technical Field

[0001] The invention relates to the technical field of low-temperature freeze-drying equipment, and in particular to low-temperature freeze-drying equipment and a freeze-drying method for producing freeze-dried powder. Background Art

[0002] Freeze-dried powder is a sterile powder injection made by freezing the liquid medicine into a solid state in a sterile environment, and then sublimating the water to dry it in a vacuum. Freeze-dried powder is made by pre-freezing the water in the liquid medicine using a freeze dryer and then sublimating the frozen water in the liquid medicine in a vacuum sterile environment. In short, the water in the liquid medicine is drained in a low-temperature environment to retain its original medicinal effect.

[0003] Chinese patent CN212987793U discloses a low-temperature freeze-drying device for biomedical experiments. The sealed door is opened by a door handle, and then the drug to be freeze-dried in the experiment is placed on a placement tray, the placement tray is placed above a placement seat, and then the sealed door is closed by the door handle. The sealed door is sealed by an installed connecting lock and a lock buckle, which can effectively improve the freeze-drying effect. A glass observation window is installed inside the sealed door, so that during the experiment, the state changes of the drug when it is freeze-dried can be observed in real time very conveniently.

[0004] When using existing low-temperature freeze-drying equipment, workers are required to place all the vials containing medicines neatly on a placement board. Each vial needs to be manually placed and adjusted in position, which is very time-consuming, especially when the number is large. This process affects the overall work efficiency. In addition, workers need to pick up the placement board full of vials and insert it into the freeze-drying equipment. Since the vials are usually glass bottles, during transportation, if the operation is improper or the placement board is unstable, the bottles are easy to fall from the placement board, causing damage, waste or safety hazards, resulting in delays in the entire freeze-drying process. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a low-temperature freeze-drying device and a freeze-drying method for freeze-dried powder production, which has the advantages of intermittent automatic unloading and placement, and solves the problem of long time required for manual placement.

[0006] In order to achieve the above, the problem of long time required for manual placement is solved, and the safety of the vials on the placement board can be ensured. The present invention provides the following technical solutions: A low-temperature freeze-drying device comprises a freeze-drying box, an intermittent feeding mechanism and a locking stepping mechanism, wherein the locking stepping mechanism comprises a placement plate and a stepping assembly for driving the placement plate to slide into the freeze-drying box, the intermittent feeding mechanism comprises a docking box fixedly mounted on the freeze-drying box, a feeding box is fixedly connected to the lower surface of the docking box, a feeding chute is evenly provided in the feeding box, the docking box is used to place a storage assembly, the storage assembly is used to store vials to be freeze-dried at low temperatures and automatically push the vials into the feeding chute in an orderly manner for feeding, a plurality of L-blocks are fixedly connected to the lower side of the feeding box, and the A feeding slide is slidably connected between the L block and the feeding box, and a plurality of feeding troughs are evenly opened on the feeding slide. An intermittent component is arranged at one end of the feeding slide. The intermittent component can be triggered when the placement plate slides into the freeze-drying box. The intermittent component can drive the feeding slide to move forward so that the feeding trough drives the vials on the L block to translate. After the plurality of vials are synchronously translated to the corresponding sides of the L block, they can fall onto the placement plate, thereby realizing the loading of a row of vials, and then the intermittent component drives the feeding slide to move in the opposite direction and reset, and this cycle is repeated to load the vials in the storage assembly onto the placement plate row by row.

[0007] As a preferred solution of the low-temperature freeze-drying equipment described in the present invention, a handle is fixedly connected to the end of the placement plate, a sliding column is fixedly connected to the lower surface of one side of the placement plate, and a clamping plate is connected to the outer wall on the other side of the placement plate through an elastic element. The inner wall surfaces on both sides of the freeze-drying box are respectively fixedly connected with a locking slide and a U-shaped limit frame. After the sliding column and the clamping plate are respectively aligned and inserted into the locking slide and the U-shaped limit frame, the stepping assembly can drive the sliding column to move to drive the placement plate to slide into the interior of the freeze-drying box.

[0008] As a preferred embodiment of the low-temperature freeze-drying equipment of the present invention, the storage assembly includes a storage box plugged into the docking box, one end of the storage box is closed and has a handle fixedly connected to the outside, and the other end of the storage box is provided with a sloped outlet.

[0009] As a preferred solution of the low-temperature freeze-drying equipment described in the present invention, a limiting slide groove is provided on the lower surface of the storage box, a push block is slidably connected in the limiting slide groove, a sliding plate is fixedly connected to the upper surface of the push block, limiting tracks are provided on both sides of the inner wall of the storage box, the sliding plate is slidably connected in the limiting track, and the limiting track extends from the bottom surface of the storage box to the inclined surface outlet.

[0010] As a preferred solution of the low-temperature freeze-drying equipment of the present invention, the end of the sliding piece away from the storage box is connected to a push plate, a sliding inclined block is slidably connected inside the storage box, and a reset spring is connected between the sliding inclined block and the inner wall of the storage box.

[0011] As a preferred solution of the low-temperature freeze-drying equipment described in the present invention, the intermittent component includes a limit plate, a sliding groove, a folding spring piece, an arc-shaped top block and a ratchet plate. The limit plate is fixedly connected to one side of the unloading box, a sliding groove is opened at one end of the unloading slide plate, the limit plate is slidably connected in the sliding groove, a folding spring piece is fixedly installed between the inner wall of the sliding groove and the side of the limit plate, one end of the unloading slide plate is connected to an arc-shaped top block, and one side of the placement plate is fixedly connected to a ratchet plate. In the process of the placement plate sliding into the interior of the freeze-drying box, the arc-shaped top block at one end of the unloading slide plate can contact the ratchet plate on the inner wall of the placement plate.

[0012] As a preferred embodiment of the low-temperature freeze-drying equipment described in the present invention, the stepping assembly includes a motor, a driving disc, a transmission rod, a groove wheel, a rotating roller, a conveyor belt, an L-shaped limit frame, a second folding spring sheet, a second folding spring sheet and a removal slide. The motor is fixedly connected to the freeze-drying box body, and the output end of the motor is fixedly connected to the driving disc. One end of the transmission rod is fixedly connected to the driving disc, and the cylinder at the other end of the transmission rod intermittently contacts the groove wheel, and the groove wheel is rotatably connected to the inner wall of the freeze-drying box body.

[0013] As a preferred solution of the low-temperature freeze-drying equipment described in the present invention, a rotating roller is fixedly connected to one side of the groove wheel, a conveyor belt is sleeved on the rotating roller, an L-shaped limit frame is fixedly connected to one side of the conveyor belt, and the lower surface of the L-shaped limit frame is slidably connected to the locking slide.

[0014] As a preferred solution of the low-temperature freeze-drying equipment described in the present invention, a folding spring sheet 2 is fixedly installed in the L-shaped limit frame, one end of the folding spring sheet 2 is fixedly connected to a snap-in bevel block, the snap-in bevel block is slidably connected in the L-shaped limit frame, and one end of the locking slide is fixedly connected to a removal slide.

[0015] To achieve the above object, the present invention provides the following technical solution: a freeze-drying method for freeze-dried powder production, using the above low-temperature freeze-drying equipment, comprising the following steps: First, by inserting the storage components with vials into the docking box respectively, the storage components will automatically push the built-in vials to the unloading chute below. After the vials are removed from the storage components, they will slide along the unloading chute to be arranged in the unloading box. Since an L block is installed under each unloading chute to limit the outlet under the unloading chute, when the placement plate has not yet been snapped onto the freeze-drying box, the unloading troughs on the unloading slide board are vertically aligned with the outlet of the upper unloading chute. The first vial pushed out of the storage component will slide from the unloading chute to the upper surface of the L block and be located in the unloading trough below the unloading box. The rest The vials will then be arranged and stacked in the unloading chute. When the sliding columns and the clamping plates on both sides of the placement plate are aligned with the locking slide and the U-shaped limit frame respectively, the placement plate will be placed on the freeze-drying chamber for clamping. The placement plate will be driven gradually into the freeze-drying chamber by the stepping assembly on the inner wall of the freeze-drying chamber. While the placement plate moves, it will drive the intermittent assembly at one end to push the unloading slide to slide back and forth on the L block, intermittently pushing the vials that fall into the unloading chute to fall from the L block to the placement plate. When the placement plate is completely entered into the freeze-drying chamber, the intermittent assembly will stop pushing, so that all the vials enter the freeze-drying chamber on the placement plate for freeze-drying.

[0016] Compared with the known prior art, the technical solution provided by the present invention has the following beneficial effects: 1. After aligning the sliding columns and the clamping plate on both sides of the placement plate with the locking slide plate and the U-shaped limit frame respectively, the placement plate is placed on the freeze-drying box for clamping, ensuring that the placement plate can be limited at the entrance of the freeze-drying box to prevent the placement plate from loosening and sliding from the freeze-drying box. The placement plate is driven to gradually enter the freeze-drying box through the stepping assembly on the inner wall of the freeze-drying box. While the placement plate moves, it drives the intermittent assembly at one end to push the unloading slide plate to slide back and forth on the L block, and intermittently pushes the vials that fall into the unloading chute to fall from the L block to the placement plate, which can ensure that the arrangement of the vials is consistent, which is beneficial to the uniformity and efficiency of the freeze-drying process. When the placement plate enters the freeze-drying box, the vials can be quickly and accurately placed side by side on the placement plate, reducing the time of manual operation, thereby significantly improving the overall efficiency of the production line.

[0017] 2. When the storage assembly is inserted into the docking box, the push block on the lower surface of the storage box will come into contact with the discharge box below the docking box, and the push block will drive the sliding piece to slide into the storage box along the limit track to open the inclined outlet. The reset spring will push the sliding inclined block to slide under the reaction force, and the sliding inclined block will slide along the inner wall of the storage box to push the vial to gradually slide along the inclined edge into the discharge chute, which can better manage inventory and avoid downtime or delays caused by out-of-stock. The automated replenishment process can bring a smoother user experience and reduce the dependence on operator skills, thereby improving the reliability and stability of the system.

[0018] 3. When the placement plate is driven by the stepping component to gradually enter the freeze-drying chamber, the intermittent component will be triggered at the same time, so that the arc-shaped top block at one end of the unloading slide slides along the surface of the sliding piece, driving the unloading slide to slide left and right on the L block. The limit plate will squeeze the folding spring piece 1 in the sliding groove, so that the vials in the unloading trough are intermittently unloaded and dropped into the placement plate for arrangement. Intermittent unloading can ensure that the vials are neatly arranged on the placement plate, which is convenient for subsequent retrieval and operation, improves work efficiency, and can better monitor the quantity and status of each unloading to avoid accumulation of vials when they are arranged on the placement plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the prior art descriptions. Obviously, the drawings described below are only some embodiments of the present invention, and for ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0020] Figure 1 It is a schematic diagram of the overall three-dimensional structure of the low-temperature freeze-drying equipment in the present invention; Figure 2 It is a structural schematic diagram of the freeze-drying box of the low-temperature freeze-drying equipment in the present invention; Figure 3 This is a schematic diagram of the structure of the placement plate of the low-temperature freeze-drying equipment in the present invention; Figure 4 This is a structural schematic diagram of the unloading slide plate of the low-temperature freeze-drying equipment of the present invention; Figure 5 This is a schematic diagram of the structure of the feed box of the low-temperature freeze-drying equipment of the present invention; Figure 6 This is a schematic diagram of the structure of the storage component of the low-temperature freeze-drying equipment of the present invention; Figure 7 This is a schematic diagram of the structure of the storage box of the low-temperature freeze-drying equipment in the present invention; Figure 8 This is a structural schematic diagram of the clamping plate of the low-temperature freeze-drying equipment in the present invention; Fig. 9 It is a structural schematic diagram of the stepping assembly of the low-temperature freeze-drying equipment of the present invention; Fig.10 It is a structural schematic diagram of the enlarged portion of the stepping component A of the low-temperature freeze-drying equipment in the present invention.

[0021] In the figure: 100, freeze-drying box; 200, intermittent feeding mechanism; 201, docking box; 202, feeding box; 203, feeding slide; 204, vial; 205, L stopper; 206, feeding slide; 207, feeding trough; 208, storage box; 209, handle 1; 210, push block; 211, sliding plate; 212, limit slide; 213, limit track; 214, push plate; 215, sliding inclined block; 216, reset spring; 217, limit plate; 218, sliding trough; 2 19. Folding spring piece 1; 220. Arc-shaped top block; 221. Ratchet plate; 300. Locking stepping mechanism; 301. Placement plate; 302. Handle 2; 303. Sliding column; 304. Snap-on plate; 305. Locking slide plate; 306. U-shaped limit frame; 307. Motor; 308. Driving disc; 309. Transmission rod; 310. Grooved wheel; 311. Rotating roller; 312. Conveyor belt; 313. L-shaped limit frame; 314. Folding spring piece 2; 315. Snap-on oblique block; 316. Take out slide plate. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] The present invention will be further described below in conjunction with the embodiments. Example 1

[0024] Reference Figure 1-Figure 5 , Figure 8 , which is the first embodiment of the present invention, provides a low-temperature freeze-drying device, including a freeze-drying box 100, an intermittent feeding mechanism 200 and a locking stepping mechanism 300, the locking stepping mechanism 300 includes a placement plate 301 and a stepping assembly for driving the placement plate 301 to slide into the freeze-drying box 100, the intermittent feeding mechanism 200 includes a docking box 201 fixedly mounted on the freeze-drying box 100, the lower surface of the docking box 201 is fixedly connected to a feeding box 202, and the feeding box 202 is evenly opened The material discharge slide 203 and the docking box 201 are used to place the storage assembly, and the storage assembly is used to store the vials 204 to be freeze-dried and automatically push the vials 204 to enter the material discharge slide 203 in an orderly manner for refilling. A plurality of L-blocks 205 are fixedly connected to the lower side of the material discharge box 202, and a material discharge slide 206 is slidably connected between the L-blocks 205 and the material discharge box 202. A plurality of material discharge grooves 207 are evenly opened on the material discharge slide 206, and an intermittent assembly is arranged at one end of the material discharge slide 206; When the placement plate 301 slides into the freeze-drying box 100, the intermittent component can be triggered, and the intermittent component can drive the unloading slide 206 to move forward so that the unloading chute 207 drives the vials 204 on the L block 205 to move horizontally. After several vials 204 are synchronously translated to the corresponding sides of the L block 205, they can fall onto the placement plate 301 to realize the loading of a row of vials 204, and then the intermittent component drives the unloading slide 206 to move in the opposite direction and reset, and this cycle is repeated to load the vials 204 in the storage component onto the placement plate 301 row by row.

[0025] Specifically, the bottom surface of the placement plate 301 is provided with placement slots in a linear array, the number of placement slots in each row of the placement plate 301 is consistent with the number of storage components that can be placed in the docking box 201, and the number of placement slots in each column is consistent with the number of vials 204 that can be stored in the storage component; The positions and quantities of the L-blocks 205 correspond one to one with the material discharge chute 203 , and the quantity of the material discharge troughs 207 is consistent with the quantity of the L-blocks 205 .

[0026] A handle 302 is fixedly connected to the end of the placement plate 301, a sliding column 303 is fixedly connected to the lower surface of one side of the placement plate 301, and a clamping plate 304 is connected to the outer wall on the other side of the placement plate 301 through an elastic element. The inner wall surfaces on both sides of the freeze-drying box 100 are respectively fixedly connected with a locking slide 305 and a U-shaped limit frame 306. After the sliding column 303 and the clamping plate 304 are aligned and inserted into the locking slide 305 and the U-shaped limit frame 306 respectively, the stepping assembly can drive the sliding column 303 to move to drive the placement plate 301 to slide into the interior of the freeze-drying box 100.

[0027] Specifically, by inserting the storage components containing the vials 204 into the docking box 201 respectively, the storage components will automatically push the built-in vials 204 to the unloading chute 203 below. After the vials 204 are removed from the storage components, they will slide along the unloading chute 203 to be arranged in the unloading box 202. Since an L stopper 205 is installed under each unloading chute 203, the outlet under the unloading chute 203 is limited and blocked. When the placement plate 301 has not yet been snapped onto the freeze-drying box 100, the unloading trough 207 on the unloading slide plate 206 is vertically aligned with the outlet of the upper unloading chute 203. The first vial 204 pushed out from the storage component will slide from the unloading chute 203 to the upper surface of the L stopper 205 and into the unloading trough 207 below the unloading box 202. 4 will be immediately arranged in the unloading slide 203 for stacking. When the sliding columns 303 and the clamping plate 304 on both sides of the placing plate 301 are aligned with the locking slide 305 and the U-shaped limit frame 306 respectively, the placing plate 301 is placed on the freeze-drying box 100 for clamping. The placing plate 301 is driven by the stepping assembly on the inner wall of the freeze-drying box 100 to gradually enter the freeze-drying box 100. When the placing plate 301 moves, it drives the intermittent assembly at one end to push the unloading slide 206 to slide back and forth on the L stopper 205, and intermittently pushes the vials 204 that fall into the unloading chute 207 to fall from the L stopper 205 to the placing plate 301. When the placing plate 301 completely enters the freeze-drying box 100, the intermittent assembly will stop pushing, so that all the vials 204 on the placing plate 301 enter the freeze-drying box 100 for freeze drying.

[0028] After the sliding posts 303 and the clamping plates 304 on both sides of the placing plate 301 are aligned with the locking slide plate 305 and the U-shaped limiting frame 306 respectively, the placing plate 301 is placed on the freeze-drying box 100 for clamping, ensuring that the placing plate 301 can be limited at the entrance of the freeze-drying box 100 to prevent the placing plate 301 from loosening and sliding off the freeze-drying box 100. The placing plate 301 is driven gradually into the freeze-drying box 100 by the stepping assembly on the inner wall of the freeze-drying box 100, and the intermittent plate 306 at one end is driven while the placing plate 301 moves. The component pushes the unloading slide 206 to slide back and forth on the L block 205, and intermittently pushes the vials 204 that fall into the unloading chute 207 to fall from the L block 205 to the placement plate 301, which can ensure that the arrangement of the vials 204 is consistent, which is beneficial to the uniformity and efficiency of the freeze-drying process. The placement plate 301 can quickly and accurately place the vials 204 side by side on the placement plate 301 while entering the freeze-drying box 100, reducing the time of manual operation, thereby significantly improving the overall efficiency of the production line. Example 2

[0029] Reference Figure 5-Figure 8, which is the second embodiment of the present invention, provides a low-temperature freeze-drying device, wherein the storage assembly includes a storage box 208 plugged into a docking box 201, one end of the storage box 208 is closed and has a handle 209 fixedly connected to the outside, and the other end of the storage box 208 is provided with a bevel outlet, and the docking box 201 and its corresponding inner wall are also provided with a bevel.

[0030] A limiting groove 212 is provided on the lower surface of the storage box 208, and a push block 210 is slidably connected in the limiting groove 212. A sliding piece 211 is fixedly connected to the upper surface of the push block 210. Limiting tracks 213 are provided on both sides of the inner wall of the storage box 208. The sliding piece 211 is slidably connected in the limiting track 213. The limiting track 213 extends from the bottom surface of the storage box 208 to the inclined surface exit.

[0031] The end of the sliding piece 211 away from the storage box 208 is connected to a push plate 214, and a sliding bevel block 215 is slidably connected inside the storage box 208. A reset spring piece 216 is connected between the sliding bevel block 215 and the inner wall of the storage box 208. The sliding bevel block 215 is in the shape of an inclined rectangle, and the size of the sliding bevel block 215 fits the inner wall of the storage box 208. The sliding bevel block 215 cooperates with the reset spring piece 216 to push the vial 204 in the storage box 208 out.

[0032] Specifically, the sliding piece 211 is made of a relatively flexible metal material, which can adapt to the inclined outlet at one end of the storage box 208. When the push block 210 or the push plate 214 moves under the action of an external force, it can drive the sliding piece 211 to slide along the limiting track 213. The intermittent component includes a limit plate 217, a sliding groove 218, a folding spring piece 219, an arc-shaped top block 220 and a ratchet plate 221. The limit plate 217 is fixedly connected to one side of the unloading box 202. A sliding groove 218 is provided at one end of the unloading slide 206. The limit plate 217 is slidably connected in the sliding groove 218. A folding spring piece 219 is fixedly installed between the inner wall of the sliding groove 218 and the side of the limit plate 217. One end of the unloading slide 206 is connected to the arc-shaped top block 220. One side of the placement plate 301 is fixedly connected to the ratchet plate 221. When the placement plate 301 slides into the freeze-drying box, the arc-shaped top block 220 at one end of the unloading slide 206 will contact the ratchet plate 221 on the inner wall of the placement plate 301.

[0033] Specifically, when the storage assembly has not yet been inserted into the docking box 201, a certain amount of vials 204 are contained in the storage box 208. At this time, the sliding bevel block 215 in the storage box 208 is pushed to one end by the vials 204 to squeeze the reset spring piece 216, and the push plate 214 is pulled upward obliquely to drive the sliding piece 211 to slide along the limiting slide groove 212 to the inclined surface outlet to close. By making the sliding piece 211 cover the inclined surface outlet of the storage box 208, the vials 204 in the storage box 208 can be prevented from falling. When the storage box 208 is inserted into the docking box 201, the push block 210 on the lower surface of the storage box 208 will contact the unloading box 202 below the docking box 201. As the storage box 208 is inserted, the push block 210 slides in the opposite direction along the limiting slide groove 212, driving the sliding piece 211 to slide along the limiting track 213 into the storage box 208, opening the inclined surface outlet, and the reset spring piece 216 pushes the sliding inclined block 215 to slide under the reaction force, and the sliding inclined block 215 slides along the inner wall of the storage box 208 to push the cillin bottle 204 along the inclined surface. When the stepping assembly drives the placing plate 301 to gradually enter the freeze-drying box 100, it will also drive the intermittent assembly to be triggered, and the ratchet plate 221 on one side of the placing plate 301 will contact the arc-shaped top block 220 at one end of the unloading slide plate 206. As the placing plate 301 moves into the freeze-drying box 100, the ratchet plate 221 intermittently pushes the unloading slide plate 2 06 slides back and forth left and right on the L stopper 205. During this process, the limit plate 217 moves along the sliding groove 218. The limit plate 217 squeezes the folding spring piece 219 in the sliding groove 218 while moving. When the arc top block 220 passes along the ratchet block on the ratchet plate 221, the compressed folding spring piece 219 pushes the arc top block 220 to slide and reset under the reaction force, and reciprocates in sequence, so that the vials 204 in the feed chute 207 are intermittently discharged and fall into the placement plate 301 for arrangement. Example 3

[0034] Reference Figure 9-10 , which is the third embodiment of the present invention, provides a low-temperature freeze-drying device, the stepping assembly includes a motor 307, a driving disc 308, a transmission rod 309, a groove wheel 310, a rotating roller 311, a conveyor belt 312, an L-shaped limit frame 313, a folding spring sheet 314, a folding spring sheet 314 and a removal slide 316, the motor 307 is fixedly connected to the freeze-drying box 100, the driving disc 308 is fixedly connected to the output end of the motor 307, one end of the transmission rod 309 is fixedly connected to the driving disc 308, and the cylinder at the other end intermittently contacts with the groove wheel 310, and the groove wheel 310 is rotatably connected to the inner wall of the freeze-drying box 100.

[0035] A rotating roller 311 is fixedly connected to one side of the groove wheel 310, and a conveyor belt 312 is sleeved on the rotating roller 311. An L-shaped limit frame 313 is fixedly connected to one side of the conveyor belt 312. There are two rotating rollers 311, one is fixedly connected to the groove wheel 310, and the other is rotatably connected to the inner wall of the freeze-drying box 100. The lower surface of the L-shaped limit frame 313 is slidably connected to the locking slide 305.

[0036] A folding spring sheet 314 is fixedly installed in the L-shaped limit frame 313, one end of the folding spring sheet 314 is fixedly connected to a snap-in bevel block 315, the snap-in bevel block 315 is slidably connected in the L-shaped limit frame 313, one end of the locking slide 305 is fixedly connected to a removal slide 316, and the locking slide 305 and the removal slide 316 are connected to form a U-shaped and connected slide.

[0037] Specifically, when the placement plate 301 has not been inserted into the freeze-drying box 100, the L-shaped limit frame 313 and the clamping bevel block 315 will be at the entrance of the locking slide 305. By placing the placement plate 301 on the freeze-drying box 100, when the slide column 303 and the clamping plate 304 are aligned with the locking slide 305 and the U-shaped limit frame 306 and inserted, the slide column 303 will slide along the locking slide 305 as soon as it is inserted, and push the clamping bevel block 315 along the inclined surface to contract and squeeze the folded spring piece 2 314 into the L-shaped limit frame 313, and the slide column 303 will pass over the clamping bevel block 315. After the block 315 is moved, the compressed folded spring sheet 314 will push the clamping inclined block 315 outward under the reaction force, clamp the sliding column 303 between the L-shaped limit frame 313 and the clamping inclined block 315, and drive the driving disc 308 and the transmission rod 309 to rotate simultaneously through the output end of the motor 307. While driving the transmission rod 309 to rotate, the driving disc 308 will intermittently contact the groove wheel 310, and drive the rotating roller 311 on the groove wheel 310 to rotate intermittently. The rotating roller 311 rotates to drive the L-shaped limit frame on one side of the conveyor belt 312 The locking plate 301 is pushed into the freeze-drying box 100 by the locking plate 305, and the locking plate 301 is pushed into the freeze-drying box 100. When the vial 204 on the plate 301 is freeze-dried inside the freeze-drying box 100, the vial 204 will be connected to the plate 301 by frost, so that the vial 204 will not shake in the plate 301 when it is taken out. The staff can slide the plate 301 to the right by holding the handle 302, and the locking plate 304 will move under the elastic compression of the elastic element. The placement plate 301 contracts, and the sliding column 303 slides to the right along the gap between the L-shaped limit frame 313 and the clamping bevel block 315 into the removal slide plate 316. At the same time, the placement plate 301 drives the ratchet plate 221 to slide to the right and no longer contacts the reset arc top block 220, so that the ratchet plate 221 can no longer limit the arc top block 220. The placement plate 301 is smoothly taken out of the freeze-drying box 100 by pulling the handle 2 302, and the sliding column 303 pulls the placement plate 301 out of the freeze-drying box 100 along the removal slide plate 316. Example 4

[0038] Reference Figure 1-Figure 5 , Figure 8 , which is a fourth embodiment of the present invention, provides a freeze-drying method for producing freeze-dried powder, using the above-mentioned low-temperature freeze-drying equipment, comprising the following steps: First, by inserting the storage components containing the vials 204 into the docking box 201 respectively, the storage components will automatically push the built-in vials 204 to the unloading chute 203 below. After the vials 204 are removed from the storage components, they will slide along the unloading chute 203 to be arranged in the unloading box 202. Since an L stopper 205 is installed under each unloading chute 203, the outlet under the unloading chute 203 is limited and resisted. When the placement plate 301 has not yet been snapped onto the freeze-drying box 100, the unloading trough 207 on the unloading slide plate 206 is vertically aligned with the outlet of the upper unloading chute 203. The first vial 204 pushed out from the storage component will slide from the unloading chute 203 to the upper surface of the L stopper 205 and into the unloading trough 207 under the unloading box 202. The remaining vials 204 They will then be arranged and stacked in the unloading slide 203. When the sliding columns 303 and the clamping plate 304 on both sides of the placement plate 301 are aligned with the locking slide 305 and the U-shaped limit frame 306 respectively, the placement plate 301 is placed on the freeze-drying box 100 for clamping, and the placement plate 301 is driven by the stepping assembly on the inner wall of the freeze-drying box 100 to gradually enter the freeze-drying box 100. While the placement plate 301 moves, it drives the intermittent assembly at one end to push the unloading slide 206 to slide back and forth on the L block 205, and intermittently pushes the vials 204 that fall into the unloading chute 207 to fall from the L block 205 to the placement plate 301. When the placement plate 301 completely enters the freeze-drying box 100, the intermittent assembly will stop pushing, so that all the vials 204 on the placement plate 301 enter the freeze-drying box 100 for freeze drying.

[0039] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements will not cause the essence of the corresponding technical solutions to deviate from the protection scope of the technical solutions of the embodiments of the present invention.

Claims

1. A low-temperature freeze-drying device, comprising a freeze-drying box, an intermittent feeding mechanism and a locking stepping mechanism, characterized in that: The locking stepping mechanism comprises a placing plate and a stepping assembly for driving the placing plate to slide into the inside of the freeze-drying box, the intermittent feeding mechanism comprises a docking box fixedly mounted on the freeze-drying box, the lower surface of the docking box is fixedly connected to a feeding box, feeding slides are evenly provided in the feeding box, the docking box is used to place a storage assembly, the storage assembly is used to store the vials to be freeze-dried and automatically push the vials into the feeding slide in an orderly manner for feeding, a plurality of L blocks are fixedly connected to the bottom of the feeding box, a feeding slide is slidably connected between the L block and the feeding box, a plurality of feeding grooves are evenly provided on the feeding slide, and an intermittent assembly is provided at one end of the feeding slide; The intermittent component can be triggered during the process of the placement plate sliding into the freeze-drying box, and the intermittent component can drive the unloading slide plate to move forward so that the unloading chute drives the vials on the L block to move horizontally, and the vials can fall onto the placement plate after being synchronously translated to the corresponding sides of the L block, thereby realizing the loading of a row of vials, and then the intermittent component drives the unloading slide plate to move in the opposite direction and reset, and this cycle is repeated to load the vials in the storage component onto the placement plate row by row.

2. A low temperature freeze drying device according to claim 1, characterized in that: A second handle is fixedly connected to the end of the placement plate, a sliding column is fixedly connected to the lower surface of one side of the placement plate, a clamping plate is connected to the outer wall on the other side of the placement plate through an elastic element, and a locking slide and a U-shaped limit frame are fixedly connected to the inner wall surfaces on both sides of the freeze-drying box respectively. After the sliding column and the clamping plate are aligned and inserted into the locking slide and the U-shaped limit frame respectively, the stepping assembly can drive the sliding column to move to drive the placement plate to slide into the interior of the freeze-drying box.

3. A low temperature freeze drying device according to claim 2, characterized in that: The storage assembly comprises a storage box inserted in the docking box, one end of the storage box is closed and has a handle fixedly connected to the outside, and the other end of the storage box is provided with an inclined outlet.

4. A low temperature freeze drying device according to claim 3, characterized in that: A limiting slide groove is provided on the lower surface of the storage box, a push block is slidably connected in the limiting slide groove, a sliding plate is fixedly connected to the upper surface of the push block, limiting tracks are provided on both sides of the inner wall of the storage box, the sliding plate is slidably connected in the limiting track, and the limiting track extends from the bottom surface of the storage box to the inclined surface exit.

5. A low temperature freeze drying device according to claim 4, characterized in that: The end of the sliding sheet away from the storage box is connected with a push plate, the storage box is slidably connected with a sliding inclined block, and a reset spring is connected between the sliding inclined block and the inner wall of the storage box.

6. A low temperature freeze drying device according to claim 5, characterized in that: The intermittent component includes a limit plate, a sliding groove, a folding spring piece, an arc-shaped top block and a ratchet plate, the limit plate is fixedly connected to one side of the unloading box, a sliding groove is opened at one end of the unloading slide plate, the limit plate is slidably connected in the sliding groove, a folding spring piece is fixedly installed between the inner wall of the sliding groove and the side of the limit plate, one end of the unloading slide plate is connected to an arc-shaped top block, and one side of the placement plate is fixedly connected to a ratchet plate. In the process of the placement plate sliding into the interior of the freeze-drying box, the arc-shaped top block at one end of the unloading slide plate can contact the ratchet plate on the inner wall of the placement plate.

7. A low temperature freeze drying device according to claim 6, characterized in that: The stepping assembly includes a motor, a driving disc, a transmission rod, a groove wheel, a rotating roller, a conveyor belt, an L-shaped limit frame, a second folding spring sheet, a second folding spring sheet and a removal slide. The motor is fixedly connected to the motor on the freeze-drying box body, and the output end of the motor is fixedly connected to the driving disc. One end of the transmission rod is fixedly connected to the driving disc, and the cylinder at the other end of the transmission rod intermittently contacts the groove wheel, and the groove wheel is rotatably connected to the inner wall of the freeze-drying box body.

8. A low temperature freeze drying device according to claim 7, characterized in that: A rotating roller is fixedly connected to one side of the groove wheel, a conveyor belt is sleeved on the rotating roller, an L-shaped limit frame is fixedly connected to one side of the conveyor belt, and the lower surface of the L-shaped limit frame is slidably connected to the locking slide.

9. A low temperature freeze drying device according to claim 8, characterized in that: A folding spring sheet 2 is fixedly installed in the L-shaped limit frame, one end of the folding spring sheet 2 is fixedly connected to a clamping oblique block, the clamping oblique block is slidably connected in the L-shaped limit frame, and one end of the locking slide is fixedly connected to a removal slide.

10. A freeze-drying method for producing freeze-dried powder, using the low-temperature freeze-drying equipment according to any one of claims 1 to 9, comprising the following steps: First, by inserting the storage components with vials into the docking box respectively, the storage components will automatically push the built-in vials to the unloading chute below. After the vials are removed from the storage components, they will slide along the unloading chute to be arranged in the unloading box. Since an L block is installed under each unloading chute to limit the outlet under the unloading chute, when the placement plate has not yet been snapped onto the freeze-drying box, the unloading troughs on the unloading slide board are vertically aligned with the outlet of the upper unloading chute. The first vial pushed out of the storage component will slide from the unloading chute to the upper surface of the L block and be located in the unloading trough below the unloading box. The rest The vials will then be arranged and stacked in the unloading chute. When the sliding columns and the clamping plates on both sides of the placement plate are aligned with the locking slide and the U-shaped limit frame respectively, the placement plate will be placed on the freeze-drying chamber for clamping. The placement plate will be driven gradually into the freeze-drying chamber by the stepping assembly on the inner wall of the freeze-drying chamber. While the placement plate moves, it will drive the intermittent assembly at one end to push the unloading slide to slide back and forth on the L block, intermittently pushing the vials that fall into the unloading chute to fall from the L block to the placement plate. When the placement plate is completely entered into the freeze-drying chamber, the intermittent assembly will stop pushing, so that all the vials enter the freeze-drying chamber on the placement plate for freeze-drying.

Images